KEGG   PATHWAY: achc04010
Entry
achc04010                   Pathway                                
Name
MAPK signaling pathway - Aquila chrysaetos chrysaetos (golden eagle)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
achc04010  MAPK signaling pathway
achc04010

Other DBs
GO: 0000165
Organism
Aquila chrysaetos chrysaetos (golden eagle) [GN:achc]
Gene
115333267  DUSP7; dual specificity protein phosphatase 7 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
115333325  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
115333423  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
115333479  NRK; nik-related protein kinase isoform X1 [KO:K04407] [EC:2.7.11.1]
115333491  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
115333495  [KO:K05096] [EC:2.7.10.1]
115333634  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
115333806  FOS; LOW QUALITY PROTEIN: proto-oncogene c-Fos [KO:K04379]
115333915  FGF16; fibroblast growth factor 16 [KO:K04358]
115334029  [KO:K16342] [EC:3.1.1.4]
115334052  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
115334063  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
115334108  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
115334242  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
115334261  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
115334290  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
115334328  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
115334399  FGF18; fibroblast growth factor 18 [KO:K04358]
115334502  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
115334517  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
115334714  VEGFD; vascular endothelial growth factor D [KO:K05449]
115334762  NGF; beta-nerve growth factor [KO:K02582]
115334823  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
115334828  [KO:K04441] [EC:2.7.11.24]
115334933  ELK4; LOW QUALITY PROTEIN: ETS domain-containing protein Elk-4 [KO:K04376]
115335049  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
115335051  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
115335056  RAP1A; ras-related protein Rap-1A [KO:K04353]
115335203  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
115335241  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
115335375  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
115335407  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
115335439  NRAS; GTPase NRas isoform X1 [KO:K07828]
115335462  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
115335542  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
115335619  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
115335761  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
115335808  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
115335844  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
115335855  CACNA1H; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
115335899  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
115335939  CACNG3; voltage-dependent calcium channel gamma-3 subunit isoform X1 [KO:K04868]
115336097  RAP1B; ras-related protein Rap-1b isoform X2 [KO:K07836]
115336149  KITLG; kit ligand isoform X1 [KO:K05461]
115336288  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
115336342  TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
115336345  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
115336501  RASA1; ras GTPase-activating protein 1 isoform X2 [KO:K04352]
115336686  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
115336699  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
115336889  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
115336915  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X2 [KO:K04416] [EC:2.7.11.25]
115336920  [KO:K16342] [EC:3.1.1.4]
115336927  [KO:K16342] [EC:3.1.1.4]
115336931  [KO:K16342] [EC:3.1.1.4]
115336937  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
115337108  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
115337246  FGF10; fibroblast growth factor 10 [KO:K04358]
115337258  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
115337302  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
115337354  PGF; placenta growth factor [KO:K16859]
115337438  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
115337676  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
115337723  RELB; transcription factor RelB isoform X1 [KO:K09253]
115337976  CACNA1A; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
115337979  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
115338049  [KO:K04456] [EC:2.7.11.1]
115338050  [KO:K04456] [EC:2.7.11.1]
115338081  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
115338168  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
115338229  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
115338264  TP53; LOW QUALITY PROTEIN: cellular tumor antigen p53 [KO:K04451]
115338339  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
115338356  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
115338447  MAX; protein max isoform X1 [KO:K04453]
115338603  [KO:K16342] [EC:3.1.1.4]
115338604  [KO:K16342] [EC:3.1.1.4]
115338798  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
115338920  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
115338925  CDC25B; M-phase inducer phosphatase 2 isoform X2 [KO:K05866] [EC:3.1.3.48]
115339160  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
115339371  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
115339459  STK4; serine/threonine-protein kinase 4 isoform X2 [KO:K04411]
115339536  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
115339666  CACNB2; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-2 [KO:K04863]
115339806  [KO:K04421] [EC:2.7.11.25]
115339876  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
115340248  EREG; proepiregulin isoform X1 [KO:K09784]
115340251  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
115340706  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
115340741  MYC; LOW QUALITY PROTEIN: myc proto-oncogene protein [KO:K04377]
115340744  ANGPT1; angiopoietin-1 [KO:K05465]
115340931  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
115340958  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
115341010  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
115341041  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
115341064  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
115341184  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
115341201  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
115341210  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
115341249  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X4 [KO:K04858]
115341261  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
115341327  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
115341437  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
115341441  CACNG4; voltage-dependent calcium channel gamma-4 subunit isoform X1 [KO:K04869]
115341443  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
115341444  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
115341473  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
115341623  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
115341693  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
115341759  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
115341817  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
115341838  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
115341991  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
115342009  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
115342153  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
115342457  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
115342465  [KO:K04388] [EC:2.7.11.30]
115342525  MAP3K20; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 20 [KO:K04424] [EC:2.7.11.25]
115342576  VEGFC; vascular endothelial growth factor C [KO:K05449]
115342678  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
115342720  FGF20; fibroblast growth factor 20 [KO:K04358]
115342739  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
115342885  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
115342928  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
115342940  MRAS; ras-related protein M-Ras [KO:K07831]
115343136  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
115343423  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
115343515  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X2 [KO:K03158]
115343528  FGF2; fibroblast growth factor 2 [KO:K18497]
115343601  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
115343644  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
115343684  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
115344245  PLA2G4C; cytosolic phospholipase A2 gamma isoform X1 [KO:K16342] [EC:3.1.1.4]
115344320  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
115344333  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
115344344  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
115344350  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
115344366  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
115344484  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
115344542  CACNB1; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-1 [KO:K04862]
115344703  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
115344756  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
115344910  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
115344932  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
115344983  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
115345123  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
115345137  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
115345236  DUSP3; dual specificity protein phosphatase 3 isoform X1 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
115345406  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
115345654  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
115345685  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
115345772  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
115345819  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
115346006  CRKL; crk-like protein [KO:K04438]
115346130  EFNA3; ephrin-A3 [KO:K05462]
115346131  EFNA4; ephrin-A4 [KO:K05462]
115346261  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
115346275  PDGFC; platelet-derived growth factor C [KO:K05450]
115346407  AREG; amphiregulin [KO:K09782]
115346437  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
115346709  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
115346773  CRK; adapter molecule crk isoform X2 [KO:K04438]
115346822  HSPB1; heat shock protein beta-1 [KO:K04455]
115346843  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
115346855  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
115346927  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
115346976  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
115347332  [KO:K04723]
115347333  FGF5; LOW QUALITY PROTEIN: fibroblast growth factor 5 [KO:K04358]
115347508  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
115347721  MAP3K13; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
115347735  NF1; neurofibromin isoform X7 [KO:K08052]
115347882  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
115347910  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
115347976  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
115348022  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
115348054  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
115348147  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
115348153  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
115348378  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
115348471  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
115348494  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
115348644  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
115348680  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
115348713  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
115348746  JUN; transcription factor AP-1 [KO:K04448]
115348854  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
115348865  EFNA2; ephrin-A2 isoform X1 [KO:K05462]
115348869  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
115348898  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
115349017  FGF22; fibroblast growth factor 22 [KO:K04358]
115349086  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
115349117  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
115349144  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
115349300  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
115349318  [KO:K25414]
115349379  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
115349510  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
115349602  JUND; transcription factor jun-D [KO:K04449]
115349636  ARTN; artemin isoform X1 [KO:K25415]
115349650  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
115349808  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
115349939  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
115350076  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
115350086  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
115350114  [KO:K04519]
115350211  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
115350228  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
115350251  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
115350253  SRF; serum response factor isoform X1 [KO:K04378]
115350283  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
115350306  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
115350352  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
115350364  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
115350500  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
115350855  ERBB3; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
115350857  [KO:K16342] [EC:3.1.1.4]
115350990  NR4A1; LOW QUALITY PROTEIN: nuclear receptor subfamily 4 group A member 1 [KO:K04465]
115351012  CACNB3; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-3 [KO:K04864]
115351083  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
115351117  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
115351224  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
115351326  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
115351593  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
115351734  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
115351768  STMN1; LOW QUALITY PROTEIN: stathmin [KO:K04381]
115351806  FGF3; fibroblast growth factor 3 [KO:K04358]
115351819  HRAS; GTPase HRas [KO:K02833]
115351860  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
115351873  FGF4; fibroblast growth factor 4 [KO:K04358]
115351885  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
115351945  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
115352007  IGF2; insulin-like growth factor II [KO:K13769]
115352047  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
115352064  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X2 [KO:K04425] [EC:2.7.11.25]
115352123  [KO:K04526]
115352126  BDNF; brain-derived neurotrophic factor isoform X2 [KO:K04355]
115352127  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
115352222  FGF19; fibroblast growth factor 19 [KO:K22603]
115352274  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
115352314  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
115352336  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
115352340  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
115352405  FGF23; fibroblast growth factor 23 [KO:K22428]
115352412  FGF6; fibroblast growth factor 6 [KO:K04358]
115352456  CACNG2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
115352540  KRAS; GTPase KRas isoform X2 [KO:K07827]
115352684  CACNA1I; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
115352695  IGF1; insulin-like growth factor I [KO:K05459]
115352715  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
115352782  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
115352795  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
115352803  NTF3; neurotrophin-3 [KO:K04356]
115352808  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
115352971  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
115353083  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
115353237  FGF9; fibroblast growth factor 9 [KO:K04358]
115353383  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
115353436  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
115353439  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
115353441  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
115353500  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
115353588  [KO:K16342] [EC:3.1.1.4]
115353609  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
115353699  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
115353734  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
115353765  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
115353843  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
121232770  [KO:K04352]
121232827  [KO:K04358]
121232898  [KO:K04416] [EC:2.7.11.25]
121233001  [KO:K05452]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
achc04070  Phosphatidylinositol signaling system
achc04110  Cell cycle
achc04115  p53 signaling pathway
achc04210  Apoptosis
achc04310  Wnt signaling pathway
KO pathway
ko04010   

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