KEGG   PATHWAY: bpec04148
Entry
bpec04148                   Pathway                                
Name
Efferocytosis - Boleophthalmus pectinirostris (great blue-spotted mudskipper)
Class
Cellular Processes; Transport and catabolism
Pathway map
bpec04148  Efferocytosis
bpec04148

Organism
Boleophthalmus pectinirostris (great blue-spotted mudskipper) [GN:bpec]
Gene
110160793  caspase-3-like [KO:K02187] [EC:3.4.22.56]
110167549  caspase-3-like [KO:K02187] [EC:3.4.22.56]
110157710  caspase-3-like [KO:K02187] [EC:3.4.22.56]
110157737  caspase-3-like [KO:K02187] [EC:3.4.22.56]
110157738  caspase-7-like [KO:K02187] [EC:3.4.22.56]
110157739  caspase-3-like [KO:K02187] [EC:3.4.22.56]
110154157  casp7; caspase-7 [KO:K04397] [EC:3.4.22.60]
110161916  caspase-7-like [KO:K04397] [EC:3.4.22.60]
110163616  caspase-1-A-like [KO:K01370] [EC:3.4.22.36]
110172724  pannexin-1-like [KO:K03443]
110175686  panx1; pannexin-1 [KO:K03443]
110174440  p2ry2; P2Y purinoceptor 2 [KO:K04269]
110174441  p2ry6; P2Y purinoceptor 6 [KO:K04272]
110163700  P2Y purinoceptor 3-like [KO:K04272]
110163702  P2Y purinoceptor 12-like [KO:K04298]
110160669  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
110166231  sphk1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
110162977  sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
110172384  s1pr1; sphingosine 1-phosphate receptor 1 [KO:K04288]
110168247  pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
110166147  abca1; ATP-binding cassette sub-family A member 1 [KO:K05641]
110162848  ATP-binding cassette sub-family A member 1-like [KO:K05641]
110165876  LOW QUALITY PROTEIN: ATP-binding cassette sub-family A member 1-like [KO:K05641]
110159332  ATP-binding cassette sub-family A member 1-like [KO:K05641]
110168326  probable G-protein coupled receptor 132 [KO:K08426]
110155414  adam17; disintegrin and metalloproteinase domain-containing protein 17 [KO:K06059] [EC:3.4.24.86]
110164254  disintegrin and metalloproteinase domain-containing protein 17-like [KO:K06059] [EC:3.4.24.86]
110175225  adam10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
110169553  disintegrin and metalloproteinase domain-containing protein 10-like [KO:K06704] [EC:3.4.24.81]
110160182  disintegrin and metalloproteinase domain-containing protein 10-like isoform X1 [KO:K06704] [EC:3.4.24.81]
110155833  nuclear factor of activated T-cells, cytoplasmic 2-like [KO:K17332]
110156309  nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
110171668  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
110173322  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
110175213  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
110166763  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
110157822  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
110155253  hif1a; hypoxia-inducible factor 1-alpha [KO:K08268]
110172690  hypoxia-inducible factor 1-alpha-like [KO:K08268]
110163199  aryl hydrocarbon receptor nuclear translocator-like [KO:K09097]
110163897  epo; erythropoietin isoform X1 [KO:K05437]
110172149  erythropoietin receptor-like isoform X1 [KO:K05079]
110174127  tyrosine-protein kinase JAK2-like [KO:K04447] [EC:2.7.10.2]
110155263  tyrosine-protein kinase JAK2-like [KO:K04447] [EC:2.7.10.2]
110158255  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
110155433  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
110164627  CCAAT/enhancer-binding protein beta-like [KO:K10048]
110168463  pparg; peroxisome proliferator-activated receptor gamma [KO:K08530]
110171398  retinoic acid receptor RXR-beta-A-like isoform X1 [KO:K08524]
110172337  retinoic acid receptor RXR-alpha-A [KO:K08524]
110174514  lactadherin-like isoform X1 [KO:K17253]
110160310  lactadherin-like isoform X1 [KO:K17253]
110172926  gas6; growth arrest-specific protein 6 [KO:K05464]
110157153  tyrosine-protein kinase Mer-like [KO:K05117] [EC:2.7.10.1]
110161478  cd36; platelet glycoprotein 4 [KO:K06259]
110155241  thrombospondin-1-like [KO:K16857]
110172375  thrombospondin-1-like [KO:K16857]
110160811  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110173999  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
110167945  ptgs2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
110153267  ptger2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
110174787  prostaglandin E2 receptor EP4 subtype-like [KO:K04261]
110157320  prostaglandin E2 receptor EP4 subtype-like [KO:K04261]
110162789  prostaglandin E2 receptor EP4 subtype-like [KO:K04261]
110167050  prostaglandin E2 receptor EP4 subtype-like [KO:K04261]
110156323  DNA (cytosine-5)-methyltransferase 3A-like isoform X1 [KO:K17398] [EC:2.1.1.37]
110157419  DNA (cytosine-5)-methyltransferase 3A-like [KO:K17398] [EC:2.1.1.37]
110165862  cyclic AMP-responsive element-binding protein 1-like [KO:K05870]
110170896  cyclic AMP-responsive element-binding protein 1-like [KO:K05870]
110163549  transforming growth factor beta-1-like [KO:K13375]
110163298  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like isoform X1 [KO:K05853] [EC:7.2.2.10]
110167546  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like [KO:K05853] [EC:7.2.2.10]
110174208  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
110170971  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
110165121  atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
110158201  sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like [KO:K05853] [EC:7.2.2.10]
110158726  calcium/calmodulin-dependent protein kinase type II delta chain-like [KO:K04515] [EC:2.7.11.17]
110175026  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
110159519  calcium/calmodulin-dependent protein kinase type II subunit gamma-like [KO:K04515] [EC:2.7.11.17]
110157225  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
110172133  calcium/calmodulin-dependent protein kinase type II subunit beta-like [KO:K04515] [EC:2.7.11.17]
110165319  calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
110166699  camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
110161784  mitogen-activated protein kinase 11-like isoform X1 [KO:K04441] [EC:2.7.11.24]
110158048  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
110164828  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
110165819  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
110158114  mitogen-activated protein kinase 13-like isoform X1 [KO:K04441] [EC:2.7.11.24]
110165889  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
110161445  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
110171263  MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
110164412  alox5; arachidonate 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
110156896  LOW QUALITY PROTEIN: dual specificity protein phosphatase 2-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110164666  dual specificity protein phosphatase 7-like isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110165891  dusp8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110166378  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110168357  dual specificity protein phosphatase 7-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110166158  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110161526  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110167743  dual specificity protein phosphatase 8-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110161632  ano6; anoctamin-6 [KO:K19500]
110169669  anoctamin-3-like [KO:K19498]
110161428  anoctamin-4-like [KO:K19499]
110172845  anoctamin-5-like [KO:K19480]
110169668  ano5; anoctamin-5 [KO:K19480]
110158102  anoctamin-7-like [KO:K19501]
110172716  ano7; anoctamin-7 isoform X1 [KO:K19501]
110162611  anoctamin-9-like [KO:K19503]
110169621  anoctamin-9-like [KO:K19503]
110174005  bsg; basigin isoform X1 [KO:K06535]
110162639  XK-related protein 8-like [KO:K26813]
110162623  XK-related protein 8-like [KO:K26813]
110161013  xkr9; XK-related protein 9 [KO:K26814]
110164749  XK-related protein 7-like [KO:K26811]
110169966  xkr7; XK-related protein 7 [KO:K26811]
110153308  XK-related protein 6-like [KO:K26811]
110156022  xkr6; XK-related protein 6 [KO:K26811]
110174111  xkr4; LOW QUALITY PROTEIN: XK-related protein 4 [KO:K26811]
110158830  atp8a1; phospholipid-transporting ATPase IA isoform X1 [KO:K14802] [EC:7.6.2.1]
110160973  phospholipid-transporting ATPase IB-like isoform X1 [KO:K14802] [EC:7.6.2.1]
110159029  phospholipid-transporting ATPase 11C-like [KO:K26934] [EC:7.6.2.1]
110160597  atp11b; probable phospholipid-transporting ATPase IF [KO:K26934] [EC:7.6.2.1]
110170537  atp11a; probable phospholipid-transporting ATPase IH [KO:K26934] [EC:7.6.2.1]
110174549  probable phospholipid-transporting ATPase IH [KO:K26934] [EC:7.6.2.1]
110155271  tmem30a; cell cycle control protein 50A [KO:K26935]
110172949  pros1; LOW QUALITY PROTEIN: vitamin K-dependent protein S [KO:K03908]
110162930  itgav; integrin alpha-V [KO:K06487]
110161461  integrin beta-3-like [KO:K06493]
110154280  itgb3; integrin beta-3 [KO:K06493]
110170582  itgb5; integrin beta-5 [KO:K06588]
110163612  axl; tyrosine-protein kinase receptor UFO [KO:K05115] [EC:2.7.10.1]
110159241  tyrosine-protein kinase receptor TYRO3-like [KO:K05116] [EC:2.7.10.1]
110174489  adgrb1; brain-specific angiogenesis inhibitor 1 [KO:K04596]
110166421  stab1; stabilin-1 isoform X1 [KO:K19020]
110161658  stab2; stabilin-2 [KO:K19013]
110171400  ptk2; LOW QUALITY PROTEIN: focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
110168868  focal adhesion kinase 1-like [KO:K05725] [EC:2.7.10.2]
110169470  bcar1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
110160359  crk; adapter molecule crk [KO:K04438]
110166352  crkl; crk-like protein [KO:K04438]
110167314  engulfment and cell motility protein 1 [KO:K12366]
110169990  dedicator of cytokinesis protein 1-like [KO:K13708]
110174602  dedicator of cytokinesis protein 1-like [KO:K13708]
110159668  rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
110166449  disintegrin and metalloproteinase domain-containing protein 9-like [KO:K06834] [EC:3.4.24.-]
110159193  adam9; disintegrin and metalloproteinase domain-containing protein 9 [KO:K06834] [EC:3.4.24.-]
110164082  calreticulin-like isoform X1 [KO:K08057]
110160209  calreticulin-like [KO:K08057]
110173579  complement C1q subcomponent subunit B-like [KO:K03988]
110164947  low-density lipoprotein receptor-related protein 1-like [KO:K04550]
110171260  low-density lipoprotein receptor-related protein 1-like [KO:K04550]
110161539  megf10; multiple epidermal growth factor-like domains protein 10 [KO:K24068]
110162155  multiple epidermal growth factor-like domains protein 11 [KO:K24068]
110154146  scarf1; scavenger receptor class F member 1 [KO:K24318]
110175847  gulp1; PTB domain-containing engulfment adapter protein 1 [KO:K23285]
110158093  PTB domain-containing engulfment adapter protein 1-like [KO:K23285]
110160759  ras-related protein Rab-17-like [KO:K07909]
110175549  ras-related protein Rab-5A-like [KO:K07887]
110167156  ras-related protein Rab-5A [KO:K07887]
110170657  ras-related protein Rab-5C-like [KO:K07888]
110154185  ras-related protein Rab-5C-like [KO:K07889]
110161503  rab5c; ras-related protein Rab-5C [KO:K07889]
110172888  LOW QUALITY PROTEIN: transforming growth factor-beta receptor-associated protein 1 homolog [KO:K20177]
110156823  vps8; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 8 homolog [KO:K20178]
110169046  vps11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
110173782  vps16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
110155073  vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
110169838  vps33a; vacuolar protein sorting-associated protein 33A [KO:K20182]
110166400  ras-related protein Rab-14-like [KO:K07881]
110160515  rab14; ras-related protein Rab-14 [KO:K07881]
110157381  vps39; vam6/Vps39-like protein [KO:K20183]
110170033  vps41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
110165695  ras-related protein rab7 [KO:K07897]
110170175  ras-related protein Rab-7a-like [KO:K07897]
110171882  pqlc2l; putative uncharacterized protein PQLC2L [KO:K23678]
110157941  pqlc2; lysosomal amino acid transporter 1 homolog [KO:K23678]
110171214  arginase-1-like [KO:K01476] [EC:3.5.3.1]
110157401  arg2; arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
110165860  LOW QUALITY PROTEIN: ornithine decarboxylase 1-like [KO:K01581] [EC:4.1.1.17]
110155481  odc1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
110161056  cholesterol 25-hydroxylase-like [KO:K10223] [EC:1.14.99.38]
110156548  cholesterol 25-hydroxylase-like protein 1, member 2 [KO:K10223] [EC:1.14.99.38]
110156554  cholesterol 25-hydroxylase-like protein 1, member 1 [KO:K10223] [EC:1.14.99.38]
110157477  cholesterol 25-hydroxylase-like protein 2 [KO:K10223] [EC:1.14.99.38]
110162465  nr1h3; oxysterols receptor LXR-alpha isoform X1 [KO:K08536]
110159816  carnitine O-palmitoyltransferase 1, liver isoform-like [KO:K08765] [EC:2.3.1.21]
110165903  carnitine O-palmitoyltransferase 1, liver isoform-like isoform X1 [KO:K08765] [EC:2.3.1.21]
110166861  carnitine O-palmitoyltransferase 1, liver isoform-like [KO:K08765] [EC:2.3.1.21]
110172624  carnitine O-palmitoyltransferase 1, liver isoform-like [KO:K08765] [EC:2.3.1.21]
110161331  cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
110162579  cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
110162160  sirt1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
110154791  pre-B-cell leukemia transcription factor 1-like isoform X1 [KO:K09355]
110157505  pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
110171287  interleukin-10-like [KO:K05443]
110166058  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
110169666  group XV phospholipase A2-like [KO:K06129] [EC:3.1.1.5]
110164798  ppard; peroxisome proliferator-activated receptor delta [KO:K04504]
110157522  solute carrier family 2, facilitated glucose transporter member 1-like [KO:K07299]
110165620  solute carrier family 2, facilitated glucose transporter member 1-like [KO:K07299]
110174176  solute carrier family 2, facilitated glucose transporter member 1-like [KO:K07299]
110174353  monocarboxylate transporter 1-like [KO:K08179]
110175822  monocarboxylate transporter 1-like [KO:K08179]
110162628  serine/threonine-protein kinase Sgk1-like isoform X1 [KO:K13302] [EC:2.7.11.1]
110171528  serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
110153756  sgk1; serine/threonine-protein kinase Sgk1 [KO:K13302] [EC:2.7.11.1]
110173824  platelet endothelial cell adhesion molecule-like isoform X1 [KO:K06471]
110158210  platelet endothelial cell adhesion molecule-like isoform X1 [KO:K06471]
110163058  ptpn6; tyrosine-protein phosphatase non-receptor type 6 [KO:K05697] [EC:3.1.3.48]
110157366  ptpn11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
110157943  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
bpec00010  Glycolysis / Gluconeogenesis
bpec04140  Autophagy - animal
bpec04145  Phagosome
KO pathway
ko04148   
LinkDB

DBGET integrated database retrieval system