KEGG   PATHWAY: bbuf04820
Entry
bbuf04820                   Pathway                                
Name
Cytoskeleton in muscle cells - Bufo bufo (common toad)
Class
Cellular Processes; Cell motility
Pathway map
bbuf04820  Cytoskeleton in muscle cells
bbuf04820

Organism
Bufo bufo (common toad) [GN:bbuf]
Gene
121005078  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
121002619  COL1A2; collagen alpha-2(I) chain [KO:K06236]
121007374  COL3A1; collagen alpha-1(III) chain [KO:K19720]
121007442  COL5A2; collagen alpha-2(V) chain [KO:K19721]
120977178  COL27A1; collagen alpha-1(XXVII) chain [KO:K19721]
120986375  COL5A3; collagen alpha-3(V) chain isoform X1 [KO:K19721]
120977696  collagen alpha-1(I) chain-like [KO:K19721]
120978201  COL11A2; collagen alpha-2(XI) chain [KO:K19721]
120978233  COL5A1; collagen alpha-1(V) chain isoform X1 [KO:K19721]
120978999  COL24A1; collagen alpha-1(XXIV) chain [KO:K19721]
120979187  COL11A1; collagen alpha-1(XI) chain [KO:K19721]
120999162  LOW QUALITY PROTEIN: collagen alpha-1(IX) chain-like [KO:K08131]
120993795  collagen alpha-2(IX) chain-like [KO:K08131]
121003842  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
120979809  DCN; decorin [KO:K04660]
120992499  VCAN; versican core protein isoform X1 [KO:K06793]
120994800  ELN; elastin isoform X1 [KO:K14211]
121007350  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
121007351  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
121007732  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
121001130  collagen alpha-6(VI) chain-like isoform X1 [KO:K06238]
121002731  collagen alpha-6(VI) chain-like [KO:K06238]
120981693  THBS1; thrombospondin-1 [KO:K16857]
120998615  THBS2; thrombospondin-2 [KO:K04659]
120991617  cartilage oligomeric matrix protein [KO:K04659]
120981816  THBS3; thrombospondin-3 [KO:K04659]
120992406  THBS4; thrombospondin-4 [KO:K04659]
120985829  FBN1; fibrillin-1 [KO:K06825]
120989621  fibrillin-2-like [KO:K23342]
120988486  FBN2; fibrillin-2 [KO:K23342]
121009304  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
121009306  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
120995794  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
120995795  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
121006300  FBLN1; fibulin-1 isoform X1 [KO:K17307]
120979061  FBLN2; fibulin-2 [KO:K17307]
120994841  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein isoform X1 [KO:K06255]
120982212  NID2; LOW QUALITY PROTEIN: nidogen-2 [KO:K06826]
121007631  FN1; fibronectin isoform X1 [KO:K05717]
120997334  SDC1; syndecan-1 isoform X1 [KO:K06257]
120995268  SDC3; syndecan-3 [KO:K16337]
121006157  syndecan 4-B-like [KO:K16338]
120997099  AGRN; agrin isoform X1 [KO:K06254]
120977953  BGN; biglycan [KO:K08118]
121002055  DSG2; desmoglein-2 isoform X1 [KO:K07597]
121003827  PKP2; plakophilin-2 isoform X1 [KO:K12642]
121005251  LOW QUALITY PROTEIN: junction plakoglobin [KO:K10056]
121001158  desmoplakin isoform X1 [KO:K10381]
120991059  vimentin-like [KO:K07606]
121002612  VIM; LOW QUALITY PROTEIN: vimentin [KO:K07606]
121002874  vimentin-1/2 [KO:K07606]
120998219  glial fibrillary acidic protein-like [KO:K07610]
121008866  DES; desmin isoform X1 [KO:K07610]
120998483  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
121001486  LAMA1; laminin subunit alpha-1 [KO:K05637]
120992343  ITGA1; integrin alpha-1 [KO:K06480]
120992342  ITGA2; integrin alpha-2 [KO:K06481]
121003938  ITGA2B; integrin alpha-IIb [KO:K06476]
121003312  ITGA3; integrin alpha-3 [KO:K06482]
121007514  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
120996129  ITGA5; integrin alpha-5 [KO:K06484]
121008514  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
120995974  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
121002908  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
121002489  ITGA9; integrin alpha-9 [KO:K06585]
120982595  ITGA10; integrin alpha-10 [KO:K06586]
120986039  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
120977161  LOW QUALITY PROTEIN: integrin alpha-V-like [KO:K06487]
121002751  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
121003743  ITGB3; LOW QUALITY PROTEIN: integrin beta-3 [KO:K06493]
121005942  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
121007755  ITGB5; integrin beta-5 [KO:K06588]
121008886  ITGB6; integrin beta-6 [KO:K06589]
120996091  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
121001489  ITGB8; integrin beta-8 [KO:K06591]
120991940  TLN1; talin-1 isoform X1 [KO:K06271]
120985625  TLN2; LOW QUALITY PROTEIN: talin-2 [KO:K06271]
121005853  VCL; LOW QUALITY PROTEIN: vinculin [KO:K05700]
120980520  ACTN3; alpha-actinin-3 [KO:K21073]
120998787  ACTN2; alpha-actinin-2 [KO:K21073]
121008493  actin, cytoplasmic 1 [KO:K05692]
121003202  ACTG1; actin, cytoplasmic 2 [KO:K05692]
120979750  DAG1; dystroglycan [KO:K06265]
121003652  SGCA; alpha-sarcoglycan [KO:K12565]
121000641  SGCE; epsilon-sarcoglycan isoform X1 [KO:K27061]
120990219  SGCB; beta-sarcoglycan isoform X1 [KO:K12566]
121007792  SGCD; delta-sarcoglycan [KO:K12563]
120996346  SGCG; gamma-sarcoglycan isoform X1 [KO:K12564]
120990186  SGCZ; zeta-sarcoglycan isoform X1 [KO:K27062]
121003733  SSPN; sarcospan [KO:K22194]
120995647  DMD; LOW QUALITY PROTEIN: dystrophin [KO:K10366]
121004824  SNTA1; alpha-1-syntrophin [KO:K24063]
120980500  SNTB2; beta-2-syntrophin [KO:K24064]
121001087  SNTB1; beta-1-syntrophin [KO:K24064]
121001316  DTNA; dystrobrevin alpha isoform X1 [KO:K26998]
120985258  FLNC; filamin-C isoform X1 [KO:K27393]
120990871  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 isoform X1 [KO:K01539] [EC:7.2.2.13]
120981733  sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
120994305  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
120997622  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
120994939  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
120977676  ATP1B4; protein ATP1B4 [KO:K01540]
120986732  sodium/potassium-transporting ATPase subunit beta-2-like [KO:K01540]
121004881  ANK3; ankyrin-3 isoform X1 [KO:K09259]
120977045  SPTAN1; spectrin alpha chain, non-erythrocytic 1 isoform X1 [KO:K06114]
120998873  SPTBN1; spectrin beta chain, non-erythrocytic 1 isoform X1 [KO:K06115]
120982533  SPTBN5; spectrin beta chain, non-erythrocytic 5 [KO:K06115]
120977965  SPTBN4; spectrin beta chain, non-erythrocytic 4 [KO:K06115]
120980793  SPTBN2; spectrin beta chain, non-erythrocytic 2 isoform X1 [KO:K23932]
120980188  CSRP3; cysteine and glycine-rich protein 3 [KO:K09377]
120997985  cysteine and glycine-rich protein 2 [KO:K09377]
120980890  CSRP2; cysteine and glycine-rich protein 2 [KO:K09377]
121005322  myosin-3 [KO:K24220]
121005323  myosin-1B [KO:K24220]
121005827  myosin-1B-like [KO:K24220]
121009399  myosin-4-like [KO:K24220]
121009588  myosin-4-like [KO:K24220]
121009589  myosin-4-like [KO:K24220]
120977573  myosin-4-like [KO:K24220]
120995607  MYH15; myosin-15 isoform X1 [KO:K24220]
121003258  MYH7B; myosin-7B isoform X1 [KO:K24220]
120989043  myosin-6 isoform X1 [KO:K17751]
121005005  MYH10; myosin-10 isoform X1 [KO:K10352]
121008895  MYH11; myosin-11 isoform X1 [KO:K10352]
120995361  myosin-10-like [KO:K10352]
120978955  MYH9; myosin-9 isoform X1 [KO:K10352]
121008317  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
121002039  MYL3; myosin light chain 3 [KO:K12749]
121004825  MYL4; myosin light chain 4 [KO:K12750]
120988545  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
120986174  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
121003248  MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
120983732  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
120978881  MYBPC1; myosin-binding protein C, slow-type isoform X1 [KO:K12557]
121001720  myosin-binding protein C, fast-type-like isoform X1 [KO:K12558]
121001740  myosin-binding protein C, fast-type-like isoform X1 [KO:K12558]
120980236  MYBPC3; myosin-binding protein C, cardiac-type isoform X1 [KO:K12568]
120980701  actin, alpha skeletal muscle 3 [KO:K10354]
120998599  actin, alpha cardiac muscle 2 [KO:K12314]
120981786  ACTC1; actin, alpha cardiac muscle 1 [KO:K12314]
120988887  actin, alpha cardiac muscle 1 [KO:K12314]
120979457  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
120998220  troponin C, slow skeletal and cardiac muscles-like [KO:K05865]
120995150  TNNI1; troponin I, slow skeletal muscle [KO:K10371]
120986958  troponin I, slow skeletal muscle-like [KO:K10371]
121001408  TNNT1; troponin T, slow skeletal muscle isoform X1 [KO:K10372]
121004818  TNNC2; troponin C, skeletal muscle isoform X1 [KO:K12042]
120980808  TNNI2; troponin I, fast skeletal muscle [KO:K12043]
120980616  TNNT3; troponin T, fast skeletal muscle isoform X1 [KO:K12046]
121001385  TNNI3; troponin I, cardiac muscle isoform X1 [KO:K12044]
120995152  TNNT2; troponin T, cardiac muscle isoform X1 [KO:K12045]
120991942  TPM2; tropomyosin beta chain isoform X1 [KO:K09290]
120982367  tropomyosin alpha-3 chain-like isoform X1 [KO:K09290]
120985624  TPM1; tropomyosin alpha-1 chain isoform X1 [KO:K09290]
120989523  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
121008927  TTN; titin isoform X1 [KO:K12567] [EC:2.7.11.1]
121004790  telethonin [KO:K19879]
121008667  NEB; nebulin isoform X1 [KO:K18267]
121002835  NEBL; nebulette isoform X1 [KO:K25865]
121005035  MYOZ1; myozenin-1 [KO:K26050]
120989887  MYOZ2; myozenin-2 [KO:K26050]
121008124  MYOZ3; myozenin-3 [KO:K26050]
120990153  PDLIM3; LOW QUALITY PROTEIN: PDZ and LIM domain protein 3 [KO:K23353]
120977306  PDLIM4; PDZ and LIM domain protein 4 isoform X1 [KO:K23353]
121003126  PDLIM1; PDZ and LIM domain protein 1 isoform X1 [KO:K23353]
120981728  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
120994968  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
120994203  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
121002341  XIRP1; xin actin-binding repeat-containing protein 1 [KO:K27381]
121008430  XIRP2; xin actin-binding repeat-containing protein 2 isoform X1 [KO:K27381]
121004617  nebulin-related-anchoring protein [KO:K24421]
121004072  MYPN; LOW QUALITY PROTEIN: myopalladin [KO:K22028]
120989823  PDLIM5; PDZ and LIM domain protein 5 isoform X1 [KO:K19867]
121004671  LDB3; LIM domain-binding protein 3 isoform X1 [KO:K19867]
120977491  PDLIM7; PDZ and LIM domain protein 7 isoform X1 [KO:K19867]
120981751  TMOD4; tropomodulin-4 [KO:K10370]
120985805  tropomodulin-3-like [KO:K10370]
120985806  tropomodulin-2-like [KO:K10370]
120989285  TMOD1; tropomodulin-1 isoform X1 [KO:K10370]
121003148  ZYX; zyxin isoform X1 [KO:K06273]
121009176  FHL1; four and a half LIM domains protein 1 [KO:K14365]
120995660  FHL2; four and a half LIM domains protein 2 [KO:K14380]
120995313  FHL3; four and a half LIM domains protein 3 [KO:K24414]
120997649  leiomodin-1-like [KO:K22030]
120981977  LMOD2; leiomodin-2 [KO:K22030]
120995182  LMOD1; leiomodin-1 [KO:K22030]
120978455  LMOD3; leiomodin-3 [KO:K22030]
121003669  ANKRD1; ankyrin repeat domain-containing protein 1 [KO:K21433]
121005259  ANKRD2; ankyrin repeat domain-containing protein 2 [KO:K21434]
121005858  FMNL1; formin-like protein 1 [KO:K23957]
121008661  FMNL2; formin-like protein 2 isoform X1 [KO:K23957]
120995944  FMNL3; formin-like protein 3 isoform X1 [KO:K23957]
120982376  INF2; inverted formin-2 isoform X1 [KO:K23958]
120981680  DAAM1; disheveled-associated activator of morphogenesis 1 isoform X1 [KO:K04512]
120999788  DAAM2; LOW QUALITY PROTEIN: disheveled-associated activator of morphogenesis 2 [KO:K04512]
121008781  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
121009313  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
120995893  DIAPH3; LOW QUALITY PROTEIN: protein diaphanous homolog 3 [KO:K05745]
120998068  MYOM2; myomesin-2 isoform X1 [KO:K24495]
121001030  MYOM1; LOW QUALITY PROTEIN: myomesin-1 [KO:K24495]
120995353  MYOM3; myomesin-3 isoform X1 [KO:K24495]
120997258  ENO1; enolase isoform X1 [KO:K01689] [EC:4.2.1.11]
120990556  beta-enolase-like [KO:K01689] [EC:4.2.1.11]
120986650  beta-enolase [KO:K01689] [EC:4.2.1.11]
120989897  ANK2; ankyrin-2 isoform X1 [KO:K09255]
120984654  CKM; creatine kinase M-type [KO:K27382] [EC:2.7.3.2]
120997001  TRIM54; tripartite motif-containing protein 54 [KO:K10653]
121001369  TRIM55; tripartite motif-containing protein 55 isoform X1 [KO:K10654]
120995194  TRIM63; E3 ubiquitin-protein ligase TRIM63 [KO:K10655] [EC:2.3.2.27]
120980962  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
120994995  AMPD1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
120995086  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
121000925  OBSCN; obscurin isoform X1 [KO:K17531] [EC:2.7.11.1]
120981853  CAPN3; calpain-3 isoform X1 [KO:K08573] [EC:3.4.22.54]
121001927  PLEC; plectin isoform X1 [KO:K10388]
120982607  SYNE3; nesprin-3 isoform X1 [KO:K21761]
120998709  SYNE1; nesprin-1 isoform X1 [KO:K19326]
120982528  SYNE2; nesprin-2 [KO:K19346]
120979645  SUN2; SUN domain-containing protein 2 isoform X1 [KO:K19347]
121009024  SUN1; SUN domain-containing protein 1 isoform X1 [KO:K19347]
120979451  TMEM43; transmembrane protein 43 [KO:K27488]
120977313  EMD; emerin isoform X1 [KO:K12569]
120999603  LBR; delta(14)-sterol reductase LBR isoform X1 [KO:K19532] [EC:1.3.1.70]
120982346  LMNA; lamin [KO:K12641]
120989612  LMNB2; lamin-B2 [KO:K07611]
120985868  lamin-L(III)-like isoform X1 [KO:K07611]
120988482  LMNB1; lamin-B1 isoform X1 [KO:K07611]
Reference
PMID:12142273
  Authors
Clark KA, McElhinny AS, Beckerle MC, Gregorio CC
  Title
Striated muscle cytoarchitecture: an intricate web of form and function.
  Journal
Annu Rev Cell Dev Biol 18:637-706 (2002)
DOI:10.1146/annurev.cellbio.18.012502.105840
Reference
PMID:31407867
  Authors
Mukund K, Subramaniam S
  Title
Skeletal muscle: A review of molecular structure and function, in health and disease.
  Journal
Wiley Interdiscip Rev Syst Biol Med 12:e1462 (2020)
DOI:10.1002/wsbm.1462
Reference
PMID:24481844
  Authors
Stroud MJ, Banerjee I, Veevers J, Chen J
  Title
Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease.
  Journal
Circ Res 114:538-48 (2014)
DOI:10.1161/CIRCRESAHA.114.301236
Reference
PMID:28640448
  Authors
Henderson CA, Gomez CG, Novak SM, Mi-Mi L, Gregorio CC
  Title
Overview of the Muscle Cytoskeleton.
  Journal
Compr Physiol 7:891-944 (2017)
DOI:10.1002/cphy.c160033
Reference
PMID:32265741
  Authors
Csapo R, Gumpenberger M, Wessner B
  Title
Skeletal Muscle Extracellular Matrix - What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review.
  Journal
Front Physiol 11:253 (2020)
DOI:10.3389/fphys.2020.00253
Reference
PMID:27114860
  Authors
Pinch M, Guth R, Samanta MP, Chaidez A, Unguez GA
  Title
The myogenic electric organ of Sternopygus macrurus: a non-contractile tissue with a skeletal muscle transcriptome.
  Journal
PeerJ 4:e1828 (2016)
DOI:10.7717/peerj.1828
Reference
PMID:23860255
  Authors
Sequeira V, Nijenkamp LL, Regan JA, van der Velden J
  Title
The physiological role of cardiac cytoskeleton and its alterations in heart failure.
  Journal
Biochim Biophys Acta 1838:700-22 (2014)
DOI:10.1016/j.bbamem.2013.07.011
Reference
PMID:36960155
  Authors
Zhang B, Powers JD, McCulloch AD, Chi NC
  Title
Nuclear mechanosignaling in striated muscle diseases.
  Journal
Front Physiol 14:1126111 (2023)
DOI:10.3389/fphys.2023.1126111
Reference
PMID:21464301
  Authors
Al-Amoudi A, Castano-Diez D, Devos DP, Russell RB, Johnson GT, Frangakis AS
  Title
The three-dimensional molecular structure of the desmosomal plaque.
  Journal
Proc Natl Acad Sci U S A 108:6480-5 (2011)
DOI:10.1073/pnas.1019469108
Reference
PMID:33067392
  Authors
Sikora M, Ermel UH, Seybold A, Kunz M, Calloni G, Reitz J, Vabulas RM, Hummer G, Frangakis AS
  Title
Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography.
  Journal
Proc Natl Acad Sci U S A 117:27132-27140 (2020)
DOI:10.1073/pnas.2004563117
Reference
PMID:26910421
  Authors
Xu XP, Kim E, Swift M, Smith JW, Volkmann N, Hanein D
  Title
Three-Dimensional Structures of Full-Length, Membrane-Embedded Human alpha(IIb)beta(3) Integrin Complexes.
  Journal
Biophys J 110:798-809 (2016)
DOI:10.1016/j.bpj.2016.01.016
Reference
PMID:22945352
  Authors
Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z
  Title
Structural insights into SUN-KASH complexes across the nuclear envelope.
  Journal
Cell Res 22:1440-52 (2012)
DOI:10.1038/cr.2012.126
Reference
PMID:23597672
  Authors
Sosa BA, Kutay U, Schwartz TU
  Title
Structural insights into LINC complexes.
  Journal
Curr Opin Struct Biol 23:285-91 (2013)
DOI:10.1016/j.sbi.2013.03.005
Reference
PMID:33058875
  Authors
Cruz VE, Esra Demircioglu F, Schwartz TU
  Title
Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.
  Journal
J Mol Biol 432:6028-6041 (2020)
DOI:10.1016/j.jmb.2020.09.019
Reference
PMID:36523505
  Authors
Schuler SC, Liu Y, Dumontier S, Grandbois M, Le Moal E, Cornelison D, Bentzinger CF
  Title
Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche.
  Journal
Front Cell Dev Biol 10:1056523 (2022)
DOI:10.3389/fcell.2022.1056523
Reference
PMID:30425656
  Authors
Brull A, Morales Rodriguez B, Bonne G, Muchir A, Bertrand AT
  Title
The Pathogenesis and Therapies of Striated Muscle Laminopathies.
  Journal
Front Physiol 9:1533 (2018)
DOI:10.3389/fphys.2018.01533
Reference
PMID:36552829
  Authors
Storey EC, Fuller HR
  Title
Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary.
  Journal
Cells 11:cells11244065 (2022)
DOI:10.3390/cells11244065
Related
pathway
bbuf04512  ECM-receptor interaction
bbuf04814  Motor proteins
KO pathway
ko04820   
LinkDB

DBGET integrated database retrieval system