KEGG   PATHWAY: ecra03013
Entry
ecra03013                   Pathway                                
Name
Nucleocytoplasmic transport - Etheostoma cragini (Arkansas darter)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
ecra03013  Nucleocytoplasmic transport
ecra03013

Other DBs
GO: 0050658
Organism
Etheostoma cragini (Arkansas darter) [GN:ecra]
Gene
117947722  aaas; aladin isoform X1 [KO:K14320]
117956235  nup42; nucleoporin NUP42 [KO:K14321]
117945408  gle1; nucleoporin GLE1 [KO:K18723]
117943864  ddx19; ATP-dependent RNA helicase DDX19B [KO:K18655] [EC:5.6.2.7]
117947677  zgc:193690; ATP-dependent RNA helicase DDX19A [KO:K18655] [EC:5.6.2.7]
117942758  rae1; mRNA export factor isoform X1 [KO:K14298]
117956035  nup98; nuclear pore complex protein Nup98-Nup96 [KO:K14297]
117959372  nup214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
117942217  nup88; nucleoporin 88 [KO:K14318]
117952354  ranbp2; E3 SUMO-protein ligase RanBP2 isoform X1 [KO:K12172] [EC:2.3.2.-]
117936566  rangap1b; ran GTPase-activating protein 1b isoform X1 [KO:K14319]
117958057  rangap1a; ran GTPase-activating protein 1a isoform X1 [KO:K14319]
117957771  SUMO-conjugating enzyme UBC9-like [KO:K10577]
117937197  ube2ib; SUMO-conjugating enzyme UBC9-A [KO:K10577]
117935909  sumo3a; small ubiquitin-related modifier 3-like [KO:K12160]
117957558  small ubiquitin-related modifier 2-like [KO:K12160]
117959761  sumo2a; small ubiquitin-related modifier 2 [KO:K12160]
117939379  sumo1; small ubiquitin-related modifier 1 [KO:K12160]
117953499  sumo3b; small ubiquitin-related modifier 3 [KO:K12160]
117948945  nuclear pore complex protein Nup160-like [KO:K14303]
117957554  nup85; nuclear pore complex protein Nup85 [KO:K14304]
117943459  sec13; protein SEC13 homolog isoform X1 [KO:K14004]
117938485  nup107; nuclear pore complex protein Nup107 isoform X1 [KO:K14301]
117946041  seh1l; nucleoporin SEH1 isoform X1 [KO:K14299]
117961777  nup43; nucleoporin Nup43 isoform X1 [KO:K14305]
117938742  nup37; nucleoporin Nup37 [KO:K14302]
117947699  ahctf1; protein ELYS isoform X1 [KO:K25129]
117952617  nup62l; nucleoporin 62 like [KO:K14306]
117937816  nup58; nucleoporin p58/p45 isoform X1 [KO:K14307]
117959450  nup54; nucleoporin p54 isoform X1 [KO:K14308]
117949052  nup205; nuclear pore complex protein Nup205 isoform X1 [KO:K14310]
117959844  nup188; nucleoporin NUP188 homolog [KO:K14311]
117959259  nup155; nuclear pore complex protein Nup155 [KO:K14312]
117948435  nup93; nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
117953113  nup35; nucleoporin NUP35 isoform X1 [KO:K14313]
117954748  ndc1; nucleoporin NDC1 isoform X1 [KO:K14315]
117948128  nup210; nuclear pore membrane glycoprotein 210 [KO:K14314]
117955023  pom121; nuclear envelope pore membrane protein POM 121 isoform X1 [KO:K14316]
117951869  tmem33; transmembrane protein 33 [KO:K20724]
117949849  tprb; translocated promoter region b, nuclear basket protein isoform X1 [KO:K09291]
117954431  nucleoprotein TPR-like isoform X1 [KO:K09291]
117956537  nup153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
117936133  senp2; sentrin-specific protease 2 isoform X1 [KO:K03345] [EC:3.4.22.68]
117937652  kpna1; importin subunit alpha-5 [KO:K23940]
117935158  kpna7; importin subunit alpha-8 [KO:K15043]
117936446  importin subunit alpha-1-like [KO:K15043]
117957834  kpna2; importin subunit alpha-1 [KO:K15043]
117942403  kpna4; importin subunit alpha-3 [KO:K23583]
117952432  kpna3; importin subunit alpha-4 [KO:K23583]
117956720  kpna6; importin subunit alpha-7 [KO:K15042]
117959807  tnpo1; transportin-1 [KO:K18752]
117957406  transportin-2-like isoform X1 [KO:K18727]
117958872  transportin-2 isoform X1 [KO:K18727]
117939025  tnpo3; LOW QUALITY PROTEIN: transportin-3 [KO:K15436]
117937979  ipo4; importin-4 isoform X1 [KO:K20221]
117939140  kpnb3; importin-5 [KO:K20222]
117950481  ipo7; importin-7 [KO:K20223]
117938517  ipo8; importin-8 isoform X1 [KO:K18755]
117943681  ipo9; importin-9 isoform X1 [KO:K20224]
117944627  ipo11; importin-11 [KO:K25201]
117950385  importin-13-like isoform X1 [KO:K25202]
117954341  importin-13-like isoform X1 [KO:K25202]
117949339  snupn; snurportin-1 [KO:K13151]
117961834  xpo1a; exportin-1 [KO:K14290]
117959994  xpo1b; exportin-1 isoform X1 [KO:K14290]
117943686  cse1l; exportin-2 [KO:K18423]
117953284  xpo4; exportin-4 [KO:K25203]
117960093  exportin-5 [KO:K14289]
117957666  xpo6; exportin-6 [KO:K25204]
117951967  ran; GTP-binding nuclear protein Ran [KO:K07936]
117956955  elongation factor 1-alpha-like isoform X1 [KO:K03231]
117956956  elongation factor 1-alpha [KO:K03231]
117938101  si:dkey-37o8.1; elongation factor 1-alpha [KO:K03231]
117960153  eef1a1a; elongation factor 1-alpha 1a [KO:K03231]
117939995  phax; phosphorylated adapter RNA export protein [KO:K14291]
117951905  nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
117950472  ncbp2; nuclear cap-binding protein subunit 2 [KO:K12883]
117942289  nmd3; 60S ribosomal export protein NMD3 [KO:K07562]
117945687  rbm8a; RNA-binding protein 8A isoform X1 [KO:K12876]
117949886  magoh; protein mago nashi homolog [KO:K12877]
117941040  protein CASC3-like [KO:K14323]
117934696  acin1b; apoptotic chromatin condensation inducer 1b isoform X1 [KO:K12875]
117953857  acin1a; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
117939318  sap18; histone deacetylase complex subunit SAP18 [KO:K14324]
117936881  RNA-binding protein with serine-rich domain 1-like isoform X1 [KO:K14325]
117958100  RNA-binding protein with serine-rich domain 1-like [KO:K14325]
117935806  pnn; pinin [KO:K13114]
117956328  THO complex subunit 4-like [KO:K12881]
117957527  alyref; THO complex subunit 4 [KO:K12881]
117950817  regulator of nonsense transcripts 1-like [KO:K14326] [EC:5.6.2.5 5.6.2.3]
117953609  upf1; regulator of nonsense transcripts 1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
117938800  upf2; regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
117951749  upf3b; regulator of nonsense transcripts 3B [KO:K14328]
117952736  upf3a; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
117951649  zgc:153681; nuclear RNA export factor 1 isoform X1 [KO:K14284]
117952047  nxt2; NTF2-related export protein 2 [KO:K14285]
117935370  srrm1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
117948077  pym1; partner of Y14 and mago [KO:K14294]
117953726  thoc1; THO complex subunit 1 [KO:K12878]
117954981  thoc2; THO complex subunit 2 [KO:K12879]
117945173  thoc5; THO complex subunit 5 homolog [KO:K13174]
117942954  thoc7; THO complex subunit 7 homolog [KO:K13176]
117952115  thoc3; THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
ecra03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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