KEGG   PATHWAY: cge04218
Entry
cge04218                    Pathway                                
Name
Cellular senescence - Cricetulus griseus (Chinese hamster)
Description
Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of factors, such as telomere shortening, oncogene activation, irradiation, DNA damage and oxidative stress. It is characterized by enlarged flattened morphology, senescence-associated beta-galactosidase (SA-b-gal) activity, secretion of inflammatory cytokines, growth factors and matrix metalloproteinases, as part of the senescence-associated secretory phenotype (SASP). Cellular senescence is functionally associated with many biological processes including aging, tumor suppression, placental biology, embryonic development, and wound healing.
Class
Cellular Processes; Cell growth and death
Pathway map
cge04218  Cellular senescence
cge04218

Other DBs
GO: 0090398
Organism
Cricetulus griseus (Chinese hamster) [GN:cge]
Gene
100773359  Tgfb1; transforming growth factor beta-1 proprotein isoform X2 [KO:K13375]
100774918  Tgfb2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
100756831  Tgfb3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
100772727  Tgfbr1; TGF-beta receptor type-1 isoform X3 [KO:K04674] [EC:2.7.11.30]
100773953  Tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
100771578  Smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
100759220  Smad3; mothers against decapentaplegic homolog 3 isoform X3 [KO:K23605]
113833995  cyclin-dependent kinase 4 inhibitor B [KO:K04685]
100760122  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100764515  Cdk6; cyclin-dependent kinase 6 isoform X2 [KO:K02091] [EC:2.7.11.22]
100689063  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
100771544  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
100766025  Ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
100752928  Rb1; LOW QUALITY PROTEIN: retinoblastoma-associated protein isoform X2 [KO:K06618]
100755818  Rbl1; retinoblastoma-like protein 1 isoform X2 [KO:K04681]
100770221  Rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
100758556  E2f1; LOW QUALITY PROTEIN: transcription factor E2F1 isoform X2 [KO:K17454]
100754522  E2f2; transcription factor E2F2 isoform X2 [KO:K09389]
100754647  E2f3; transcription factor E2F3 isoform X1 [KO:K06620]
103160151  E2f5; transcription factor E2F5 [KO:K04682]
100765561  E2f4; transcription factor E2F4 isoform X3 [KO:K04682]
100689251  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100769225  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
100689252  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
100771181  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X2 [KO:K02649]
100750761  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100774067  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100768647  Foxo1; forkhead box protein O1 isoform X2 [KO:K07201]
100770315  Foxo3; forkhead box protein O3 [KO:K09408]
103160601  Cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625]
100689039  Cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
100760464  Ccne2; G1/S-specific cyclin-E2 isoform X3 [KO:K06626]
100753358  Ccne1; G1/S-specific cyclin-E1 isoform X2 [KO:K06626]
100689010  MHC class I antigen Hm1-C2 precursor [KO:K06751]
100689011  MHC class I antigen Hm1-C3 precursor [KO:K06751]
103162117  H-2 class I histocompatibility antigen, K-D alpha chain [KO:K06751]
100751667  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
100771128  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like isoform X2 [KO:K06751]
100751953  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like [KO:K06751]
113832472  class I histocompatibility antigen, Gogo-A*0101 alpha chain-like [KO:K06751]
113832473  HLA class I histocompatibility antigen, alpha chain F-like [KO:K06751]
100772658  HLA class I histocompatibility antigen, alpha chain F [KO:K06751]
100772949  saoe class I histocompatibility antigen, A alpha chain isoform X2 [KO:K06751]
100757234  H-2 class I histocompatibility antigen, alpha chain [KO:K06751]
100757524  popy Class I histocompatibility antigen, A-1 alpha chain-like isoform X2 [KO:K06751]
100758961  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
100758095  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, A-126 alpha chain-like isoform X2 [KO:K06751]
100753528  RT1 class I histocompatibility antigen, AA alpha chain isoform X2 [KO:K06751]
100762763  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X2 [KO:K06751]
100762478  H-2 class I histocompatibility antigen, Q10 alpha chain isoform X2 [KO:K06751]
100757615  H-2 class I histocompatibility antigen, Q10 alpha chain isoform X1 [KO:K06751]
100759246  H-2 class I histocompatibility antigen, Q10 alpha chain [KO:K06751]
100751378  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
100689009  MHC class I antigen Hm1-C4 precursor [KO:K06751]
100689008  MHC class I antigen Hm1-C5 isoform X1 [KO:K06751]
103158895  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
100761901  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q10 alpha chain isoform X2 [KO:K06751]
113831254  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X4 [KO:K06751]
100773242  patr class I histocompatibility antigen, A-2 alpha chain [KO:K06751]
118237718  RT1 class I histocompatibility antigen, AA alpha chain-like isoform X1 [KO:K06751]
100763178  Kras; GTPase KRas isoform X4 [KO:K07827]
113839127  GTPase KRas-like [KO:K07827]
113837935  GTPase KRas-like isoform X2 [KO:K07827]
113837956  GTPase KRas-like [KO:K07827]
113838653  GTPase KRas-like isoform X2 [KO:K07827]
113838692  GTPase KRas-like [KO:K07827]
113838722  GTPase KRas-like isoform X1 [KO:K07827]
113838818  GTPase KRas-like [KO:K07827]
113837633  GTPase KRas-like isoform X1 [KO:K07827]
113838146  GTPase KRas-like isoform X1 [KO:K07827]
113838876  GTPase KRas-like [KO:K07827]
113838228  GTPase KRas-like isoform X1 [KO:K07827]
113839011  GTPase KRas-like [KO:K07827]
100771078  GTPase KRas-like isoform X2 [KO:K07827]
113837960  GTPase KRas-like [KO:K07827]
113838098  GTPase KRas-like [KO:K07827]
113838326  GTPase KRas-like [KO:K07827]
113838417  GTPase KRas-like isoform X1 [KO:K07827]
113838488  GTPase KRas-like [KO:K07827]
113838583  GTPase KRas-like isoform X1 [KO:K07827]
113838676  GTPase KRas-like [KO:K07827]
113838679  GTPase KRas-like isoform X1 [KO:K07827]
113838746  GTPase KRas-like [KO:K07827]
113838796  GTPase KRas-like isoform X1 [KO:K07827]
113838871  GTPase KRas-like [KO:K07827]
113838872  GTPase KRas-like [KO:K07827]
113838892  GTPase KRas-like [KO:K07827]
113838898  GTPase KRas-like [KO:K07827]
113838914  GTPase KRas-like [KO:K07827]
113838921  GTPase KRas-like [KO:K07827]
113838942  GTPase KRas-like isoform X1 [KO:K07827]
113838943  GTPase KRas-like isoform X1 [KO:K07827]
113839007  GTPase HRas-like isoform X1 [KO:K07827]
118239746  GTPase KRas-like isoform X1 [KO:K07827]
118239767  GTPase KRas-like isoform X1 [KO:K07827]
118239768  GTPase KRas-like [KO:K07827]
118239770  GTPase KRas-like [KO:K07827]
118239801  GTPase KRas-like [KO:K07827]
118239825  GTPase KRas-like isoform X1 [KO:K07827]
100757614  Nras; GTPase NRas [KO:K07828]
100766263  Rras; ras-related protein R-Ras isoform X1 [KO:K07829]
100771410  Rras2; ras-related protein R-Ras2 isoform X2 [KO:K07830]
100767950  Mras; ras-related protein M-Ras isoform X1 [KO:K07831]
100773737  Hras; GTPase HRas isoform X2 [KO:K02833]
100768351  Akt2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100752454  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100769460  Akt1; RAC-alpha serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100767621  Tsc1; hamartin isoform X1 [KO:K07206]
100755849  Tsc2; tuberin isoform X1 [KO:K07207]
100768233  Rheb; GTP-binding protein Rheb isoform X2 [KO:K07208]
100755421  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100764294  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X3 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100763298  Sirt1; LOW QUALITY PROTEIN: NAD-dependent protein deacetylase sirtuin-1 isoform X2 [KO:K11411] [EC:2.3.1.286]
100759649  Ccna2; cyclin-A2 isoform X2 [KO:K06627]
100769969  Ccna1; cyclin-A1 isoform X2 [KO:K06627]
100773251  Mybl2; myb-related protein B isoform X2 [KO:K21769]
100774401  Lin9; protein lin-9 homolog isoform X3 [KO:K21773]
100754605  Lin37; protein lin-37 homolog isoform X2 [KO:K21774]
100755280  Lin52; protein lin-52 homolog isoform X1 [KO:K21775]
100755318  Lin54; protein lin-54 homolog isoform X1 [KO:K21776]
100757871  Rbbp4; histone-binding protein RBBP4 isoform X2 [KO:K10752]
100769341  Foxm1; forkhead box protein M1 isoform X1 [KO:K09406]
100773301  Myc; myc proto-oncogene protein isoform X2 [KO:K04377]
100764983  tumor suppressor ARF isoform X2 [KO:K06621]
100770120  Mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X3 [KO:K06643] [EC:2.3.2.27]
100682525  Tp53; cellular tumor antigen p53 [KO:K04451]
100758747  Rassf5; ras association domain-containing protein 5 isoform X3 [KO:K08015]
100753568  F-box/WD repeat-containing protein 11 isoform X2 [KO:K03362]
100750426  Btrc; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
100772242  Fbxw11; F-box/WD repeat-containing protein 11 isoform X3 [KO:K03362]
100767468  Hipk2; homeodomain-interacting protein kinase 2 isoform X6 [KO:K08826] [EC:2.7.11.1]
100759237  Hipk1; homeodomain-interacting protein kinase 1 isoform X1 [KO:K08826] [EC:2.7.11.1]
100772418  Hipk3; homeodomain-interacting protein kinase 3 isoform X1 [KO:K08826] [EC:2.7.11.1]
100763406  Hipk4; homeodomain-interacting protein kinase 4 [KO:K08826] [EC:2.7.11.1]
100761524  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X2 [KO:K06269] [EC:3.1.3.16]
100760810  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
100774547  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X2 [KO:K06269] [EC:3.1.3.16]
100769018  Raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
100689403  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
113835540  dual specificity mitogen-activated protein kinase kinase 1-like isoform X1 [KO:K04368] [EC:2.7.12.2]
103158537  dual specificity mitogen-activated protein kinase kinase 1-like isoform X2 [KO:K04368] [EC:2.7.12.2]
100774204  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X2 [KO:K04369] [EC:2.7.12.2]
100759514  Mapk1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
100753149  Mapk3; mitogen-activated protein kinase 3 isoform X2 [KO:K04371] [EC:2.7.11.24]
100767456  Ets1; protein C-ets-1 isoform X2 [KO:K02678]
100756793  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 isoform X3 [KO:K04432] [EC:2.7.12.2]
100771767  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
100689104  Mapk14; mitogen-activated protein kinase 14 isoform X3 [KO:K04441] [EC:2.7.11.24]
100759172  Mapk11; mitogen-activated protein kinase 11 isoform X2 [KO:K04441] [EC:2.7.11.24]
100754042  Mapk12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
100763519  Mapk13; mitogen-activated protein kinase 13 isoform X2 [KO:K04441] [EC:2.7.11.24]
103159266  Gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X2 [KO:K04402]
100759228  Gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
100766127  Gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
100766716  Cdk1; cyclin-dependent kinase 1 isoform X1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
100770842  Ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
100773656  Ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
100755282  Ccnb3; G2/mitotic-specific cyclin-B3 [KO:K21771]
100750877  Mre11; double-strand break repair protein MRE11 [KO:K10865]
100755349  Rad50; DNA repair protein RAD50 isoform X2 [KO:K10866] [EC:3.6.-.-]
100750782  Nbn; nibrin isoform X2 [KO:K10867]
100754226  serine-protein kinase ATM isoform X6 [KO:K04728] [EC:2.7.11.1]
100769280  Chek2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
100761098  Rad9a; cell cycle checkpoint control protein RAD9A isoform X1 [KO:K10994] [EC:3.1.11.2]
100764146  Rad9b; cell cycle checkpoint control protein RAD9B [KO:K10995]
100756835  Rad1; cell cycle checkpoint protein RAD1 [KO:K02830] [EC:3.1.11.2]
100754140  Hus1; checkpoint protein HUS1 isoform X1 [KO:K10903]
100766256  Atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
100751099  Chek1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
100767961  Cdc25a; M-phase inducer phosphatase 1 [KO:K06645] [EC:3.1.3.48]
100768352  Sqstm1; sequestosome-1 isoform X3 [KO:K14381]
100756123  Gata4; LOW QUALITY PROTEIN: transcription factor GATA-4 isoform X2 [KO:K09183]
100774308  Traf3ip2; adapter protein CIKS [KO:K21124]
100770607  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
100763542  Rela; transcription factor p65 isoform X4 [KO:K04735]
100769260  Il1a; interleukin-1 alpha [KO:K04383]
100689186  Il6; interleukin-6 [KO:K05405]
100764858  Igfbp3; insulin-like growth factor-binding protein 3 isoform X2 [KO:K10138]
100759702  Serpine1; plasminogen activator inhibitor 1 isoform X2 [KO:K03982]
100769654  Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
100762218  Mapkapk2; MAP kinase-activated protein kinase 2 isoform X2 [KO:K04443] [EC:2.7.11.1]
100759015  Zfp36l1; mRNA decay activator protein ZFP36L1 [KO:K18753]
103162508  zinc finger protein 36, C3H1 type-like 3 [KO:K18753]
113835924  mRNA decay activator protein ZFP36L2 [KO:K18753]
100772497  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
100751070  Trpv4; transient receptor potential cation channel subfamily V member 4 isoform X1 [KO:K04973]
100752689  Trpm7; transient receptor potential cation channel subfamily M member 7 isoform X4 [KO:K04982] [EC:2.7.11.1]
100758636  Capn1; calpain-1 catalytic subunit isoform X3 [KO:K01367] [EC:3.4.22.52]
100771239  Capn2; calpain-2 catalytic subunit isoform X2 [KO:K03853] [EC:3.4.22.53]
100766751  Calml3; calmodulin-like protein 3 [KO:K02183]
100767046  Calml5; calmodulin-like protein 5 isoform X1 [KO:K02183]
100762749  Calm3; calmodulin-3 isoform X2 [KO:K02183]
100765281  Calm2; calmodulin-2 isoform X2 [KO:K02183]
100771772  Calm1; calmodulin-1 isoform X2 [KO:K02183]
100757500  Calml4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
100751814  calmodulin-like isoform X2 [KO:K02183]
100751412  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X6 [KO:K04348] [EC:3.1.3.16]
100752571  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
100764987  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100754314  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
100773706  Ppp3r1; calcineurin subunit B type 1 isoform X2 [KO:K06268]
100764851  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446]
100762227  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X2 [KO:K17332]
100760989  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
100768420  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
100764450  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X9 [KO:K04958]
100758965  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X2 [KO:K04959]
100751775  inositol 1,4,5-trisphosphate receptor type 3 isoform X3 [KO:K04960]
100769087  Slc25a5; ADP/ATP translocase 2 isoform X2 [KO:K05863]
100751779  Slc25a4; ADP/ATP translocase 1 isoform X2 [KO:K05863]
100773145  Slc25a31; ADP/ATP translocase 4 [KO:K05863]
100761654  LOW QUALITY PROTEIN: ADP/ATP translocase 2-like isoform X2 [KO:K05863]
100755641  LOW QUALITY PROTEIN: peptidyl-prolyl cis-trans isomerase D-like [KO:K05864] [EC:5.2.1.8]
100752921  peptidyl-prolyl cis-trans isomerase D isoform X2 [KO:K05864] [EC:5.2.1.8]
100765792  Vdac1; LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1 isoform X2 [KO:K05862]
100750613  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1-like [KO:K05862]
100761812  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
100774187  Vdac3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
100762628  Mcu; calcium uniporter protein, mitochondrial isoform X3 [KO:K20858]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07909  Sirolimus
C16844  Hydroxyl radical
Reference
PMID:24954210
  Authors
Munoz-Espin D, Serrano M
  Title
Cellular senescence: from physiology to pathology.
  Journal
Nat Rev Mol Cell Biol 15:482-96 (2014)
DOI:10.1038/nrm3823
Reference
PMID:26646499
  Authors
Childs BG, Durik M, Baker DJ, van Deursen JM
  Title
Cellular senescence in aging and age-related disease: from mechanisms to therapy.
  Journal
Nat Med 21:1424-35 (2015)
DOI:10.1038/nm.4000
Reference
PMID:26105537
  Authors
Sharpless NE, Sherr CJ
  Title
Forging a signature of in vivo senescence.
  Journal
Nat Rev Cancer 15:397-408 (2015)
DOI:10.1038/nrc3960
Reference
PMID:26435346
  Authors
Fridlyanskaya I, Alekseenko L, Nikolsky N
  Title
Senescence as a general cellular response to stress: A mini-review.
  Journal
Exp Gerontol 72:124-8 (2015)
DOI:10.1016/j.exger.2015.09.021
Reference
PMID:27417123
  Authors
Lujambio A
  Title
To clear, or not to clear (senescent cells)? That is the question.
  Journal
Bioessays 38 Suppl 1:S56-64 (2016)
DOI:10.1002/bies.201670910
Reference
PMID:26564316
  Authors
Di Mitri D, Alimonti A
  Title
Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer.
  Journal
Trends Cell Biol 26:215-26 (2016)
DOI:10.1016/j.tcb.2015.10.005
Reference
PMID:27574725
  Authors
Francica P, Aebersold DM, Medova M
  Title
Senescence as biologic endpoint following pharmacological targeting of receptor tyrosine kinases in cancer.
  Journal
Biochem Pharmacol 126:1-12 (2017)
DOI:10.1016/j.bcp.2016.08.022
Reference
PMID:23982440
  Authors
Bartling B
  Title
Cellular senescence in normal and premature lung aging.
  Journal
Z Gerontol Geriatr 46:613-22 (2013)
DOI:10.1007/s00391-013-0543-3
Reference
PMID:24238962
  Authors
Munoz-Espin D, Canamero M, Maraver A, Gomez-Lopez G, Contreras J, Murillo-Cuesta S, Rodriguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M
  Title
Programmed cell senescence during mammalian embryonic development.
  Journal
Cell 155:1104-18 (2013)
DOI:10.1016/j.cell.2013.10.019
Reference
PMID:26697828
  Authors
Herranz N, Gallage S, Gil J
  Title
TORn about SASP regulation.
  Journal
Cell Cycle 14:3771-2 (2015)
DOI:10.1080/15384101.2015.1105694
Reference
PMID:28410770
  Authors
Martin N, Bernard D
  Title
Calcium signaling and cellular senescence.
  Journal
Cell Calcium S0143-4160(17)30049-0 (2017)
DOI:10.1016/j.ceca.2017.04.001
Reference
PMID:25764980
  Authors
Farfariello V, Iamshanova O, Germain E, Fliniaux I, Prevarskaya N
  Title
Calcium homeostasis in cancer: A focus on senescence.
  Journal
Biochim Biophys Acta 1853:1974-9 (2015)
DOI:10.1016/j.bbamcr.2015.03.005
Reference
PMID:24062309
  Authors
McCarthy DA, Clark RR, Bartling TR, Trebak M, Melendez JA
  Title
Redox control of the senescence regulator interleukin-1alpha and the secretory phenotype.
  Journal
J Biol Chem 288:32149-59 (2013)
DOI:10.1074/jbc.M113.493841
Reference
PMID:27288568
  Authors
Donninger H, Schmidt ML, Mezzanotte J, Barnoud T, Clark GJ
  Title
Ras signaling through RASSF proteins.
  Journal
Semin Cell Dev Biol 58:86-95 (2016)
DOI:10.1016/j.semcdb.2016.06.007
Reference
PMID:28455242
  Authors
Barnoud T, Schmidt ML, Donninger H, Clark GJ
  Title
The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence.
  Journal
Cancer Lett 400:30-36 (2017)
DOI:10.1016/j.canlet.2017.04.030
Reference
PMID:26404840
  Authors
Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ
  Title
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
  Journal
Science 349:aaa5612 (2015)
DOI:10.1126/science.aaa5612
Reference
PMID:26777575
  Authors
Cao X, Li M
  Title
A New Pathway for Senescence Regulation.
  Journal
Genomics Proteomics Bioinformatics 13:333-5 (2015)
DOI:10.1016/j.gpb.2015.11.002
Reference
PMID:25564883
  Authors
Gire V, Dulic V
  Title
Senescence from G2 arrest, revisited.
  Journal
Cell Cycle 14:297-304 (2015)
DOI:10.1080/15384101.2014.1000134
Reference
PMID:24981831
  Authors
Mowla SN, Lam EW, Jat PS
  Title
Cellular senescence and aging: the role of B-MYB.
  Journal
Aging Cell 13:773-9 (2014)
DOI:10.1111/acel.12242
Reference
PMID:22546858
  Authors
Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Ronty M, Kinnula VL, Rahman I
  Title
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.
  Journal
J Clin Invest 122:2032-45 (2012)
DOI:10.1172/JCI60132
Reference
PMID:23542362
  Authors
Hwang JW, Yao H, Caito S, Sundar IK, Rahman I
  Title
Redox regulation of SIRT1 in inflammation and cellular senescence.
  Journal
Free Radic Biol Med 61:95-110 (2013)
DOI:10.1016/j.freeradbiomed.2013.03.015
Related
pathway
cge04020  Calcium signaling pathway
cge04068  FoxO signaling pathway
cge04110  Cell cycle
cge04115  p53 signaling pathway
cge04150  mTOR signaling pathway
KO pathway
ko04218   
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