KEGG   PATHWAY: cpea04148
Entry
cpea04148                   Pathway                                
Name
Efferocytosis - Chaetura pelagica (chimney swift)
Class
Cellular Processes; Transport and catabolism
Pathway map
cpea04148  Efferocytosis
cpea04148

Organism
Chaetura pelagica (chimney swift) [GN:cpea]
Gene
104393005  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
104392791  caspase-3-like [KO:K04397] [EC:3.4.22.60]
104397904  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
104391009  LOW QUALITY PROTEIN: caspase-13-like [KO:K01370] [EC:3.4.22.36]
104390250  PANX1; pannexin-1 [KO:K03443]
104397245  P2RY2; P2Y purinoceptor 2 [KO:K04269]
104397250  P2RY6; P2Y purinoceptor 6 [KO:K04272]
104395059  P2RY12; P2Y purinoceptor 12 [KO:K04298]
104396771  S1PR1; sphingosine 1-phosphate receptor 1 [KO:K04288]
104393820  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 [KO:K16343] [EC:3.1.1.4]
104389216  ABCA1; ATP-binding cassette sub-family A member 1 [KO:K05641]
104391416  GPR132; probable G-protein coupled receptor 132 [KO:K08426]
104390068  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 [KO:K06059] [EC:3.4.24.86]
104386000  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
104394560  CX3CL1; fractalkine [KO:K05508]
104392306  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
104389723  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
104398582  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
104394800  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
104391425  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
104385232  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
104391373  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
104388745  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104398704  PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
104389810  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
104394448  MFGE8; lactadherin [KO:K17253]
104389016  GAS6; growth arrest-specific protein 6 [KO:K05464]
104395028  MERTK; tyrosine-protein kinase Mer [KO:K05117] [EC:2.7.10.1]
104392394  CD36; platelet glycoprotein 4 [KO:K06259]
104397730  THBS1; thrombospondin-1 [KO:K16857]
104386653  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104391569  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
104388922  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
104394622  prostaglandin E2 receptor EP2 subtype-like [KO:K04259]
104398589  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
104392766  DNMT3A; DNA (cytosine-5)-methyltransferase 3A [KO:K17398] [EC:2.1.1.37]
104397373  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
104389413  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
104396241  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
104391460  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
104392185  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
104392612  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
104393372  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
104387234  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
104387330  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
104393872  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
104393877  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
104388631  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
104391514  ALOX5; arachidonate 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
104394328  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104395103  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104387145  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104387253  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104397911  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104396461  ANO6; anoctamin-6 [KO:K19500]
104394625  ANO3; anoctamin-3 [KO:K19498]
104389977  ANO4; anoctamin-4 [KO:K19499]
104387165  ANO5; anoctamin-5 [KO:K19480]
104392116  ANO9; anoctamin-9 [KO:K19503]
104392441  BSG; basigin [KO:K06535]
104393422  XKR8; XK-related protein 8 [KO:K26813]
104386921  XKR9; XK-related protein 9 [KO:K26814]
104385532  XKR7; XK-related protein 7 [KO:K26811]
104392802  XKR6; XK-related protein 6 [KO:K26811]
104396897  XKR4; XK-related protein 4 [KO:K26811]
104395880  ATP8A2; phospholipid-transporting ATPase IB [KO:K14802] [EC:7.6.2.1]
104396270  ATP8A1; phospholipid-transporting ATPase IA [KO:K14802] [EC:7.6.2.1]
104388389  ATP11C; phospholipid-transporting ATPase IG [KO:K26934] [EC:7.6.2.1]
104389024  ATP11A; probable phospholipid-transporting ATPase IH [KO:K26934] [EC:7.6.2.1]
104390224  ATP11B; probable phospholipid-transporting ATPase IF [KO:K26934] [EC:7.6.2.1]
104394019  TMEM30A; cell cycle control protein 50A [KO:K26935]
104384987  PROS1; vitamin K-dependent protein S [KO:K03908]
104386619  ITGAV; LOW QUALITY PROTEIN: integrin alpha-V [KO:K06487]
104390236  ITGB3; integrin beta-3 [KO:K06493]
104387304  ITGB5; integrin beta-5 [KO:K06588]
104390434  TYRO3; tyrosine-protein kinase receptor TYRO3 [KO:K05116] [EC:2.7.10.1]
104392694  TIMD4; T-cell immunoglobulin and mucin domain-containing protein 4 [KO:K26936]
104392589  HAVCR2; hepatitis A virus cellular receptor 2 [KO:K20413]
104387147  STAB1; stabilin-1 [KO:K19020]
104396081  STAB2; stabilin-2 [KO:K19013]
104387818  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
104386318  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
104384916  CRK; adapter molecule crk [KO:K04438]
104395117  CRKL; crk-like protein [KO:K04438]
104392722  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
104392476  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
104393800  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
104389134  disintegrin and metalloproteinase domain-containing protein 9-like [KO:K06834] [EC:3.4.24.-]
104384880  ADAM9; disintegrin and metalloproteinase domain-containing protein 9 [KO:K06834] [EC:3.4.24.-]
104394870  calreticulin-like [KO:K08057]
104388894  CALR3; calreticulin-3 [KO:K08057]
104397614  LRP1; LOW QUALITY PROTEIN: prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
104389194  MEGF10; multiple epidermal growth factor-like domains protein 10 isoform X1 [KO:K24068]
104386656  MEGF11; multiple epidermal growth factor-like domains protein 11 [KO:K24068]
104384919  SCARF1; scavenger receptor class F member 1 [KO:K24318]
104386605  GULP1; PTB domain-containing engulfment adapter protein 1 isoform X1 [KO:K23285]
104395723  RAB17; ras-related protein Rab-17 [KO:K07909]
104397548  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
104385659  RAB5C; ras-related protein Rab-5C isoform X1 [KO:K07889]
104388954  TGFBRAP1; transforming growth factor-beta receptor-associated protein 1 [KO:K20177]
104385121  VPS8; vacuolar protein sorting-associated protein 8 homolog [KO:K20178]
104398749  VPS11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
104390466  VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
104389423  VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182]
104389797  RAB14; ras-related protein Rab-14 [KO:K07881]
104389212  VPS39; vam6/Vps39-like protein [KO:K20183]
104392153  VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
104387868  RAB7A; ras-related protein Rab-7a [KO:K07897]
104388614  RAB7B; ras-related protein Rab-7b [KO:K07898]
104387047  PQLC2L; putative uncharacterized protein C3orf55 homolog [KO:K23678]
104387066  PQLC2; lysosomal amino acid transporter 1 homolog [KO:K23678]
104397719  ARG2; arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
104390062  ODC1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
104390825  CH25H; cholesterol 25-hydroxylase [KO:K10223] [EC:1.14.99.38]
104390408  NR1H3; oxysterols receptor LXR-alpha [KO:K08536]
104387650  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
104388605  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
104386297  SIRT1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
104392906  PBX1; pre-B-cell leukemia transcription factor 1 [KO:K09355]
104388630  IL10; interleukin-10 [KO:K05443]
104390891  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
104390893  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
104391134  LOW QUALITY PROTEIN: lipase member K-like [KO:K01052] [EC:3.1.1.13]
104394803  PLA2G15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
104397157  PPARD; peroxisome proliferator-activated receptor delta isoform X1 [KO:K04504]
104387762  solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
104392466  SLC16A1; LOW QUALITY PROTEIN: monocarboxylate transporter 1 [KO:K08179]
104390056  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
104384965  CD47; leukocyte surface antigen CD47 [KO:K06266]
104393215  PECAM1; platelet endothelial cell adhesion molecule [KO:K06471]
104397370  tyrosine-protein phosphatase non-receptor type substrate 1-like [KO:K06551]
104389465  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
104395555  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
104388006  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
cpea00010  Glycolysis / Gluconeogenesis
cpea04140  Autophagy - animal
cpea04145  Phagosome
KO pathway
ko04148   
LinkDB

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