KEGG   PATHWAY: cgib03320
Entry
cgib03320                   Pathway                                
Name
PPAR signaling pathway - Carassius gibelio (silver crucian carp)
Description
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.
Class
Organismal Systems; Endocrine system
Pathway map
cgib03320  PPAR signaling pathway
cgib03320

Organism
Carassius gibelio (silver crucian carp) [GN:cgib]
Gene
127973008  platelet glycoprotein 4 [KO:K06259]
127956719  platelet glycoprotein 4-like [KO:K06259]
127953582  long-chain fatty acid transport protein 1a [KO:K08745] [EC:6.2.1.-]
127966362  long-chain fatty acid transport protein 4-like [KO:K08745] [EC:6.2.1.-]
128021536  long-chain fatty acid transport protein 4-like [KO:K08745] [EC:6.2.1.-]
128025762  long-chain fatty acid transport protein 1b [KO:K08745] [EC:6.2.1.-]
127934621  zgc:158482; long-chain fatty acid transport protein 2 [KO:K08746] [EC:6.2.1.- 6.2.1.3]
127946827  long-chain fatty acid transport protein 2-like isoform X1 [KO:K08746] [EC:6.2.1.- 6.2.1.3]
127946828  long-chain fatty acid transport protein 2-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
127977182  solute carrier family 27 member 2a [KO:K08746] [EC:6.2.1.- 6.2.1.3]
128013958  long-chain fatty acid transport protein 2-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
128013959  long-chain fatty acid transport protein 2-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
128021569  long-chain fatty acid transport protein 6 [KO:K08749]
128021570  long-chain fatty acid transport protein 6 [KO:K08749]
127962930  fatty acid binding protein 1-B.1-like [KO:K08750]
127958906  fatty acid binding protein 1-A, liver isoform X1 [KO:K08750]
128018078  fatty acid binding protein 1-B.1 [KO:K08750]
127952255  fatty acid-binding protein, intestinal-like [KO:K08751]
127949157  fatty acid-binding protein, intestinal-like [KO:K08751]
127979576  fatty acid-binding protein, adipocyte-like [KO:K08752]
127935922  fatty acid-binding protein, heart-like [KO:K08752]
127935933  fatty acid-binding protein, adipocyte-like [KO:K08752]
127978832  fatty acid-binding protein, heart-like [KO:K08752]
127970435  fatty acid-binding protein, adipocyte-like [KO:K08753]
127975146  fatty acid-binding protein, adipocyte-like [KO:K08753]
127969627  fatty acid-binding protein, adipocyte-like [KO:K08753]
128029990  fatty acid-binding protein, adipocyte-like [KO:K08753]
127941531  gastrotropin [KO:K08755]
127986564  gastrotropin-like [KO:K08755]
127976143  fatty acid binding protein 7, brain, a [KO:K08756]
127938078  fatty acid-binding protein, brain-like [KO:K08756]
128031516  fatty acid-binding protein, brain-like [KO:K08756]
127984314  fatty acid-binding protein, brain-like [KO:K08756]
127974460  peroxisome proliferator-activated receptor alpha-like isoform X1 [KO:K07294]
127947225  peroxisome proliferator-activated receptor alpha-like [KO:K07294]
128014146  peroxisome proliferator-activated receptor alpha b [KO:K07294]
127941792  retinoic acid receptor RXR-alpha-A-like isoform X1 [KO:K08524]
127951657  retinoic acid receptor RXR-gamma-A isoform X1 [KO:K08524]
127957057  retinoic acid receptor RXR-alpha-B isoform X1 [KO:K08524]
127985863  retinoic acid receptor RXR-alpha-A isoform X1 [KO:K08524]
127996973  retinoic acid receptor RXR-alpha-B-like isoform X1 [KO:K08524]
128027352  retinoic acid receptor RXR-gamma-A-like isoform X1 [KO:K08524]
127978908  retinoic acid receptor RXR-beta-A-like isoform X1 [KO:K08525]
127935741  retinoic acid receptor RXR-beta-A isoform X1 [KO:K08525]
127983898  retinoic acid receptor RXR-gamma-B isoform X1 [KO:K08526]
127938879  retinoic acid receptor RXR-gamma-B-like isoform X1 [KO:K08526]
127943073  peroxisome proliferator-activated receptor delta-like [KO:K04504]
127963428  peroxisome proliferator-activated receptor delta b [KO:K04504]
127987682  peroxisome proliferator-activated receptor delta [KO:K04504]
128018676  peroxisome proliferator-activated receptor delta-like isoform X1 [KO:K04504]
127968264  peroxisome proliferator-activated receptor gamma-like isoform X1 [KO:K08530]
128022687  peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
127966717  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1 [KO:K01641] [EC:2.3.3.10]
128021437  hydroxymethylglutaryl-CoA synthase, cytoplasmic-like isoform X1 [KO:K01641] [EC:2.3.3.10]
127972835  apolipoprotein A-Ib [KO:K08757]
128003950  apolipoprotein A-I [KO:K08757]
127974442  type-4 ice-structuring protein LS-12-like [KO:K08758]
127974443  type-4 ice-structuring protein LS-12-like [KO:K08758]
128031203  type-4 ice-structuring protein LS-12-like [KO:K08758]
128031204  type-4 ice-structuring protein LS-12-like [KO:K08758]
127960279  phospholipid transfer protein [KO:K08761]
128016026  phospholipid transfer protein-like [KO:K08761]
127964365  NADP-dependent malic enzyme, mitochondrial [KO:K00029] [EC:1.1.1.40]
127975419  NADP-dependent malic enzyme-like [KO:K00029] [EC:1.1.1.40]
128019966  NADP-dependent malic enzyme, mitochondrial-like [KO:K00029] [EC:1.1.1.40]
128030535  NADP-dependent malic enzyme [KO:K00029] [EC:1.1.1.40]
127946970  acyl-CoA 6-desaturase [KO:K10226] [EC:1.14.19.3]
128014141  acyl-CoA 6-desaturase [KO:K10226] [EC:1.14.19.3]
127968884  acyl-CoA desaturase [KO:K00507] [EC:1.14.19.1]
127969818  stearoyl-CoA desaturase b [KO:K00507] [EC:1.14.19.1]
128025567  acyl-CoA desaturase-like [KO:K00507] [EC:1.14.19.1]
128026329  acyl-CoA desaturase-like [KO:K00507] [EC:1.14.19.1]
127950474  cytochrome P450 7A1-like [KO:K00489] [EC:1.14.14.23]
127961200  cytochrome P450 7A1 [KO:K00489] [EC:1.14.14.23]
128027733  cytochrome P450 7A1 [KO:K00489] [EC:1.14.14.23]
127950969  5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase-like [KO:K07431] [EC:1.14.14.139]
128024980  5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase-like [KO:K07431] [EC:1.14.14.139]
128024994  5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase-like [KO:K07431] [EC:1.14.14.139]
127961992  oxysterols receptor LXR-alpha-like [KO:K08536]
128016889  oxysterols receptor LXR-alpha-like [KO:K08536]
127964813  sterol 26-hydroxylase, mitochondrial-like isoform X1 [KO:K00488] [EC:1.14.15.15]
127965339  sterol 26-hydroxylase, mitochondrial-like [KO:K00488] [EC:1.14.15.15]
127959978  si:ch211-113j14.1; sterol 26-hydroxylase, mitochondrial [KO:K00488] [EC:1.14.15.15]
128016157  sterol 26-hydroxylase, mitochondrial-like [KO:K00488] [EC:1.14.15.15]
128019738  sterol 26-hydroxylase, mitochondrial-like [KO:K00488] [EC:1.14.15.15]
128020024  sterol 26-hydroxylase, mitochondrial-like [KO:K00488] [EC:1.14.15.15]
127965099  acyl-CoA-binding protein-like isoform X1 [KO:K08762]
128019558  acyl-CoA-binding protein-like [KO:K08762]
127951104  lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
127943264  lipoprotein lipase-like [KO:K01059] [EC:3.1.1.34]
127987964  lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
127988557  lipoprotein lipase isoform X1 [KO:K01059] [EC:3.1.1.34]
127971397  long-chain-fatty-acid--CoA ligase 4-like [KO:K01897] [EC:6.2.1.3]
127971581  long-chain-fatty-acid--CoA ligase 1b [KO:K01897] [EC:6.2.1.3]
127972953  fatty acid CoA ligase Acsl3-like [KO:K01897] [EC:6.2.1.3]
127957526  long-chain-fatty-acid--CoA ligase 4b [KO:K01897] [EC:6.2.1.3]
127966589  long-chain-fatty-acid--CoA ligase 1-like isoform X1 [KO:K01897] [EC:6.2.1.3]
127935224  fatty acid CoA ligase Acsl3-like [KO:K01897] [EC:6.2.1.3]
127968879  long-chain-fatty-acid--CoA ligase 5-like [KO:K01897] [EC:6.2.1.3]
127949366  long-chain-fatty-acid--CoA ligase 1-like isoform X1 [KO:K01897] [EC:6.2.1.3]
127941422  long-chain-fatty-acid--CoA ligase 6-like isoform X1 [KO:K01897] [EC:6.2.1.3]
127950996  fatty acid CoA ligase Acsl3-like [KO:K01897] [EC:6.2.1.3]
128025376  long-chain-fatty-acid--CoA ligase 5-like [KO:K01897] [EC:6.2.1.3]
127985953  long-chain-fatty-acid--CoA ligase 6-like isoform X1 [KO:K01897] [EC:6.2.1.3]
128018257  long-chain-fatty-acid--CoA ligase 1-like [KO:K01897] [EC:6.2.1.3]
128027302  long-chain-fatty-acid--CoA ligase 4-like [KO:K01897] [EC:6.2.1.3]
128027710  long-chain-fatty-acid--CoA ligase 1-like [KO:K01897] [EC:6.2.1.3]
128028579  long-chain-fatty-acid--CoA ligase 3a [KO:K01897] [EC:6.2.1.3]
127963906  long-chain-fatty-acid--CoA ligase ACSBG2-like isoform X1 [KO:K15013] [EC:6.2.1.3]
127947284  long-chain-fatty-acid--CoA ligase ACSBG1-like isoform X1 [KO:K15013] [EC:6.2.1.3]
127958759  long-chain-fatty-acid--CoA ligase ACSBG2-like [KO:K15013] [EC:6.2.1.3]
127998171  long-chain-fatty-acid--CoA ligase ACSBG2-like [KO:K15013] [EC:6.2.1.3]
128018763  long-chain-fatty-acid--CoA ligase ACSBG2-like isoform X1 [KO:K15013] [EC:6.2.1.3]
127965244  peroxisomal bifunctional enzyme [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
127946603  3-ketoacyl-CoA thiolase A, peroxisomal-like [KO:K07513] [EC:2.3.1.16]
127951060  sterol carrier protein 2 isoform X1 [KO:K08764] [EC:2.3.1.176]
127962094  peroxisomal acyl-coenzyme A oxidase 3 [KO:K00232] [EC:1.3.3.6]
128016218  peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
127961859  carnitine palmitoyltransferase 1Aa (liver) [KO:K08765] [EC:2.3.1.21]
127945923  carnitine O-palmitoyltransferase 1, liver isoform-like [KO:K08765] [EC:2.3.1.21]
127934005  carnitine O-palmitoyltransferase 1, liver isoform-like isoform X1 [KO:K08765] [EC:2.3.1.21]
127946710  carnitine O-palmitoyltransferase 1, liver isoform-like isoform X1 [KO:K08765] [EC:2.3.1.21]
127949662  carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
127977595  carnitine O-palmitoyltransferase 1, liver isoform-like [KO:K08765] [EC:2.3.1.21]
128014321  carnitine O-palmitoyltransferase 1, liver isoform-like isoform X1 [KO:K08765] [EC:2.3.1.21]
128016617  carnitine O-palmitoyltransferase 1, liver isoform-like [KO:K08765] [EC:2.3.1.21]
128016624  carnitine O-palmitoyltransferase 1, liver isoform-like [KO:K08765] [EC:2.3.1.21]
128013202  carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
127963924  carnitine O-palmitoyltransferase 2, mitochondrial [KO:K08766] [EC:2.3.1.21]
128018740  carnitine O-palmitoyltransferase 2, mitochondrial-like [KO:K08766] [EC:2.3.1.21]
127934185  long-chain specific acyl-CoA dehydrogenase, mitochondrial-like isoform X1 [KO:K00255] [EC:1.3.8.8]
127977733  long-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00255] [EC:1.3.8.8]
127951660  medium-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00249] [EC:1.3.8.7]
128029104  medium-chain specific acyl-CoA dehydrogenase, mitochondrial-like [KO:K00249] [EC:1.3.8.7]
127951402  angiopoietin-related protein 4-like [KO:K08767]
128028740  angiopoietin-related protein 4-like [KO:K08767]
127970060  sorbin and SH3 domain-containing protein 1 isoform X1 [KO:K06086]
128026249  sorbin and SH3 domain-containing protein 1-like isoform X1 [KO:K06086]
127977169  perilipin-1-like isoform X1 [KO:K08768]
127972351  perilipin-2-like isoform X1 [KO:K17284]
128029329  perilipin-2-like [KO:K17284]
127951502  adiponectin, C1Q and collagen domain containing, b [KO:K07296]
128012956  adiponectin [KO:K07296]
127966624  integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
128021203  integrin-linked protein kinase-like [KO:K06272] [EC:2.7.11.1]
127952379  3-phosphoinositide-dependent protein kinase 1-like isoform X1 [KO:K06276] [EC:2.7.11.1]
127953250  3-phosphoinositide-dependent protein kinase 1-like isoform X1 [KO:K06276] [EC:2.7.11.1]
127945931  3-phosphoinositide-dependent protein kinase 1-like isoform X1 [KO:K06276] [EC:2.7.11.1]
128013271  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
127965811  polyubiquitin-B isoform X1 [KO:K08770]
127957979  polyubiquitin-C [KO:K08770]
128000895  polyubiquitin-C isoform X1 [KO:K08770]
128020768  polyubiquitin-B isoform X1 [KO:K08770]
127946541  phosphoenolpyruvate carboxykinase, cytosolic [GTP]-like [KO:K01596] [EC:4.1.1.32]
128016087  phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
128013009  phosphoenolpyruvate carboxykinase, cytosolic [GTP]-like [KO:K01596] [EC:4.1.1.32]
127949649  glycerol kinase-like isoform X1 [KO:K00864] [EC:2.7.1.30]
128015315  glycerol kinase-like isoform X1 [KO:K00864] [EC:2.7.1.30]
127985781  aquaporin-7 isoform X1 [KO:K08771]
Compound
C02165  Leukotriene B4
C14762  13(S)-HODE
C14767  9(S)-HODE
C14776  8(S)-HETE
C15493  9-cis-Retinoic acid
Reference
PMID:15828220
  Authors
Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T.
  Title
[The structures and functions of peroxisome proliferator-activated receptors (PPARs)]
  Journal
Nippon Rinsho 63:557-64 (2005)
Reference
PMID:15828221
  Authors
Fujii H.
  Title
[PPARs-mediated intracellular signal transduction]
  Journal
Nippon Rinsho 63:565-71 (2005)
Reference
PMID:15828222
  Authors
Takada I, Kato S.
  Title
[PPARs target genes]
  Journal
Nippon Rinsho 63:573-7 (2005)
Reference
PMID:15828223
  Authors
Inoue H.
  Title
[Endogenous ligands for PPARs]
  Journal
Nippon Rinsho 63:578-83 (2005)
Reference
PMID:16476485
  Authors
Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W.
  Title
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.
  Journal
Prog Lipid Res 45:120-59 (2006)
DOI:10.1016/j.plipres.2005.12.002
Reference
PMID:16601267
  Authors
Desvergne B, Michalik L, Wahli W.
  Title
Transcriptional regulation of metabolism.
  Journal
Physiol Rev 86:465-514 (2006)
DOI:10.1152/physrev.00025.2005
Reference
PMID:14999402
  Authors
Mandard S, Muller M, Kersten S.
  Title
Peroxisome proliferator-activated receptor alpha target genes.
  Journal
Cell Mol Life Sci 61:393-416 (2004)
DOI:10.1007/s00018-003-3216-3
Reference
PMID:10529898
  Authors
Desvergne B, Wahli W.
  Title
Peroxisome proliferator-activated receptors: nuclear control of metabolism.
  Journal
Endocr Rev 20:649-88 (1999)
DOI:10.1210/edrv.20.5.0380
Reference
PMID:15673477
  Authors
Savage DB.
  Title
PPARgamma as a metabolic regulator: insights from genomics and pharmacology.
  Journal
Expert Rev Mol Med 2005:1-16 (2005)
DOI:10.1017/S1462399405008793
Reference
PMID:16511590
  Authors
Semple RK, Chatterjee VK, O'Rahilly S.
  Title
PPAR gamma and human metabolic disease.
  Journal
J Clin Invest 116:581-9 (2006)
DOI:10.1172/JCI28003
Reference
PMID:16360030
  Authors
Lehrke M, Lazar MA.
  Title
The many faces of PPARgamma.
  Journal
Cell 123:993-9 (2005)
DOI:10.1016/j.cell.2005.11.026
Reference
PMID:11921433
  Authors
Hauner H.
  Title
The mode of action of thiazolidinediones.
  Journal
Diabetes Metab Res Rev 18 Suppl 2:S10-5 (2002)
DOI:10.1002/dmrr.249
Related
pathway
cgib00071  Fatty acid degradation
cgib00120  Primary bile acid biosynthesis
cgib00564  Glycerophospholipid metabolism
cgib04920  Adipocytokine signaling pathway
KO pathway
ko03320   
LinkDB

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