KEGG   PATHWAY: cud04148
Entry
cud04148                    Pathway                                
Name
Efferocytosis - Cheilinus undulatus (humphead wrasse)
Class
Cellular Processes; Transport and catabolism
Pathway map
cud04148  Efferocytosis
cud04148

Organism
Cheilinus undulatus (humphead wrasse) [GN:cud]
Gene
121506610  caspase-3-like [KO:K02187] [EC:3.4.22.56]
121508374  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
121528758  casp7; caspase-7 [KO:K04397] [EC:3.4.22.60]
121516260  caspase a-like isoform X1 [KO:K01370] [EC:3.4.22.36]
121508746  pannexin-1-like isoform X1 [KO:K03443]
121526555  pannexin-1-like [KO:K03443]
121526503  p2ry2.1; P2Y purinoceptor 2 [KO:K04269]
121515266  P2Y purinoceptor 3 [KO:K04272]
121524898  p2ry12; P2Y purinoceptor 12 [KO:K04298]
121508668  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
121503886  sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
121514234  sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
121512383  s1pr1; sphingosine 1-phosphate receptor 1 [KO:K04288]
121508835  pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
121512157  abca7; phospholipid-transporting ATPase ABCA1 isoform X1 [KO:K05641]
121508842  phospholipid-transporting ATPase ABCA1-like isoform X1 [KO:K05641]
121504174  phospholipid-transporting ATPase ABCA1-like isoform X1 [KO:K05641]
121516223  abca1b; phospholipid-transporting ATPase ABCA1b [KO:K05641]
121504588  si:dkey-165a24.9; probable G-protein coupled receptor 132 [KO:K08426]
121521586  gpr132b; probable G-protein coupled receptor 132b [KO:K08426]
121526184  adam17a; disintegrin and metalloproteinase domain-containing protein 17a [KO:K06059] [EC:3.4.24.86]
121521362  adam17b; disintegrin and metalloproteinase domain-containing protein 17 [KO:K06059] [EC:3.4.24.86]
121512543  si:ch1073-396h14.1; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
121508420  adam10a; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
121514982  disintegrin and metalloproteinase domain-containing protein 10-like isoform X1 [KO:K06704] [EC:3.4.24.81]
121503802  nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
121517730  nfatc2a; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
121513106  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
121524237  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
121515389  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
121523851  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
121519562  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
121526038  hif1aa; hypoxia inducible factor 1 subunit alpha a [KO:K08268]
121526435  hif1al; hypoxia inducible factor 1 subunit alpha, like isoform X1 [KO:K08268]
121514230  arnt; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
121504923  epoa; erythropoietin [KO:K05437]
121529459  epor; erythropoietin receptor [KO:K05079]
121509629  jak2b; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
121524648  jak2a; tyrosine-protein kinase JAK2a [KO:K04447] [EC:2.7.10.2]
121509618  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121529066  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
121517278  cebpb; CCAAT/enhancer-binding protein beta [KO:K10048]
121506534  pparg; peroxisome proliferator-activated receptor gamma [KO:K08530]
121524981  rxraa; retinoic acid receptor RXR-alpha-A isoform X1 [KO:K08524]
121513592  rxrbb; retinoic acid receptor RXR-beta-B [KO:K08524]
121510315  mfge8a; milk fat globule EGF and factor V/VIII domain containing a [KO:K17253]
121514942  mfge8b; milk fat globule EGF and factor V/VIII domain containing b isoform X1 [KO:K17253]
121508109  gas6; growth arrest-specific protein 6 [KO:K05464]
121511256  mertka; tyrosine-protein kinase Mer [KO:K05117] [EC:2.7.10.1]
121505593  cd36; platelet glycoprotein 4 [KO:K06259]
121526103  thrombospondin-1-like [KO:K16857]
121521470  thbs1b; thrombospondin-1 [KO:K16857]
121515443  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
121512343  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
121520316  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
121511973  ptgs2b; LOW QUALITY PROTEIN: prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
121506411  ptger2a; prostaglandin E receptor 2a (subtype EP2) [KO:K04259]
121511760  prostaglandin E2 receptor EP4 subtype-like [KO:K04261]
121509326  ptger4a; prostaglandin E receptor 4 (subtype EP4) a [KO:K04261]
121525641  ptger4b; prostaglandin E receptor 4 (subtype EP4) b [KO:K04261]
121520213  ptger4c; prostaglandin E receptor 4 (subtype EP4) c [KO:K04261]
121525847  DNA (cytosine-5)-methyltransferase 3A-like isoform X1 [KO:K17398] [EC:2.1.1.37]
121521335  DNA (cytosine-5)-methyltransferase 3A-like isoform X1 [KO:K17398] [EC:2.1.1.37]
121506134  cyclic AMP-responsive element-binding protein 1-like [KO:K05870]
121522312  creb1b; cyclic AMP-responsive element-binding protein 1b [KO:K05870]
121521145  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
121508266  si:dkey-28b4.8; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
121509605  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like isoform X1 [KO:K05853] [EC:7.2.2.10]
121524640  atp2a2b; sarcoplasmic/endoplasmic reticulum calcium ATPase 2b isoform X1 [KO:K05853] [EC:7.2.2.10]
121518728  atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
121528103  atp2a1l; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like isoform X1 [KO:K05853] [EC:7.2.2.10]
121529643  atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
121508869  camk2d2; calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
121509845  camk2b1; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
121504420  camk2d1; calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
121510861  camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
121518659  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
121524964  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
121528829  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
121504460  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
121517916  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
121514771  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
121517191  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
121517463  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
121504519  mapkapk2a; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
121517754  MAP kinase-activated protein kinase 2-like isoform X1 [KO:K04443] [EC:2.7.11.1]
121511083  polyunsaturated fatty acid 5-lipoxygenase-like [KO:K00461] [EC:1.13.11.34]
121511143  polyunsaturated fatty acid 5-lipoxygenase-like isoform X1 [KO:K00461] [EC:1.13.11.34]
121511190  polyunsaturated fatty acid 5-lipoxygenase-like isoform X1 [KO:K00461] [EC:1.13.11.34]
121510776  polyunsaturated fatty acid 5-lipoxygenase-like [KO:K00461] [EC:1.13.11.34]
121505356  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121507019  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121507863  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121509358  dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121503984  si:ch211-195b15.8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121518010  dual specificity protein phosphatase 7-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121525384  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121514848  dusp8a; dual specificity protein phosphatase 8a isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121505427  ano6; anoctamin-6 [KO:K19500]
121515747  ano3; anoctamin-3 isoform X1 [KO:K19498]
121505486  anoctamin-4-like isoform X1 [KO:K19499]
121512350  ano5b; anoctamin-5b isoform X1 [KO:K19480]
121515746  ano5a; anoctamin-5 isoform X1 [KO:K19480]
121517780  ano11; anoctamin-7 [KO:K19501]
121524124  ano7; anoctamin-7 isoform X1 [KO:K19501]
121509374  ano9b; anoctamin-9 [KO:K19503]
121515752  anoctamin-9 [KO:K19503]
121512052  bsg; basigin isoform X1 [KO:K06535]
121523729  XK-related protein 8-like [KO:K26813]
121523730  xkr8.3; XK-related protein 8.3 [KO:K26813]
121527378  xkr9; XK-related protein 9 [KO:K26814]
121517479  xkr5l; XK-related protein 7 [KO:K26811]
121517861  xkr7; XK-related protein 7 [KO:K26811]
121520643  xkr4; XK-related protein 4 [KO:K26811]
121506417  XK-related protein 6 [KO:K26811]
121521851  xkr6b; XK-related protein 6b [KO:K26811]
121527407  atp8a2; phospholipid-transporting ATPase IB isoform X1 [KO:K14802] [EC:7.6.2.1]
121516250  phospholipid-transporting ATPase IA isoform X1 [KO:K14802] [EC:7.6.2.1]
121516085  atp11c; phospholipid-transporting ATPase 11C [KO:K26934] [EC:7.6.2.1]
121511802  atp11b; phospholipid-transporting ATPase IF [KO:K26934] [EC:7.6.2.1]
121522904  phospholipid-transporting ATPase IH-like isoform X1 [KO:K26934] [EC:7.6.2.1]
121506240  atp11a; phospholipid-transporting ATPase IH isoform X1 [KO:K26934] [EC:7.6.2.1]
121525936  cell cycle control protein 50A-like [KO:K26935]
121521484  cell cycle control protein 50A-like [KO:K26935]
121509646  pros1; vitamin K-dependent protein S isoform X1 [KO:K03908]
121522710  itgav; integrin alpha-V [KO:K06487]
121528686  integrin beta-3-like [KO:K06493]
121529295  itgb3a; integrin beta-3a [KO:K06493]
121522122  itgb5; integrin beta-5 [KO:K06588]
121518121  tyrosine-protein kinase receptor UFO isoform X1 [KO:K05115] [EC:2.7.10.1]
121526508  tyro3; tyrosine-protein kinase receptor TYRO3 [KO:K05116] [EC:2.7.10.1]
121513673  adgrb1a; adhesion G protein-coupled receptor B1 [KO:K04596]
121523173  adhesion G protein-coupled receptor B1-like isoform X1 [KO:K04596]
121507405  stab1; stabilin-1 isoform X1 [KO:K19020]
121505268  stab2; stabilin-2 isoform X1 [KO:K19013]
121514041  focal adhesion kinase 1-like isoform X1 [KO:K05725] [EC:2.7.10.2]
121523996  ptk2aa; protein tyrosine kinase 2aa isoform X1 [KO:K05725] [EC:2.7.10.2]
121514840  bcar1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
121518573  crk; adapter molecule crk [KO:K04438]
121525084  crkl; crk-like protein [KO:K04438]
121523731  elmo1; engulfment and cell motility protein 1 [KO:K12366]
121528183  dock1; dedicator of cytokinesis protein 1 [KO:K13708]
121528143  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
121529378  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
121509357  disintegrin and metalloproteinase domain-containing protein 9-like isoform X1 [KO:K06834] [EC:3.4.24.-]
121528465  zgc:174164; disintegrin and metalloproteinase domain-containing protein 9 [KO:K06834] [EC:3.4.24.-]
121511792  calr; calreticulin [KO:K08057]
121512533  calr3a; calreticulin 3a [KO:K08057]
121520729  calr3b; calreticulin 3b [KO:K08057]
121504218  complement C1q subcomponent subunit C-like [KO:K03986]
121529413  c1qb; complement C1q subcomponent subunit B [KO:K03987]
121507229  complement C1q subcomponent subunit C-like [KO:K03988]
121504520  low-density lipoprotein receptor-related protein 1-like [KO:K04550]
121516997  lrp1ab; low-density lipoprotein receptor-related protein 1 [KO:K04550]
121511398  multiple epidermal growth factor-like domains protein 11 [KO:K24068]
121525215  megf10; multiple epidermal growth factor-like domains protein 10 isoform X1 [KO:K24068]
121514508  megf11; multiple epidermal growth factor-like domains protein 11 [KO:K24068]
121515410  scarf1; scavenger receptor class F member 1 isoform X1 [KO:K24318]
121518123  PTB domain-containing engulfment adapter protein 1-like [KO:K23285]
121522909  gulp1a; PTB domain-containing engulfment adapter protein 1 isoform X1 [KO:K23285]
121522839  ras-related protein Rab-17-like [KO:K07909]
121513770  rab5ab; RAB5A, member RAS oncogene family, b [KO:K07887]
121523937  rab5aa; RAB5A, member RAS oncogene family, a [KO:K07887]
121522408  rab5b; ras-related protein Rab-5B [KO:K07888]
121528891  ras-related protein Rab-5C-like [KO:K07889]
121529635  rab5c; ras-related protein Rab-5C [KO:K07889]
121509300  tgfbrap1; transforming growth factor-beta receptor-associated protein 1 homolog [KO:K20177]
121526023  si:ch211-266g18.9; transforming growth factor-beta receptor-associated protein 1 [KO:K20177]
121511010  vps8; vacuolar protein sorting-associated protein 8 homolog [KO:K20178]
121519153  vps11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
121506510  vps16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
121521692  vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
121510413  vps33a; vacuolar protein sorting-associated protein 33A [KO:K20182]
121509603  ras-related protein Rab-14-like [KO:K07881]
121525279  rab14l; RAB14, member RAS oncogene family, like [KO:K07881]
121526052  vps39; vam6/Vps39-like protein isoform X1 [KO:K20183]
121527723  vps41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
121505006  si:dkey-13a21.4; ras-related protein rab7 [KO:K07897]
121506692  rab7a; ras-related protein Rab-7a [KO:K07897]
121506916  ras-related protein rab7-like [KO:K07897]
121518161  slc66a1; lysosomal amino acid transporter 1 homolog isoform X1 [KO:K23678]
121525630  lysosomal amino acid transporter 1 homolog [KO:K23678]
121526457  arg2; arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
121528389  arg1; arginase-1 [KO:K01476] [EC:3.5.3.1]
121526704  odc1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
121529532  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
121509691  ch25hl3; cholesterol 25-hydroxylase-like protein [KO:K10223] [EC:1.14.99.38]
121525603  ch25hl2; cholesterol 25-hydroxylase-like protein 2 [KO:K10223] [EC:1.14.99.38]
121514558  ch25hl1.2; cholesterol 25-hydroxylase-like protein 1, member 2 [KO:K10223] [EC:1.14.99.38]
121515688  ch25hl1.1; cholesterol 25-hydroxylase-like protein 1, member 1 [KO:K10223] [EC:1.14.99.38]
121528501  ch25h; cholesterol 25-hydroxylase-like protein [KO:K10223] [EC:1.14.99.38]
121510751  nr1h3; oxysterols receptor LXR-alpha [KO:K08536]
121514789  cpt1ab; carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
121515470  cpt1b; carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
121528201  carnitine O-palmitoyltransferase 1, liver isoform-like isoform X1 [KO:K08765] [EC:2.3.1.21]
121529381  cpt1a2b; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
121508219  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
121514775  cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
121511152  sirt1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
121512354  pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
121520519  pbx1a; pre-B-cell leukemia homeobox 1a isoform X1 [KO:K09355]
121528730  il10; interleukin-10 [KO:K05443]
121528168  lipf; gastric triacylglycerol lipase isoform X1 [KO:K01052] [EC:3.1.1.13]
121515129  pla2g15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
121517229  ppardb; peroxisome proliferator-activated receptor delta b [KO:K04504]
121506190  slc2a1b; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
121525750  solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
121517473  solute carrier family 2, facilitated glucose transporter member 1-like [KO:K07299]
121504048  slc16a1a; monocarboxylate transporter 1a [KO:K08179]
121517198  monocarboxylate transporter 1-like [KO:K08179]
121514278  sgk2b; serine/threonine-protein kinase Sgk2b [KO:K13302] [EC:2.7.11.1]
121521495  serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
121524097  si:ch211-195b13.1; STKc_SGK domain-containing protein isoform X1 [KO:K13302] [EC:2.7.11.1]
121508312  pecam1b; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
121503350  pecam1a; platelet endothelial cell adhesion molecule [KO:K06471]
121513467  sialic acid-binding Ig-like lectin 10 isoform X1 [KO:K06749]
121512963  ptpn6; tyrosine-protein phosphatase non-receptor type 6 [KO:K05697] [EC:3.1.3.48]
121518221  ptpn11b; tyrosine-protein phosphatase non-receptor type 11b isoform X1 [KO:K07293] [EC:3.1.3.48]
121524755  ptpn11a; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
cud00010  Glycolysis / Gluconeogenesis
cud04140  Autophagy - animal
cud04145  Phagosome
KO pathway
ko04148   
LinkDB

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