Entry Name Lysosome - Oryctolagus cuniculus (rabbit)
Description Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class Cellular Processes; Transport and catabolismBRITE hierarchy
Pathway map Other DBs Organism Oryctolagus cuniculus (rabbit) [GN:
ocu ]
Gene 100008746 NPC1; NPC intracellular cholesterol transporter 1 precursor [KO:K12385 ]
100009331 LAPTM4A; lysosomal-associated transmembrane protein 4A [KO:K12387 ]
100328697 OSTM1; osteopetrosis-associated transmembrane protein 1 precursor [KO:K23863 ]
100346451 SLC11A1; natural resistance-associated macrophage protein 1 [KO:K12347 ]
Compound Reference Authors Eskelinen EL, Tanaka Y, Saftig P
Title At the acidic edge: emerging functions for lysosomal membrane proteins.
Journal Reference Authors Neufeld EF
Title Lysosomal storage diseases.
Journal Reference Authors von Figura K, Hasilik A
Title Lysosomal enzymes and their receptors.
Journal Reference Authors Janvier K, Bonifacino JS
Title Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
Journal Reference Authors Vergarajauregui S, Puertollano R
Title Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
Journal Reference Authors Jaskolka MC, Winkley SR, Kane PM
Title RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
Journal Reference Authors Majdoul S, Compton AA
Title Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
Journal Reference Authors Saftig P, Klumperman J
Title Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function.
Journal Reference Authors Savini M, Zhao Q, Wang MC
Title Lysosomes: Signaling Hubs for Metabolic Sensing and Longevity.
Journal Reference Authors Meyer-Schwesinger C
Title Lysosome function in glomerular health and disease.
Journal Reference Authors Allemailem KS, Almatroudi A, Alrumaihi F, Almatroodi SA, Alkurbi MO, Basfar GT, Rahmani AH, Khan AA
Title Novel Approaches of Dysregulating Lysosome Functions in Cancer Cells by Specific Drugs and Its Nanoformulations: A Smart Approach of Modern Therapeutics.
Journal Reference Authors Zhang W, Yang X, Li Y, Yu L, Zhang B, Zhang J, Cho WJ, Venkatarangan V, Chen L, Burugula BB, Bui S, Wang Y, Duan C, Kitzman JO, Li M
Title GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway.
Journal Reference Authors Liu Q, Wang W, Xu L, Zhang Q, Wang H
Title The host mannose-6-phosphate pathway and viral infection.
Journal Reference Authors He Y, Fan Y, Ahmadpoor X, Wang Y, Li ZA, Zhu W, Lin H
Title Targeting lysosomal quality control as a therapeutic strategy against aging and diseases.
Journal Reference Authors Radulovic M, Yang C, Stenmark H
Title Lysosomal membrane homeostasis and its importance in physiology and disease.
Journal Reference Authors Watson ET, Wegeng WR, Aravani S, Ernst AM, von Blume J
Title Mechanistic insights into cargo sorting and export from the Golgi apparatus.
Journal Related ocu04130 SNARE interactions in vesicular transport
ocu04620 Toll-like receptor signaling pathway
KO pathway
