KEGG   PATHWAY: nvs04148
Entry
nvs04148                    Pathway                                
Name
Efferocytosis - Neogale vison (American mink)
Class
Cellular Processes; Transport and catabolism
Pathway map
nvs04148  Efferocytosis
nvs04148

Organism
Neogale vison (American mink) [GN:nvs]
Gene
122889136  ATP8A1; phospholipid-transporting ATPase IA isoform X1 [KO:K14802] [EC:7.6.2.1]
122889234  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
122889698  XKR6; XK-related protein 6 [KO:K26811]
122889870  ADAM9; disintegrin and metalloproteinase domain-containing protein 9 [KO:K06834] [EC:3.4.24.-]
122889955  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122889990  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
122890142  [KO:K06469]
122891117  STAB2; stabilin-2 [KO:K19013]
122891358  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
122891580  ANO4; anoctamin-4 isoform X1 [KO:K19499]
122891683  ANO6; anoctamin-6 isoform X1 [KO:K19500]
122891843  LRP1; prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
122891909  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
122891921  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
122891975  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
122892198  MEGF10; multiple epidermal growth factor-like domains protein 10 [KO:K24068]
122892324  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122892414  RAB5B; ras-related protein Rab-5B [KO:K07888]
122892626  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
122892916  TYRO3; tyrosine-protein kinase receptor TYRO3 [KO:K05116] [EC:2.7.10.1]
122892919  TMEM30B; cell cycle control protein 50B [KO:K26935]
122892965  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
122892966  MEGF11; multiple epidermal growth factor-like domains protein 11 isoform X1 [KO:K24068]
122893415  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
122893446  MFGE8; lactadherin [KO:K17253]
122893492  VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
122893553  HAVCR1; hepatitis A virus cellular receptor 1 isoform X1 [KO:K20413]
122893569  TIMD4; T-cell immunoglobulin and mucin domain-containing protein 4 isoform X1 [KO:K26936]
122893622  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
122893685  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
122894069  GPR132; probable G-protein coupled receptor 132 [KO:K08426]
122894107  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
122894129  ARG2; arginase-2, mitochondrial isoform X1 [KO:K01476] [EC:3.5.3.1]
122894188  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
122894202  THBS1; thrombospondin-1 [KO:K16857]
122894360  VPS39; vam6/Vps39-like protein [KO:K20183]
122894832  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
122895342  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
122895703  EPO; LOW QUALITY PROTEIN: erythropoietin [KO:K05437]
122895963  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
122895969  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
122896913  [KO:K06469]
122897230  [KO:K06469]
122897238  [KO:K06469]
122897426  ATP11C; phospholipid-transporting ATPase IG isoform X1 [KO:K26934]
122898527  CD24; signal transducer CD24 [KO:K06469]
122898607  C1QA; complement C1q subcomponent subunit A [KO:K03986]
122898608  C1QC; complement C1q subcomponent subunit C [KO:K03988]
122898609  C1QB; complement C1q subcomponent subunit B [KO:K03987]
122899196  ARG1; arginase-1 isoform X1 [KO:K01476] [EC:3.5.3.1]
122899519  SLC66A1; lysosomal amino acid transporter 1 homolog isoform X1 [KO:K23678]
122899644  XKR8; XK-related protein 8 [KO:K26813]
122899844  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
122900251  S1PR1; sphingosine 1-phosphate receptor 1 [KO:K04288]
122900338  [KO:K08179]
122900339  [KO:K08179]
122900431  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
122900650  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase isoform X1 [KO:K01052] [EC:3.1.1.13]
122900657  CH25H; cholesterol 25-hydroxylase [KO:K10223] [EC:1.14.99.38]
122900725  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
122900805  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
122900884  ALOX5; polyunsaturated fatty acid 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
122901106  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122901125  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
122901212  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
122901801  ANO7; anoctamin-7 [KO:K19501]
122902030  HAVCR2; hepatitis A virus cellular receptor 2 [KO:K20414]
122902103  GULP1; PTB domain-containing engulfment adapter protein 1 isoform X1 [KO:K23285]
122902244  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
122902452  RAB17; ras-related protein Rab-17 [KO:K07909]
122902666  ITGAV; integrin alpha-V [KO:K06487]
122902796  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
122903051  VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182]
122903191  CRKL; crk-like protein [KO:K04438]
122903200  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122903412  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
122903443  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
122904266  ADGRB1; adhesion G protein-coupled receptor B1 [KO:K04596]
122904271  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
122904524  XKR9; XK-related protein 9 [KO:K26814]
122904591  XKR4; XK-related protein 4 [KO:K26811]
122904626  VPS41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
122904673  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
122904760  CD36; platelet glycoprotein 4 [KO:K06259]
122904984  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
122905383  TMEM30A; LOW QUALITY PROTEIN: cell cycle control protein 50A [KO:K26935]
122905958  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
122906077  PECAM1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
122906101  ITGB3; integrin beta-3 [KO:K06493]
122906201  RAB5C; ras-related protein Rab-5C [KO:K07889]
122906348  SCARF1; scavenger receptor class F member 1 isoform X1 [KO:K24318]
122906356  CRK; adapter molecule crk isoform X1 [KO:K04438]
122906460  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
122906818  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
122906949  ATP8A2; phospholipid-transporting ATPase IB [KO:K14802] [EC:7.6.2.1]
122907253  ATP11A; phospholipid-transporting ATPase IH isoform X1 [KO:K26934]
122907267  GAS6; growth arrest-specific protein 6 [KO:K05464]
122907411  [KO:K14802] [EC:7.6.2.1]
122907757  [KO:K00460] [EC:1.13.11.33]
122908413  PROS1; vitamin K-dependent protein S [KO:K03908]
122908481  CD47; leukocyte surface antigen CD47 isoform X1 [KO:K06266]
122908611  P2RY12; P2Y purinoceptor 12 [KO:K04298]
122908730  ATP11B; phospholipid-transporting ATPase IF isoform X1 [KO:K26934]
122908767  VPS8; vacuolar protein sorting-associated protein 8 homolog isoform X1 [KO:K20178]
122908860  ITGB5; integrin beta-5 [KO:K06588]
122909015  RAB5A; ras-related protein Rab-5A [KO:K07887]
122909064  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
122909146  RAB7A; ras-related protein Rab-7a [KO:K07897] [EC:3.6.5.2]
122909195  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
122909356  STAB1; stabilin-1 [KO:K19020]
122909369  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122909675  CALR; calreticulin [KO:K08057]
122909708  EPOR; erythropoietin receptor [KO:K05079]
122909871  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
122909988  BSG; basigin [KO:K06535]
122910048  [KO:K26935]
122910068  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
122910086  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
122910115  [KO:K00411] [EC:7.1.1.8]
122910126  [KO:K06469]
122910194  PPARD; peroxisome proliferator-activated receptor delta [KO:K04504]
122911232  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
122911312  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
122911315  PLA2G15; phospholipase A2 group XV isoform X1 [KO:K06129] [EC:3.1.1.5]
122911416  CX3CL1; fractalkine [KO:K05508]
122911488  [KO:K00411] [EC:7.1.1.8]
122911752  SIGLEC10; sialic acid-binding Ig-like lectin 10 isoform X1 [KO:K06749]
122911788  NR1H2; oxysterols receptor LXR-beta isoform X1 [KO:K08535]
122911809  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform isoform X1 [KO:K19524] [EC:2.3.1.21]
122911860  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
122912059  AXL; tyrosine-protein kinase receptor UFO isoform X1 [KO:K05115] [EC:2.7.10.1]
122912064  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
122912353  VPS11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
122912481  PANX1; pannexin-1 [KO:K03443]
122912605  P2RY6; P2Y purinoceptor 6 [KO:K04272]
122912606  P2RY2; P2Y purinoceptor 2 [KO:K04269]
122912788  ANO5; anoctamin-5 [KO:K19480]
122912793  ANO3; anoctamin-3 isoform X1 [KO:K19498]
122912893  NR1H3; oxysterols receptor LXR-alpha isoform X1 [KO:K08536]
122913212  ANO9; anoctamin-9 isoform X1 [KO:K19503]
122913242  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122913275  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
122915094  MERTK; tyrosine-protein kinase Mer [KO:K05117] [EC:2.7.10.1]
122915260  DNMT3A; DNA (cytosine-5)-methyltransferase 3A isoform X1 [KO:K17398] [EC:2.1.1.37]
122915316  ODC1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
122915325  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
122915384  [KO:K06551]
122915385  [KO:K06551]
122915594  XKR7; XK-related protein 7 [KO:K26811]
122915614  [KO:K06551]
122915616  [KO:K06551]
122915617  [KO:K06551]
122915618  [KO:K06551]
122915619  [KO:K06551]
122915620  [KO:K06551]
122915770  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122915966  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
122915979  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
122916161  DNMT3B; DNA (cytosine-5)-methyltransferase 3B isoform X1 [KO:K17398] [EC:2.1.1.37]
122916196  [KO:K06551]
122916207  VPS16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
122916352  [KO:K01476] [EC:3.5.3.1]
122916406  TGFBRAP1; transforming growth factor-beta receptor-associated protein 1 [KO:K20177]
122917108  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
122917301  RAB14; ras-related protein Rab-14 [KO:K07881]
122917384  ABCA1; phospholipid-transporting ATPase ABCA1 [KO:K05641]
122917753  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
122918166  IL10; interleukin-10 [KO:K05443]
122918397  PBX1; pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
122918633  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
122918746  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
122918854  RAB7B; ras-related protein Rab-7b [KO:K07898]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
nvs00010  Glycolysis / Gluconeogenesis
nvs04140  Autophagy - animal
nvs04145  Phagocytosis
KO pathway
ko04148   

DBGET integrated database retrieval system