KEGG   PATHWAY: mpah04810
Entry
mpah04810                   Pathway                                
Name
Regulation of actin cytoskeleton - Mus pahari (shrew mouse)
Class
Cellular Processes; Cell motility
Pathway map
mpah04810  Regulation of actin cytoskeleton
mpah04810

Other DBs
GO: 0030036
Organism
Mus pahari (shrew mouse) [GN:mpah]
Gene
110312794  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
110312844  Gna12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
110312874  Ssh1; protein phosphatase Slingshot homolog 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
110312881  Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
110312925  Arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
110312960  Myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
110312973  Myl10; myosin regulatory light chain 10 isoform X1 [KO:K12756]
110313074  Actb; actin, cytoplasmic 1 [KO:K05692]
110313245  Fgd1; FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
110313345  Msn; moesin isoform X1 [KO:K05763]
110313482  Tmsb4x; thymosin beta-4 [KO:K05764]
110313491  Lpar4; lysophosphatidic acid receptor 4 [KO:K04275]
110313556  Arhgef6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
110314005  Fgf16; fibroblast growth factor 16 [KO:K04358]
110314031  Pak3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
110314168  Diaph2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
110314283  Araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
110314416  [KO:K05759]
110314464  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
110314893  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
110316115  Pip5k1b; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
110316188  Actr3b; actin-related protein 3B [KO:K18584]
110316221  Kras; GTPase KRas isoform X1 [KO:K07827]
110316269  Braf; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
110316323  Arpc4; actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
110316336  Cyfip1; cytoplasmic FMR1-interacting protein 1 [KO:K05749]
110316396  Wasl; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
110316423  Cxcl12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
110316513  Brk1; protein BRICK1 [KO:K05752]
110316713  Chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
110317128  Lpar5; lysophosphatidic acid receptor 5 [KO:K08390]
110317154  Fgf6; fibroblast growth factor 6 [KO:K04358]
110317198  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
110317258  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110317286  Fgf23; fibroblast growth factor 23 [KO:K22428]
110317477  Itga6; integrin alpha-6 isoform X1 [KO:K06485]
110317495  Nckap1; nck-associated protein 1 isoform X1 [KO:K05750]
110317539  C5; complement C5 [KO:K03994]
110317622  Vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
110317761  Pak5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
110317793  Src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
110317810  Itga8; integrin alpha-8 isoform X1 [KO:K06584]
110317852  Pak6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
110317910  Itga4; integrin alpha-4 [KO:K06483]
110318150  C8g; complement component C8 gamma chain [KO:K03999]
110318229  Itgav; integrin alpha-V isoform X1 [KO:K06487]
110318289  Pip4k2a; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
110318312  Myl9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
110318541  Arpc5l; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
110318603  Fgf7; fibroblast growth factor 7 [KO:K04358]
110318956  Gsn; gelsolin isoform X1 [KO:K05768]
110318967  [KO:K02833]
110318980  Chrm5; muscarinic acetylcholine receptor M5 [KO:K04133]
110319039  Chrm4; muscarinic acetylcholine receptor M4 [KO:K04132]
110319095  Itgb6; integrin beta-6 [KO:K06589]
110319115  F2; prothrombin isoform X1 [KO:K01313] [EC:3.4.21.5]
110319274  Mylk2; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
110319567  Hras; GTPase HRas [KO:K02833]
110319750  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110319786  Insrr; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
110319828  Iqgap3; ras GTPase-activating-like protein IQGAP3 [KO:K05767]
110319846  Vav3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
110319929  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
110319957  Pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
110320000  Pfn2; profilin-2 isoform X1 [KO:K05759]
110320006  Egf; pro-epidermal growth factor isoform X1 [KO:K04357]
110320020  Mapk3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
110320340  Nras; GTPase NRas [KO:K07828]
110320512  Fgf2; fibroblast growth factor 2 isoform X1 [KO:K18497]
110320586  Itga10; integrin alpha-10 isoform X1 [KO:K06586]
110320843  Pip5k1a; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
110321148  Pikfyve; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
110321151  Fn1; fibronectin isoform X1 [KO:K05717]
110321188  Abi2; abl interactor 2 isoform X1 [KO:K05751]
110321193  Arhgef4; rho guanine nucleotide exchange factor 4 isoform X1 [KO:K05769]
110321226  Actr3; actin-related protein 3 [KO:K18584]
110321362  Arpc2; actin-related protein 2/3 complex subunit 2 isoform X1 [KO:K05758]
110321418  Cfl1; cofilin-1 [KO:K05765]
110321732  Rras2; ras-related protein R-Ras2 [KO:K07830]
110321734  Arpc5; actin-related protein 2/3 complex subunit 5 isoform X1 [KO:K05754]
110321771  Enah; protein enabled homolog isoform X1 [KO:K05746]
110321797  Cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
110322008  Ppp1r12b; protein phosphatase 1 regulatory subunit 12B [KO:K12329]
110322284  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110322847  Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
110322856  Slc9a1; sodium/hydrogen exchanger 1 [KO:K05742]
110322865  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
110322872  Lpar1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
110322998  Wasf2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
110323245  Pak4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
110323447  C8b; complement component C8 beta chain isoform X1 [KO:K03998]
110323448  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110323615  C8a; complement component C8 alpha chain [KO:K03997]
110324181  Rock2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
110324314  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
110324329  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
110324386  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110324417  Itgb8; integrin beta-8 isoform X1 [KO:K06591]
110324445  Scin; adseverin isoform X1 [KO:K05768]
110324475  Fam49a; protein FAM49A isoform X1 [KO:K27976]
110324632  Cfl2; cofilin-2 [KO:K05765]
110324855  Bdkrb2; B2 bradykinin receptor isoform X1 [KO:K03916]
110324882  Pfn4; profilin-4 [KO:K05759]
110324934  Actn1; alpha-actinin-1 isoform X1 [KO:K05699]
110325005  Bdkrb1; B1 bradykinin receptor [KO:K03915]
110325031  Diaph3; protein diaphanous homolog 3 [KO:K05745]
110325180  Vcl; vinculin isoform X1 [KO:K05700]
110325518  Fgf9; fibroblast growth factor 9 [KO:K04358]
110325540  [KO:K06594]
110325549  Spata13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
110325631  Rgcc; regulator of cell cycle RGCC [KO:K26108]
110325648  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
110325851  Mylpf; myosin regulatory light chain 2, skeletal muscle isoform isoform X1 [KO:K12758]
110325865  Ssh3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
110326173  Apc2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
110326185  Ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
110326220  Itga7; integrin alpha-7 isoform X1 [KO:K06583]
110326224  Pip5k1c; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
110326235  Pip4k2c; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1 [KO:K00920] [EC:2.7.1.149]
110326321  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
110326371  Wasf1; wiskott-Aldrich syndrome protein family member 1 [KO:K05753]
110326378  [KO:K04513]
110326410  [KO:K04526]
110326449  Fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
110326486  Fgf8; fibroblast growth factor 8 isoform X1 [KO:K04358]
110326926  Itgb2; integrin beta-2 [KO:K06464]
110327081  Fgf22; fibroblast growth factor 22 isoform X1 [KO:K04358]
110327234  Rdx; radixin isoform X1 [KO:K05762]
110327244  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110327251  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110327271  Itgax; integrin alpha-X [KO:K06462]
110327315  Itga11; integrin alpha-11 [KO:K06587]
110327401  Mras; ras-related protein M-Ras [KO:K07831]
110327439  Arhgef12; rho guanine nucleotide exchange factor 12 [KO:K07532]
110327528  Itgam; integrin alpha-M isoform X1 [KO:K06461]
110327901  Itga9; integrin alpha-9 isoform X1 [KO:K06585]
110327907  Rhoa; transforming protein RhoA isoform X1 [KO:K04513]
110327924  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
110328811  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110328853  Itga1; integrin alpha-1 [KO:K06480]
110328891  C7; complement component C7 [KO:K03996]
110328985  F2r; proteinase-activated receptor 1 [KO:K03914]
110329030  Itga2; integrin alpha-2 [KO:K06481]
110329060  Fgf10; fibroblast growth factor 10 [KO:K04358]
110329162  C9; complement component C9 [KO:K04000]
110329165  C6; complement component C6 [KO:K03995]
110329290  Iqgap2; ras GTPase-activating-like protein IQGAP2 [KO:K05767]
110329343  Mapk1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
110329345  Itgb5; integrin beta-5 isoform X1 [KO:K06588]
110329346  Mylk; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
110329400  Rras; ras-related protein R-Ras [KO:K07829]
110329471  Myh11; myosin-11 isoform X1 [KO:K10352]
110329559  Pak2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
110329586  Crkl; crk-like protein isoform X1 [KO:K04438]
110329894  Kng1; kininogen-1 [KO:K03898]
110330025  [KO:K03898]
110330040  [KO:K06464]
110330159  Tiam1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
110330408  Limk2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
110330480  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
110330537  Actr2; actin-related protein 2 isoform X1 [KO:K17260]
110330683  Myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
110330786  Fgf5; fibroblast growth factor 5 isoform X1 [KO:K04358]
110330788  Fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
110331028  Pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
110331089  Myh10; myosin-10 isoform X1 [KO:K10352]
110331106  Actg1; actin, cytoplasmic 2 [KO:K05692]
110331194  Baiap2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
110331363  Cyfip2; cytoplasmic FMR1-interacting protein 2 [KO:K05749]
110331523  Pfn1; profilin-1 [KO:K05759]
110331528  Rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
110331534  Git1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
110331582  Itga3; integrin alpha-3 isoform X1 [KO:K06482]
110331648  Ssh2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
110331717  Crk; adapter molecule crk isoform X1 [KO:K04438]
110331761  Gna13; guanine nucleotide-binding protein subunit alpha-13 isoform X1 [KO:K04639]
110331831  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
110331896  Pip4k2b; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
110331902  Itga2b; integrin alpha-IIb [KO:K06476]
110331915  Itgb3; integrin beta-3 [KO:K06493]
110332000  Fgf18; fibroblast growth factor 18 [KO:K04358]
110332021  Itgae; integrin alpha-E isoform X1 [KO:K06524]
110332769  Itgb4; integrin beta-4 isoform X1 [KO:K06525]
110332926  Diaph1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
110333009  Iqgap1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
110333065  Pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
110333164  Myh14; myosin-14 isoform X1 [KO:K10352]
110333195  Apc; adenomatous polyposis coli protein isoform X1 [KO:K02085]
110333309  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
110333346  [KO:K02833]
110333420  [KO:K04526]
110333549  Rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
110333873  Fgd3; FYVE, RhoGEF and PH domain-containing protein 3 [KO:K05722]
110333959  Chrm3; muscarinic acetylcholine receptor M3 [KO:K04131]
110333988  Pfn3; profilin-3 [KO:K05759]
110333996  Fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
110334129  Mylk4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
110334478  Ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
110334491  Itgb7; integrin beta-7 [KO:K06590]
110334582  Myh9; myosin-9 [KO:K10352]
110334621  Itga5; integrin alpha-5 isoform X1 [KO:K06484]
110334678  Rac2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
110334901  Fam49b; protein FAM49B isoform X1 [KO:K27976]
110334904  Fgf19; fibroblast growth factor 19 [KO:K22603]
110334927  Pdgfb; platelet-derived growth factor subunit B [KO:K17386]
110335339  Nckap1l; nck-associated protein 1-like [KO:K05750]
110335458  Myl12b; myosin regulatory light chain 12B isoform X1 [KO:K12757]
110335459  [KO:K12757]
110335780  Sos1; son of sevenless homolog 1 [KO:K03099]
110336107  Vav1; proto-oncogene vav isoform X1 [KO:K05730]
110336309  Arhgap35; rho GTPase-activating protein 35 [KO:K05732]
110336315  Arhgef1; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 1 [KO:K12330]
110336360  Ppp1r12c; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
110336420  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
110336606  Fgf4; fibroblast growth factor 4 [KO:K04358]
110336782  Arhgef7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
110336807  Fgf20; fibroblast growth factor 20 [KO:K04358]
110336809  Fgfr1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
110336830  Lpar2; lysophosphatidic acid receptor 2 [KO:K04291]
110337225  Itgb1; integrin beta-1 isoform X1 [KO:K05719]
110337335  Dock1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
110337447  Bcar1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
110337577  Mylk3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
110337711  Gng14; uncharacterized LOC105372280 homolog [KO:K04347]
110337766  Fgf3; fibroblast growth factor 3 [KO:K04358]
110338480  [KO:K02833]
110338525  Ezr; ezrin isoform X1 [KO:K08007]
110338744  Actn4; alpha-actinin-4 isoform X1 [KO:K05699]
110338839  Fgf21; fibroblast growth factor 21 [KO:K22429]
110338926  Itgal; integrin alpha-L isoform X1 [KO:K05718]
110338978  Mos; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
110339030  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
110339043  Limk1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
110339090  Arpc1b; actin-related protein 2/3 complex subunit 1B isoform X1 [KO:K05757]
110339109  Pxn; LOW QUALITY PROTEIN: paxillin [KO:K05760]
110339155  Arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
mpah04010  MAPK signaling pathway
mpah04510  Focal adhesion
mpah04520  Adherens junction
KO pathway
ko04810   

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