KEGG   PATHWAY: cmao04068
Entry
cmao04068                   Pathway                                
Name
FoxO signaling pathway - Colossoma macropomum (tambaqui)
Description
The forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative stress resistance, and longevity. A central regulatory mechanism of FOXO proteins is phosphorylation by the serine-threonine kinase Akt/protein kinase B (Akt/PKB), downstream of phosphatidylinositol 3-kinase (PI3K), in response to insulin or several growth factors. Phosphorylation at three conserved residues results in the export of FOXO proteins from the nucleus to the cytoplasm, thereby decreasing expression of FOXO target genes. In contrast, the stress-activated c-Jun N-terminal kinase (JNK) and the energy sensing AMP-activated protein kinase (AMPK), upon oxidative and nutrient stress stimuli phosphorylate and activate FoxOs. Aside from PKB, JNK and AMPK, FOXOs are regulated by multiple players through several post-translational modifications, including phosphorylation, but also acetylation, methylation and ubiquitylation.
Class
Environmental Information Processing; Signal transduction
Pathway map
cmao04068  FoxO signaling pathway
cmao04068

Other DBs
GO: 0009267
Organism
Colossoma macropomum (tambaqui) [GN:cmao]
Gene
118819844  tgfb1b; transforming growth factor beta-1 proprotein [KO:K13375]
118796969  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
118806906  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
118819641  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
118823493  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
118816435  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
118807159  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
118801892  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
118819778  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
118816927  si:dkey-239n17.4; mothers against decapentaplegic homolog 4 [KO:K04501]
118825297  smad4a; mothers against decapentaplegic homolog 4a isoform X1 [KO:K04501]
118827315  smad4; mothers against decapentaplegic homolog 4 [KO:K04501]
118805292  si:dkey-222b8.1; mothers against decapentaplegic homolog 4 [KO:K04501]
118817497  smad3a; mothers against decapentaplegic homolog 3a [KO:K23605]
118817717  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
118796994  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
118802406  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
118815456  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
118813077  prkab1b; 5'-AMP-activated protein kinase subunit beta-1b isoform X1 [KO:K07199]
118824972  prkab1a; 5'-AMP-activated protein kinase subunit beta-1a [KO:K07199]
118797122  prkab2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
118798670  5'-AMP-activated protein kinase subunit gamma-2-like isoform X1 [KO:K07200]
118806829  prkag3b; 5'-AMP-activated protein kinase subunit gamma-3b isoform X1 [KO:K07200]
118825561  prkag2b; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
118802319  prkag3a; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
118808407  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
118804040  nlk2; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
118820972  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
118819980  skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
118812327  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
118806996  setd7; histone-lysine N-methyltransferase SETD7 [KO:K11431] [EC:2.1.1.364]
118804602  LOW QUALITY PROTEIN: CREB-binding protein-like [KO:K04498] [EC:2.3.1.48]
118805374  ep300b; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
118809498  ep300a; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
118810738  sirt1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
118821065  usp7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
118825642  solute carrier family 2, facilitated glucose transporter member 4-like [KO:K07191]
118810413  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118820022  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
118820354  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
118809785  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118808687  serine/threonine-protein kinase 4-like [KO:K04411]
118812612  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
118818325  igf1ra; insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
118819471  igf1rb; insulin-like growth factor 1b receptor [KO:K05087] [EC:2.7.10.1]
118806420  insb; preproinsulin b [KO:K04526]
118800533  insulin [KO:K04526]
118801651  ins; insulin [KO:K04526]
118818705  insrb; insulin receptor b isoform X1 [KO:K04527] [EC:2.7.10.1]
118826559  insra; insulin receptor a [KO:K04527] [EC:2.7.10.1]
118798903  irs1; insulin receptor substrate 1-B [KO:K16172]
118798413  irs2a; insulin receptor substrate 2a [KO:K07187]
118824744  irs2b; insulin receptor substrate 2 [KO:K07187]
118820113  irs4a; insulin receptor substrate 2-B [KO:K07187]
118826746  insulin receptor substrate 2-B [KO:K07187]
118822140  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
118822617  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
118818810  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118801967  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118808170  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
118814571  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118805760  pdpk1a; 3-phosphoinositide-dependent protein kinase 1a [KO:K06276] [EC:2.7.11.1]
118822345  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
118810516  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
118810719  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
118813511  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
118823275  ptena; phosphatase and tensin homolog A isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
118809576  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
118810240  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118815953  LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
118798278  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118823237  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118818017  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118798768  sgk2b; serine/threonine-protein kinase Sgk2b [KO:K13302] [EC:2.7.11.1]
118805276  si:ch211-195b13.1; STKc_SGK domain-containing protein isoform X1 [KO:K13302] [EC:2.7.11.1]
118822004  LOW QUALITY PROTEIN: serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
118822424  sgk2a; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
118798629  sgk3; serine/threonine-protein kinase Sgk3 [KO:K13304] [EC:2.7.11.1]
118824428  foxo1b; forkhead box protein O1-B [KO:K07201]
118802946  foxo1a; forkhead box protein O1-A [KO:K07201]
118823431  foxo3a; forkhead box protein O3a [KO:K09408]
118815901  foxo3b; forkhead box protein O3B [KO:K09408]
118807219  foxo4; forkhead box protein O4 [KO:K12358]
118818928  foxo6a; forkhead box protein O6 [KO:K17847]
118824045  grm1b; metabotropic glutamate receptor 1b isoform X1 [KO:K04603]
118815893  grm1a; metabotropic glutamate receptor 1 [KO:K04603]
118819124  homer3b; homer protein homolog 3b [KO:K15010]
118820292  homer protein homolog 1 [KO:K15010]
118803973  homer2; homer protein homolog 2 [KO:K15010]
118796926  LOW QUALITY PROTEIN: homer protein homolog 3 [KO:K15010]
118827500  homer1b; homer protein homolog 1b isoform X1 [KO:K15010]
118822582  agap2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
118799512  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like [KO:K17848]
118800242  csnk1e; casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
118804519  casein kinase I [KO:K08960] [EC:2.7.11.1]
118806159  il6; interleukin-6 [KO:K05405]
118799562  il10; interleukin-10 [KO:K05443]
118800021  interleukin-10-like [KO:K05443]
118821460  stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
118806475  egf; pro-epidermal growth factor [KO:K04357]
118823220  epidermal growth factor receptor-like isoform X1 [KO:K04361] [EC:2.7.10.1]
118796721  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
118808138  grb2a; LOW QUALITY PROTEIN: growth factor receptor-bound protein 2a [KO:K04364]
118820918  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
118811059  sos2; son of sevenless homolog 2 [KO:K03099]
118819349  sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
118817540  hrasb; HRas proto-oncogene, GTPase b isoform X1 [KO:K02833]
118811525  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
118811569  kras; GTPase KRas isoform X1 [KO:K07827]
118821270  zgc:55558; GTPase HRas [KO:K07827]
118813822  nras; GTPase NRas [KO:K07828]
118812517  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
118822149  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
118799451  raf1b; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
118827772  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
118818240  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
118818647  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
118797185  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
118820974  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
118827508  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
118822615  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
118799753  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
118818088  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
118812248  mapk12b; mitogen-activated protein kinase 12b isoform X1 [KO:K04441] [EC:2.7.11.24]
118812249  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
118813192  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
118813814  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
118799445  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
118800522  prmt1; protein arginine N-methyltransferase 1 [KO:K11434] [EC:2.1.1.319]
118816840  foxg1d; forkhead box protein G1 [KO:K09385]
118823675  foxg1a; forkhead box protein G1 [KO:K09385]
118819087  foxg1b; forkhead box protein G1b [KO:K09385]
118814570  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
118817342  ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
118820194  G2/mitotic-specific cyclin-B3-like [KO:K21771]
118826727  ccnb3; G2/mitotic-specific cyclin-B3 [KO:K21771]
118818888  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
118806699  ccnd2a; G1/S-specific cyclin-D2a isoform X1 [KO:K10151]
118812280  ccnd2b; G1/S-specific cyclin-D2b [KO:K10151]
118819736  ccng2; cyclin-G2 [KO:K10146]
118810754  cdkn2a/b; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
118807906  cdkn2d; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
118799630  cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
118812411  cdkn1d; cyclin-dependent kinase inhibitor 1D [KO:K06625]
118811853  cdkn1bb; cyclin-dependent kinase inhibitor 1Bb [KO:K06624]
118812475  cdkn1ba; cyclin-dependent kinase inhibitor 1Ba [KO:K06624]
118811624  rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
118802152  plk1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
118824296  plk2a; LOW QUALITY PROTEIN: serine/threonine-protein kinase PLK2 [KO:K08861] [EC:2.7.11.21]
118813852  plk2b; serine/threonine-protein kinase PLK2b [KO:K08861] [EC:2.7.11.21]
118826398  plk3; serine/threonine-protein kinase PLK3 isoform X1 [KO:K08862] [EC:2.7.11.21]
118824008  plk4; serine/threonine-protein kinase PLK4 [KO:K08863] [EC:2.7.11.21]
118818878  gadd45ba; growth arrest and DNA-damage-inducible, beta a isoform X1 [KO:K04402]
118813019  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
118807727  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
118820040  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
118825864  gadd45bb; growth arrest and DNA-damage-inducible, beta b [KO:K04402]
118797223  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
118816146  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
118810097  bcl2l11; bcl-2-like protein 11 [KO:K16341]
118798701  tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
118808029  bcl6aa; BCL6A transcription repressor a isoform X1 [KO:K15618]
118826107  bcl6ab; BCL6A transcription repressor b isoform X1 [KO:K15618]
118809090  bnip3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
118814353  atg12; ubiquitin-like protein ATG12 [KO:K08336]
118806558  gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
118824886  zgc:92606; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
118826752  gabarapb; GABA(A) receptor-associated protein b [KO:K08341]
118814956  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
118810427  si:ch73-6k14.2; protein DEPP [KO:K27679]
118811972  cat; catalase [KO:K03781] [EC:1.11.1.6]
118815611  sod2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
118796987  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
118801245  pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
118808615  pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
118809162  g6pca.2; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
118809163  g6pca.1; glucose-6-phosphatase a, catalytic subunit, tandem duplicate 1 [KO:K01084] [EC:3.1.3.9]
118809805  g6pc3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
118821809  g6pcb; glucose-6-phosphatase b [KO:K01084] [EC:3.1.3.9]
118820374  il7r; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
118819310  klf2a; Krueppel-like factor 2a [KO:K17845]
118797245  klf2b; Krueppel-like factor 2b [KO:K17845]
118819371  s1pr1; sphingosine 1-phosphate receptor 1 [KO:K04288]
118819518  s1pr4; sphingosine 1-phosphate receptor 4 [KO:K04293]
118811587  rag1; V(D)J recombination-activating protein 1 [KO:K10628] [EC:2.3.2.27]
118811588  rag2; V(D)J recombination-activating protein 2 [KO:K10988]
118822146  fbxo25; F-box only protein 25 isoform X1 [KO:K10305]
118824036  fbxo32; F-box only protein 32 [KO:K10305]
Compound
C00008  ADP
C00020  AMP
C00025  L-Glutamate
C00031  D-Glucose
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17470511
  Authors
Glauser DA, Schlegel W
  Title
The emerging role of FOXO transcription factors in pancreatic beta cells.
  Journal
J Endocrinol 193:195-207 (2007)
DOI:10.1677/JOE-06-0191
Reference
PMID:17522590
  Authors
van der Horst A, Burgering BM
  Title
Stressing the role of FoxO proteins in lifespan and disease.
  Journal
Nat Rev Mol Cell Biol 8:440-50 (2007)
DOI:10.1038/nrm2190
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:23325358
  Authors
Eijkelenboom A, Burgering BM
  Title
FOXOs: signalling integrators for homeostasis maintenance.
  Journal
Nat Rev Mol Cell Biol 14:83-97 (2013)
DOI:10.1038/nrm3507
Reference
PMID:17569704
  Authors
Daitoku H, Fukamizu A
  Title
FOXO transcription factors in the regulatory networks of longevity.
  Journal
J Biochem 141:769-74 (2007)
DOI:10.1093/jb/mvm104
Reference
PMID:19701188
  Authors
Hedrick SM
  Title
The cunning little vixen: Foxo and the cycle of life and death.
  Journal
Nat Immunol 10:1057-63 (2009)
DOI:10.1038/ni.1784
Reference
PMID:15516968
  Authors
Coffer PJ, Burgering BM
  Title
Forkhead-box transcription factors and their role in the immune system.
  Journal
Nat Rev Immunol 4:889-99 (2004)
DOI:10.1038/nri1488
Reference
PMID:22902436
  Authors
Ro SH, Liu D, Yeo H, Paik JH
  Title
FoxOs in neural stem cell fate decision.
  Journal
Arch Biochem Biophys 534:55-63 (2013)
DOI:10.1016/j.abb.2012.07.017
Reference
PMID:18403263
  Authors
Maiese K, Chong ZZ, Shang YC
  Title
OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteins.
  Journal
Trends Mol Med 14:219-27 (2008)
DOI:10.1016/j.molmed.2008.03.002
Reference
PMID:23801966
  Authors
Hagenbuchner J, Ausserlechner MJ
  Title
Mitochondria and FOXO3: breath or die.
  Journal
Front Physiol 4:147 (2013)
DOI:10.3389/fphys.2013.00147
Reference
PMID:18045156
  Authors
Maiese K, Chong ZZ, Shang YC
  Title
"Sly as a FOXO": new paths with Forkhead signaling in the brain.
  Journal
Curr Neurovasc Res 4:295-302 (2007)
DOI:10.2174/156720207782446306
Reference
PMID:22761423
  Authors
Oh HM, Yu CR, Dambuza I, Marrero B, Egwuagu CE
  Title
STAT3 protein interacts with Class O Forkhead transcription factors in the cytoplasm and regulates nuclear/cytoplasmic localization of FoxO1 and FoxO3a proteins in CD4(+) T cells.
  Journal
J Biol Chem 287:30436-43 (2012)
DOI:10.1074/jbc.M112.359661
Reference
PMID:21238503
  Authors
Huang H, Tindall DJ
  Title
Regulation of FOXO protein stability via ubiquitination and proteasome degradation.
  Journal
Biochim Biophys Acta 1813:1961-4 (2011)
DOI:10.1016/j.bbamcr.2011.01.007
Reference
PMID:16288288
  Authors
Greer EL, Brunet A
  Title
FOXO transcription factors at the interface between longevity and tumor suppression.
  Journal
Oncogene 24:7410-25 (2005)
DOI:10.1038/sj.onc.1209086
Reference
PMID:15084259
  Authors
Seoane J, Le HV, Shen L, Anderson SA, Massague J
  Title
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.
  Journal
Cell 117:211-23 (2004)
DOI:10.1016/S0092-8674(04)00298-3
Reference
PMID:18951090
  Authors
Yamagata K, Daitoku H, Takahashi Y, Namiki K, Hisatake K, Kako K, Mukai H, Kasuya Y, Fukamizu A
  Title
Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.
  Journal
Mol Cell 32:221-31 (2008)
DOI:10.1016/j.molcel.2008.09.013
Reference
PMID:16964248
  Authors
van der Horst A, de Vries-Smits AM, Brenkman AB, van Triest MH, van den Broek N, Colland F, Maurice MM, Burgering BM
  Title
FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP.
  Journal
Nat Cell Biol 8:1064-73 (2006)
DOI:10.1038/ncb1469
Reference
PMID:21613825
  Authors
Zhang Y, Gan B, Liu D, Paik JH
  Title
FoxO family members in cancer.
  Journal
Cancer Biol Ther 12:253-9 (2011)
DOI:10.4161/cbt.12.4.15954
Reference
PMID:15005655
  Authors
Van Der Heide LP, Hoekman MF, Smidt MP
  Title
The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation.
  Journal
Biochem J 380:297-309 (2004)
DOI:10.1042/BJ20040167
Related
pathway
cmao00010  Glycolysis / Gluconeogenesis
cmao00020  Citrate cycle (TCA cycle)
cmao00190  Oxidative phosphorylation
cmao04010  MAPK signaling pathway
cmao04110  Cell cycle
cmao04120  Ubiquitin mediated proteolysis
cmao04140  Autophagy - animal
cmao04210  Apoptosis
cmao04350  TGF-beta signaling pathway
cmao04910  Insulin signaling pathway
KO pathway
ko04068   
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