KEGG   PATHWAY: dro05415
Entry
dro05415                    Pathway                                
Name
Diabetic cardiomyopathy - Desmodus rotundus (common vampire bat)
Description
Diabetic cardiomyopathy has been defined as left ventricular dysfunction that occurs among patients with diabetes mellitus independent of a recognized cause such as coronary artery disease or hypertension. The pathogenesis of diabetic cardiomyopathy broadly involves hyperglycemia, increased circulating fatty acids, and insulin resistance contributing to reactive oxygen species (ROS) generation, mitochondrial dysfunction, impaired calcium metabolism, Renin-Angiotensin System (RAS) activation, and altered substrate metabolism. These effects result in cardiac fibrosis, hypertrophy, cardiomyocyte death, contractile dysfunction, endothelial cell damage and eventually heart failure. In the process of cardiac fibrosis, cardiac fibroblasts are the final effector cell.
Class
Human Diseases; Cardiovascular disease
Pathway map
dro05415  Diabetic cardiomyopathy
dro05415

Organism
Desmodus rotundus (common vampire bat) [GN:dro]
Gene
112299413  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
112308641  SLC2A4; solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
112296413  GFPT2; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 [KO:K00820] [EC:2.6.1.16]
112302962  GFPT1; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 [KO:K00820] [EC:2.6.1.16]
112305463  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
112306861  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
112312435  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
112319561  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
112313852  TNNI3; troponin I, cardiac muscle [KO:K12044]
112306096  RYR2; ryanodine receptor 2 [KO:K04962]
112297038  PLN; cardiac phospholamban [KO:K05852]
112310624  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
112308396  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
112304763  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
112318338  SP1; transcription factor Sp1 [KO:K04684]
112305985  AGT; angiotensinogen [KO:K09821]
112314863  REN; renin [KO:K01380] [EC:3.4.23.15]
112300811  LOW QUALITY PROTEIN: mast cell protease 4-like [KO:K01329] [EC:3.4.21.39]
112300507  chymase-like isoform X1 [KO:K01329] [EC:3.4.21.39]
112304830  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
112302184  AGER; advanced glycosylation end product-specific receptor [KO:K19722]
112307613  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
112314894  NCF1; neutrophil cytosol factor 1 [KO:K08011]
112300849  cytochrome b-245 light chain [KO:K08009]
112296739  NCF2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
112321854  NCF4; neutrophil cytosol factor 4 [KO:K08012]
112319549  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
112321719  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
112301009  AGTR1; type-1 angiotensin II receptor [KO:K04166]
112317867  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
112317202  RELA; transcription factor p65 [KO:K04735]
112302047  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
112321896  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
112302140  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
112322057  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
112296379  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
112305558  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
112317841  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
112296673  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
112304108  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
112319841  COL1A2; collagen alpha-2(I) chain [KO:K06236]
112316389  COL1A1; collagen alpha-1(I) chain [KO:K06236]
112307967  COL3A1; collagen alpha-1(III) chain [KO:K19720]
112320009  TGFB1; transforming growth factor beta-1 [KO:K13375]
112318906  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
112311221  TGFB3; transforming growth factor beta-3 [KO:K13377]
112303442  CD36; platelet glycoprotein 4 [KO:K06259]
112321755  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
112321760  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
112316178  PDK2; pyruvate dehydrogenase kinase, isozyme 2 [KO:K00898] [EC:2.7.11.2]
112313227  PDK3; pyruvate dehydrogenase kinase, isozyme 3 isoform X1 [KO:K00898] [EC:2.7.11.2]
112319795  PDK4; pyruvate dehydrogenase kinase, isozyme 4 [KO:K00898] [EC:2.7.11.2]
112316515  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
112301220  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
112306360  PTPA; serine/threonine-protein phosphatase 2A activator [KO:K17605]
112297802  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
112317227  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
112310655  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
112317266  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
112299039  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
112314640  CPT2; carnitine O-palmitoyltransferase 2, mitochondrial isoform X1 [KO:K08766] [EC:2.3.1.21]
112296365  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
112307950  IRS1; insulin receptor substrate 1 [KO:K16172]
112310002  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
112299448  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
112307667  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112321016  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112305224  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
112314466  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
112307354  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
112311458  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112318919  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112320130  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112299108  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
112320540  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
112310186  GYS1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
112318340  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
112312545  TBC1D4; TBC1 domain family member 4 isoform X1 [KO:K17902]
112297163  MPC1; mitochondrial pyruvate carrier 1 [KO:K22138]
112322423  MPC1L; mitochondrial pyruvate carrier 1-like protein [KO:K22138]
112298708  MPC2; mitochondrial pyruvate carrier 2 [KO:K22139]
112317856  PDHA2; pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial isoform X1 [KO:K00161] [EC:1.2.4.1]
112313353  PDHA1; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial [KO:K00161] [EC:1.2.4.1]
112301271  PDHB; pyruvate dehydrogenase E1 component subunit beta, mitochondrial [KO:K00162] [EC:1.2.4.1]
17046640  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
17046643  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
17046637  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
17046627  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
17046631  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
17046641  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
17046628  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
112317410  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
112322679  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
112306093  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
112303408  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
112310507  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
112318106  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
112305021  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
112321282  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
112319170  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
112319834  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
112299939  NDUFA5; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
112321783  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
112305159  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
112306425  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
112313094  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
112307837  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
112304755  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
112312492  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
112321926  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
112305228  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
112311794  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
112299902  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
112307804  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
112320640  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
112307720  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
112304586  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
112301387  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
112300388  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
112315325  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
112298294  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
112322448  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
112307774  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
112298899  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
112303379  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
112315253  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
112299378  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
112321034  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
112312661  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
112317128  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
112312496  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
112316078  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
112321014  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
112299141  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
112298888  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
112314355  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
112319551  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial-like [KO:K00237]
112296783  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
17046636  CYTB; cytochrome b [KO:K00412]
112315682  cytochrome c1, heme protein, mitochondrial [KO:K00413]
112309855  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
112304767  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
112314624  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
112315581  cytochrome b-c1 complex subunit 7 [KO:K00417]
112318142  cytochrome b-c1 complex subunit 8 [KO:K00418]
112310709  cytochrome b-c1 complex subunit 9 [KO:K00419]
112312414  cytochrome b-c1 complex subunit 10 [KO:K00420]
17046617  COX3; cytochrome c oxidase subunit III [KO:K02262]
17046649  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
17046633  COX2; cytochrome c oxidase subunit II [KO:K02261]
112304202  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
112300797  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
112301898  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
112315210  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
112310631  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
112304878  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
112313525  cytochrome c oxidase subunit 6B2 [KO:K02267]
112320945  cytochrome c oxidase subunit 6B1-like [KO:K02267]
112318743  cytochrome c oxidase subunit 6B1-like [KO:K02267]
112320116  cytochrome c oxidase subunit 6B1 [KO:K02267]
112303723  cytochrome c oxidase subunit 6B1-like [KO:K02267]
112304781  cytochrome c oxidase subunit 6C-like [KO:K02268]
112315524  cytochrome c oxidase subunit 6C [KO:K02268]
112297964  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
112319300  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
112320156  cytochrome c oxidase subunit 7A1, mitochondrial isoform X1 [KO:K02270]
112316645  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
112317931  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
112307507  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
112317280  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
112322763  ATP5F1A; LOW QUALITY PROTEIN: ATP synthase subunit alpha, mitochondrial [KO:K02132]
112319107  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
112322744  ATP5F1C; ATP synthase subunit gamma, mitochondrial [KO:K02136]
112312379  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
112300834  ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
112300842  ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
112303928  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
17046618  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
112313721  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
112318265  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
112305812  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
112309410  ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
112316280  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
112298792  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
112305628  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
112306721  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
17046642  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
112318103  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
112303041  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 2-like [KO:K15040]
112305359  VDAC2; LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 2 [KO:K15040]
112321447  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
112310580  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
112313387  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
112301943  ADP/ATP translocase 3-like [KO:K05863]
112312642  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
112306713  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
112305493  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
112321262  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
112308288  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
112318647  LOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
112309911  LOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
112316500  LOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
112304834  glyceraldehyde-3-phosphate dehydrogenase-like isoform X1 [KO:K00134] [EC:1.2.1.12]
112315864  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
112304977  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
112317239  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
112313136  LOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
112323174  LOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
112323175  LOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
112321904  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
112321514  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
112300915  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
112322594  LOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
112318849  PARP1; poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
112296260  G6PD; glucose-6-phosphate 1-dehydrogenase isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
112306684  GSR; glutathione reductase, mitochondrial [KO:K00383] [EC:1.8.1.7]
112304528  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
112309970  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
112322688  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
112304122  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
112311437  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
112304255  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
112317151  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
112316275  ACE; angiotensin-converting enzyme [KO:K01283] [EC:3.4.15.1]
Compound
C00001  H2O
C00002  ATP
C00005  NADPH
C00006  NADP+
C00022  Pyruvate
C00024  Acetyl-CoA
C00027  Hydrogen peroxide
C00031  D-Glucose
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00051  Glutathione
C00076  Calcium cation
C00085  D-Fructose 6-phosphate
C00092  D-Glucose 6-phosphate
C00095  D-Fructose
C00118  D-Glyceraldehyde 3-phosphate
C00127  Glutathione disulfide
C00162  Fatty acid
C00165  Diacylglycerol
C00195  N-Acylsphingosine
C00236  3-Phospho-D-glyceroyl phosphate
C00318  L-Carnitine
C00352  D-Glucosamine 6-phosphate
C00369  Starch
C00533  Nitric oxide
C00546  Methylglyoxal
C00704  Superoxide
C00794  D-Sorbitol
C00873  Angiotensin I
C02135  Angiotensin II
C02843  Long-chain acyl-CoA
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06156  alpha-D-Glucosamine 1-phosphate
C16844  Hydroxyl radical
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
C22310  Fructose 3-phosphate
C22311  3-Deoxyglucosone
Reference
PMID:30443826
  Authors
Riehle C, Bauersachs J
  Title
Of mice and men: models and mechanisms of diabetic cardiomyopathy.
  Journal
Basic Res Cardiol 114:2 (2018)
DOI:10.1007/s00395-018-0711-0
Reference
PMID:24462787
  Authors
Huynh K, Bernardo BC, McMullen JR, Ritchie RH
  Title
Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways.
  Journal
Pharmacol Ther 142:375-415 (2014)
DOI:10.1016/j.pharmthera.2014.01.003
Reference
PMID:28231848
  Authors
Lorenzo-Almoros A, Tunon J, Orejas M, Cortes M, Egido J, Lorenzo O
  Title
Diagnostic approaches for diabetic cardiomyopathy.
  Journal
Cardiovasc Diabetol 16:28 (2017)
DOI:10.1186/s12933-017-0506-x
Reference
PMID:32080423
  Authors
Tan Y, Zhang Z, Zheng C, Wintergerst KA, Keller BB, Cai L
  Title
Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence.
  Journal
Nat Rev Cardiol 17:585-607 (2020)
DOI:10.1038/s41569-020-0339-2
Reference
PMID:31212580
  Authors
Zamora M, Villena JA
  Title
Contribution of Impaired Insulin Signaling to the Pathogenesis of Diabetic Cardiomyopathy.
  Journal
Int J Mol Sci 20:E2833 (2019)
DOI:10.3390/ijms20112833
Reference
PMID:29605388
  Authors
Palomer X, Pizarro-Delgado J, Vazquez-Carrera M
  Title
Emerging Actors in Diabetic Cardiomyopathy: Heartbreaker Biomarkers or Therapeutic Targets?
  Journal
Trends Pharmacol Sci 39:452-467 (2018)
DOI:10.1016/j.tips.2018.02.010
Reference
PMID:28439258
  Authors
Mishra PK, Ying W, Nandi SS, Bandyopadhyay GK, Patel KK, Mahata SK
  Title
Diabetic Cardiomyopathy: An Immunometabolic Perspective.
  Journal
Front Endocrinol (Lausanne) 8:72 (2017)
DOI:10.3389/fendo.2017.00072
Reference
PMID:28177068
  Authors
Chong CR, Clarke K, Levelt E
  Title
Metabolic Remodeling in Diabetic Cardiomyopathy.
  Journal
Cardiovasc Res 113:422-430 (2017)
DOI:10.1093/cvr/cvx018
Reference
PMID:11742414
  Authors
Brownlee M
  Title
Biochemistry and molecular cell biology of diabetic complications.
  Journal
Nature 414:813-20 (2001)
DOI:10.1038/414813a
Reference
PMID:32821697
  Authors
Gollmer J, Zirlik A, Bugger H
  Title
Established and Emerging Mechanisms of Diabetic Cardiomyopathy.
  Journal
J Lipid Atheroscler 8:26-47 (2019)
DOI:10.12997/jla.2019.8.1.26
Reference
PMID:17592090
  Authors
Boudina S, Abel ED
  Title
Diabetic cardiomyopathy revisited.
  Journal
Circulation 115:3213-23 (2007)
DOI:10.1161/CIRCULATIONAHA.106.679597
Reference
PMID:29109032
  Authors
Varma U, Koutsifeli P, Benson VL, Mellor KM, Delbridge LMD
  Title
Molecular mechanisms of cardiac pathology in diabetes - Experimental insights.
  Journal
Biochim Biophys Acta Mol Basis Dis 1864:1949-1959 (2018)
DOI:10.1016/j.bbadis.2017.10.035
Reference
PMID:23147391
  Authors
Mandavia CH, Aroor AR, Demarco VG, Sowers JR
  Title
Molecular and metabolic mechanisms of cardiac dysfunction in diabetes.
  Journal
Life Sci 92:601-8 (2013)
DOI:10.1016/j.lfs.2012.10.028
Reference
PMID:21626163
  Authors
Falcao-Pires I, Leite-Moreira AF
  Title
Diabetic cardiomyopathy: understanding the molecular and cellular basis to progress in diagnosis and treatment.
  Journal
Heart Fail Rev 17:325-44 (2012)
DOI:10.1007/s10741-011-9257-z
Reference
PMID:27148064
  Authors
Westermeier F, Riquelme JA, Pavez M, Garrido V, Diaz A, Verdejo HE, Castro PF, Garcia L, Lavandero S
  Title
New Molecular Insights of Insulin in Diabetic Cardiomyopathy.
  Journal
Front Physiol 7:125 (2016)
DOI:10.3389/fphys.2016.00125
Reference
PMID:33276047
  Authors
Randhawa VK, Dhanvantari S, Connelly K
  Title
How Diabetes and Heart Failure Modulate Each Other and Condition Management.
  Journal
Can J Cardiol S0828-282X(20)31115-6 (2020)
DOI:10.1016/j.cjca.2020.11.014
Reference
PMID:31641426
  Authors
Athithan L, Gulsin GS, McCann GP, Levelt E
  Title
Diabetic cardiomyopathy: Pathophysiology, theories and evidence to date.
  Journal
World J Diabetes 10:490-510 (2019)
DOI:10.4239/wjd.v10.i10.490
Reference
PMID:21111987
  Authors
Murarka S, Movahed MR
  Title
Diabetic cardiomyopathy.
  Journal
J Card Fail 16:971-9 (2010)
DOI:10.1016/j.cardfail.2010.07.249
Reference
PMID:25085967
  Authors
Thomas CM, Yong QC, Rosa RM, Seqqat R, Gopal S, Casarini DE, Jones WK, Gupta S, Baker KM, Kumar R
  Title
Cardiac-specific suppression of NF-kappaB signaling prevents diabetic cardiomyopathy via inhibition of the renin-angiotensin system.
  Journal
Am J Physiol Heart Circ Physiol 307:H1036-45 (2014)
DOI:10.1152/ajpheart.00340.2014
Reference
PMID:28236380
  Authors
Brahma MK, Pepin ME, Wende AR
  Title
My Sweetheart Is Broken: Role of Glucose in Diabetic Cardiomyopathy.
  Journal
Diabetes Metab J 41:1-9 (2017)
DOI:10.4093/dmj.2017.41.1.1
Reference
PMID:18829990
  Authors
Singh VP, Le B, Khode R, Baker KM, Kumar R
  Title
Intracellular angiotensin II production in diabetic rats is correlated with cardiomyocyte apoptosis, oxidative stress, and cardiac fibrosis.
  Journal
Diabetes 57:3297-306 (2008)
DOI:10.2337/db08-0805
Reference
PMID:18296558
  Authors
Singh VP, Baker KM, Kumar R
  Title
Activation of the intracellular renin-angiotensin system in cardiac fibroblasts by high glucose: role in extracellular matrix production.
  Journal
Am J Physiol Heart Circ Physiol 294:H1675-84 (2008)
DOI:10.1152/ajpheart.91493.2007
Reference
PMID:26678809
  Authors
Jia G, DeMarco VG, Sowers JR
  Title
Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy.
  Journal
Nat Rev Endocrinol 12:144-53 (2016)
DOI:10.1038/nrendo.2015.216
Reference
PMID:18309108
  Authors
Kim JA, Wei Y, Sowers JR
  Title
Role of mitochondrial dysfunction in insulin resistance.
  Journal
Circ Res 102:401-14 (2008)
DOI:10.1161/CIRCRESAHA.107.165472
Reference
PMID:30170598
  Authors
Ormazabal V, Nair S, Elfeky O, Aguayo C, Salomon C, Zuniga FA
  Title
Association between insulin resistance and the development of cardiovascular disease.
  Journal
Cardiovasc Diabetol 17:122 (2018)
DOI:10.1186/s12933-018-0762-4
Reference
PMID:31269778
  Authors
Evangelista I, Nuti R, Picchioni T, Dotta F, Palazzuoli A
  Title
Molecular Dysfunction and Phenotypic Derangement in Diabetic Cardiomyopathy.
  Journal
Int J Mol Sci 20:E3264 (2019)
DOI:10.3390/ijms20133264
Reference
PMID:24307101
  Authors
Joshi M, Kotha SR, Malireddy S, Selvaraju V, Satoskar AR, Palesty A, McFadden DW, Parinandi NL, Maulik N
  Title
Conundrum of pathogenesis of diabetic cardiomyopathy: role of vascular endothelial dysfunction, reactive oxygen species, and mitochondria.
  Journal
Mol Cell Biochem 386:233-49 (2014)
DOI:10.1007/s11010-013-1861-x
Reference
PMID:29867137
  Authors
Knapp M, Tu X, Wu R
  Title
Vascular endothelial dysfunction, a major mediator in diabetic cardiomyopathy.
  Journal
Acta Pharmacol Sin 40:1-8 (2019)
DOI:10.1038/s41401-018-0042-6
Reference
PMID:16487830
  Authors
Asbun J, Villarreal FJ
  Title
The pathogenesis of myocardial fibrosis in the setting of diabetic cardiomyopathy.
  Journal
J Am Coll Cardiol 47:693-700 (2006)
DOI:10.1016/j.jacc.2005.09.050
Reference
PMID:32024054
  Authors
Levick SP, Widiapradja A
  Title
The Diabetic Cardiac Fibroblast: Mechanisms Underlying Phenotype and Function.
  Journal
Int J Mol Sci 21:E970 (2020)
DOI:10.3390/ijms21030970
Related
pathway
dro00010  Glycolysis / Gluconeogenesis
dro00020  Citrate cycle (TCA cycle)
dro00190  Oxidative phosphorylation
dro00520  Amino sugar and nucleotide sugar metabolism
dro03320  PPAR signaling pathway
dro04071  Sphingolipid signaling pathway
dro04150  mTOR signaling pathway
dro04210  Apoptosis
dro04260  Cardiac muscle contraction
dro04350  TGF-beta signaling pathway
dro04614  Renin-angiotensin system
dro04910  Insulin signaling pathway
dro04930  Type II diabetes mellitus
dro04931  Insulin resistance
dro04933  AGE-RAGE signaling pathway in diabetic complications
dro04940  Type I diabetes mellitus
KO pathway
ko05415   
LinkDB

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