Entry Name Axon guidance - Cavia porcellus (domestic guinea pig)
Description Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
Class Organismal Systems; Development and regenerationBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Cavia porcellus (domestic guinea pig) [GN:
cpoc ]
Gene 100726796 Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2 [KO:K05859 ] [EC:3.1.4.11 ]
100713312 Trpc1; short transient receptor potential channel 1 isoform X2 [KO:K04964 ]
100727741 Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
100725315 Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
100728974 Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348 ] [EC:3.1.3.16 ]
100722868 Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332 ]
100728433 Nfatc3; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333 ]
100734178 Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X2 [KO:K17334 ]
100727219 Rac1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392 ]
100731468 Rac2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860 ]
100736181 Rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861 ]
100717195 Cdc42; cell division control protein 42 homolog isoform X2 [KO:K04393 ]
100728195 Lrig2; leucine-rich repeats and immunoglobulin-like domains protein 2 [KO:K24609 ]
100731341 Cxcr4; LOW QUALITY PROTEIN: C-X-C chemokine receptor type 4 [KO:K04189 ]
100135528 Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
100135529 Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
100135530 Gnai3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630 ]
100720492 Srgap3; SLIT-ROBO Rho GTPase-activating protein 3 isoform X2 [KO:K07526 ]
100716665 Srgap2; LOW QUALITY PROTEIN: SLIT-ROBO Rho GTPase-activating protein 2 [KO:K07526 ]
100713864 Srgap1; SLIT-ROBO Rho GTPase-activating protein 1 isoform X1 [KO:K07526 ]
100720336 Rhod; LOW QUALITY PROTEIN: rho-related GTP-binding protein RhoD [KO:K07530 ]
100727059 Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X2 [KO:K04515 ] [EC:2.7.11.17 ]
100719406 Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X12 [KO:K04515 ] [EC:2.7.11.17 ]
100720622 Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
100727986 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
100735084 Pik3ca; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
100734206 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
100730242 Pik3r1; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
100734044 Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
100732023 Pard6a; partitioning defective 6 homolog alpha isoform X1 [KO:K06093 ]
Compound Reference Authors Guan KL, Rao Y.
Title Signalling mechanisms mediating neuronal responses to guidance cues.
Journal Reference Authors Govek EE, Newey SE, Van Aelst L.
Title The role of the Rho GTPases in neuronal development.
Journal Reference Authors Huber AB, Kolodkin AL, Ginty DD, Cloutier JF.
Title Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance.
Journal Reference Authors Negishi M, Oinuma I, Katoh H.
Title Plexins: axon guidance and signal transduction.
Journal Reference Authors Huot J.
Title Ephrin signaling in axon guidance.
Journal Reference Authors Patel BN, Van Vactor DL.
Title Axon guidance: the cytoplasmic tail.
Journal Reference Authors Yu TW, Bargmann CI.
Title Dynamic regulation of axon guidance.
Journal Reference Authors Dickson BJ.
Title Molecular mechanisms of axon guidance.
Journal Reference Authors Barallobre MJ, Pascual M, Del Rio JA, Soriano E.
Title The Netrin family of guidance factors: emphasis on Netrin-1 signalling.
Journal Reference Authors Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M.
Title The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.
Journal Reference Authors Fujita Y, Yamashita T
Title Axon growth inhibition by RhoA/ROCK in the central nervous system.
Journal Reference Authors Yamashita T, Mueller BK, Hata K
Title Neogenin and repulsive guidance molecule signaling in the central nervous system.
Journal Reference Authors van Erp S, van den Heuvel DMA, Fujita Y, Robinson RA, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JAA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ
Title Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.
Journal Related cpoc04060 Cytokine-cytokine receptor interaction
KO pathway LinkDB All DBs
