Entry
Name
B cell receptor signaling pathway - Eptesicus fuscus (big brown bat)
Description
B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Eptesicus fuscus (big brown bat) [GN:
efus ]
Gene
103303219 CD79A; B-cell antigen receptor complex-associated protein alpha chain [KO:K06506 ]
103293140 CD79B; B-cell antigen receptor complex-associated protein beta chain isoform X1 [KO:K06507 ]
103299797 DAPP1; dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide isoform X4 [KO:K12229 ]
103296145 VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730 ]
103299146 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
103289468 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
103295071 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348 ] [EC:3.1.3.16 ]
103304832 NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446 ]
103285754 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332 ]
103284606 NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
103298291 GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364 ]
103299195 CARD11; caspase recruitment domain-containing protein 11 [KO:K07367 ]
103293287 MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1 [KO:K07369 ] [EC:3.4.22.-]
103299551 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
103305161 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
103294784 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
103286747 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
103296140 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
103295411 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
103296486 FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b isoform X5 [KO:K12560 ]
114229328 leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512 ]
129147114 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
103303417 leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512 ]
129147537 leukocyte immunoglobulin-like receptor subfamily A member 3 [KO:K06512 ]
103303407 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
103303374 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
129147538 LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
129147540 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
129147541 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
129147542 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
129147543 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
103303394 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
103303386 leukocyte immunoglobulin-like receptor subfamily A member 3 [KO:K06512 ]
129147079 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
103303401 leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X1 [KO:K06512 ]
103303414 leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X1 [KO:K06512 ]
129147615 LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
129147616 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
103303419 leukocyte immunoglobulin-like receptor subfamily A member 5 isoform X1 [KO:K06512 ]
103303707 leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512 ]
129147618 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
103303701 LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
129147692 leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X1 [KO:K06512 ]
129147693 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
103303392 leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X1 [KO:K06512 ]
129147753 LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
129147075 LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
103303415 leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512 ]
103303371 leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X1 [KO:K06512 ]
103303404 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
103303406 leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
114229790 leukocyte immunoglobulin-like receptor subfamily A member 2 [KO:K06512 ]
129147819 leukocyte immunoglobulin-like receptor subfamily B member 3 isoform X1 [KO:K06512 ]
103303399 LOW QUALITY PROTEIN: immunoglobulin superfamily member 1 [KO:K06512 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Niiro H, Clark EA.
Title
Regulation of B-cell fate by antigen-receptor signals.
Journal
Reference
Authors
Kurosaki T.
Title
Genetic analysis of B cell antigen receptor signaling.
Journal
Reference
Authors
Nitschke L.
Title
The role of CD22 and other inhibitory co-receptors in B-cell activation.
Journal
Reference
Authors
Morgan BP, Marchbank KJ, Longhi MP, Harris CL, Gallimore AM.
Title
Complement: central to innate immunity and bridging to adaptive responses.
Journal
Reference
Authors
Kurosaki T.
Title
Regulation of B-cell signal transduction by adaptor proteins.
Journal
Reference
Authors
Nitschke L, Tsubata T.
Title
Molecular interactions regulate BCR signal inhibition by CD22 and CD72.
Journal
Reference
Authors
Jumaa H, Hendriks RW, Reth M.
Title
B cell signaling and tumorigenesis.
Journal
Reference
Authors
Rickert RC.
Title
Regulation of B lymphocyte activation by complement C3 and the B cell coreceptor complex.
Journal
Reference
Authors
Zouali M, Sarmay G
Title
B lymphocyte signaling pathways in systemic autoimmunity: implications for pathogenesis and treatment.
Journal
Reference
Authors
Chiles TC.
Title
Regulation and function of cyclin D2 in B lymphocyte subsets.
Journal
Reference
Authors
Allam A, Marshall AJ
Title
Role of the adaptor proteins Bam32, TAPP1 and TAPP2 in lymphocyte activation.
Journal
Reference
Authors
Gold MR
Title
To make antibodies or not: signaling by the B-cell antigen receptor.
Journal
Reference
Authors
Fu C, Turck CW, Kurosaki T, Chan AC
Title
BLNK: a central linker protein in B cell activation.
Journal
Reference
Authors
Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T
Title
BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation.
Journal
Reference
Authors
Shinohara H, Maeda S, Watarai H, Kurosaki T
Title
IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells.
Journal
Related pathway
efus04610 Complement and coagulation cascades
KO pathway
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