KEGG   PATHWAY: asao04621
Entry
asao04621                   Pathway                                
Name
NOD-like receptor signaling pathway - Anolis sagrei ordinatus (Brown anole)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
asao04621  NOD-like receptor signaling pathway
asao04621

Organism
Anolis sagrei ordinatus (Brown anole) [GN:asao]
Gene
132778647  NOD1; nucleotide-binding oligomerization domain-containing protein 1 [KO:K08727]
132783158  receptor-interacting serine/threonine-protein kinase 2-like [KO:K08846] [EC:2.7.11.1]
132774966  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
132767870  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
132771394  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
132782482  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
132782149  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
132765024  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
132776959  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
132764274  RELA; transcription factor p65 [KO:K04735]
132782531  IL1B; interleukin-1 beta [KO:K04519]
132782337  interleukin-18-like [KO:K05482]
132779144  IL6; interleukin-6 [KO:K05405]
132766766  tumor necrosis factor-like [KO:K03156]
132766767  tumor necrosis factor-like [KO:K03156]
132766768  tumor necrosis factor-like [KO:K03156]
132778418  interleukin-8-like [KO:K10030]
132779476  interleukin-8-like [KO:K10030]
132763895  C-C motif chemokine 5-like [KO:K12499]
132779087  cathelicidin-2-like [KO:K13916]
132779714  lutzicidin-like [KO:K13916]
132779812  cathelicidin-2-like [KO:K13916]
132779815  lutzicidin-like [KO:K13916]
132779816  cathelicidin-3-like [KO:K13916]
132760802  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
132775956  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
132761043  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
132771750  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
132761327  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3-like [KO:K12793]
132781607  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
132777818  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
132771385  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
132777024  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
132768923  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
132776292  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
132776293  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
132773738  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
132773739  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
132773982  JUN; transcription factor Jun [KO:K04448]
132770799  ATG16L1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
132760832  ATG5; autophagy protein 5 [KO:K08339]
132767222  ATG12; ubiquitin-like protein ATG12 [KO:K08336]
132782913  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
132782928  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
132777541  GABARAP; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
132767967  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
132766588  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
132783353  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
132773234  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
132762090  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
132771406  SUGT1; protein SGT1 homolog isoform X1 [KO:K12795]
132765852  protein SGT1 homolog [KO:K12795]
132772996  RBCK1; ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K10630] [EC:2.3.2.31]
132775190  SHARPIN; sharpin isoform X1 [KO:K10630] [EC:2.3.2.31]
132777608  RNF31; E3 ubiquitin-protein ligase RNF31 [KO:K11974] [EC:2.3.2.31]
132763055  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
132777521  TRIP6; thyroid receptor-interacting protein 6 isoform X1 [KO:K12792]
132767031  ERBIN; erbin isoform X1 [KO:K12796]
132772203  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
132763641  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
132761451  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
132768609  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
132763798  CARD9; caspase recruitment domain-containing protein 9 [KO:K12794]
132760998  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
132762146  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
132776194  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
132773608  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
132776297  TANK; TRAF family member-associated NF-kappa-B activator [KO:K12650]
132778114  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
132771432  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
132765406  interferon beta-like [KO:K05414]
132765408  interferon beta-like [KO:K05414]
132765409  interferon beta-like [KO:K05414]
132765410  interferon kappa-like [KO:K05414]
132765411  interferon beta-like [KO:K05414]
132765412  interferon beta-like [KO:K05414]
132765413  interferon kappa-like [KO:K05414]
132766469  interferon beta-like [KO:K05414]
132767057  interferon omega-1-like [KO:K05414]
132782631  NLRX1; NLR family member X1 [KO:K12653]
132782333  ANTXR1; anthrax toxin receptor 1 [KO:K20909]
132777052  ANTXR2; anthrax toxin receptor 2 isoform X1 [KO:K20909]
132779267  caspase recruitment domain-containing protein 8-like [KO:K12798]
132779352  pyrin domain-containing protein 1-like [KO:K12799]
132763419  caspase-1-like [KO:K01370] [EC:3.4.22.36]
132774529  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
132772984  BCL2L1; bcl-2-like protein 1 [KO:K04570]
132761610  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
132772226  PANX1; pannexin-1 [KO:K03443]
132781324  P2RX7; P2X purinoceptor 7 isoform X1 [KO:K05220]
132770756  TRPM2; transient receptor potential cation channel subfamily M member 2 [KO:K04977] [EC:3.6.1.13]
132762349  TRPM7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
132763403  TRPV2; transient receptor potential cation channel subfamily V member 2 [KO:K04971]
132767524  CASR; extracellular calcium-sensing receptor [KO:K04612]
132760910  GPRC6A; G-protein coupled receptor family C group 6 member A [KO:K04622]
132764411  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like [KO:K05858] [EC:3.1.4.11]
132765970  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
132781449  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
132781466  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
132769383  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
132776516  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
132773708  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
132768880  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
132771294  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
132782483  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
132771148  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
132769121  OAS1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
132774392  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
132763380  DHX33; ATP-dependent RNA helicase DHX33 [KO:K17820] [EC:5.6.2.6]
132770490  MFN1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
132764997  MFN2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
132774553  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
132765356  receptor-interacting serine/threonine-protein kinase 3-like [KO:K08847] [EC:2.7.11.1]
132777698  RIPK3; receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
132767867  dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
132775807  DNM1L; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
132776566  NAMPT; nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
132771762  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
132783070  cytochrome b-245 light chain [KO:K08009]
132764037  TXNIP; thioredoxin-interacting protein [KO:K20910]
132775898  TXN2; thioredoxin, mitochondrial [KO:K03671]
132767471  thioredoxin-like [KO:K03671]
132774444  NEK7; serine/threonine-protein kinase Nek7 [KO:K20876] [EC:2.7.11.34]
132763007  BRCC3; lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
132761304  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
132762304  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
132765946  G-protein-signaling modulator 3-like [KO:K15838]
132762598  PSTPIP1; proline-serine-threonine phosphatase-interacting protein 1 [KO:K12804]
132768935  FADD; FAS-associated death domain protein [KO:K02373]
132771796  NACHT, LRR and PYD domains-containing protein 12-like [KO:K20865]
132765378  NAIP; baculoviral IAP repeat-containing protein 1 [KO:K12807]
132761269  NLRC4; NLR family CARD domain-containing protein 4 [KO:K12805]
132769200  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
132768030  guanylate-binding protein 1-like [KO:K20898]
132762468  TP53BP1; TP53-binding protein 1 isoform X1 [KO:K20915]
132767620  transforming protein RhoA-like [KO:K04513]
132769106  RHOA; transforming protein RhoA [KO:K04513]
132768473  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
132774112  PKN2; serine/threonine-protein kinase N2 [KO:K23691] [EC:2.7.11.13]
132763459  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
132765861  guanylate-binding protein 1-like [KO:K20899]
132766208  guanylate-binding protein 1-like isoform X1 [KO:K20899]
132766364  guanylate-binding protein 1-like [KO:K20899]
132766372  guanylate-binding protein 1-like [KO:K20899]
132766374  guanylate-binding protein 1-like [KO:K20899]
132772528  guanylate-binding protein 1-like [KO:K20899]
132767996  guanylate-binding protein 1-like [KO:K20899]
132768012  guanylate-binding protein 1-like [KO:K20899]
132768051  guanylate-binding protein 3-like [KO:K20899]
132775341  guanylate-binding protein 1-like [KO:K20899]
132771883  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
132771885  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
132774014  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
132768045  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
132778013  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
132768316  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
132777606  IRF9; interferon regulatory factor 9 [KO:K04693]
132763647  TLR4; toll-like receptor 4 [KO:K10160]
132781041  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
132779005  MYD88; LOW QUALITY PROTEIN: myeloid differentiation primary response protein MyD88 [KO:K04729]
132769661  myeloid differentiation primary response protein MyD88-like [KO:K04729]
132776222  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
132774232  STING1; stimulator of interferon genes protein [KO:K12654]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:23124073
  Authors
Vandenabeele P, Bertrand MJ
  Title
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
  Journal
Nat Rev Immunol 12:833-44 (2012)
DOI:10.1038/nri3325
Reference
PMID:16493424
  Authors
Strober W, Murray PJ, Kitani A, Watanabe T
  Title
Signalling pathways and molecular interactions of NOD1 and NOD2.
  Journal
Nat Rev Immunol 6:9-20 (2006)
DOI:10.1038/nri1747
Reference
PMID:24718315
  Authors
Estornes Y, Bertrand MJ
  Title
IAPs, regulators of innate immunity and inflammation.
  Journal
Semin Cell Dev Biol 39:106-14 (2015)
DOI:10.1016/j.semcdb.2014.03.035
Reference
PMID:24707857
  Authors
Jakopin Z
  Title
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
  Journal
J Med Chem 57:6897-918 (2014)
DOI:10.1021/jm401841p
Reference
PMID:25526305
  Authors
Caruso R, Warner N, Inohara N, Nunez G
  Title
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
  Journal
Immunity 41:898-908 (2014)
DOI:10.1016/j.immuni.2014.12.010
Reference
PMID:19767725
  Authors
Murray PJ
  Title
Beyond peptidoglycan for Nod2.
  Journal
Nat Immunol 10:1053-4 (2009)
DOI:10.1038/ni1009-1053
Reference
PMID:20643110
  Authors
Lecat A, Piette J, Legrand-Poels S
  Title
The protein Nod2: an innate receptor more complex than previously assumed.
  Journal
Biochem Pharmacol 80:2021-31 (2010)
DOI:10.1016/j.bcp.2010.07.016
Reference
PMID:26655628
  Authors
Man SM, Kanneganti TD
  Title
Converging roles of caspases in inflammasome activation, cell death and innate immunity.
  Journal
Nat Rev Immunol 16:7-21 (2016)
DOI:10.1038/nri.2015.7
Reference
PMID:27291964
  Authors
Broz P, Dixit VM
  Title
Inflammasomes: mechanism of assembly, regulation and signalling.
  Journal
Nat Rev Immunol 16:407-20 (2016)
DOI:10.1038/nri.2016.58
Reference
PMID:25879280
  Authors
Man SM, Kanneganti TD
  Title
Regulation of inflammasome activation.
  Journal
Immunol Rev 265:6-21 (2015)
DOI:10.1111/imr.12296
Reference
PMID:26549800
  Authors
Jo EK, Kim JK, Shin DM, Sasakawa C
  Title
Molecular mechanisms regulating NLRP3 inflammasome activation.
  Journal
Cell Mol Immunol 13:148-59 (2016)
DOI:10.1038/cmi.2015.95
Reference
PMID:23846113
  Authors
Broz P, Monack DM
  Title
Newly described pattern recognition receptors team up against intracellular pathogens.
  Journal
Nat Rev Immunol 13:551-65 (2013)
DOI:10.1038/nri3479
Reference
PMID:22430786
  Authors
Rathinam VA, Vanaja SK, Fitzgerald KA
  Title
Regulation of inflammasome signaling.
  Journal
Nat Immunol 13:333-42 (2012)
DOI:10.1038/ni.2237
Reference
PMID:24840700
  Authors
Sutterwala FS, Haasken S, Cassel SL
  Title
Mechanism of NLRP3 inflammasome activation.
  Journal
Ann N Y Acad Sci 1319:82-95 (2014)
DOI:10.1111/nyas.12458
Reference
PMID:23702978
  Authors
Latz E, Xiao TS, Stutz A
  Title
Activation and regulation of the inflammasomes.
  Journal
Nat Rev Immunol 13:397-411 (2013)
DOI:10.1038/nri3452
Reference
PMID:25145756
  Authors
Blander JM
  Title
A long-awaited merger of the pathways mediating host defence and programmed cell death.
  Journal
Nat Rev Immunol 14:601-18 (2014)
DOI:10.1038/nri3720
Reference
PMID:23215645
  Authors
von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
  Title
Recognition of bacteria by inflammasomes.
  Journal
Annu Rev Immunol 31:73-106 (2013)
DOI:10.1146/annurev-immunol-032712-095944
Reference
PMID:25330206
  Authors
Abais JM, Xia M, Zhang Y, Boini KM, Li PL
  Title
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
  Journal
Antioxid Redox Signal 22:1111-29 (2015)
DOI:10.1089/ars.2014.5994
Reference
PMID:25879288
  Authors
Storek KM, Monack DM
  Title
Bacterial recognition pathways that lead to inflammasome activation.
  Journal
Immunol Rev 265:112-29 (2015)
DOI:10.1111/imr.12289
Reference
PMID:27012466
  Authors
Hu H, Sun SC
  Title
Ubiquitin signaling in immune responses.
  Journal
Cell Res 26:457-83 (2016)
DOI:10.1038/cr.2016.40
Reference
PMID:26121197
  Authors
Guo H, Callaway JB, Ting JP
  Title
Inflammasomes: mechanism of action, role in disease, and therapeutics.
  Journal
Nat Med 21:677-87 (2015)
DOI:10.1038/nm.3893
Reference
PMID:26482951
  Authors
Man SM, Kanneganti TD
  Title
Gasdermin D: the long-awaited executioner of pyroptosis.
  Journal
Cell Res 25:1183-4 (2015)
DOI:10.1038/cr.2015.124
Reference
PMID:22819539
  Authors
Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
  Title
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
  Journal
Cell 150:606-19 (2012)
DOI:10.1016/j.cell.2012.07.007
Reference
PMID:21575908
  Authors
Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
  Title
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
  Journal
Cell Host Microbe 9:363-75 (2011)
DOI:10.1016/j.chom.2011.04.008
Reference
PMID:29148036
  Authors
Heilig R, Broz P
  Title
Function and mechanism of the pyrin inflammasome.
  Journal
Eur J Immunol 48:230-238 (2018)
DOI:10.1002/eji.201746947
Reference
PMID:25816776
  Authors
Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
  Title
RNase L activates the NLRP3 inflammasome during viral infections.
  Journal
Cell Host Microbe 17:466-77 (2015)
DOI:10.1016/j.chom.2015.02.010
Related
pathway
asao04010  MAPK signaling pathway
asao04140  Autophagy - animal
asao04620  Toll-like receptor signaling pathway
KO pathway
ko04621   
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