KEGG   PATHWAY: achc04510
Entry
achc04510                   Pathway                                
Name
Focal adhesion - Aquila chrysaetos chrysaetos (golden eagle)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
achc04510  Focal adhesion
achc04510

Other DBs
GO: 0005925
Organism
Aquila chrysaetos chrysaetos (golden eagle) [GN:achc]
Gene
115344337  COL1A1; LOW QUALITY PROTEIN: collagen alpha-1(I) chain [KO:K06236]
115339332  COL1A2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
115350854  COL2A1; LOW QUALITY PROTEIN: collagen alpha-1(II) chain [KO:K19719]
115333514  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
115333515  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
115347688  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
115347689  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
115334510  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
115334511  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
115343010  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
115342793  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
115342795  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
115338690  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
115339039  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
115352154  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
115344599  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
115340241  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
115338771  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
115340547  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
115336697  LAMA4; laminin subunit alpha-4 [KO:K06241]
115341098  LAMB1; laminin subunit beta-1 [KO:K05636]
115353759  laminin subunit beta-2-like isoform X1 [KO:K06243]
115353757  LOW QUALITY PROTEIN: laminin subunit beta-2-like [KO:K06243]
115335073  LAMB3; laminin subunit beta-3 isoform X1 [KO:K06244]
115342319  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
115349081  LAMC1; laminin subunit gamma-1 [KO:K05635]
115349362  LAMC2; laminin subunit gamma-2 [KO:K06246]
115335396  LAMC3; laminin subunit gamma-3 isoform X1 [KO:K06247]
115342087  CHAD; LOW QUALITY PROTEIN: chondroadherin [KO:K06248]
115341399  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
115336101  THBS1; thrombospondin-1 [KO:K16857]
115349574  cartilage oligomeric matrix protein [KO:K04659]
115350361  THBS2; thrombospondin-2 [KO:K04659]
115337173  THBS4; thrombospondin-4 isoform X1 [KO:K04659]
115346290  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
115342628  FN1; fibronectin isoform X1 [KO:K05717]
115342701  SPP1; osteopontin isoform X1 [KO:K06250]
115347424  VTN; vitronectin [KO:K06251]
115338478  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
115349663  TNN; tenascin-N [KO:K06252]
115335124  TNC; tenascin isoform X1 [KO:K06252]
115349187  TNR; tenascin-R isoform X1 [KO:K06252]
115352510  VWF; von Willebrand factor [KO:K03900]
115347051  bone sialoprotein 2 isoform X1 [KO:K06253]
115336652  ITGA1; integrin alpha-1 [KO:K06480]
115336494  ITGA2; integrin alpha-2 isoform X2 [KO:K06481]
115344825  ITGA2B; LOW QUALITY PROTEIN: integrin alpha-IIb [KO:K06476]
115344340  ITGA3; integrin alpha-3 [KO:K06482]
115342518  ITGA4; integrin alpha-4 [KO:K06483]
115342642  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
115350858  ITGA7; integrin alpha-7 [KO:K06583]
115339680  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
115339665  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
115345835  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
115341970  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
115343263  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
115339345  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
115345001  ITGB3; integrin beta-3 [KO:K06493]
115341344  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
115342811  ITGB5; LOW QUALITY PROTEIN: integrin beta-5 [KO:K06588]
115343304  ITGB6; integrin beta-6 [KO:K06589]
115351399  ITGB7; integrin beta-7 [KO:K06590]
115338779  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
115335898  EMP2; epithelial membrane protein 2 [KO:K26256]
115335808  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
115352795  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
115346275  PDGFC; platelet-derived growth factor C [KO:K05450]
115353500  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
115344703  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
115352695  IGF1; insulin-like growth factor I [KO:K05459]
115350086  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
115337354  PGF; placenta growth factor [KO:K16859]
115334714  VEGFD; vascular endothelial growth factor D [KO:K05449]
115342576  VEGFC; vascular endothelial growth factor C [KO:K05449]
115341991  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
115341064  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
115334242  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
115341184  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
115343684  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
115338920  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
115333495  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
115353436  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
115334261  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
115341817  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
115344932  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
115336354  EMP1; epithelial membrane protein 1 [KO:K26255]
115339513  SRC; proto-oncogene tyrosine-protein kinase Src isoform X3 [KO:K05704] [EC:2.7.10.2]
115338290  rho GTPase-activating protein 35 [KO:K05732]
115338291  rho GTPase-activating protein 35-like [KO:K05732]
115351406  ARHGAP5; rho GTPase-activating protein 5 [KO:K13709]
115353760  RHOA; transforming protein RhoA [KO:K04513]
115340145  ROCK1; rho-associated protein kinase 1 isoform X2 [KO:K04514] [EC:2.7.11.1]
115351142  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
115345956  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
115349922  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
115339909  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
115347623  MYL10; myosin regulatory light chain 10 [KO:K12756]
115340208  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
115350480  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
115337541  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
115346179  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
115336095  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
115334870  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
115339138  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
115346654  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
115353120  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
115342719  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
115345195  LOW QUALITY PROTEIN: myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
115336472  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
115345542  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
115348832  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X2 [KO:K00889] [EC:2.7.1.68]
115336033  ACTB; actin, cytoplasmic 1 [KO:K05692]
115340949  ACTG1; actin, cytoplasmic 2 [KO:K05692]
115341775  actin, cytoplasmic type 5 [KO:K05692]
115341759  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
115349962  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
115338181  ACTN4; alpha-actinin-4 isoform X2 [KO:K05699]
115353066  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
115336764  TLN1; talin-1 [KO:K06271]
115341116  TLN2; talin-2 isoform X1 [KO:K06271]
115353823  FLNB; filamin-B isoform X3 [KO:K27392]
115346227  PXN; paxillin isoform X1 [KO:K05760]
115353222  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
115343992  ZYX; zyxin isoform X1 [KO:K06273]
115338052  vasodilator-stimulated phosphoprotein-like isoform X2 [KO:K06274]
115338053  LOW QUALITY PROTEIN: vasodilator-stimulated phosphoprotein-like [KO:K06274]
115348369  VCL; vinculin isoform X1 [KO:K05700]
115351920  PARVA; alpha-parvin isoform X1 [KO:K06275]
115352609  PARVB; beta-parvin isoform X1 [KO:K06275]
115352727  PARVG; gamma-parvin [KO:K06275]
115335528  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
115350251  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
115338049  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
115338050  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
115347910  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
115344107  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
115338857  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
115341437  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
115335844  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
115340288  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
115347173  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
115347305  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
115342450  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
115349575  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
115337134  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
121233034  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
115348975  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
115348120  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
115335021  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
115348546  LOW QUALITY PROTEIN: proto-oncogene vav-like [KO:K05730]
115348976  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
115335619  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
115352715  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
115340958  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
115353441  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
115346855  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
115333461  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
115338174  serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
115338183  serine/threonine-protein kinase PAK 4-like [KO:K05734] [EC:2.7.11.1]
115344239  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
115352095  serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
115342739  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
115345831  BCAR1; LOW QUALITY PROTEIN: breast cancer anti-estrogen resistance protein 1 [KO:K05726]
115346006  CRKL; crk-like protein [KO:K04438]
115346773  CRK; adapter molecule crk isoform X2 [KO:K04438]
115347969  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
115334989  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
115335056  RAP1A; ras-related protein Rap-1A [KO:K04353]
115336097  RAP1B; ras-related protein Rap-1b isoform X2 [KO:K07836]
115338798  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
115334063  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
115347976  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
115348746  JUN; transcription factor AP-1 [KO:K04448]
115352782  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
115342024  CAV1; caveolin-1 [KO:K06278]
115342018  CAV2; caveolin-2 [KO:K12958]
115333448  CAV3; caveolin-3 [KO:K12959]
115349460  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
115345778  SHC1; SHC-transforming protein 1 isoform X3 [KO:K06279]
115349526  SHC2; SHC-transforming protein 2 [KO:K17447]
115337159  SHC3; LOW QUALITY PROTEIN: SHC-transforming protein 3 [KO:K17448]
115341918  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
115341010  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
115351224  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
115352127  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
115351819  HRAS; GTPase HRas [KO:K02833]
115353699  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
115342153  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
115346261  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
115351476  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
115352414  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
115335097  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
115353209  inhibitor of apoptosis protein isoform X1 [KO:K16060]
115333630  E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
115353069  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
achc04010  MAPK signaling pathway
achc04060  Cytokine-cytokine receptor interaction
achc04070  Phosphatidylinositol signaling system
achc04110  Cell cycle
achc04310  Wnt signaling pathway
achc04512  ECM-receptor interaction
achc04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
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