KEGG   PATHWAY: efus04151
Entry
efus04151                   Pathway                                
Name
PI3K-Akt signaling pathway - Eptesicus fuscus (big brown bat)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
efus04151  PI3K-Akt signaling pathway
efus04151

Other DBs
GO: 0043491
Organism
Eptesicus fuscus (big brown bat) [GN:efus]
Gene
103283198  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
103283222  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
103283312  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
103283323  METTL8; tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial isoform X1 [KO:K05070]
103283378  ITGB6; integrin beta-6 [KO:K06589]
103283472  ITGA4; integrin alpha-4 isoform X2 [KO:K06483]
103283488  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
103283571  PGF; placenta growth factor isoform X1 [KO:K16859]
103283666  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
103283745  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
103283761  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
103283776  ITGA11; integrin alpha-11 [KO:K06587]
103283794  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
103283856  IL7; interleukin-7 isoform X1 [KO:K05431]
103284058  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
103284092  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
103284108  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
103284162  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
103284166  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
103284312  AKT2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
103284413  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
103284641  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
103284864  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
103284970  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
103284972  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
103284973  KDR; vascular endothelial growth factor receptor 2 isoform X2 [KO:K05098] [EC:2.7.10.1]
103285100  CDKN1B; cyclin-dependent kinase inhibitor 1B isoform X1 [KO:K06624]
103285142  GYS2; glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
103285152  LAMA2; laminin subunit alpha-2 [KO:K05637]
103285154  KRAS; GTPase KRas isoform X1 [KO:K07827]
103285236  COL2A1; collagen alpha-1(II) chain [KO:K19719]
103285309  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
103285332  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
103285340  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
103285371  ITGA5; integrin alpha-5 [KO:K06484]
103285537  FGF1; fibroblast growth factor 1 [KO:K18496]
103285555  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
103285583  BCL2L1; bcl-2-like protein 1 [KO:K04570]
103285773  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
103285814  ANGPT4; angiopoietin-4 [KO:K05467]
103285992  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
103285995  EPO; LOW QUALITY PROTEIN: erythropoietin [KO:K05437]
103286022  YWHAG; 14-3-3 protein gamma [KO:K16198]
103286349  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
103286442  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
103286474  [KO:K04542]
103286498  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
103286557  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
103286718  [KO:K04382] [EC:3.1.3.16]
103286747  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103286752  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
103286857  OSM; oncostatin-M [KO:K05418]
103287001  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
103287126  YWHAH; 14-3-3 protein eta [KO:K16198]
103287256  FGFR4; fibroblast growth factor receptor 4 isoform X3 [KO:K05095] [EC:2.7.10.1]
103287300  THBS1; thrombospondin-1 [KO:K16857]
103287415  FGF7; fibroblast growth factor 7 [KO:K04358]
103287561  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
103287584  IL2; interleukin-2 [KO:K05429]
103287682  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
103287830  EIF4E; eukaryotic translation initiation factor 4E isoform X2 [KO:K03259]
103287865  SPP1; osteopontin isoform X1 [KO:K06250]
103287868  IBSP; bone sialoprotein 2 [KO:K06253]
103287907  FGF5; fibroblast growth factor 5 [KO:K04358]
103287940  AREG; amphiregulin [KO:K09782]
103288015  EREG; proepiregulin [KO:K09784]
103288032  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
103288035  FGF6; fibroblast growth factor 6 [KO:K04358]
103288064  KITLG; kit ligand isoform X2 [KO:K05461]
103288115  FGF23; fibroblast growth factor 23 [KO:K22428]
103288179  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103288231  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
103288305  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
103288435  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
103288450  TLR2; toll-like receptor 2 [KO:K10159]
103288473  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
103288651  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
103288691  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X3 [KO:K04354]
103288735  EFNA5; ephrin-A5 isoform X2 [KO:K05462]
103288794  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
103288848  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
103288853  PDGFB; platelet-derived growth factor subunit B isoform X2 [KO:K17386]
103288895  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
103288948  HSP90B1; endoplasmin isoform X1 [KO:K09487]
103288953  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
103288995  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
103288998  VWF; von Willebrand factor [KO:K03900]
103289027  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
103289119  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
103289149  JAK2; tyrosine-protein kinase JAK2 isoform X2 [KO:K04447] [EC:2.7.10.2]
103289188  RPS6; 40S ribosomal protein S6 isoform X1 [KO:K02991]
103289195  IFNB1; interferon beta [KO:K05415]
103289256  IRS1; insulin receptor substrate 1 [KO:K16172]
103289335  FN1; fibronectin isoform X1 [KO:K05717]
103289342  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
103289363  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
103289387  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
103289388  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
103289482  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
103289675  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
103289767  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
103289837  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
103289864  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
103289928  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
103289966  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
103289983  TNR; tenascin-R [KO:K06252]
103290016  LAMC1; laminin subunit gamma-1 [KO:K05635]
103290017  LAMC2; laminin subunit gamma-2 [KO:K06246]
103290054  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
103290074  LAMB3; laminin subunit beta-3 [KO:K06244]
103290097  TNN; tenascin-N [KO:K06252]
103290101  IL4; interleukin-4 [KO:K05430]
103290147  PRL; prolactin isoform X2 [KO:K05439]
103290240  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
103290249  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
103290263  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
103290305  FGF20; fibroblast growth factor 20 [KO:K04358]
103290347  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
103290440  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]
103290502  TSC2; tuberin isoform X9 [KO:K07207]
103290506  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
103290523  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
103290656  ITGAV; integrin alpha-V [KO:K06487]
103290720  GSK3B; glycogen synthase kinase-3 beta isoform X3 [KO:K03083] [EC:2.7.11.26]
103290849  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
103290903  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
103291051  FGF3; fibroblast growth factor 3 [KO:K04358]
103291052  FGF4; fibroblast growth factor 4 [KO:K04358]
103291053  FGF19; fibroblast growth factor 19 [KO:K22603]
103291072  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
103291087  RELA; transcription factor p65 isoform X1 [KO:K04735]
103291212  NRAS; GTPase NRas [KO:K07828]
103291218  NGF; beta-nerve growth factor [KO:K02582]
103291338  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
103291375  THEM4; acyl-coenzyme A thioesterase THEM4 isoform X1 [KO:K16339] [EC:3.1.2.2]
103291446  TGFA; protransforming growth factor alpha [KO:K08774]
103291622  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
103291632  CREB5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
103291706  VTN; vitronectin [KO:K06251]
103291757  YWHAE; 14-3-3 protein epsilon [KO:K06630]
103292019  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
103292032  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
103292051  IL6; interleukin-6 [KO:K05405]
103292129  ITGB8; integrin beta-8 [KO:K06591]
103292196  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
103292308  YWHAZ; 14-3-3 protein zeta/delta isoform X1 [KO:K16197]
103292334  CCNE2; G1/S-specific cyclin-E2 isoform X2 [KO:K06626]
103292358  MYC; myc proto-oncogene protein [KO:K04377]
103292405  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
103292412  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
103292479  CDK4; cyclin-dependent kinase 4 isoform X2 [KO:K02089] [EC:2.7.11.22]
103292522  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
103292531  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
103292609  [KO:K04542]
103292699  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
103292730  COL1A2; collagen alpha-2(I) chain [KO:K06236]
103292756  [KO:K04546]
103292850  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
103292852  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
103293042  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
103293060  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
103293066  G6PC1; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
103293119  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
103293159  ITGB3; integrin beta-3 [KO:K06493]
103293178  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
103293222  ITGA2B; integrin alpha-IIb [KO:K06476]
103293247  [KO:K05438]
103293251  HGF; hepatocyte growth factor [KO:K05460]
103293480  RELN; reelin isoform X2 [KO:K06249] [EC:3.4.21.-]
103293483  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103293513  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
103293615  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
103293759  LAMB1; laminin subunit beta-1 [KO:K05636]
103293765  LAMB4; laminin subunit beta-4 [KO:K06245]
103293769  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
103293793  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
103293963  SGK3; serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
103294018  ITGA8; integrin alpha-8 [KO:K06584]
103294106  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
103294109  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
103294199  NRTN; neurturin [KO:K25414]
103294228  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
103294231  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103294241  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
103294263  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
103294296  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
103294302  EFNA2; ephrin-A2 [KO:K05462]
103294320  FGF22; fibroblast growth factor 22 isoform X2 [KO:K04358]
103294377  PSPN; persephin [KO:K25416]
103294548  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
103294577  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
103294776  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
103294784  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103294862  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
103294880  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
103294913  ARTN; artemin [KO:K25415]
103295001  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
103295052  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X2 [KO:K04354]
103295085  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
103295224  FGF10; fibroblast growth factor 10 isoform X1 [KO:K04358]
103295279  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X3 [KO:K04536]
103295323  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
103295411  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103295457  VEGFC; vascular endothelial growth factor C [KO:K05449]
103295571  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
103295667  TNC; tenascin isoform X2 [KO:K06252]
103295671  TLR4; toll-like receptor 4 [KO:K10160]
103295744  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
103295746  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
103295757  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103295856  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
103295948  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
103295987  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
103296041  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692]
103296140  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103296157  TSC1; hamartin isoform X1 [KO:K07206]
103296167  LAMC3; laminin subunit gamma-3 [KO:K06247]
103296283  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103296345  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
103296377  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
103296529  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
103296621  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
103296626  VEGFA; vascular endothelial growth factor A [KO:K05448]
103296627  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
103296633  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
103296652  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
103296752  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
103296863  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
103296897  TP53; cellular tumor antigen p53 isoform X2 [KO:K04451]
103296965  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
103297056  CHAD; chondroadherin [KO:K06248]
103297064  COL1A1; collagen alpha-1(I) chain [KO:K06236]
103297069  ITGA3; integrin alpha-3 [KO:K06482]
103297077  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
103297082  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
103297187  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
103297192  CSF3; granulocyte colony-stimulating factor isoform X2 [KO:K05423]
103297376  TEK; LOW QUALITY PROTEIN: angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
103297641  NTF4; neurotrophin-4 [KO:K12457]
103297644  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
103297653  FGF21; fibroblast growth factor 21 [KO:K22429]
103297769  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
103297851  [KO:K04542]
103298031  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
103298034  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X4 [KO:K11584]
103298082  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
103298090  ITGA2; integrin alpha-2 [KO:K06481]
103298091  ITGA1; integrin alpha-1 [KO:K06480]
103298098  PRLR; prolactin receptor isoform X1 [KO:K05081]
103298181  VEGFD; vascular endothelial growth factor D [KO:K05449]
103298209  ITGA9; integrin alpha-9 [KO:K06585]
103298282  ITGB4; integrin beta-4 isoform X3 [KO:K06525]
103298291  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
103298364  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
103298729  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
103298815  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
103298830  GHR; growth hormone receptor isoform X1 [KO:K05080]
103298835  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
103298839  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
103298850  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
103298897  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
103298900  LAMB2; laminin subunit beta-2 [KO:K06243]
103298904  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
103298905  EFNA3; ephrin-A3 isoform X4 [KO:K05462]
103298906  EFNA4; LOW QUALITY PROTEIN: ephrin-A4 [KO:K05462]
103298930  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
103298932  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
103298971  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
103299022  IL6R; interleukin-6 receptor subunit alpha isoform X2 [KO:K05055]
103299031  [KO:K16197]
103299146  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
103299170  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
103299452  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
103299486  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
103299489  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
103299502  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
103299530  COMP; cartilage oligomeric matrix protein [KO:K04659]
103299551  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103299558  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
103299657  [KO:K04542]
103299759  PTK2; focal adhesion kinase 1 isoform X3 [KO:K05725] [EC:2.7.10.2]
103299785  FOXO3; forkhead box protein O3 isoform X1 [KO:K09408]
103299786  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
103299842  [KO:K06238]
103299845  THBS2; thrombospondin-2 isoform X1 [KO:K04659]
103300004  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
103300242  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
103300280  LAMA5; laminin subunit alpha-5 [KO:K06240]
103300452  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
103300518  TNXB; tenascin-X [KO:K06252]
103300702  [KO:K06243]
103300750  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
103300826  CD19; B-lymphocyte antigen CD19 [KO:K06465]
103300850  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
103300870  PKN2; serine/threonine-protein kinase N2 [KO:K23691]
103300985  PKN1; serine/threonine-protein kinase N1 isoform X2 [KO:K06071] [EC:2.7.11.13]
103301022  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
103301132  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
103301161  EPOR; erythropoietin receptor [KO:K05079]
103301270  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
103301495  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
103301538  SGK2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
103301676  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
103301717  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
103301777  RHEB; GTP-binding protein Rheb [KO:K07208]
103301781  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
103301793  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103301919  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
103301950  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
103301982  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
103302042  VEGFB; vascular endothelial growth factor B isoform X2 [KO:K16858]
103302047  BAD; bcl2-associated agonist of cell death [KO:K02158]
103302063  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
103302137  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
103302255  IKBKG; NF-kappa-B essential modulator [KO:K07210]
103302464  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
103302479  MTCP1; protein p13 MTCP-1 [KO:K16837]
103302548  HRAS; GTPase HRas isoform X1 [KO:K02833]
103302909  LAMA4; laminin subunit alpha-4 [KO:K06241]
103302915  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
103303256  IGF2; insulin-like growth factor II [KO:K13769]
103303257  INS; insulin [KO:K04526]
103303646  FGF16; fibroblast growth factor 16 [KO:K04358]
103303724  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
103303728  BCL2; apoptosis regulator Bcl-2 isoform X3 [KO:K02161]
103303734  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 isoform X1 [KO:K04540]
103304154  FGF9; fibroblast growth factor 9 isoform X1 [KO:K04358]
103304255  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
103304360  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
103304570  LAMA1; laminin subunit alpha-1 [KO:K05637]
103304576  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
103304805  [KO:K10167]
103304881  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
103304978  [KO:K10167]
103305028  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
103305161  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103305203  F2R; proteinase-activated receptor 1 [KO:K03914]
103305350  THBS4; thrombospondin-4 [KO:K04659]
103305383  MYB; transcriptional activator Myb isoform X2 [KO:K09420]
103305472  SGK1; serine/threonine-protein kinase Sgk1 isoform X3 [KO:K13302] [EC:2.7.11.1]
103305598  YWHAQ; 14-3-3 protein theta isoform X2 [KO:K16197]
103305666  SOS1; son of sevenless homolog 1 [KO:K03099]
114226821  [KO:K05071]
114227350  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
114228018  [KO:K10167]
114228405  [KO:K05071]
114229025  [KO:K05096] [EC:2.7.10.1]
114234667  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
114234933  [KO:K04548]
129148251  [KO:K06856]
129148810  [KO:K10167]
129149245  FGF2; fibroblast growth factor 2 [KO:K18497]
129150036  IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
129150159  [KO:K02991]
129150929  [KO:K04542]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
efus00010  Glycolysis / Gluconeogenesis
efus04010  MAPK signaling pathway
efus04012  ErbB signaling pathway
efus04062  Chemokine signaling pathway
efus04064  NF-kappa B signaling pathway
efus04068  FoxO signaling pathway
efus04110  Cell cycle
efus04115  p53 signaling pathway
efus04150  mTOR signaling pathway
efus04210  Apoptosis
efus04370  VEGF signaling pathway
efus04510  Focal adhesion
efus04620  Toll-like receptor signaling pathway
efus04630  JAK-STAT signaling pathway
efus04662  B cell receptor signaling pathway
efus04910  Insulin signaling pathway
KO pathway
ko04151   

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