KEGG   PATHWAY: gga05168
Entry
gga05168                    Pathway                                
Name
Herpes simplex virus 1 infection - Gallus gallus (chicken)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
gga05168  Herpes simplex virus 1 infection
gga05168

Organism
Gallus gallus (chicken) [GN:gga]
Gene
417287  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
374055  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
426792  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
423669  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
396093  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
396033  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
396027  RELA; transcription factor p65 [KO:K04735]
374012  BIRC2; inhibitor of apoptosis protein [KO:K16060]
100857875  NECTIN1; nectin-1 isoform X1 [KO:K06081]
395815  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
419429  protein tyrosine phosphatase, non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
374209  ITGB3; integrin beta-3 precursor [KO:K06493]
396442  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
427272  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
427756  CARD9; caspase recruitment domain-containing protein 9 isoform X2 [KO:K12794]
554219  IFNW1; interferon type B precursor [KO:K05415]
396370  C3; complement C3 precursor [KO:K03990]
417122  C5; complement C5 isoform X2 [KO:K03994]
112533495  CFP; properdin [KO:K15412]
374141  TLR2A; toll-like receptor 2 type-1 precursor [KO:K10159]
769014  TLR2B; toll-like receptor 2 type-2 precursor [KO:K10159]
420420  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
396330  IRF7; interferon regulatory factor 3 [KO:K09447]
422720  TLR3; toll-like receptor 3 precursor [KO:K05401]
100008585  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
417796  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
423163  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
421808  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
418014  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
421622  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X2 [KO:K04404]
395196  IL1B; interleukin-1 beta [KO:K04519]
417465  CCL5; C-C motif chemokine 5 precursor [KO:K12499]
395337  IL6; interleukin-6 precursor [KO:K05405]
407090  IL12A; interleukin-12 subunit alpha precursor [KO:K05406]
404671  IL12B; interleukin-12 subunit beta precursor [KO:K05425]
424185  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
422936  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
423471  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
430480  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X4 [KO:K07211] [EC:2.7.11.10]
417825  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
768614  IFA3L; interferon type A3 [KO:K05414]
396398  IFNA3; interferon type A1/A2 precursor [KO:K05414]
100859032  IFNAL6; interferon type A1/A2 [KO:K05414]
100858177  interferon type A1/A2 [KO:K05414]
100857947  IFNAL5; interferon type A1/A2 [KO:K05414]
100857744  IFNAL4; interferon type A1/A2 [KO:K05414]
101750245  IFNKL1; interferon kappa isoform X2 [KO:K05414]
421864  MB21D1; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
768990  TMEM173; stimulator of interferon genes protein [KO:K12654]
396019  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
416872  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
100858156  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
395360  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
395147  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
422930  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
423285  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
423279  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
100857736  EIF2B1; translation initiation factor eIF-2B subunit alpha [KO:K03239]
423359  EIF2B2; translation initiation factor eIF-2B subunit beta [KO:K03754]
424587  EIF2B3; translation initiation factor eIF-2B subunit gamma [KO:K03241]
425800  EIF2B4; translation initiation factor eIF-2B subunit delta isoform X2 [KO:K03680]
424948  EIF2B5; translation initiation factor eIF-2B subunit epsilon isoform X1 [KO:K03240]
424410  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
418083  HCFC2; host cell factor 2 isoform X4 [KO:K27390]
396463  POU2F1; POU domain, class 2, transcription factor 1 [KO:K09364]
428240  POU2F3; POU domain, class 2, transcription factor 3 isoform X1 [KO:K09364]
395665  IFNAR1; interferon alpha/beta receptor 1 precursor [KO:K05130]
395664  IFNAR2; interferon alpha/beta receptor 2 precursor [KO:K05131]
395299  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
395681  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
430113  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
424044  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
100858732  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
417303  ZNF302; zinc finger protein 302 [KO:K09228]
420370  ZNF746; zinc finger protein 777 isoform X2 [KO:K09228]
426408  ZNF555; KRAB domain-containing protein 1 [KO:K09228]
430731  ZNF226L; zinc finger protein 501 isoform X4 [KO:K09228]
420372  ZNF767; zinc finger family member 767 [KO:K09228]
101747780  ZNF398L; zinc finger protein 777 [KO:K09228]
107052489  zinc finger protein 282-like isoform X1 [KO:K09228]
769660  zinc finger protein 501 [KO:K09228]
112531035  zinc finger protein 665-like [KO:K09228]
396054  IFNG; interferon gamma precursor [KO:K04687]
421685  IFNGR1; interferon gamma receptor 1 precursor [KO:K05132]
418502  IFNGR2; interferon gamma receptor 2 precursor [KO:K05133]
374199  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
415302  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
100857563  PMLL; protein PML [KO:K10054] [EC:2.3.2.-]
427727  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
427728  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
417048  TAPBP; tapasin isoform 1 precursor [KO:K08058]
373899  PDIA3; protein disulfide-isomerase A3 precursor [KO:K08056] [EC:5.3.4.1]
100859104  CALR; calreticulin [KO:K08057]
420146  CALR3; calreticulin-3 precursor [KO:K08057]
417057  MHCIA6; class I histocompatibility antigen, F10 alpha chain [KO:K06751]
417067  MICA; class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
100859134  HLA-F10AL4; class I histocompatibility antigen, F10 alpha chain [KO:K06751]
100859374  MHCIA2; class I histocompatibility antigen, F10 alpha chain isoform X1 [KO:K06751]
107049124  class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
107050538  class I histocompatibility antigen, F10 alpha chain-like isoform X2 [KO:K06751]
425389  BF2; Major histocompatibility complex class I antigen BF2 precursor [KO:K06751]
427746  YF5; MHC class I antigen YF5 precursor [KO:K06751]
430600  MHCIA7; class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
693260  BF1; MHC BF1 class I precursor [KO:K06751]
414830  B2M; beta-2-microglobulin precursor [KO:K08055]
425256  BLB3; class II histocompatibility antigen, B-L beta chain isoform X1 [KO:K06752]
693256  BLB1; Major histocompatibility complex class II beta chain BLB1, (similar to HLA class II, D beta chain) precursor [KO:K06752]
417051  DMB2; major histocompatibility complex, class II, DM beta 2 precursor [KO:K06752]
417050  MHCDMA; B locus M alpha chain 1 precursor [KO:K06752]
430189  BLA; B-LA precursor [KO:K06752]
101747454  BLB2; uncharacterized protein LOC101747454 precursor [KO:K06752]
101748499  MHCBL2; class II histocompatibility antigen, B-L beta chain-like isoform X1 [KO:K06752]
107057103  class II histocompatibility antigen, B-L beta chain-like [KO:K06752]
414741  CD74; HLA class II histocompatibility antigen gamma chain [KO:K06505]
424971  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
419444  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
424826  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
429096  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
771142  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
427171  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
395928  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
421497  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101750560  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
417166  TSC1; hamartin isoform X2 [KO:K07206]
416552  TSC2; tuberin isoform X1 [KO:K07207]
420434  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
419455  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
426773  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
421185  SRPK1; SRSF protein kinase 1 isoform X2 [KO:K15409] [EC:2.7.11.1]
772264  SRSF1; serine/arginine-rich splicing factor 1 [KO:K12890]
396195  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
419815  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
419600  SRSF4; serine/arginine-rich splicing factor 4 isoform X1 [KO:K12893]
423258  SRSF5; serine/arginine-rich splicing factor 5 [KO:K12893]
419116  SRSF6; splicing factor, arginine/serine-rich 6 [KO:K12893]
423265  SRSF5A; serine/arginine-rich splicing factor 5a [KO:K12893]
426265  SRSF7; serine and arginine rich splicing factor 7 [KO:K12896]
100859609  SRSF7L; serine/arginine-rich splicing factor 7 [KO:K12896]
101748079  NXF1; nuclear RNA export factor 1 [KO:K14284]
769169  ALYREF; THO complex subunit 4 [KO:K12881]
429064  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
395274  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
418325  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158]
415700  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
423146  FADD; FAS-associated death domain protein [KO:K02373]
395284  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
693266  CASP18; initiator caspase [KO:K04398] [EC:3.4.22.61]
395236  BID; BH3-interacting domain death agonist [KO:K04726]
419912  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
396282  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
373954  BCL2L1; bcl-2-like protein 1 [KO:K04570]
420624  CYCS; cytochrome c [KO:K08738]
417926  APAF1; apoptotic protease-activating factor 1 isoform X3 [KO:K02084]
426970  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
395476  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
  Journal
Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4
Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
  Journal
PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
  Journal
Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
  Journal
J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
  Journal
J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
  Journal
Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5
Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
  Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
  Journal
Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
  Journal
J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17
Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
  Journal
Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9
Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
Reference
PMID:12826401
  Authors
Wysocka J, Herr W
  Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
  Journal
Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
PMID:27367734
  Authors
Fleming SB
  Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
  Journal
Vaccines (Basel) 4:E23 (2016)
DOI:10.3390/vaccines4030023
Reference
PMID:15163721
  Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
  Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
  Journal
J Virol 78:6282-6 (2004)
DOI:10.1128/JVI.78.12.6282-6286.2004
Reference
PMID:23864622
  Authors
Gu H, Zheng Y, Roizman B
  Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
  Journal
J Virol 87:10244-54 (2013)
DOI:10.1128/JVI.01487-13
Reference
PMID:21994592
  Authors
Tavalai N, Stamminger T
  Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
  Journal
Viruses 1:1240-64 (2009)
DOI:10.3390/v1031240
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:12960333
  Authors
Neumann J, Eis-Hubinger AM, Koch N
  Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
  Journal
J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075
Reference
PMID:25798530
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
  Journal
Virology 479-480:568-77 (2015)
DOI:10.1016/j.virol.2015.02.040
Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
  Journal
J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
Reference
PMID:18508584
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
  Journal
Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
PMID:15078920
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
  Journal
J Virol 78:4389-96 (2004)
DOI:10.1128/JVI.78.9.4389-4396.2004
Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
  Journal
Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
gga03040  Spliceosome
gga03050  Proteasome
gga04115  p53 signaling pathway
gga04210  Apoptosis
gga04620  Toll-like receptor signaling pathway
gga04622  RIG-I-like receptor signaling pathway
KO pathway
ko05168   
LinkDB

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