Entry
Name
Cytokine-cytokine receptor interaction - Cuculus canorus (common cuckoo)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
cuca04060 Cytokine-cytokine receptor interaction
Ortholog table
Organism
Cuculus canorus (common cuckoo) [GN:
cuca ]
Gene
104058367 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
104055883 TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478 ]
104063347 TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
104056514 TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
104055884 tumor necrosis factor ligand superfamily member 8-like [KO:K05471 ]
104062978 TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476 ]
104067491 BMP3; LOW QUALITY PROTEIN: bone morphogenetic protein 3 [KO:K05496 ]
104060922 AMH; LOW QUALITY PROTEIN: muellerian-inhibiting factor [KO:K04665 ]
104057118 GDF7; LOW QUALITY PROTEIN: growth/differentiation factor 7 [KO:K20013 ]
104067627 ACKR4; LOW QUALITY PROTEIN: atypical chemokine receptor 4 [KO:K04186 ]
104065902 LOW QUALITY PROTEIN: cytokine receptor common subunit beta-like [KO:K04738 ]
104063742 LOW QUALITY PROTEIN: granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066 ]
104063743 granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066 ]
104065363 CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061 ]
104066593 IL12RB2; LOW QUALITY PROTEIN: interleukin-12 receptor subunit beta-2 [KO:K05064 ]
104056546 CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059 ]
104056641 LOW QUALITY PROTEIN: interleukin-1 receptor type 1-like [KO:K05172 ]
104055867 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
104060604 TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141 ]
104060818 TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143 ]
104067957 FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390 ]
104068597 tumor necrosis factor receptor superfamily member 10A-like [KO:K04722 ]
104057114 TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157 ]
104056627 EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X1 [KO:K05162 ]
104054338 EDA2R; tumor necrosis factor receptor superfamily member 27 [KO:K05163 ]
104068265 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
104066188 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
104066954 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147 ]
104060562 TNFRSF8; tumor necrosis factor receptor superfamily member 8 [KO:K05145 ]
104057073 CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160 ]
104055586 TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142 ]
104055618 TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154 ]
104058775 TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153 ]
104062502 TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150 ]
104064152 TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155 ]
104064210 RELT; tumor necrosis factor receptor superfamily member 19L [KO:K05156 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway
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