Entry Name Axon guidance - Eptesicus fuscus (big brown bat)
Description Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
Class Organismal Systems; Development and regenerationBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Eptesicus fuscus (big brown bat) [GN:
efus ]
Gene 103301578 TRPC1; short transient receptor potential channel 1 isoform X1 [KO:K04964 ]
103301646 TRPC3; short transient receptor potential channel 3 isoform X1 [KO:K04966 ]
103292957 TRPC6; short transient receptor potential channel 6 isoform X1 [KO:K04969 ]
103289468 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
103295071 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348 ] [EC:3.1.3.16 ]
103285754 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332 ]
103284606 NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
103301468 NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334 ]
103299146 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
103291971 CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393 ]
103289160 LOW QUALITY PROTEIN: cell division control protein 42 homolog [KO:K04393 ]
103293801 ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X2 [KO:K07532 ]
103291197 LRIG2; leucine-rich repeats and immunoglobulin-like domains protein 2 [KO:K24609 ]
103291154 GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630 ]
103293295 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630 ]
103298642 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
103297482 SRGAP2; SLIT-ROBO Rho GTPase-activating protein 2 isoform X4 [KO:K07526 ]
103291073 RHOD; rho-related GTP-binding protein RhoD isoform X2 [KO:K07530 ]
103295047 DPYSL2; dihydropyrimidinase-related protein 2 isoform X1 [KO:K07528 ]
103298154 CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
103289578 CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
103286747 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
103296140 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
103295411 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
103299551 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
103305161 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
103294784 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
103284587 PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093 ]
103285746 PARD6B; partitioning defective 6 homolog beta isoform X1 [KO:K06093 ]
Compound Reference Authors Guan KL, Rao Y.
Title Signalling mechanisms mediating neuronal responses to guidance cues.
Journal Reference Authors Govek EE, Newey SE, Van Aelst L.
Title The role of the Rho GTPases in neuronal development.
Journal Reference Authors Huber AB, Kolodkin AL, Ginty DD, Cloutier JF.
Title Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance.
Journal Reference Authors Negishi M, Oinuma I, Katoh H.
Title Plexins: axon guidance and signal transduction.
Journal Reference Authors Huot J.
Title Ephrin signaling in axon guidance.
Journal Reference Authors Patel BN, Van Vactor DL.
Title Axon guidance: the cytoplasmic tail.
Journal Reference Authors Yu TW, Bargmann CI.
Title Dynamic regulation of axon guidance.
Journal Reference Authors Dickson BJ.
Title Molecular mechanisms of axon guidance.
Journal Reference Authors Barallobre MJ, Pascual M, Del Rio JA, Soriano E.
Title The Netrin family of guidance factors: emphasis on Netrin-1 signalling.
Journal Reference Authors Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M.
Title The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.
Journal Reference Authors Fujita Y, Yamashita T
Title Axon growth inhibition by RhoA/ROCK in the central nervous system.
Journal Reference Authors Yamashita T, Mueller BK, Hata K
Title Neogenin and repulsive guidance molecule signaling in the central nervous system.
Journal Reference Authors van Erp S, van den Heuvel DMA, Fujita Y, Robinson RA, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JAA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ
Title Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.
Journal Related efus04060 Cytokine-cytokine receptor interaction
KO pathway LinkDB All DBs
