KEGG   PATHWAY: lve05225
Entry
lve05225                    Pathway                                
Name
Hepatocellular carcinoma - Lipotes vexillifer (Yangtze River dolphin)
Description
Hepatocellular carcinoma (HCC) is a major type of primary liver cancer and one of the rare human neoplasms etiologically linked to viral factors. It has been shown that, after HBV/HCV infection and alcohol or aflatoxin B1 exposure, genetic and epigenetic changes occur. The recurrent mutated genes were found to be highly enriched in multiple key driver signaling processes, including telomere maintenance, TP53, cell cycle regulation, the Wnt/beta-catenin pathway (CTNNB1 and AXIN1), the phosphatidylinositol-3 kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway. Recent studies using whole-exome sequencing have revealed recurrent mutations in new driver genes involved in the chromatin remodelling (ARID1A and ARID2) and the oxidative stress (NFE2L2) pathways.
Class
Human Diseases; Cancer: specific types
Pathway map
lve05225  Hepatocellular carcinoma
lve05225

Organism
Lipotes vexillifer (Yangtze River dolphin) [GN:lve]
Gene
103076982  TGFA; protransforming growth factor alpha [KO:K08774]
103071962  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
103084737  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
103081291  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
103068930  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
103070997  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
103073028  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
103090549  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
103086653  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
103091628  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
103074885  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
103088833  SHC2; SHC-transforming protein 2 [KO:K17447]
103078122  SHC3; SHC-transforming protein 3 [KO:K17448]
103088900  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
103079766  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
103079242  SOS1; son of sevenless homolog 1 [KO:K03099]
103081084  SOS2; son of sevenless homolog 2-like [KO:K03099]
103076043  HRAS; GTPase HRas isoform X1 [KO:K02833]
103077579  KRAS; GTPase KRas [KO:K07827]
103068734  NRAS; GTPase NRas [KO:K07828]
103090018  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
103079256  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
103087933  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103082805  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
103090769  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103070260  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
103075543  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103089257  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
103088756  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
103085303  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103070370  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103078725  PIK3R3; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103083960  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103074298  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
103084975  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103076365  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103068921  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103083889  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
103090358  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
103073645  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
103083608  BAD; bcl2 antagonist of cell death [KO:K02158]
103080887  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
103089962  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
103072166  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
103070408  E2F1; transcription factor E2F1 [KO:K17454]
103081780  E2F2; transcription factor E2F2 [KO:K09389]
103085882  E2F3; transcription factor E2F3 [KO:K06620]
103088173  TERT; LOW QUALITY PROTEIN: telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
103089875  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
103080733  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
103080866  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
103089793  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
103079241  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
103084066  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
103069848  putative Bcl-2 homologous antagonist/killer 2-like [KO:K14021]
103079116  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
103080788  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
103072667  CDKN2A; cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3 [KO:K06621]
103084826  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
103081338  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
103090612  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
103075846  TGFB1; transforming growth factor beta-1 isoform X1 [KO:K13375]
103070826  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
103086562  TGFB3; transforming growth factor beta-3 [KO:K13377]
103071954  TGFBR1; LOW QUALITY PROTEIN: TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
103077265  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
103069124  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
103085090  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
103084261  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
103078640  WNT1; proto-oncogene Wnt-1 [KO:K03209]
103089709  WNT2B; protein Wnt-2b [KO:K00182]
103089326  WNT2; protein Wnt-2 [KO:K00182]
103087738  WNT3A; protein Wnt-3a [KO:K00312]
103081536  WNT3; proto-oncogene Wnt-3 [KO:K00312]
103087836  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
103070287  WNT5A; protein Wnt-5a-like isoform X1 [KO:K00444]
103086235  WNT5B; protein Wnt-5b [KO:K00444]
103079243  WNT6; protein Wnt-6 [KO:K00445]
103083305  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
103068582  WNT7A; protein Wnt-7a [KO:K00572]
103086715  WNT8B; protein Wnt-8b [KO:K00714]
103091305  WNT8A; protein Wnt-8a [KO:K00714]
103087468  WNT9A; protein Wnt-9a [KO:K01064]
103081263  WNT9B; protein Wnt-9b [KO:K01064]
103078970  WNT10A; protein Wnt-10a [KO:K01357]
103078356  WNT10B; protein Wnt-10b [KO:K01357]
103091035  WNT11; protein Wnt-11 [KO:K01384]
103085163  WNT16; protein Wnt-16 [KO:K01558]
103091081  FZD7; frizzled-7 [KO:K02432]
103086341  FZD1; frizzled-1 [KO:K02432]
103076632  frizzled-2-like [KO:K02235]
103079251  FZD3; frizzled-3 [KO:K02329]
103086596  FZD4; frizzled-4 [KO:K02354]
103088051  FZD8; LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
103087849  FZD5; frizzled-5 [KO:K02375]
103074920  FZD6; frizzled-6 isoform X1 [KO:K02376]
103081501  FZD10; LOW QUALITY PROTEIN: frizzled class receptor 10 [KO:K02842]
103080648  FZD9; frizzled-9 [KO:K02842]
103090555  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
103073192  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
103082466  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
103078766  DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
103086975  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
103084685  FRAT1; proto-oncogene FRAT1 [KO:K03069]
103072485  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
103074757  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
103085333  AXIN1; axin-1 [KO:K02157]
103072027  AXIN2; axin-2 [KO:K04385]
103084983  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
103083467  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
103078301  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
103073450  CSNK1A1; casein kinase I isoform alpha isoform X1 [KO:K08957] [EC:2.7.11.1]
103074150  TCF7; transcription factor 7 [KO:K02620]
103069353  TCF7L1; transcription factor 7-like 1 [KO:K04490]
103068781  TCF7L2; transcription factor 7-like 2 [KO:K04491]
103068879  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
103083057  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
103071090  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
103077914  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
103077151  NQO1; LOW QUALITY PROTEIN: NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
103076713  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
103081051  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
103078333  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
103078618  GSTM1; LOW QUALITY PROTEIN: glutathione S-transferase mu 1 [KO:K00799] [EC:2.5.1.18]
103081925  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
103082472  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
103087449  GSTO1; glutathione S-transferase omega-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
103087887  GSTO2; glutathione S-transferase omega-2 isoform X1 [KO:K00799] [EC:2.5.1.18]
103085403  GSTA2; glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
103085685  GSTA4; glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
103071326  MGST2; LOW QUALITY PROTEIN: microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
103082194  glutathione S-transferase theta-4-like [KO:K00799] [EC:2.5.1.18]
103070610  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
103079831  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
103091064  thioredoxin reductase 1, cytoplasmic-like isoform X1 [KO:K22182] [EC:1.8.1.9]
103069409  TXNRD3; thioredoxin reductase 3 [KO:K22182] [EC:1.8.1.9]
103080865  TXNRD2; thioredoxin reductase 2, mitochondrial [KO:K22182] [EC:1.8.1.9]
103079072  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
103090984  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
103085000  GAB1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
103086383  ACTG1; actin, cytoplasmic 2 [KO:K05692]
103077223  ACTB; actin, cytoplasmic 1 [KO:K05692]
103083367  ACTL6A; actin-like protein 6A isoform X1 [KO:K11340]
103072358  ACTL6B; actin-like protein 6B [KO:K11652]
103077190  SMARCD2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 [KO:K11650]
103088170  SMARCD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 isoform X1 [KO:K11650]
103081289  SMARCD3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 isoform X1 [KO:K11650]
103081801  PHF10; PHD finger protein 10 isoform X1 [KO:K22197]
103089246  DPF1; zinc finger protein neuro-d4 isoform X1 [KO:K22198]
103090302  DPF3; zinc finger protein DPF3 [KO:K22198]
103090931  ARID1A; AT-rich interactive domain-containing protein 1A [KO:K11653]
103085772  ARID1B; AT-rich interactive domain-containing protein 1B [KO:K11653]
103084730  SMARCE1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 isoform X1 [KO:K11651]
103072102  SMARCB1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 isoform X1 [KO:K11648]
103084073  SMARCC1; SWI/SNF complex subunit SMARCC1 [KO:K11649]
103085379  SMARCC2; SWI/SNF complex subunit SMARCC2 [KO:K11649]
103080451  SMARCA2; probable global transcription activator SNF2L2-like isoform X1 [KO:K11647] [EC:5.6.2.-]
103086661  SMARCA4; transcription activator BRG1 [KO:K11647] [EC:5.6.2.-]
103077019  ARID2; AT-rich interactive domain-containing protein 2 [KO:K11765]
103089517  PBRM1; LOW QUALITY PROTEIN: protein polybromo-1 [KO:K11757]
103078195  BRD7; bromodomain-containing protein 7 isoform X1 [KO:K11723]
Compound
C00027  Hydrogen peroxide
C00039  DNA
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01471  Acrolein
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06793  Vinyl chloride
C06800  Aflatoxin B1
C16844  Hydroxyl radical
C21641  Hydroperoxyl radical
C21642  4-Hydroxynonenal
Reference
PMID:20639898
  Authors
Whittaker S, Marais R, Zhu AX
  Title
The role of signaling pathways in the development and treatment of hepatocellular carcinoma.
  Journal
Oncogene 29:4989-5005 (2010)
DOI:10.1038/onc.2010.236
Reference
PMID:26099527
  Authors
Zucman-Rossi J, Villanueva A, Nault JC, Llovet JM
  Title
Genetic Landscape and Biomarkers of Hepatocellular Carcinoma.
  Journal
Gastroenterology 149:1226-1239.e4 (2015)
DOI:10.1053/j.gastro.2015.05.061
Reference
PMID:17295177
  Authors
Villanueva A, Newell P, Chiang DY, Friedman SL, Llovet JM.
  Title
Genomics and signaling pathways in hepatocellular carcinoma.
  Journal
Semin Liver Dis 27:55-76 (2007)
DOI:10.1055/s-2006-960171
Reference
PMID:16799620
  Authors
Breuhahn K, Longerich T, Schirmacher P
  Title
Dysregulation of growth factor signaling in human hepatocellular carcinoma.
  Journal
Oncogene 25:3787-800 (2006)
DOI:10.1038/sj.onc.1209556
Reference
PMID:19387255
  Authors
Minguez B, Tovar V, Chiang D, Villanueva A, Llovet JM
  Title
Pathogenesis of hepatocellular carcinoma and molecular therapies.
  Journal
Curr Opin Gastroenterol 25:186-94 (2009)
DOI:10.1097/MOG.0b013e32832962a1
Reference
PMID:21829020
  Authors
Kudo M
  Title
Signaling pathway and molecular-targeted therapy for hepatocellular carcinoma.
  Journal
Dig Dis 29:289-302 (2011)
DOI:10.1159/000327562
Reference
PMID:23994386
  Authors
Nault JC, Zucman-Rossi J
  Title
Genetics of hepatocellular carcinoma: the next generation.
  Journal
J Hepatol 60:224-6 (2014)
DOI:10.1016/j.jhep.2013.08.019
Reference
PMID:11935086
  Authors
Rocken C, Carl-McGrath S.
  Title
Pathology and pathogenesis of hepatocellular carcinoma.
  Journal
Dig Dis 19:269-78 (2001)
DOI:10.1159/000050693
Reference
PMID:21303380
  Authors
Cornella H, Alsinet C, Villanueva A
  Title
Molecular pathogenesis of hepatocellular carcinoma.
  Journal
Alcohol Clin Exp Res 35:821-5 (2011)
DOI:10.1111/j.1530-0277.2010.01406.x
Reference
PMID:27895396
  Authors
Niu ZS, Niu XJ, Wang WH
  Title
Genetic alterations in hepatocellular carcinoma: An update.
  Journal
World J Gastroenterol 22:9069-9095 (2016)
DOI:10.3748/wjg.v22.i41.9069
Reference
PMID:11956813
  Authors
Tannapfel A, Wittekind C
  Title
Genes involved in hepatocellular carcinoma: deregulation in cell cycling and apoptosis.
  Journal
Virchows Arch 440:345-52 (2002)
DOI:10.1007/s00428-002-0617-x
Reference
PMID:23426905
  Authors
Shiraha H, Yamamoto K, Namba M
  Title
Human hepatocyte carcinogenesis (review).
  Journal
Int J Oncol 42:1133-8 (2013)
DOI:10.3892/ijo.2013.1829
Reference
PMID:23887712
  Authors
Nault JC, Mallet M, Pilati C, Calderaro J, Bioulac-Sage P, Laurent C, Laurent A, Cherqui D, Balabaud C, Zucman-Rossi J
  Title
High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions.
  Journal
Nat Commun 4:2218 (2013)
DOI:10.1038/ncomms3218
Reference
PMID:22561517
  Authors
Guichard C, Amaddeo G, Imbeaud S, Ladeiro Y, Pelletier L, Maad IB, Calderaro J, Bioulac-Sage P, Letexier M, Degos F, Clement B, Balabaud C, Chevet E, Laurent A, Couchy G, Letouze E, Calvo F, Zucman-Rossi J
  Title
Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma.
  Journal
Nat Genet 44:694-8 (2012)
DOI:10.1038/ng.2256
Reference
  Authors
Praslicka BJ, Kerins MJ, Ooi A
  Title
The complex role of NRF2 in cancer: a genomic view
  Journal
Curr Opin Toxicol 1:37-45 (2016)
DOI:10.1016/j.cotox.2016.09.003
Reference
PMID:24024136
  Authors
Kansanen E, Kuosmanen SM, Leinonen H, Levonen AL
  Title
The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer.
  Journal
Redox Biol 1:45-9 (2013)
DOI:10.1016/j.redox.2012.10.001
Reference
PMID:21251164
  Authors
Taguchi K, Motohashi H, Yamamoto M
  Title
Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution.
  Journal
Genes Cells 16:123-40 (2011)
DOI:10.1111/j.1365-2443.2010.01473.x
Reference
PMID:20019356
  Authors
Klaunig JE, Kamendulis LM, Hocevar BA
  Title
Oxidative stress and oxidative damage in carcinogenesis.
  Journal
Toxicol Pathol 38:96-109 (2010)
DOI:10.1177/0192623309356453
Reference
PMID:11193292
  Authors
Krupp G, Bonatz G, Parwaresch R
  Title
Telomerase, immortality and cancer.
  Journal
Biotechnol Annu Rev 6:103-40 (2000)
DOI:10.1016/S1387-2656(00)06020-8
Reference
PMID:27323951
  Authors
Jafri MA, Ansari SA, Alqahtani MH, Shay JW
  Title
Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies.
  Journal
Genome Med 8:69 (2016)
DOI:10.1186/s13073-016-0324-x
Reference
PMID:27029895
  Authors
Shay JW
  Title
Role of Telomeres and Telomerase in Aging and Cancer.
  Journal
Cancer Discov 6:584-93 (2016)
DOI:10.1158/2159-8290.CD-16-0062
Reference
PMID:27508192
  Authors
Granito A, Guidetti E, Gramantieri L
  Title
c-MET receptor tyrosine kinase as a molecular target in advanced hepatocellular carcinoma.
  Journal
J Hepatocell Carcinoma 2:29-38 (2015)
DOI:10.2147/JHC.S77038
Reference
PMID:16934487
  Authors
Vita M, Henriksson M
  Title
The Myc oncoprotein as a therapeutic target for human cancer.
  Journal
Semin Cancer Biol 16:318-30 (2006)
DOI:10.1016/j.semcancer.2006.07.015
Reference
PMID:24096051
  Authors
Qu A, Jiang C, Cai Y, Kim JH, Tanaka N, Ward JM, Shah YM, Gonzalez FJ
  Title
Role of Myc in hepatocellular proliferation and hepatocarcinogenesis.
  Journal
J Hepatol 60:331-8 (2014)
DOI:10.1016/j.jhep.2013.09.024
Related
pathway
lve04010  MAPK signaling pathway
lve04020  Calcium signaling pathway
lve04110  Cell cycle
lve04115  p53 signaling pathway
lve04151  PI3K-Akt signaling pathway
lve04310  Wnt signaling pathway
lve04350  TGF-beta signaling pathway
lve04932  Non-alcoholic fatty liver disease
lve04936  Alcoholic liver disease
lve05160  Hepatitis C
lve05161  Hepatitis B
KO pathway
ko05225   
LinkDB

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