KEGG   PATHWAY: lve04936
Entry
lve04936                    Pathway                                
Name
Alcoholic liver disease - Lipotes vexillifer (Yangtze River dolphin)
Description
Alcoholic liver disease (ALD) refers to the damages to the liver and its functions due to alcohol overconsumption. It ranges from simple steatosis to steatohepatitis, cirrhosis, and even hepatocellular carcinoma. Alcohol consumption promotes liver inflammation by increasing the translocation of gut-derived endotoxins to the portal circulation and activating Kupffer cells to produce TNF-alpha through the LPS/Toll like receptor (TLR) 4 pathways. TNF-alpha induces hepatocellular damage. When alcohol intake is chronic and heavy, steatosis is caused via generation of acetaldehyde, reactive oxygen species (ROS) and ER stress. ROS inhibits key hepatic transcriptional regulators such as AMP-activated kinase (AMPK) and peroxisome proliferator-activated receptor alpha (PPAR-alpha), which are responsible for fatty acid oxidation and export via ACC and CPT-1. The blockade of AMPK also leads to overexpression of SREBP-1, resulting in an increase of de novo lipogenesis. Moreover, excessive intracellular ROS production induced by ethanol and its metabolite have a critical role in ethanol-induced apoptosis, which may be the critical process in the exacerbation of ALD. It is inferred that the apoptotic signal derived from ROS that was produced by NOX, is mainly transduced through the JNK and p38 MAPK pathways.
Class
Human Diseases; Endocrine and metabolic disease
Pathway map
lve04936  Alcoholic liver disease
lve04936

Disease
H02516  Alcoholic liver disease
Organism
Lipotes vexillifer (Yangtze River dolphin) [GN:lve]
Gene
103068485  LBP; lipopolysaccharide-binding protein [KO:K05399]
103068617  [KO:K05414]
103068644  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
103068754  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
103068781  TCF7L2; transcription factor 7-like 2 [KO:K04491]
103068879  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
103068921  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103068972  MLYCD; malonyl-CoA decarboxylase, mitochondrial [KO:K01578] [EC:4.1.1.9]
103069029  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
103069181  [KO:K05414]
103069202  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
103069353  TCF7L1; transcription factor 7-like 1 [KO:K04490]
103069680  LPIN3; phosphatidate phosphatase LPIN3 [KO:K15728] [EC:3.1.3.4]
103069739  [KO:K05414]
103069819  LY96; lymphocyte antigen 96 [KO:K05400]
103070063  FABP1; fatty acid-binding protein, liver [KO:K08750]
103070103  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
103070943  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
103071176  TRA2B; transformer-2 protein homolog beta [KO:K12897]
103071404  [KO:K05505]
103071578  C2; complement C2 isoform X1 [KO:K01332] [EC:3.4.21.43]
103071675  [KO:K05505]
103071798  SREBF1; sterol regulatory element-binding protein 1 isoform X1 [KO:K07197]
103071959  [KO:K05505]
103072325  ADH4; LOW QUALITY PROTEIN: alcohol dehydrogenase 4 (class II), pi polypeptide [KO:K13980] [EC:1.1.1.1]
103072461  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
103072605  ADH7; LOW QUALITY PROTEIN: alcohol dehydrogenase class 4 mu/sigma chain [KO:K13951] [EC:1.1.1.1]
103073041  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
103073066  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
103073152  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform [KO:K19524] [EC:2.3.1.21]
103073219  [KO:K05414]
103073403  ADIPOR1; adiponectin receptor protein 1 [KO:K07297]
103073461  PPARGC1A; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
103073664  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
103073772  [KO:K05415]
103073819  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
103074150  TCF7; transcription factor 7 [KO:K02620]
103074326  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
103074334  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
103074413  ALDH1B1; LOW QUALITY PROTEIN: aldehyde dehydrogenase X, mitochondrial [KO:K00128] [EC:1.2.1.3]
103074495  ACOX1; LOW QUALITY PROTEIN: peroxisomal acyl-coenzyme A oxidase 1 [KO:K00232] [EC:1.3.3.6]
103074659  TLR4; toll-like receptor 4 [KO:K10160]
103074757  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
103074848  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
103074882  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
103075340  MAP3K7; mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]
103075877  [KO:K00128] [EC:1.2.1.3]
103076365  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103076883  IL17RA; interleukin-17 receptor A [KO:K05164]
103077054  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
103077095  ACADVL; very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1 [KO:K09479] [EC:1.3.8.9]
103077530  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103077747  FASN; fatty acid synthase [KO:K00665] [EC:2.3.1.85]
103077793  IL17RC; interleukin-17 receptor C isoform X1 [KO:K05166]
103078049  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
103078296  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
103078301  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
103078347  ADIPOQ; adiponectin [KO:K07296]
103078399  CD14; monocyte differentiation antigen CD14 [KO:K04391]
103078419  ACADM; medium-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00249] [EC:1.3.8.7]
103078710  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103078792  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
103079195  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
103079299  IL12A; LOW QUALITY PROTEIN: interleukin-12 subunit alpha [KO:K05406]
103079471  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
103079524  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200]
103079861  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
103079935  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
103080104  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
103080304  SIRT1; LOW QUALITY PROTEIN: NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
103080339  FADD; FAS-associated death domain protein [KO:K02373]
103080404  ALDH9A1; 4-trimethylaminobutyraldehyde dehydrogenase isoform X1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
103080704  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
103080924  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
103081469  C3AR1; C3a anaphylatoxin chemotactic receptor [KO:K04009]
103081545  IL6; LOW QUALITY PROTEIN: interleukin-6 [KO:K05405]
103081641  [KO:K04433] [EC:2.7.12.2]
103081814  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
103082490  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
103083032  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
103083150  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
103083209  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103083231  TNF; tumor necrosis factor [KO:K03156]
103083295  IL17A; interleukin-17A [KO:K05489]
103083613  ALDH3A2; fatty aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
103083690  C3; complement C3 [KO:K03990]
103083704  IL12B; interleukin-12 subunit beta [KO:K05425]
103083892  [KO:K05489]
103084128  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
103084326  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793]
103084467  FOXO3; forkhead box protein O3 [KO:K09408]
103084510  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
103084630  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
103084745  TRA2A; transformer-2 protein homolog alpha isoform X1 [KO:K12897]
103084975  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103085220  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103085288  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
103085597  C5; LOW QUALITY PROTEIN: complement C5 [KO:K03994]
103086219  IL8; interleukin-8 [KO:K10030]
103086274  C1QB; complement C1q subcomponent subunit B [KO:K03987]
103086439  SCD; acyl-CoA desaturase [KO:K00507] [EC:1.14.19.1]
103086559  C1QC; complement C1q subcomponent subunit C [KO:K03988]
103086718  [KO:K07415] [EC:1.14.14.-]
103086786  ADIPOR2; adiponectin receptor protein 2 [KO:K07297]
103086829  C1QA; complement C1q subcomponent subunit A [KO:K03986]
103086905  FOXO1; forkhead box protein O1 [KO:K07201]
103087111  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase isoform X1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
103087112  ADH5; alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
103087304  RELA; transcription factor p65 isoform X1 [KO:K04735]
103087645  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
103087664  [KO:K13951] [EC:1.1.1.1]
103087676  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
103087928  C4A; complement C4-A [KO:K03989]
103088062  SCD5; stearoyl-CoA desaturase 5 [KO:K00507] [EC:1.14.19.1]
103088205  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
103088633  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103088737  C5AR1; C5a anaphylatoxin chemotactic receptor 1 [KO:K04010]
103088795  [KO:K03175] [EC:2.3.2.27]
103089470  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
103089784  ACOX3; LOW QUALITY PROTEIN: peroxisomal acyl-coenzyme A oxidase 3 [KO:K00232] [EC:1.3.3.6]
103089998  ACACB; acetyl-CoA carboxylase 2 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
103090099  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
103090612  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
103090661  [KO:K05414]
103090784  IL1B; interleukin-1 beta [KO:K04519]
103091039  ALDH16A1; aldehyde dehydrogenase family 16 member A1 isoform X1 [KO:K00128] [EC:1.2.1.3]
103091202  [KO:K05414]
103091203  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
103091411  ACACA; acetyl-CoA carboxylase 1 isoform X1 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
103091499  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
103091611  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
Compound
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00033  Acetate
C00040  Acyl-CoA
C00076  Calcium cation
C00083  Malonyl-CoA
C00084  Acetaldehyde
C00469  Ethanol
C22381  Reactive oxygen species
Reference
PMID:25782093
  Authors
Louvet A, Mathurin P
  Title
Alcoholic liver disease: mechanisms of injury and targeted treatment.
  Journal
Nat Rev Gastroenterol Hepatol 12:231-42 (2015)
DOI:10.1038/nrgastro.2015.35
Reference
PMID:21920463
  Authors
Gao B, Bataller R
  Title
Alcoholic liver disease: pathogenesis and new therapeutic targets.
  Journal
Gastroenterology 141:1572-85 (2011)
DOI:10.1053/j.gastro.2011.09.002
Reference
PMID:28134813
  Authors
Magdaleno F, Blajszczak CC, Nieto N
  Title
Key Events Participating in the Pathogenesis of Alcoholic Liver Disease.
  Journal
Biomolecules 7:9 (2017)
DOI:10.3390/biom7010009
Reference
PMID:19553649
  Authors
Lucey MR, Mathurin P, Morgan TR
  Title
Alcoholic hepatitis.
  Journal
N Engl J Med 360:2758-69 (2009)
DOI:10.1056/NEJMra0805786
Reference
PMID:26919968
  Authors
Nagy LE, Ding WX, Cresci G, Saikia P, Shah VH
  Title
Linking Pathogenic Mechanisms of Alcoholic Liver Disease With Clinical Phenotypes.
  Journal
Gastroenterology 150:1756-68 (2016)
DOI:10.1053/j.gastro.2016.02.035
Reference
PMID:25009376
  Authors
Fujii H, Kawada N
  Title
Fibrogenesis in alcoholic liver disease.
  Journal
World J Gastroenterol 20:8048-54 (2014)
DOI:10.3748/wjg.v20.i25.8048
Reference
PMID:26755857
  Authors
Kim MS, Ong M, Qu X
  Title
Optimal management for alcoholic liver disease: Conventional medications, natural therapy or combination?
  Journal
World J Gastroenterol 22:8-23 (2016)
DOI:10.3748/wjg.v22.i1.8
Reference
PMID:15194557
  Authors
You M, Crabb DW
  Title
Recent advances in alcoholic liver disease II. Minireview: molecular mechanisms of alcoholic fatty liver.
  Journal
Am J Physiol Gastrointest Liver Physiol 287:G1-6 (2004)
DOI:10.1152/ajpgi.00056.2004
Reference
PMID:26695748
  Authors
Nagy LE
  Title
The Role of Innate Immunity in Alcoholic Liver Disease.
  Journal
Alcohol Res 37:237-50 (2015)
Reference
PMID:21252049
  Authors
Gao B, Seki E, Brenner DA, Friedman S, Cohen JI, Nagy L, Szabo G, Zakhari S
  Title
Innate immunity in alcoholic liver disease.
  Journal
Am J Physiol Gastrointest Liver Physiol 300:G516-25 (2011)
DOI:10.1152/ajpgi.00537.2010
Reference
PMID:22524187
  Authors
Wang HJ, Gao B, Zakhari S, Nagy LE
  Title
Inflammation in alcoholic liver disease.
  Journal
Annu Rev Nutr 32:343-68 (2012)
DOI:10.1146/annurev-nutr-072610-145138
Reference
PMID:29597356
  Authors
McCullough RL, McMullen MR, Sheehan MM, Poulsen KL, Roychowdhury S, Chiang DJ, Pritchard MT, Caballeria J, Nagy LE
  Title
Complement Factor D protects mice from ethanol-induced inflammation and liver injury.
  Journal
Am J Physiol Gastrointest Liver Physiol 315:G66-G79 (2018)
DOI:10.1152/ajpgi.00334.2017
Reference
PMID:24385684
  Authors
Kawaratani H, Tsujimoto T, Douhara A, Takaya H, Moriya K, Namisaki T, Noguchi R, Yoshiji H, Fujimoto M, Fukui H
  Title
The effect of inflammatory cytokines in alcoholic liver disease.
  Journal
Mediators Inflamm 2013:495156 (2013)
DOI:10.1155/2013/495156
Reference
PMID:20238398
  Authors
Szabo G, Bala S
  Title
Alcoholic liver disease and the gut-liver axis.
  Journal
World J Gastroenterol 16:1321-9 (2010)
DOI:10.3748/wjg.v16.i11.1321
Reference
PMID:28627645
  Authors
Kawaratani H, Moriya K, Namisaki T, Uejima M, Kitade M, Takeda K, Okura Y, Kaji K, Takaya H, Nishimura N, Sato S, Sawada Y, Seki K, Kubo T, Mitoro A, Yamao J, Yoshiji H
  Title
Therapeutic strategies for alcoholic liver disease: Focusing on inflammation and fibrosis (Review).
  Journal
Int J Mol Med 40:263-270 (2017)
DOI:10.3892/ijmm.2017.3015
Reference
PMID:23855294
  Authors
Roh YS, Seki E
  Title
Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis.
  Journal
J Gastroenterol Hepatol 28 Suppl 1:38-42 (2013)
DOI:10.1111/jgh.12019
Reference
PMID:18709650
  Authors
Rogers CQ, Ajmo JM, You M
  Title
Adiponectin and alcoholic fatty liver disease.
  Journal
IUBMB Life 60:790-7 (2008)
DOI:10.1002/iub.124
Reference
PMID:26278388
  Authors
You M, Jogasuria A, Lee K, Wu J, Zhang Y, Lee YK, Sadana P
  Title
Signal Transduction Mechanisms of Alcoholic Fatty Liver Disease: Emer ging Role of Lipin-1.
  Journal
Curr Mol Pharmacol 10:226-236 (2017)
DOI:10.2174/1874467208666150817112109
Reference
PMID:26005675
  Authors
You M, Jogasuria A, Taylor C, Wu J
  Title
Sirtuin 1 signaling and alcoholic fatty liver disease.
  Journal
Hepatobiliary Surg Nutr 4:88-100 (2015)
DOI:10.3978/j.issn.2304-3881.2014.12.06
Reference
PMID:33162823
  Authors
Ren R, Wang Z, Wu M, Wang H
  Title
Emerging Roles of SIRT1 in Alcoholic Liver Disease.
  Journal
Int J Biol Sci 16:3174-3183 (2020)
DOI:10.7150/ijbs.49535
Reference
PMID:19032584
  Authors
Purohit V, Gao B, Song BJ
  Title
Molecular mechanisms of alcoholic fatty liver.
  Journal
Alcohol Clin Exp Res 33:191-205 (2009)
DOI:10.1111/j.1530-0277.2008.00827.x
Reference
PMID:34071962
  Authors
Hyun J, Han J, Lee C, Yoon M, Jung Y
  Title
Pathophysiological Aspects of Alcohol Metabolism in the Liver.
  Journal
Int J Mol Sci 22:5717 (2021)
DOI:10.3390/ijms22115717
Reference
PMID:24297186
  Authors
Combs TP, Marliss EB
  Title
Adiponectin signaling in the liver.
  Journal
Rev Endocr Metab Disord 15:137-47 (2014)
DOI:10.1007/s11154-013-9280-6
Reference
PMID:25548474
  Authors
Ceni E, Mello T, Galli A
  Title
Pathogenesis of alcoholic liver disease: role of oxidative metabolism.
  Journal
World J Gastroenterol 20:17756-72 (2014)
DOI:10.3748/wjg.v20.i47.17756
Reference
PMID:31159489
  Authors
Kong LZ, Chandimali N, Han YH, Lee DH, Kim JS, Kim SU, Kim TD, Jeong DK, Sun HN, Lee DS, Kwon T
  Title
Pathogenesis, Early Diagnosis, and Therapeutic Management of Alcoholic Liver Disease.
  Journal
Int J Mol Sci 20:E2712 (2019)
DOI:10.3390/ijms20112712
Reference
PMID:31214376
  Authors
Ohashi K, Pimienta M, Seki E
  Title
Alcoholic liver disease: A current molecular and clinical perspective.
  Journal
Liver Res 2:161-172 (2018)
DOI:10.1016/j.livres.2018.11.002
Reference
PMID:30658725
  Authors
You M, Arteel GE
  Title
Effect of ethanol on lipid metabolism.
  Journal
J Hepatol 70:237-248 (2019)
DOI:10.1016/j.jhep.2018.10.037
Reference
PMID:25595739
  Authors
Bi L, Jiang Z, Zhou J
  Title
The role of lipin-1 in the pathogenesis of alcoholic fatty liver.
  Journal
Alcohol Alcohol 50:146-51 (2015)
DOI:10.1093/alcalc/agu102
Reference
PMID:31263795
  Authors
Ali H, Assiri MA, Shearn CT, Fritz KS
  Title
Lipid peroxidation derived reactive aldehydes in alcoholic liver disease.
  Journal
Curr Opin Toxicol 13:110-117 (2019)
DOI:10.1016/j.cotox.2018.10.003
Reference
PMID:24262277
  Authors
Yin H, Hu M, Liang X, Ajmo JM, Li X, Bataller R, Odena G, Stevens SM Jr, You M
  Title
Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver.
  Journal
Gastroenterology 146:801-11 (2014)
DOI:10.1053/j.gastro.2013.11.008
Reference
PMID:22110053
  Authors
Stickel F, Hampe J
  Title
Genetic determinants of alcoholic liver disease.
  Journal
Gut 61:150-9 (2012)
DOI:10.1136/gutjnl-2011-301239
Reference
PMID:29336467
  Authors
Yang CF, Zhong YJ, Ma Z, Li L, Shi L, Chen L, Li C, Wu D, Chen Q, Li YW
  Title
NOX4/ROS mediate ethanolinduced apoptosis via MAPK signal pathway in L02 cells.
  Journal
Int J Mol Med 41:2306-2316 (2018)
DOI:10.3892/ijmm.2018.3390
Related
pathway
lve00061  Fatty acid biosynthesis
lve00071  Fatty acid degradation
lve01040  Biosynthesis of unsaturated fatty acids
lve03040  Spliceosome
lve04010  MAPK signaling pathway
lve04064  NF-kappa B signaling pathway
lve04152  AMPK signaling pathway
lve04210  Apoptosis
lve04310  Wnt signaling pathway
lve04610  Complement and coagulation cascades
lve04620  Toll-like receptor signaling pathway
lve04657  IL-17 signaling pathway
lve04668  TNF signaling pathway
lve04920  Adipocytokine signaling pathway
lve05034  Alcoholism
lve05225  Hepatocellular carcinoma
KO pathway
ko04936   

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