KEGG   PATHWAY: ecb03015
Entry
ecb03015                    Pathway                                
Name
mRNA surveillance pathway - Equus caballus (horse)
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
Pathway map
ecb03015  mRNA surveillance pathway
ecb03015

Other DBs
GO: 0071028
Organism
Equus caballus (horse) [GN:ecb]
Gene
100064523  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
100060150  NCBP2; nuclear cap-binding protein subunit 2 isoform X2 [KO:K12883]
100058559  UPF3B; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
100069294  UPF3A; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
100034052  RBM8A; RNA-binding protein 8A [KO:K12876]
100060994  MAGOH; protein mago nashi homolog [KO:K12877]
100065075  protein mago nashi homolog 2 isoform X1 [KO:K12877]
100063178  protein mago nashi homolog 2 isoform X1 [KO:K12877]
100067814  CASC3; protein CASC3 [KO:K14323]
100056586  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
100050218  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
100060952  PNN; pinin [KO:K13114]
100055865  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X4 [KO:K12875]
100065738  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
106782613  ALYREF; THO complex subunit 4 [KO:K12881]
100054938  ATP-dependent RNA helicase DDX19B isoform X2 [KO:K18655] [EC:5.6.2.7]
100068576  ATP-dependent RNA helicase DDX19A isoform X1 [KO:K18655] [EC:5.6.2.7]
100066964  GLE1; nucleoporin GLE1 [KO:K18723]
100049009  NXF1; nuclear RNA export factor 1 isoform 2 [KO:K14284]
100060240  nuclear RNA export factor 3 [KO:K14284]
100060140  nuclear RNA export factor 3 isoform X2 [KO:K14284]
100060201  nuclear RNA export factor 2 [KO:K14284]
100060857  LOW QUALITY PROTEIN: nuclear RNA export factor 2 [KO:K14284]
100067224  nuclear RNA export factor 3-like [KO:K14284]
111771475  nuclear RNA export factor 3-like [KO:K14284]
100059798  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
102149448  NXT1; NTF2-related export protein 1 [KO:K14285]
100146384  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
100059063  PYM1; partner of Y14 and mago isoform X1 [KO:K14294]
100071467  SRRM1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
100065700  RNGTT; mRNA-capping enzyme [KO:K13917] [EC:2.7.7.50 3.6.1.74]
100050190  RNMT; mRNA cap guanine-N7 methyltransferase [KO:K00565] [EC:2.1.1.56]
100063286  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
100051482  TARDBP; TAR DNA-binding protein 43 isoform X1 [KO:K23600]
100051357  PABPN1L; embryonic polyadenylate-binding protein 2 [KO:K14396]
102149994  PABPN1; polyadenylate-binding protein 2 [KO:K14396]
100051355  NUDT21; cleavage and polyadenylation specificity factor subunit 5 [KO:K14397]
100059688  CPSF6; cleavage and polyadenylation specificity factor subunit 6 isoform X1 [KO:K14398]
100059747  CPSF7; cleavage and polyadenylation specificity factor subunit 7 isoform X1 [KO:K14398]
100052114  PAPOLG; poly(A) polymerase gamma [KO:K14376] [EC:2.7.7.19]
100054383  PAPOLA; poly(A) polymerase alpha isoform X1 [KO:K14376] [EC:2.7.7.19]
111776173  PAPOLB; LOW QUALITY PROTEIN: poly(A) polymerase beta [KO:K14376] [EC:2.7.7.19]
100066955  CLP1; polyribonucleotide 5'-hydroxyl-kinase Clp1 [KO:K14399] [EC:2.7.1.78]
100061695  PCF11; pre-mRNA cleavage complex 2 protein Pcf11 isoform X1 [KO:K14400]
100063277  CPSF1; cleavage and polyadenylation specificity factor subunit 1 isoform X1 [KO:K14401]
100053213  CPSF2; cleavage and polyadenylation specificity factor subunit 2 [KO:K14402]
100072510  CPSF3; cleavage and polyadenylation specificity factor subunit 3 isoform X1 [KO:K14403] [EC:3.1.27.-]
100059364  CPSF4; cleavage and polyadenylation specificity factor subunit 4 isoform X1 [KO:K14404]
100061214  CPSF4L; putative cleavage and polyadenylation specificity factor subunit 4-like protein [KO:K14404]
100060154  FIP1L1; pre-mRNA 3'-end-processing factor FIP1 isoform X1 [KO:K14405]
100067505  WDR33; pre-mRNA 3' end processing protein WDR33 isoform X1 [KO:K15542]
100060351  WDR82; WD repeat-containing protein 82 [KO:K14962]
100071067  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
100058160  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
100059233  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
106782823  SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [KO:K15544] [EC:3.1.3.16]
100050229  CSTF1; cleavage stimulation factor subunit 1 [KO:K14406]
100057347  CSTF2; cleavage stimulation factor subunit 2 isoform X1 [KO:K14407]
100062520  CSTF2T; cleavage stimulation factor subunit 2 tau variant [KO:K14407]
100060162  CSTF3; cleavage stimulation factor subunit 3 [KO:K14408]
100070949  SYMPK; symplekin isoform X1 [KO:K06100]
100068825  DAZAP1; DAZ-associated protein 1 isoform X1 [KO:K14411]
100070744  MSI2; RNA-binding protein Musashi homolog 2 isoform X1 [KO:K14411]
100053469  MSI1; RNA-binding protein Musashi homolog 1 isoform X1 [KO:K14411]
100056021  PABPC1; polyadenylate-binding protein 1 [KO:K13126]
100071995  PABPC5; polyadenylate-binding protein 5 [KO:K13126]
100070836  PABPC1L; polyadenylate-binding protein 1-like [KO:K13126]
100146775  PABPC1L2A; polyadenylate-binding protein 1-like 2 [KO:K13126]
100054235  PABPC4; polyadenylate-binding protein 4 isoform X3 [KO:K13126]
100071641  PABPC4L; polyadenylate-binding protein 4-like [KO:K13126]
100072210  LOW QUALITY PROTEIN: polyadenylate-binding protein 1-like [KO:K13126]
100072563  ETF1; eukaryotic peptide chain release factor subunit 1 [KO:K03265]
100055960  GSPT1; eukaryotic peptide chain release factor GTP-binding subunit ERF3A [KO:K03267]
100060648  GSPT2; eukaryotic peptide chain release factor GTP-binding subunit ERF3B [KO:K03267]
100071059  UPF1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
100069342  UPF2; regulator of nonsense transcripts 2 isoform X2 [KO:K14327]
100050143  SMG1; serine/threonine-protein kinase SMG1 isoform X1 [KO:K08873] [EC:2.7.11.1]
100055474  SMG7; protein SMG7 isoform X5 [KO:K14409]
100057746  SMG5; protein SMG5 [KO:K11125]
100060172  SMG6; telomerase-binding protein EST1A isoform X2 [KO:K11124] [EC:3.1.-.-]
100062224  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
100062627  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
100070408  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
100070133  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
100060957  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X5 [KO:K04354]
100059955  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X2 [KO:K04354]
100051737  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
100060079  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
100053302  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X3 [KO:K11583]
100057766  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
100051948  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
100054880  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
100054977  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X6 [KO:K11584]
100054440  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
100050735  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
100073159  HBS1L; HBS1-like protein isoform X1 [KO:K14416]
100052424  PELO; protein pelota homolog [KO:K06965]
Reference
PMID:15040442
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
PMID:16723977
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
PMID:17183357
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
PMID:18158581
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
PMID:16715045
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
Related
pathway
ecb03013  Nucleocytoplasmic transport
ecb03018  RNA degradation
ecb03040  Spliceosome
KO pathway
ko03015   
LinkDB

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