KEGG   PATHWAY: kmr04060
Entry
kmr04060                    Pathway                                
Name
Cytokine-cytokine receptor interaction - Kryptolebias marmoratus (mangrove rivulus)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
kmr04060  Cytokine-cytokine receptor interaction
kmr04060

Organism
Kryptolebias marmoratus (mangrove rivulus) [GN:kmr]
Gene
108230571  C-C motif chemokine 25-like [KO:K13072]
108239394  C-C motif chemokine 3-like [KO:K05408]
108246589  C-C motif chemokine 4 [KO:K12964]
108234702  ccl20b; C-C motif chemokine 20b [KO:K14625]
108239481  C-C motif chemokine 20-like [KO:K14625]
108239488  ccl20a.3; C-C motif chemokine 20a.3 [KO:K14625]
108249089  cxcl19; C-X-C motif chemokine 19 [KO:K10030]
108234724  interleukin-8-like [KO:K10030]
108248985  interleukin-8-like [KO:K10030]
108249091  C-X-C motif chemokine 3-like isoform X1 [KO:K05416]
108234134  C-X-C motif chemokine 9 [KO:K05416]
108245629  interleukin-8-like [KO:K12671]
108242783  C-X-C motif chemokine 13 [KO:K10032]
108233956  cxcl12a; chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) isoform X1 [KO:K10031]
108241502  cxcl12b; chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) [KO:K10031]
108236688  cxcl14; C-X-C motif chemokine 14 [KO:K10033]
108229455  epoa; erythropoietin isoform X1 [KO:K05437]
108238150  smtla; somatolactin alpha precursor [KO:K05438]
108243233  gh1; growth hormone 1 precursor [KO:K05438]
108247088  prl; prolactin precursor [KO:K05439]
108249070  prl2; prolactin 2 isoform X1 [KO:K05439]
108233234  leptin-B [KO:K05424]
119617834  il11a; uncharacterized protein il11a [KO:K05417]
108239606  interleukin-12 subunit alpha-like [KO:K05406]
108240891  il12a; interleukin-12 subunit alpha [KO:K05406]
108233659  si:dkey-88e18.2; interleukin-12 subunit beta [KO:K05425]
108238912  il12bb; interleukin-12 subunit beta [KO:K05425]
108245805  il12ba; interleukin 12Ba [KO:K05425]
112451383  uncharacterized protein LOC112451383 [KO:K22629]
108237177  ebi3; interleukin-27 subunit beta [KO:K24476]
108243023  clcf1; uncharacterized protein clcf1 [KO:K05421]
108235691  il10; interleukin-10 [KO:K05443]
108235700  il19l; interleukin 19 like [KO:K22667]
108250528  il22; interleukin-22 [KO:K05445]
108247211  interferon a3-like [KO:K05414]
108247218  interferon a3-like [KO:K05414]
108242738  il1b; interleukin-1 beta [KO:K04519]
108247699  interleukin-18 isoform X1 [KO:K05482]
108242366  il17a/f1; interleukin 17a/f1 [KO:K05494]
108245471  il17a/f3; interleukin 17a/f3 [KO:K05494]
108250685  interleukin-17C-like [KO:K05491]
108251122  il17c; interleukin-17C [KO:K05491]
108244212  il17d; interleukin-17D [KO:K05492]
108241039  si:dkey-92i15.4; pro-interleukin-16 [KO:K22628]
108251386  il16; pro-interleukin-16 isoform X1 [KO:K22628]
108228896  il34; interleukin-34 [KO:K22633]
108248581  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
108241311  tnfsf14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
108241477  tumor necrosis factor ligand superfamily member 14 [KO:K05477]
108231281  cd40lg; CD40 ligand [KO:K04389]
108230718  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
108247980  tumor necrosis factor ligand superfamily member 10-like isoform X1 [KO:K04721]
108234661  tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
108242045  ectodysplasin-A isoform X1 [KO:K05480]
108231487  ngfb; nerve growth factor [KO:K02582]
108235167  ngfa; neurotrophin-7 isoform X1 [KO:K02582]
108247793  tnfsf12; tumor necrosis factor ligand superfamily member 12 [KO:K05474]
108242043  tumor necrosis factor ligand superfamily member 13B-like [KO:K05476]
108232434  tnfsf13b; tumor necrosis factor ligand superfamily member 13B isoform X1 [KO:K05476]
108228916  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
108231423  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
108235253  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
108242427  transforming growth factor beta-3 proprotein [KO:K13377]
108244838  growth/differentiation factor 15 [KO:K05504]
108247539  bone morphogenetic protein 10-like [KO:K22670]
108234956  bmp10; bone morphogenetic protein 10 [KO:K22670]
108242193  inha; inhibin alpha chain isoform X1 [KO:K05500]
108244553  bmp3; bone morphogenetic protein 3 [KO:K05496]
108233947  gdf10a; growth/differentiation factor 10 [KO:K22674]
108235791  growth/differentiation factor 11 isoform X1 [KO:K22679]
108247349  mstnb; growth/differentiation factor 8 [KO:K05497]
108228885  growth/differentiation factor 8-like [KO:K05497]
108250630  inhbab; inhibin subunit beta Ab [KO:K04667]
108228553  inhbaa; inhibin subunit beta Aa [KO:K04667]
108229410  inhibin beta B chain-like [KO:K22687]
108231522  inhibin beta B chain [KO:K22687]
108246724  inhbb; inhibin beta B chain [KO:K22687]
108238824  gdf3; protein DVR-1 [KO:K22672]
108232637  nodal homolog [KO:K04666]
108234526  spaw; southpaw isoform X2 [KO:K04666]
108247721  ndr2; nodal-related 2 [KO:K04666]
108240536  gdf9; growth/differentiation factor 9 [KO:K22673]
108230615  amh; muellerian-inhibiting factor [KO:K04665]
108231728  bmp2b; bone morphogenetic protein 2b isoform X1 [KO:K21283]
108240827  bmp16; bone morphogenetic protein 16 [KO:K21283]
108250775  bone morphogenetic protein 2-A-like [KO:K21283]
108232862  anti-dorsalizing morphogenic protein [KO:K21283]
108232299  bmp4; bone morphogenetic protein 4 isoform X2 [KO:K04662]
108251522  gdf5; growth/differentiation factor 5 [KO:K04664]
108234173  gdf6a; growth/differentiation factor 6-A [KO:K20012]
108250950  bmp15; bone morphogenetic protein 15 [KO:K05498]
108233959  bmp5; bone morphogenetic protein 5 [KO:K04663]
108244027  bmp6; bone morphogenetic protein 6 isoform X1 [KO:K16620]
108241192  bone morphogenetic protein 7 [KO:K16621]
108231905  bmp7b; bone morphogenetic protein 7b [KO:K16621]
108249887  bmp8a; bone morphogenetic protein 8A [KO:K16622]
108247677  C-C chemokine receptor type 8-like [KO:K04183]
108230348  ccr9b; C-C chemokine receptor type 9 [KO:K04184]
108251323  C-C chemokine receptor type 9 [KO:K04184]
108232830  ackr4a; atypical chemokine receptor 4 [KO:K04186]
108230385  ackr4b; atypical chemokine receptor 4b [KO:K04186]
108248988  ccr10; C-C chemokine receptor type 10 isoform X2 [KO:K04182]
108250303  ccr12a; chemokine (C-C motif) receptor 12a [KO:K04179]
108232271  si:cabz01093077.1; C-C chemokine receptor type 4 [KO:K04179]
108232253  cabz01093075.1; C-C chemokine receptor type 5 isoform X2 [KO:K04180]
108232214  C-C chemokine receptor type 1 [KO:K04178]
108245086  ccr6b; C-C chemokine receptor type 6 [KO:K04181]
108251507  ccr6a; C-C chemokine receptor type 6a [KO:K04181]
108251250  C-C chemokine receptor type 6 isoform X2 [KO:K04181]
108244287  C-X-C chemokine receptor type 1-like [KO:K05050]
108238526  cxcr2; C-X-C chemokine receptor type 1 [KO:K05050]
108235339  C-X-C chemokine receptor type 3-like [KO:K04188]
108235340  LOW QUALITY PROTEIN: C-X-C chemokine receptor type 3-like [KO:K04188]
108235357  cxcr3.2; C-X-C chemokine receptor type 3-2 isoform X1 [KO:K04188]
108235481  LOW QUALITY PROTEIN: C-X-C chemokine receptor type 3-like [KO:K04188]
108235993  C-X-C chemokine receptor type 5 [KO:K04190]
108238272  C-X-C chemokine receptor type 4-like [KO:K04189]
108238501  cxcr4b; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
108239713  ackr3a; atypical chemokine receptor 3a [KO:K04304]
108232842  chemokine XC receptor 1-like [KO:K04193]
108232844  chemokine XC receptor 1-like [KO:K04193]
108232856  chemokine XC receptor 1 [KO:K04193]
108230775  xcr1a.1; chemokine (C motif) receptor 1a, duplicate 1 [KO:K04193]
108251503  interleukin-2 receptor subunit beta [KO:K05069]
108236105  il2rb; interleukin-2 receptor subunit beta [KO:K05069]
108238836  uncharacterized protein LOC108238836 isoform X1 [KO:K05069]
108238920  cytokine receptor common subunit gamma [KO:K05070]
108238928  cytokine receptor common subunit gamma [KO:K05070]
108245570  il7r; interleukin-7 receptor subunit alpha [KO:K05072]
108245560  il15ra; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
108237210  interleukin-21 receptor isoform X1 [KO:K05075]
108248883  il21r.1; interleukin 21 receptor, tandem duplicate 1 [KO:K05075]
108236108  csf2rb; cytokine receptor common subunit beta [KO:K04738]
108250046  uncharacterized protein LOC108250046 [KO:K05076]
108245212  il13ra2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
108247493  epor; erythropoietin receptor [KO:K05079]
108233781  ghra; growth hormone receptor a precursor [KO:K05080]
108250916  ghrb; growth hormone receptor b precursor [KO:K05080]
108251543  growth hormone receptor-like [KO:K05080]
108231042  prlra; prolactin receptor precursor [KO:K05081]
108238404  mpl; thrombopoietin receptor [KO:K05082]
108235335  csf3r; granulocyte colony-stimulating factor receptor [KO:K05061]
108238470  lepr; leptin receptor isoform X1 [KO:K05062]
108241027  il6r; interleukin-6 receptor subunit alpha [KO:K05055]
108242804  interleukin-6 receptor subunit beta [KO:K05060]
108242572  il6st; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
108239198  il12rb2l; interleukin 12 receptor, beta 2a, like [KO:K05060]
108232533  il11ra; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056]
108234318  il12rb1; interleukin-12 receptor subunit beta-1 isoform X2 [KO:K05063]
108230530  il23r; interleukin-23 receptor [KO:K05064]
108230698  il12rb2; interleukin-12 receptor subunit beta-2 [KO:K05064]
108233366  interleukin-6 receptor subunit beta isoform X1 [KO:K22630]
108232720  cntfr; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059]
108228381  oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05058]
108233760  lifra; LIF receptor subunit alpha a [KO:K05058]
108243507  il10ra; interleukin-10 receptor subunit alpha [KO:K05134]
108251685  interleukin-10 receptor subunit beta [KO:K05135]
108251687  il10rb; interleukin-10 receptor subunit beta [KO:K05135]
108251684  ifngr2; interferon gamma receptor 2 isoform X1 [KO:K05135]
108231739  il20ra; interleukin-20 receptor subunit alpha [KO:K05136]
108229498  crfb16; cytokine receptor family member B16 [KO:K05137]
108251686  interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
108246304  ifngr1; interferon gamma receptor 1 precursor [KO:K05132]
108244190  interleukin-1 receptor type 1 isoform X1 [KO:K04386]
108249357  interleukin-1 receptor-like 1 isoform X1 [KO:K04386]
108229411  interleukin-1 receptor accessory protein [KO:K04723]
108244193  interleukin-1 receptor type 2 [KO:K04387]
108244195  interleukin-1 receptor-like 2 [KO:K05172]
108249363  interleukin-18 receptor accessory protein isoform X2 [KO:K05174]
108244180  il1rl1; interleukin-1 receptor-like 1 isoform X1 [KO:K05171]
108229489  interleukin-17 receptor A [KO:K05164]
112450189  interleukin-17 receptor A [KO:K05164]
108247396  il17rc; interleukin-17 receptor C [KO:K05166]
108231950  wu:fl23c11; uncharacterized protein wu:fl23c11 [KO:K05166]
108236763  uncharacterized protein LOC108236763 [KO:K05165]
108231913  uncharacterized protein LOC108231913 isoform X1 [KO:K05168]
108235418  cd4-1; CD4-1 molecule [KO:K06454]
108228290  macrophage colony-stimulating factor 1 receptor 2 [KO:K05090] [EC:2.7.10.1]
108240545  csf1ra; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
108235424  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
108236809  si:ch211-112c15.8; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
108231575  tnfrsf1b; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
108250565  tumor necrosis factor receptor superfamily member 14-like isoform X5 [KO:K05152]
108250566  tumor necrosis factor receptor superfamily member 14-like isoform X1 [KO:K05152]
108250568  tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152]
108229707  tumor necrosis factor receptor superfamily member 14-like isoform X1 [KO:K05152]
108232265  tumor necrosis factor receptor superfamily member 6B [KO:K05143]
108246354  tumor necrosis factor receptor superfamily member 6B [KO:K05143]
108246375  tumor necrosis factor receptor superfamily member 6B-like [KO:K05143]
108243471  fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
108247039  tumor necrosis factor receptor superfamily member 10A isoform X1 [KO:K04722]
108242614  tnfrsfa; tumor necrosis factor receptor superfamily, member a [KO:K04722]
108249899  tnfrsf21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
108240377  edar; tumor necrosis factor receptor superfamily member EDAR [KO:K05162]
108249417  ngfrb; nerve growth factor receptor b [KO:K02583]
108237797  ngfra; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
108241915  nradd; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
108232256  tumor necrosis factor receptor superfamily member 11B [KO:K05148]
108243135  tnfrsf11a; tumor necrosis factor receptor superfamily member 11A isoform X1 [KO:K05147]
108237065  tumor necrosis factor receptor superfamily member 12A [KO:K05149]
108235449  cd27; CD27 antigen [KO:K05144]
108237606  cd40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
108231249  tumor necrosis factor receptor superfamily member 5-like isoform X1 [KO:K03160]
108232104  tnfrsf9a; tumor necrosis factor receptor superfamily member 9a [KO:K05146]
108235858  tumor necrosis factor receptor superfamily member 13B [KO:K05150]
112450532  uncharacterized protein LOC112450532 [KO:K05151]
108231242  tumor necrosis factor receptor superfamily member 27 isoform X1 [KO:K05155]
108238196  tnfrsf19; tumor necrosis factor receptor superfamily member 19 isoform X1 [KO:K05155]
108244619  relt; tumor necrosis factor receptor superfamily member 19L isoform X2 [KO:K05156]
108240042  rell2; RELT-like protein 2 [KO:K26541]
108241787  rell1; RELT-like protein 1 [KO:K26541]
108248259  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
108237979  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
108247742  tgfbr2b; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
108247801  tgfbr2l; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
108235299  acvrl1; serine/threonine-protein kinase receptor R3 [KO:K13594] [EC:2.7.11.30]
108245115  activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
108250825  acvr2aa; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
108242164  bone morphogenetic protein receptor type-2 isoform X1 [KO:K04671] [EC:2.7.11.30]
108247756  bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
108232890  activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
108228932  activin receptor type-2B-like [KO:K13596] [EC:2.7.11.30]
108235245  acvr1ba; activin A receptor type 1Ba [KO:K13567] [EC:2.7.11.30]
108240717  activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
108235705  acvr1l; activin receptor type-1 isoform X1 [KO:K04675] [EC:2.7.11.30]
108240788  activin receptor type-1 isoform X2 [KO:K04675] [EC:2.7.11.30]
108247406  bone morphogenetic protein receptor type-1A isoform X1 [KO:K04673] [EC:2.7.11.30]
108234542  bmpr1ba; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
108247544  bmpr1bb; bone morphogenetic protein receptor, type IBb [KO:K13578] [EC:2.7.11.30]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   
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