KEGG   PATHWAY: cvg04144
Entry
cvg04144                    Pathway                                
Name
Endocytosis - Cyprinodon variegatus (sheepshead minnow)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
cvg04144  Endocytosis
cvg04144

Other DBs
GO: 0006897
Organism
Cyprinodon variegatus (sheepshead minnow) [GN:cvg]
Gene
107090869  ADP-ribosylation factor 6 [KO:K07941]
107085636  arf6; ADP-ribosylation factor 6 [KO:K07941]
107091854  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like [KO:K00889] [EC:2.7.1.68]
107083731  pip5k1b; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
107103656  phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like [KO:K00889] [EC:2.7.1.68]
107096302  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like [KO:K00889] [EC:2.7.1.68]
107101114  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like [KO:K00889] [EC:2.7.1.68]
107083956  pip5kl1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 [KO:K13712] [EC:2.7.1.68]
107092439  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 [KO:K13712] [EC:2.7.1.68]
107085128  LOW QUALITY PROTEIN: phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
107081817  phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
107099794  pld2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
107099747  dnm3; dynamin-3 [KO:K01528] [EC:3.6.5.5]
107095936  dnm1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
107104264  LOW QUALITY PROTEIN: dynamin-1-like [KO:K01528] [EC:3.6.5.5]
107083642  dynamin-3-like [KO:K01528] [EC:3.6.5.5]
107093407  dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
107101485  dynamin-2-like isoform X1 [KO:K23484] [EC:3.6.5.5]
107083434  clta; clathrin light chain A isoform X1 [KO:K04644]
107086561  cltb; clathrin light chain B isoform X1 [KO:K04645]
107089681  cltcl1; clathrin heavy chain 2 isoform X1 [KO:K04646]
107101887  clathrin heavy chain 1 isoform X1 [KO:K04646]
107104663  clathrin heavy chain 1-like isoform X1 [KO:K04646]
107101473  AP-2 complex subunit alpha-2-like [KO:K11824]
107103921  AP-2 complex subunit alpha-1-like [KO:K11824]
107090293  AP-1 complex subunit beta-1 [KO:K11825]
107091878  ap2m1; AP-2 complex subunit mu isoform X1 [KO:K11826]
107094183  ap2s1; AP-2 complex subunit sigma [KO:K11827]
107090652  ehd2; EH domain-containing protein 2 isoform X1 [KO:K12469]
107094209  EH domain-containing protein 2-like [KO:K12469]
107100676  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
107086189  tgfbr2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
107098322  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
107081955  zinc finger FYVE domain-containing protein 9-like [KO:K04679]
107104482  zinc finger FYVE domain-containing protein 16-like [KO:K04679]
107095434  zfyve9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
107098523  smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
107098778  mothers against decapentaplegic homolog 2 [KO:K04500]
107100800  smad3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
107097788  mothers against decapentaplegic homolog 3 [KO:K23605]
107094809  transferrin receptor protein 1-like [KO:K06503]
107083638  tfrc; transferrin receptor protein 1 [KO:K06503]
107081719  egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
107098892  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
107091563  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
107081753  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
107087110  fibroblast growth factor receptor 3-like isoform X1 [KO:K05094] [EC:2.7.10.1]
107090685  fibroblast growth factor receptor 4-like [KO:K05095] [EC:2.7.10.1]
107087242  igf1r; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
107097409  LOW QUALITY PROTEIN: insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
107088320  cbl; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
107098202  E3 ubiquitin-protein ligase CBL-like [KO:K04707] [EC:2.3.2.27]
107083535  E3 ubiquitin-protein ligase CBL-like isoform X1 [KO:K22518] [EC:2.3.2.27]
107094812  sh3kbp1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
107081972  endophilin-A2-like [KO:K11247]
107096572  endophilin-A1-like isoform X1 [KO:K11247]
107103189  sh3gl1; endophilin-A2 isoform X1 [KO:K11247]
107090435  sh3gl3; endophilin-A3 isoform X1 [KO:K11247]
107096134  sh3gl2; endophilin-A1 [KO:K11247]
107097676  endophilin-B1-like [KO:K11248]
107083949  sh3glb2; endophilin-B2 [KO:K21269]
107085103  endophilin-B1-like [KO:K21269]
107088026  endophilin-B2-like isoform X1 [KO:K21269]
107096821  myc box-dependent-interacting protein 1-like isoform X1 [KO:K12562]
107103860  myc box-dependent-interacting protein 1-like isoform X1 [KO:K12562]
107082218  epsin-1-like isoform X1 [KO:K12471]
107088097  epn2; epsin-2 isoform X1 [KO:K12471]
107100152  epsin-3-like isoform X1 [KO:K12471]
107082456  epsin-3-like isoform X1 [KO:K12471]
107085939  epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
107101199  eps15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
107080669  epidermal growth factor receptor substrate 15-like 1 [KO:K12472]
107102880  uncharacterized protein LOC107102880 [KO:K12472]
107092085  spartin-like isoform X1 [KO:K19366]
107088104  spg20; spartin isoform X1 [KO:K19366]
107100739  nedd4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
107085820  nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
107090500  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
107099447  traf6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
107088768  rnf41; E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
107103455  E3 ubiquitin-protein ligase Itchy-like isoform X1 [KO:K05632] [EC:2.3.2.26]
107098762  E3 ubiquitin-protein ligase Itchy-like [KO:K05632] [EC:2.3.2.26]
107098764  E3 ubiquitin-protein ligase Itchy-like [KO:K05632] [EC:2.3.2.26]
107104615  E3 ubiquitin-protein ligase SMURF2-like [KO:K04678] [EC:2.3.2.26]
107087195  E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
107093092  E3 ubiquitin-protein ligase SMURF2-like [KO:K04678] [EC:2.3.2.26]
107101330  smurf2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
107084904  NEDD4-like E3 ubiquitin-protein ligase WWP1 [KO:K05633] [EC:2.3.2.26]
107084905  NEDD4-like E3 ubiquitin-protein ligase WWP1 [KO:K05633] [EC:2.3.2.26]
107082788  low-density lipoprotein receptor-like [KO:K12473]
107080755  low-density lipoprotein receptor-like isoform X1 [KO:K12473]
107096429  ldlrap1; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
107082946  low density lipoprotein receptor adapter protein 1-like [KO:K12474]
107093644  low density lipoprotein receptor adapter protein 1-B-like [KO:K12474]
107095595  uncharacterized protein LOC107095595 [KO:K12474]
107093368  dab2; disabled homolog 2 isoform X1 [KO:K12475]
107101581  C-C chemokine receptor type 5-like isoform X1 [KO:K04180]
107101583  C-C chemokine receptor type 1-like [KO:K04180]
107095740  C-X-C chemokine receptor type 2-like [KO:K05050]
107092717  C-X-C chemokine receptor type 2-like [KO:K05050]
107082556  C-X-C chemokine receptor type 2-like [KO:K05050]
107086826  C-X-C chemokine receptor type 4-like [KO:K04189]
107101500  cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
107089964  G-protein-coupled receptor kinase 7A-like [KO:K00909] [EC:2.7.11.14]
107100598  rhodopsin kinase-like [KO:K00909] [EC:2.7.11.14]
107088291  grk1; rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
107083475  grk7; G protein-coupled receptor kinase 7 [KO:K00909] [EC:2.7.11.14]
107101402  beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
107092761  G protein-coupled receptor kinase 5-like isoform X1 [KO:K08291] [EC:2.7.11.16]
107093759  grk4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
107097517  grk6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
107102169  G protein-coupled receptor kinase 5-like isoform X1 [KO:K08291] [EC:2.7.11.16]
107096341  arrb1; beta-arrestin-1 [KO:K04439]
107099018  arrb2; beta-arrestin-2 isoform X1 [KO:K04439]
107094012  neural Wiskott-Aldrich syndrome protein-like [KO:K23612]
107092182  wasl; neural Wiskott-Aldrich syndrome protein [KO:K23612]
107088342  neural Wiskott-Aldrich syndrome protein-like isoform X1 [KO:K23612]
107095754  actin-related protein 2-B [KO:K17260]
107085266  actin-related protein 2-like [KO:K17260]
107098718  actr3; actin-related protein 3 [KO:K18584]
107086438  actin-related protein 3 [KO:K18584]
107084157  actin-related protein 2/3 complex subunit 1A-like [KO:K05757]
107094101  actin-related protein 2/3 complex subunit 1A [KO:K05757]
107094106  actin-related protein 2/3 complex subunit 1B-like [KO:K05757]
107095725  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
107099864  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
107094019  actin-related protein 2/3 complex subunit 4 [KO:K05755]
107102029  arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
107085949  arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
107099262  actin-related protein 2/3 complex subunit 5-like [KO:K05754]
107084321  WAS/WASL-interacting protein family member 3-like isoform X1 [KO:K19475]
107097663  wipf2; WAS/WASL-interacting protein family member 2 isoform X1 [KO:K19475]
107088887  wipf1; WAS/WASL-interacting protein family member 1 [KO:K19475]
107098841  WAS/WASL-interacting protein family member 2-like isoform X1 [KO:K19475]
107100718  heat shock cognate 71 kDa protein-like [KO:K03283]
107102697  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
107083771  heat shock cognate 71 kDa protein-like [KO:K03283]
107087461  heat shock 70 kDa protein [KO:K03283]
107087226  dnajc6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
107089475  kiaa1033; WASH complex subunit 7 isoform X1 [KO:K18465]
107089610  kiaa0196; WASH complex subunit strumpellin [KO:K18464]
107099587  fam21c; WASH complex subunit FAM21C [KO:K18462]
107090566  WAS protein family homolog 1-like [KO:K18461]
107105004  ccdc53; WASH complex subunit CCDC53 [KO:K18463]
107083208  capza2; F-actin-capping protein subunit alpha-2 [KO:K10364]
107094856  capza1; F-actin-capping protein subunit alpha-1 [KO:K10364]
107085643  capzb; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
107092996  vps29; vacuolar protein sorting-associated protein 29 [KO:K18467]
107089866  vacuolar protein sorting-associated protein 26B-like [KO:K18466]
107092169  vps26a; vacuolar protein sorting-associated protein 26A [KO:K18466]
107102115  vps26b; vacuolar protein sorting-associated protein 26B [KO:K18466]
107090851  vps35; vacuolar protein sorting-associated protein 35 [KO:K18468]
107084209  sorting nexin-12 isoform X1 [KO:K17918]
107081642  snx3; sorting nexin-3 [KO:K17918]
107085335  usp8; ubiquitin carboxyl-terminal hydrolase 8 [KO:K11839] [EC:3.4.19.12]
107095933  stambp; STAM-binding protein [KO:K11866] [EC:3.4.19.12]
107093905  ras-related protein Rab-7a-like [KO:K07897]
107100231  ras-related protein Rab-7a-like isoform X1 [KO:K07897]
107094022  rab7a; ras-related protein Rab-7a [KO:K07897]
107100153  hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
107098692  stam2; signal transducing adapter molecule 2 [KO:K04705]
107099962  stam; signal transducing adapter molecule 1 [KO:K04705]
107085432  tsg101; tumor susceptibility gene 101 protein [KO:K12183]
107081091  mvb12b; multivesicular body subunit 12B [KO:K12186]
107095935  multivesicular body subunit 12B-like isoform X1 [KO:K12186]
107083405  mvb12a; multivesicular body subunit 12A [KO:K12186]
107092443  vps28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
107102334  vacuolar protein sorting-associated protein 37C-like [KO:K12185]
107101932  vps37b; vacuolar protein sorting-associated protein 37B [KO:K12185]
107083398  vps37a; vacuolar protein sorting-associated protein 37A [KO:K12185]
107093068  vacuolar protein sorting-associated protein 37D-like [KO:K12185]
107093806  snf8; vacuolar-sorting protein SNF8 [KO:K12188]
107087907  vps36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
107092758  vps25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
107090919  chmp6; charged multivesicular body protein 6 [KO:K12195]
107102142  charged multivesicular body protein 6-like [KO:K12195]
107086700  charged multivesicular body protein 4b [KO:K12194]
107093444  charged multivesicular body protein 4b-like [KO:K12194]
107086476  charged multivesicular body protein 4c-like [KO:K24782]
107099107  chmp3; charged multivesicular body protein 3 [KO:K12193]
107093792  chmp2a; charged multivesicular body protein 2a [KO:K12191]
107090449  chmp2b; charged multivesicular body protein 2b [KO:K12192]
107081780  chmp7; charged multivesicular body protein 7 isoform X1 [KO:K15053]
107099453  vacuolar protein sorting-associated protein 4B-like [KO:K12196]
107102505  vacuolar protein sorting-associated protein 4A [KO:K12196]
107083387  vps4b; vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196]
107092027  vta1; vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
107087898  chmp1b; charged multivesicular body protein 1b [KO:K12197]
107101661  chmp1a; charged multivesicular body protein 1a [KO:K12197]
107081179  charged multivesicular body protein 5-like [KO:K12198]
107085407  chmp5; charged multivesicular body protein 5 [KO:K12198]
107091149  ist1; IST1 homolog isoform X1 [KO:K19476]
107083276  pdcd6ip; programmed cell death 6-interacting protein isoform X1 [KO:K12200]
107103441  spg21; maspardin [KO:K19367]
107083508  igf2r; cation-independent mannose-6-phosphate receptor [KO:K06564]
107100069  sorting nexin-1-like [KO:K17917]
107084623  snx2; sorting nexin-2 [KO:K17917]
107086522  sorting nexin-1-like [KO:K17917]
107082078  sorting nexin-6-like [KO:K17920]
107096058  sorting nexin-6 [KO:K17920]
107104902  snx5; sorting nexin-5 [KO:K17920]
107097107  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
107083711  proto-oncogene tyrosine-protein kinase Src-like [KO:K05704] [EC:2.7.10.2]
107085426  hras; GTPase HRas isoform X1 [KO:K02833]
107087156  interleukin-2 receptor subunit beta-like [KO:K05069]
107084266  uncharacterized protein LOC107084266 [KO:K05069]
107084171  cytokine receptor common subunit gamma-like isoform X1 [KO:K05070]
107087055  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
107100393  rho-related GTP-binding protein RhoA-C [KO:K04513]
107099133  rho-related GTP-binding protein RhoA-B [KO:K04513]
107103110  transforming protein RhoA [KO:K04513]
107092037  rho-related GTP-binding protein RhoA-D [KO:K04513]
107104175  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107104782  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107080783  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107086728  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107105054  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
107104312  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
107104336  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
107104338  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107101419  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107089589  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107089590  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107080775  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107086729  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107104337  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107101426  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107104917  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107080735  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107101424  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
107101425  major histocompatibility complex class I-related gene protein-like [KO:K06751]
107087665  rtbdn; retbindin [KO:K13649]
107091938  folate receptor beta-like [KO:K13649]
107083221  cav1; caveolin-1 [KO:K06278]
107083229  cav2; caveolin-2 [KO:K12958]
107093336  caveolin-2-like [KO:K12958]
107096117  caveolin-2-like [KO:K12958]
107093348  caveolin-3-like [KO:K12959]
107097000  EH domain-containing protein 3 [KO:K12476]
107096061  EH domain-containing protein 4-like [KO:K12477]
107104245  eea1; early endosome antigen 1 isoform X1 [KO:K12478]
107082990  ras-related protein Rab-5A-like [KO:K07887]
107083283  rab5a; ras-related protein Rab-5A [KO:K07887]
107102771  ras-related protein Rab-5B-like [KO:K07888]
107099752  ras-related protein Rab-5C [KO:K07889]
107099621  rab5c; ras-related protein Rab-5C [KO:K07889]
107093075  rabep1; LOW QUALITY PROTEIN: rab GTPase-binding effector protein 1 [KO:K12480]
107090402  rbsn; rabenosyn-5 [KO:K12481]
107092137  rab4a; ras-related protein Rab-4A [KO:K07879]
107086386  RUN and FYVE domain-containing protein 1-like [KO:K12482]
107092153  rufy2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
107090988  EH domain-containing protein 1-like [KO:K12483]
107084925  vps45; vacuolar protein sorting-associated protein 45 isoform X1 [KO:K12479]
107101625  sorting nexin-4-like [KO:K17919]
107091911  snx4; sorting nexin-4 [KO:K17919]
107089432  rab31; ras-related protein Rab-31 [KO:K07891]
107101131  rab22a; ras-related protein Rab-22A [KO:K07891]
107082865  rab10; ras-related protein Rab-10 [KO:K07903]
107085938  ras-related protein Rab-8A [KO:K07901]
107097323  rab8a; ras-related protein Rab-8A [KO:K07901]
107105068  ras-related protein Rab-8A-like [KO:K07901]
107091770  ras-related protein Rab-35-like [KO:K07876]
107099990  rab35; ras-related protein Rab-35 [KO:K07876]
107098856  rab11a; ras-related protein Rab-11A [KO:K07904]
107104048  ras-related protein Rab-11A-like [KO:K07904]
107088590  ras-related protein Rab-11B [KO:K07905]
107095305  ras-related protein Rab-11B-like [KO:K07905]
107095311  ras-related protein Rab-11B-like [KO:K07905]
107096411  rab11fip5; rab11 family-interacting protein 5 [KO:K12484]
107082308  rab11 family-interacting protein 1-like isoform X1 [KO:K12484]
107097584  uncharacterized protein LOC107097584 isoform X1 [KO:K12484]
107088063  rab11fip2; rab11 family-interacting protein 2 [KO:K12484]
107091268  rab11fip1; rab11 family-interacting protein 1 [KO:K12484]
107082483  zfyve27; protrudin isoform X1 [KO:K19368]
107086510  kinesin-1 heavy chain-like [KO:K10396]
107103069  kinesin heavy chain isoform 5A-like [KO:K10396]
107092395  kif5b; kinesin-1 heavy chain [KO:K10396]
107086677  kinesin heavy chain isoform 5A-like isoform X1 [KO:K10396]
107082811  kinesin heavy chain isoform 5C-like [KO:K10396]
107091037  kinesin heavy chain isoform 5C-like [KO:K10396]
107099351  rab11 family-interacting protein 4A-like [KO:K12485]
107085008  rab11fip3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
107095896  rab11fip4; rab11 family-interacting protein 4 [KO:K12485]
107101470  partitioning defective 3 homolog [KO:K04237]
107088350  pard3; partitioning defective 3 homolog [KO:K04237]
107087824  partitioning defective 6 homolog gamma-like [KO:K06093]
107101591  partitioning defective 6 homolog alpha-like [KO:K06093]
107094452  prkcz; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
107094237  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
107082256  cell division control protein 42 homolog [KO:K04393]
107082186  cell division control protein 42 homolog [KO:K04393]
107085118  cell division control protein 42 homolog isoform X1 [KO:K04393]
107086129  cell division control protein 42 homolog [KO:K04393]
107083933  cell division control protein 42 homolog isoform X1 [KO:K04393]
107090780  stromal membrane-associated protein 1-like [KO:K12486]
107084382  stromal membrane-associated protein 2-like isoform X1 [KO:K12486]
107081746  smap1; stromal membrane-associated protein 1 [KO:K12486]
107098224  git1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
107091298  ARF GTPase-activating protein GIT2-like isoform X1 [KO:K12487]
107097266  git2; ARF GTPase-activating protein GIT2 isoform X1 [KO:K12487]
107088072  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1-like [KO:K12488]
107085389  asap1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
107084714  asap2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
107089584  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2-like [KO:K12488]
107093178  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2-like [KO:K12488]
107085963  acap2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12489]
107099517  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3-like isoform X1 [KO:K12489]
107099528  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2-like [KO:K12489]
107098652  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3-like [KO:K12489]
107095063  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3-like [KO:K12489]
107087769  acap1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 [KO:K12489]
107091944  arap1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 [KO:K18439]
107102287  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1-like [KO:K18439]
107082704  arap3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
107101700  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3-like [KO:K12491]
107096020  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like isoform X1 [KO:K12491]
107082146  agap2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 [KO:K17848]
107088760  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like isoform X1 [KO:K17848]
107097884  arfgap1; ADP-ribosylation factor GTPase-activating protein 1 [KO:K12492]
107098849  arfgap2; ADP-ribosylation factor GTPase-activating protein 2 [KO:K12493]
107098899  ADP-ribosylation factor GTPase-activating protein 3-like [KO:K12493]
107089558  PH and SEC7 domain-containing protein 1-like isoform X1 [KO:K12494]
107096293  PH and SEC7 domain-containing protein 4-like isoform X1 [KO:K12494]
107082392  psd2; PH and SEC7 domain-containing protein 2 isoform X1 [KO:K12494]
107086538  psd; PH and SEC7 domain-containing protein 1 isoform X1 [KO:K12494]
107085974  iqsec3; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
107090535  IQ motif and SEC7 domain-containing protein 3-like isoform X1 [KO:K12495]
107088159  iqsec1; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
107097302  IQ motif and SEC7 domain-containing protein 1-like [KO:K12495]
107095076  IQ motif and SEC7 domain-containing protein 2-like [KO:K12495]
107084481  IQ motif and SEC7 domain-containing protein 2-like [KO:K12495]
107083176  cytohesin-1 isoform X1 [KO:K18441]
107100498  cytohesin-3-like [KO:K18441]
107084258  cyth4; cytohesin-4 [KO:K18441]
107082010  cytohesin-4-like isoform X1 [KO:K18441]
107088802  cytohesin-2 [KO:K18441]
107092538  cytohesin-3 [KO:K18441]
107089207  cytohesin-1-like isoform X1 [KO:K18441]
107102472  brefeldin A-inhibited guanine nucleotide-exchange protein 2-like [KO:K18442]
107090811  arfgef1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1 [KO:K18442]
107092584  gbf1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 [KO:K18443]
107100459  ADP-ribosylation factor 1-like [KO:K07937]
107084746  ADP-ribosylation factor 1-like [KO:K07937]
107101619  ADP-ribosylation factor 1-like [KO:K07937]
107093990  ADP-ribosylation factor 1 [KO:K07937]
107082145  ADP-ribosylation factor 3 [KO:K07938]
107092145  arf3; ADP-ribosylation factor 3 [KO:K07938]
107101448  ADP-ribosylation factor 4 [KO:K07939]
107104697  ADP-ribosylation factor 4 [KO:K07939]
107089245  ADP-ribosylation factor 5-like [KO:K07939]
107080822  arf4; ADP-ribosylation factor 4 [KO:K07939]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
cvg04060  Cytokine-cytokine receptor interaction
cvg04070  Phosphatidylinositol signaling system
cvg04130  SNARE interactions in vesicular transport
cvg04142  Lysosome
cvg04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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