KEGG   PATHWAY: afor04060
Entry
afor04060                   Pathway                                
Name
Cytokine-cytokine receptor interaction - Aptenodytes forsteri (emperor penguin)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
afor04060  Cytokine-cytokine receptor interaction
afor04060

Organism
Aptenodytes forsteri (emperor penguin) [GN:afor]
Gene
103906340  C-C motif chemokine 21 [KO:K16062]
103896520  C-C motif chemokine 4 homolog [KO:K12964]
103896521  C-C motif chemokine 4 [KO:K12964]
103908437  CCL22; C-C motif chemokine 22 [KO:K21083]
103908436  C-C motif chemokine 5 [KO:K21083]
103896522  C-C motif chemokine 5 [KO:K12499]
103905114  CCL20; C-C motif chemokine 20 [KO:K14625]
103898933  C-X-C motif chemokine 5-like [KO:K10030]
103898934  interleukin-8 isoform X1 [KO:K10030]
103898935  interleukin-8 [KO:K10030]
109279724  C-X-C motif chemokine 2-like [KO:K10032]
103906787  growth-regulated alpha protein [KO:K10032]
103897829  CXCL12; stromal cell-derived factor 1 [KO:K10031]
103904427  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
103907591  lymphotactin [KO:K05507]
103908389  CX3CL1; fractalkine [KO:K05508]
103907343  interleukin-15-like [KO:K05429]
103904589  IL4; interleukin-4 [KO:K05430]
103893328  interleukin-7 [KO:K05431]
103908031  IL15; interleukin-15 isoform X1 [KO:K05433]
103904588  interleukin-5 [KO:K05428]
103906046  somatotropin [KO:K05438]
103903816  PRL; prolactin [KO:K05439]
103906265  THPO; thrombopoietin [KO:K06854]
103893710  CSF3; granulocyte colony-stimulating factor [KO:K05423]
103901234  IL6; interleukin-6 [KO:K05405]
103899051  IL12A; interleukin-12 subunit alpha [KO:K05406]
103904300  IL12B; interleukin-12 subunit beta [KO:K05425]
103908516  CNTF; LOW QUALITY PROTEIN: ciliary neurotrophic factor [KO:K05420]
103896508  LIF; leukemia inhibitory factor [KO:K05419]
103893586  IL10; interleukin-10 [KO:K05443]
103893686  interleukin-20 [KO:K22667]
103893930  IL22; interleukin-22 [KO:K05445]
109279288  IL26; interleukin-26 [KO:K05446]
103903838  interferon lambda-3-like [KO:K22669]
103894835  interferon epsilon [KO:K05414]
109279355  interferon-like [KO:K05415]
103893931  IFNG; interferon gamma [KO:K04687]
103893227  interleukin-1 beta [KO:K04519]
103895889  IL18; interleukin-18 [KO:K05482]
103906899  IL17A; LOW QUALITY PROTEIN: interleukin-17A [KO:K05489]
103906898  interleukin-17F [KO:K05494]
103904307  IL17B; interleukin-17B [KO:K05490]
103896654  IL16; pro-interleukin-16 [KO:K22628]
103908469  IL34; interleukin-34 [KO:K22633]
103908277  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
103894000  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
103901373  TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478]
103906251  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
103906226  EDA; ectodysplasin-A [KO:K05480]
103893547  NGF; beta-nerve growth factor [KO:K02582]
103895905  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
103901374  TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471]
103905807  CD40LG; CD40 ligand [KO:K03161]
109279298  TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469]
103896247  TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
103896919  TGFB2; transforming growth factor beta-2 [KO:K13376]
103900124  TGFB3; transforming growth factor beta-3 [KO:K13377]
103897638  GDF2; growth/differentiation factor 2 [KO:K05503]
103894414  BMP10; bone morphogenetic protein 10 [KO:K22670]
103895358  INHA; inhibin alpha chain [KO:K05500]
103898926  BMP3; LOW QUALITY PROTEIN: bone morphogenetic protein 3 [KO:K05496]
103897823  GDF10; growth/differentiation factor 10 [KO:K22674]
103897142  MSTN; growth/differentiation factor 8 isoform X1 [KO:K05497]
103895262  INHBA; inhibin beta A chain [KO:K04667]
103895459  INHBB; LOW QUALITY PROTEIN: inhibin beta B chain [KO:K22687]
103899308  GDF1; embryonic growth/differentiation factor 1 [KO:K05495]
103899410  nodal homolog [KO:K04666]
103904453  GDF9; growth/differentiation factor 9 [KO:K22673]
103901412  inhibin beta C chain [KO:K22688]
103903627  AMH; muellerian-inhibiting factor [KO:K04665]
103897828  bone morphogenetic protein 7 [KO:K21283]
103901640  BMP2; bone morphogenetic protein 2 [KO:K21283]
103897080  LOW QUALITY PROTEIN: bone morphogenetic protein 2-like [KO:K21283]
103907630  BMP4; bone morphogenetic protein 4 [KO:K04662]
103902900  GDF5; growth/differentiation factor 5 [KO:K04664]
103899945  GDF7; growth/differentiation factor 7 [KO:K20013]
103903410  bone morphogenetic protein 15 [KO:K05498]
103899291  BMP5; bone morphogenetic protein 5 isoform X1 [KO:K04663]
103898856  BMP6; bone morphogenetic protein 6 [KO:K16620]
103894631  BMP7; bone morphogenetic protein 7 [KO:K16621]
103903624  bone morphogenetic protein 8A [KO:K16622]
103899942  C-C chemokine receptor type 8 [KO:K04183]
103907908  C-C chemokine receptor type 8 [KO:K04183]
103899932  CCR9; C-C chemokine receptor type 9 [KO:K04184]
103899846  ACKR4; atypical chemokine receptor 4 [KO:K04186]
103901512  CCR7; C-C chemokine receptor type 7 [KO:K04182]
103907887  C-C chemokine receptor type 4 [KO:K04179]
103899755  C-C chemokine receptor type 2 [KO:K04180]
103899766  C-C chemokine receptor type 5 [KO:K04180]
103893183  C-C chemokine receptor type 5 [KO:K04180]
103902323  CCR10; C-C chemokine receptor type 10 [KO:K04185]
103894798  CCR6; C-C chemokine receptor type 6 [KO:K04181]
103895449  C-X-C chemokine receptor type 2-like [KO:K05050]
103894039  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
103899500  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
103903832  ACKR3; atypical chemokine receptor 3 [KO:K04304]
103899703  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
103899745  XCR1; chemokine XC receptor 1 [KO:K04193]
103907897  CX3CR1; LOW QUALITY PROTEIN: CX3C chemokine receptor 1 [KO:K04192]
103908101  LOW QUALITY PROTEIN: interleukin-2 receptor subunit alpha [KO:K05068]
103907726  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
103905836  IL2RG; cytokine receptor common subunit gamma isoform X2 [KO:K05070]
103904948  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
103903910  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
109279686  LOW QUALITY PROTEIN: interleukin-9 receptor-like [KO:K05073]
103904949  IL21R; interleukin-21 receptor [KO:K05075]
103900635  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
103907845  LOW QUALITY PROTEIN: cytokine receptor common subunit beta-like [KO:K04738]
103907844  LOW QUALITY PROTEIN: cytokine receptor common subunit beta-like [KO:K04738]
103902494  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
103900663  granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066]
103900664  granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066]
103905823  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
103905830  IL13RA2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
103895037  GHR; growth hormone receptor [KO:K05080]
103903881  PRLR; prolactin receptor isoform X1 [KO:K05081]
103905689  MPL; LOW QUALITY PROTEIN: thrombopoietin receptor [KO:K05082]
103903583  CSF3R; LOW QUALITY PROTEIN: granulocyte colony-stimulating factor receptor [KO:K05061]
103898452  LEPR; leptin receptor [KO:K05062]
103905526  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
103893399  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
103906341  IL11RA; interleukin-11 receptor subunit alpha isoform X3 [KO:K05056]
103898471  IL12RB2; interleukin-12 receptor subunit beta-2 [KO:K05064]
103898470  IL23R; interleukin-23 receptor [KO:K05065]
103893400  IL31RA; interleukin-31 receptor subunit alpha [KO:K22630]
103906342  CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059]
103903869  LIFR; leukemia inhibitory factor receptor [KO:K05058]
103903867  OSMR; oncostatin-M-specific receptor subunit beta [KO:K05057]
103894947  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
103902067  IL10RB; interleukin-10 receptor subunit beta [KO:K05135]
103900734  IL20RA; interleukin-20 receptor subunit alpha [KO:K05136]
103897779  IL20RB; interleukin-20 receptor subunit beta [KO:K05137]
103902069  interferon alpha/beta receptor 1 [KO:K05130]
103901967  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
103900802  IFNGR1; interferon gamma receptor 1 [KO:K05132]
103901968  IFNGR2; interferon gamma receptor 2 [KO:K05133]
103896288  interleukin-1 receptor type 1 isoform X1 [KO:K04386]
103901458  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
103896327  IL1R2; interleukin-1 receptor type 2 [KO:K04387]
103896326  interleukin-1 receptor-like 2 [KO:K05172]
103896287  IL18R1; interleukin-18 receptor 1 [KO:K05173]
103896286  IL18RAP; interleukin-18 receptor accessory protein [KO:K05174]
103896325  IL1RL1; interleukin-1 receptor-like 1 [KO:K05171]
103898649  IL17RA; interleukin-17 receptor A isoform X1 [KO:K05164]
103903341  LOW QUALITY PROTEIN: uncharacterized protein LOC103903341 [KO:K05168]
103905451  T-cell surface glycoprotein CD4 [KO:K06454]
103904391  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
103905422  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
103907560  tumor necrosis factor receptor superfamily member 1B [KO:K05141]
103894701  TNFRSF14; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152]
103901794  TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143]
103897831  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
103894755  TNFRSF25; tumor necrosis factor receptor superfamily member 25 [KO:K05160]
103893823  tumor necrosis factor receptor superfamily member 10B [KO:K04722]
103906922  TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
103896271  EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X1 [KO:K05162]
103906150  EDA2R; tumor necrosis factor receptor superfamily member 27 [KO:K05163]
103905974  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
103897224  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148]
103898878  TNFRSF11A; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 11A [KO:K05147]
103907435  tumor necrosis factor receptor superfamily member 8 [KO:K05145]
103899127  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
103894748  TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146]
103894738  TNFRSF4; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 4 [KO:K05142]
103894784  TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154]
103900863  TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153]
103904898  TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150]
103907888  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151]
103907974  TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155]
103898953  RELL2; RELT-like protein 2 [KO:K26541]
103899647  RELL1; RELT-like protein 1 [KO:K26541]
103907675  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
103908596  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
103906690  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
103894912  ACVRL1; serine/threonine-protein kinase receptor R3 [KO:K13594] [EC:2.7.11.30]
103903938  ACVR2A; activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
103903448  BMPR2; bone morphogenetic protein receptor type-2 isoform X1 [KO:K04671] [EC:2.7.11.30]
103905997  ACVR2B; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
103894911  ACVR1B; activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
103893869  ACVR1C; activin receptor type-1C isoform X1 [KO:K13568] [EC:2.7.11.30]
103893871  ACVR1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
103893394  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
103894205  BMPR1B; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   
LinkDB

DBGET integrated database retrieval system