KEGG   PATHWAY: panu04620
Entry
panu04620                   Pathway                                
Name
Toll-like receptor signaling pathway - Papio anubis (olive baboon)
Description
Specific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors identified as homologs of Toll in Drosophila. Mammalian TLRs are expressed on innate immune cells, such as macrophages and dendritic cells, and respond to the membrane components of Gram-positive or Gram-negative bacteria. Pathogen recognition by TLRs provokes rapid activation of innate immunity by inducing production of proinflammatory cytokines and upregulation of costimulatory molecules. TLR signaling pathways are separated into two groups: a MyD88-dependent pathway that leads to the production of proinflammatory cytokines with quick activation of NF-{kappa}B and MAPK, and a MyD88-independent pathway associated with the induction of IFN-beta and IFN-inducible genes, and maturation of dendritic cells with slow activation of NF-{kappa}B and MAPK.
Class
Organismal Systems; Immune system
Pathway map
panu04620  Toll-like receptor signaling pathway
panu04620

Organism
Papio anubis (olive baboon) [GN:panu]
Gene
100126717  IL12B; interleukin-12 subunit beta precursor [KO:K05425]
100126718  CD86; T-lymphocyte activation antigen CD86 precursor [KO:K05413]
100126719  IL12A; interleukin-12 subunit alpha precursor [KO:K05406]
100137245  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
100137545  IFNAR2; interferon alpha/beta receptor 2 precursor [KO:K05131]
100381179  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100381195  IL6; interleukin-6 precursor [KO:K05405]
100381196  CXCL8; interleukin-8 precursor [KO:K10030]
100510871  [KO:K05408]
100510873  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X4 [KO:K02649]
100997634  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100997900  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
100998832  TLR1; toll-like receptor 1 [KO:K05398]
100998877  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100999858  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
101000363  TLR6; toll-like receptor 6 [KO:K10169]
101000402  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101001103  MAPK12; mitogen-activated protein kinase 12 isoform X2 [KO:K04441] [EC:2.7.11.24]
101001355  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X2 [KO:K07211] [EC:2.7.11.10]
101001515  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X4 [KO:K04433] [EC:2.7.12.2]
101002143  CD40; tumor necrosis factor receptor superfamily member 5 precursor [KO:K03160]
101002278  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101002393  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101002649  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101002872  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
101002971  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101003041  TLR3; toll-like receptor 3 [KO:K05401]
101003176  [KO:K12964]
101003935  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
101004074  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
101004976  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101005010  MAPK10; mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
101005316  IRF7; interferon regulatory factor 7 isoform X5 [KO:K09447]
101005327  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
101005886  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
101006756  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
101007351  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
101008394  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101008699  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101009041  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
101009470  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
101009748  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
101009981  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101010100  CXCL11; C-X-C motif chemokine 11 isoform X1 [KO:K12672]
101010826  CXCL9; C-X-C motif chemokine 9 [KO:K05416]
101010894  JUN; transcription factor AP-1 [KO:K04448]
101011339  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
101011342  STAT2; LOW QUALITY PROTEIN: signal transducer and activator of transcription 2 [KO:K11221]
101011511  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X2 [KO:K02861] [EC:2.7.11.1]
101011807  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101012041  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101012583  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X2 [KO:K04432] [EC:2.7.12.2]
101013055  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101013579  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
101013588  CD14; monocyte differentiation antigen CD14 [KO:K04391]
101015106  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
101015482  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
101015667  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X2 [KO:K04430] [EC:2.7.12.2]
101015689  SPP1; osteopontin isoform X1 [KO:K06250]
101016003  TLR9; toll-like receptor 9 isoform X3 [KO:K10161]
101016447  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X5 [KO:K07209] [EC:2.7.11.10]
101016516  [KO:K05414]
101017078  RELA; transcription factor p65 isoform X1 [KO:K04735]
101017433  FADD; FAS-associated death domain protein [KO:K02373]
101017759  LBP; lipopolysaccharide-binding protein [KO:K05399]
101017918  [KO:K05414]
101018287  [KO:K05414]
101018336  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
101018652  [KO:K05414]
101019008  [KO:K05414]
101019380  [KO:K05414]
101019884  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101020052  TOLLIP; toll-interacting protein isoform X2 [KO:K05402]
101020343  TLR7; toll-like receptor 7 isoform X1 [KO:K05404]
101020681  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
101020701  TLR8; toll-like receptor 8 isoform X1 [KO:K10170]
101020807  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
101021141  FOS; proto-oncogene c-Fos isoform X1 [KO:K04379]
101021193  CD80; T-lymphocyte activation antigen CD80 [KO:K05412]
101021706  [KO:K05414]
101022150  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
101022320  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101023118  [KO:K05414]
101023446  IL1B; interleukin-1 beta [KO:K04519]
101023751  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101023828  [KO:K05414]
101024189  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101024523  IFNB1; interferon beta [KO:K05415]
101024771  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101024944  MAP3K8; mitogen-activated protein kinase kinase kinase 8 isoform X3 [KO:K04415] [EC:2.7.11.25]
101025351  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
101025455  CCL5; C-C motif chemokine 5 isoform X1 [KO:K12499]
101025790  TLR5; toll-like receptor 5 [KO:K10168]
101025947  IRF5; interferon regulatory factor 5 isoform X1 [KO:K09446]
101026000  LY96; lymphocyte antigen 96 isoform X3 [KO:K05400]
101026781  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X6 [KO:K02580]
103884712  TLR2; toll-like receptor 2 [KO:K10159]
103885341  TICAM2; TIR domain-containing adapter molecule 2 [KO:K05409]
116270026  [KO:K05414]
Reference
PMID:17275323
  Authors
Kawai T, Akira S.
  Title
TLR signaling.
  Journal
Semin Immunol 19:24-32 (2007)
DOI:10.1016/j.smim.2006.12.004
Reference
PMID:17457343
  Authors
O'Neill LA, Bowie AG.
  Title
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling.
  Journal
Nat Rev Immunol 7:353-64 (2007)
DOI:10.1038/nri2079
Reference
PMID:16932750
  Authors
Honda K, Taniguchi T.
  Title
IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors.
  Journal
Nat Rev Immunol 6:644-58 (2006)
DOI:10.1038/nri1900
Reference
PMID:17395581
  Authors
Uematsu S, Akira S.
  Title
Toll-like receptors and Type I interferons.
  Journal
J Biol Chem 282:15319-23 (2007)
DOI:10.1074/jbc.R700009200
Reference
PMID:16497588
  Authors
Akira S, Uematsu S, Takeuchi O.
  Title
Pathogen recognition and innate immunity.
  Journal
Cell 124:783-801 (2006)
DOI:10.1016/j.cell.2006.02.015
Reference
PMID:14698224
  Authors
Yamamoto M, Takeda K, Akira S.
  Title
TIR domain-containing adaptors define the specificity of TLR signaling.
  Journal
Mol Immunol 40:861-8 (2004)
DOI:10.1016/j.molimm.2003.10.006
Reference
PMID:12734364
  Authors
Means TK, Hayashi F, Smith KD, Aderem A, Luster AD.
  Title
The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells.
  Journal
J Immunol 170:5165-75 (2003)
DOI:10.4049/jimmunol.170.10.5165
Reference
PMID:14751764
  Authors
Aderem A, Smith KD.
  Title
A systems approach to dissecting immunity and inflammation.
  Journal
Semin Immunol 16:55-67 (2004)
DOI:10.1016/j.smim.2003.10.002
Reference
PMID:17637696
  Authors
Banerjee A, Gerondakis S.
  Title
Coordinating TLR-activated signaling pathways in cells of the immune system.
  Journal
Immunol Cell Biol 85:420-4 (2007)
DOI:10.1038/sj.icb.7100098
Reference
PMID:17507094
  Authors
Loniewski KJ, Patial S, Parameswaran N.
  Title
Sensitivity of TLR4- and -7-induced NF kappa B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages.
  Journal
Mol Immunol 44:3715-23 (2007)
DOI:10.1016/j.molimm.2007.04.002
Reference
PMID:11101877
  Authors
Arbibe L, Mira JP, Teusch N, Kline L, Guha M, Mackman N, Godowski PJ, Ulevitch RJ, Knaus UG.
  Title
Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway.
  Journal
Nat Immunol 1:533-40 (2000)
DOI:10.1038/82797
Reference
PMID:16924467
  Authors
Uematsu S, Akira S.
  Title
Toll-like receptors and innate immunity.
  Journal
J Mol Med 84:712-25 (2006)
DOI:10.1007/s00109-006-0084-y
Related
pathway
panu04010  MAPK signaling pathway
panu04060  Cytokine-cytokine receptor interaction
panu04064  NF-kappa B signaling pathway
panu04120  Ubiquitin mediated proteolysis
panu04151  PI3K-Akt signaling pathway
panu04210  Apoptosis
panu04610  Complement and coagulation cascades
panu04630  JAK-STAT signaling pathway
KO pathway
ko04620   

DBGET integrated database retrieval system