KEGG   PATHWAY: mcf04714
Entry
mcf04714                    Pathway                                
Name
Thermogenesis - Macaca fascicularis (crab-eating macaque)
Description
Thermogenesis is essential for warm-blooded animals, ensuring normal cellular and physiological function under conditions of environmental challenge. Thermogenesis in brown and beige adipose tissue is mainly controlled by norepinephrine, which is released from sympathetic nervous system in response to cold or dietary stimuli. The mitochondrial uncoupling protein 1 (UCP1) is responsible for the process whereby chemical energy is converted into heat in these adipocytes. Activation of these adipocytes leads to an increase in calorie consumption and is expected to improve overweight conditions, providing a potential strategy for treating obesity and its related metabolic disorders.
Class
Organismal Systems; Environmental adaptation
Pathway map
mcf04714  Thermogenesis
mcf04714

Other DBs
GO: 1990845
Organism
Macaca fascicularis (crab-eating macaque) [GN:mcf]
Gene
102132220  ADRB3; LOW QUALITY PROTEIN: beta-3 adrenergic receptor [KO:K04143]
102145630  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X10 [KO:K04632]
107126444  neuroendocrine secretory protein 55 [KO:K04632]
102147015  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
102130114  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
101925741  ADCY3; adenylate cyclase type 3 isoform X2 [KO:K08043] [EC:4.6.1.1]
102123837  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
102135142  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
102116122  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
102125718  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
102144854  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
102135923  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
101925738  ADCY10; adenylate cyclase type 10 isoform X1 [KO:K11265] [EC:4.6.1.1]
102134704  adenylate cyclase type 10-like isoform X1 [KO:K11265] [EC:4.6.1.1]
102117414  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
102142443  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
101926461  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X4 [KO:K04345] [EC:2.7.11.11]
102141699  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X2 [KO:K05870]
102134095  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2 [KO:K09048]
102146405  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
102142378  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
102139679  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
102136437  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
102123367  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X2 [KO:K09047]
102132224  PRDM16; histone-lysine N-methyltransferase PRDM16 isoform X2 [KO:K22410] [EC:2.1.1.367]
102116717  ZNF516; zinc finger protein 516 isoform X1 [KO:K22411]
102135743  KDM1A; lysine-specific histone demethylase 1A isoform X2 [KO:K11450] [EC:1.14.99.66]
102115379  UCP1; mitochondrial brown fat uncoupling protein 1 [KO:K08769]
102126923  KDM3B; lysine-specific demethylase 3B isoform X1 [KO:K15601] [EC:1.14.11.65]
101864801  KDM3A; lysine-specific demethylase 3A isoform X1 [KO:K15601] [EC:1.14.11.65]
101865157  SMARCA4; transcription activator BRG1 isoform X5 [KO:K11647] [EC:5.6.2.-]
101925399  SMARCA2; probable global transcription activator SNF2L2 isoform X1 [KO:K11647] [EC:5.6.2.-]
101866760  SMARCB1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 isoform X2 [KO:K11648]
102129027  SMARCC1; SWI/SNF complex subunit SMARCC1 isoform X1 [KO:K11649]
102120874  SMARCC2; SWI/SNF complex subunit SMARCC2 isoform X1 [KO:K11649]
101866803  SMARCD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 isoform X1 [KO:K11650]
102139063  SMARCD2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 [KO:K11650]
101926381  SMARCD3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 isoform X1 [KO:K11650]
123569757  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2-like [KO:K11650]
102138193  SMARCE1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 isoform X1 [KO:K11651]
102139853  ACTB; actin, cytoplasmic 1 [KO:K05692]
102120642  actin, cytoskeletal 4-like [KO:K05692]
101925802  ACTG1; actin, cytoplasmic 2 [KO:K05692]
102125932  ACTL6A; actin-like protein 6A isoform X1 [KO:K11340]
102134538  ACTL6B; actin-like protein 6B isoform X1 [KO:K11652]
102136397  ARID1A; AT-rich interactive domain-containing protein 1A isoform X2 [KO:K11653]
102145166  ARID1B; AT-rich interactive domain-containing protein 1B isoform X1 [KO:K11653]
102129564  DPF3; zinc finger protein DPF3 [KO:K22198]
102142062  DPF1; zinc finger protein neuro-d4 isoform X6 [KO:K22198]
102120453  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
101925657  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
102116823  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
101867352  MAPK13; mitogen-activated protein kinase 13 isoform X2 [KO:K04441] [EC:2.7.11.24]
101926770  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
102134421  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
101867305  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
102125865  PPARGC1A; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X2 [KO:K07202]
101925838  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
102141535  SIRT6; NAD-dependent protein deacetylase sirtuin-6 isoform X1 [KO:K11416] [EC:2.3.1.286]
102126624  FGF21; fibroblast growth factor 21 [KO:K22429]
102145955  PLIN1; perilipin-1 isoform X1 [KO:K08768]
102143368  LIPE; hormone-sensitive lipase [KO:K07188] [EC:3.1.1.79]
102141858  PNPLA2; patatin-like phospholipase domain-containing protein 2 [KO:K16816] [EC:3.1.1.3]
102119084  MGLL; monoglyceride lipase isoform X1 [KO:K01054] [EC:3.1.1.23]
102143726  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
102144683  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
101925338  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
102133927  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 isoform X1 [KO:K07199]
102128414  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
102130217  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X3 [KO:K07200]
101865279  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
102134567  GCG; pro-glucagon [KO:K05259]
102117918  BMP8B; bone morphogenetic protein 8B isoform X1 [KO:K16622]
102137293  BMP8A; bone morphogenetic protein 8A [KO:K16622]
102127382  CNR1; cannabinoid receptor 1 [KO:K04277]
102116318  NPPA; natriuretic peptides A isoform X1 [KO:K12334]
102115953  NPPB; natriuretic peptides B [KO:K12335]
102143449  NPR1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
102122483  PRKG1; cGMP-dependent protein kinase 1 isoform X1 [KO:K07376] [EC:2.7.11.12]
102142098  PRKG2; cGMP-dependent protein kinase 2 isoform X1 [KO:K19477] [EC:2.7.11.12]
102147155  KLB; beta-klotho [KO:K22404]
102144714  FGFR1; fibroblast growth factor receptor 1 isoform X31 [KO:K04362] [EC:2.7.10.1]
102142977  FRS2; fibroblast growth factor receptor substrate 2 [KO:K12461]
102118276  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
102135079  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102138313  SOS2; son of sevenless homolog 2 [KO:K03099]
102118744  HRAS; GTPase HRas isoform X1 [KO:K02833]
102131483  KRAS; GTPase KRas isoform X1 [KO:K07827]
102137913  NRAS; GTPase NRas [KO:K07828]
102138330  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
102118317  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
102134699  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X3 [KO:K04373] [EC:2.7.11.1]
102142347  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
102124229  TSC1; hamartin isoform X1 [KO:K07206]
102140628  TSC2; tuberin isoform X1 [KO:K07207]
102127243  RHEB; GTP-binding protein Rheb [KO:K07208]
102116460  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
102128371  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
102147013  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
102139860  AKT1S1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
101925564  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X3 [KO:K04688] [EC:2.7.11.1]
102134845  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
101867274  RPS6; 40S ribosomal protein S6 [KO:K02991]
102129682  LOW QUALITY PROTEIN: 40S ribosomal protein S6 [KO:K02991]
123574044  40S ribosomal protein S6-like [KO:K02991]
102114880  ACSL1; long-chain-fatty-acid--CoA ligase 1 isoform X1 [KO:K01897] [EC:6.2.1.3]
102137495  ACSL3; fatty acid CoA ligase Acsl3 isoform X1 [KO:K01897] [EC:6.2.1.3]
101866093  ACSL6; long-chain-fatty-acid--CoA ligase 6 isoform X1 [KO:K01897] [EC:6.2.1.3]
102132163  ACSL4; long-chain-fatty-acid--CoA ligase 4 isoform X1 [KO:K01897] [EC:6.2.1.3]
101866585  ACSL5; long-chain-fatty-acid--CoA ligase 5 [KO:K01897] [EC:6.2.1.3]
7857751  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
7857750  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
7857744  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
7857746  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
7857745  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
7857747  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
7857748  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
123567534  NADH-ubiquinone oxidoreductase chain 6-like [KO:K03884] [EC:7.1.1.2]
123568763  NADH-ubiquinone oxidoreductase chain 6-like [KO:K03884] [EC:7.1.1.2]
101865238  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
101925833  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935] [EC:7.1.1.2]
102135711  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
102137128  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
102146369  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
102143409  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
101867140  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
123566851  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
101865852  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
102119049  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
101866792  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X6 [KO:K03941] [EC:7.1.1.2]
102124346  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
102122521  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1 [KO:K03943] [EC:7.1.1.2]
102124686  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X3 [KO:K03943] [EC:7.1.1.2]
102117222  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
102144790  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
102122243  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
101925194  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
102145434  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
102122399  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
102130049  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
102143510  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
101925169  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
102122883  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
123570998  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
123571785  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
123574038  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
123574384  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
123575129  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
123575527  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
102142948  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
102132705  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
101865843  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
123573105  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
102142308  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
102134019  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
102116683  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
102125333  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
102118472  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
101866670  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
102134986  acyl carrier protein, mitochondrial [KO:K03955]
101925928  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
102138616  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
101926508  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
102114911  NDUFB1; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
123571832  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
101865240  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial isoform X1 [KO:K03958]
107130321  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
102135950  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
102135077  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
123568388  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
102129785  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
102140432  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
101866824  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X2 [KO:K03961]
101925689  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
102115854  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
102123100  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
102138041  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial-like [KO:K03964]
102139978  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial-like [KO:K03964]
102116573  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
102133526  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
102140374  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial-like [KO:K11351]
102137623  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
102139017  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
102116918  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
102132813  NDUFAF1; complex I intermediate-associated protein 30, mitochondrial isoform X1 [KO:K18159]
102146325  NDUFAF2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 isoform X1 [KO:K18160]
101866258  NDUFAF3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 [KO:K09008]
101926042  NDUFAF4; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 [KO:K18161]
102139079  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4-like [KO:K18161]
123575170  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4-like [KO:K18161]
102119816  NDUFAF5; arginine-hydroxylase NDUFAF5, mitochondrial isoform X1 [KO:K18162] [EC:2.1.1.-]
102142677  NDUFAF6; NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 isoform X3 [KO:K18163]
101866472  NDUFAF7; protein arginine methyltransferase NDUFAF7, mitochondrial isoform X1 [KO:K18164]
102118277  protein arginine methyltransferase NDUFAF7, mitochondrial-like [KO:K18164]
102122968  NDUFAF8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8 [KO:K24726]
102126003  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
101865119  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
102145957  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X3 [KO:K00236]
102134309  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like isoform X1 [KO:K00236]
102127185  succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
102127751  succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
102132064  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
102132017  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
102133631  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
7857749  CYTB; cytochrome b [KO:K00412]
102145737  cytochrome c1, heme protein, mitochondrial isoform X1 [KO:K00413]
102117433  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
102135041  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
102136267  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
102123032  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
102115384  cytochrome b-c1 complex subunit 6, mitochondrial-like [KO:K00416]
102134501  cytochrome b-c1 complex subunit 6, mitochondrial-like [KO:K00416]
102117303  cytochrome b-c1 complex subunit 7 [KO:K00417]
102131145  LOW QUALITY PROTEIN: cytochrome b-c1 complex subunit 7-like [KO:K00417]
102133057  cytochrome b-c1 complex subunit 8 [KO:K00418]
102128183  cytochrome b-c1 complex subunit 8-like [KO:K00418]
102133949  cytochrome b-c1 complex subunit 9 isoform X1 [KO:K00419]
102128659  cytochrome b-c1 complex subunit 10 isoform X2 [KO:K00420]
7857739  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
7857740  COX2; cytochrome c oxidase subunit II [KO:K02261]
7857743  COX3; cytochrome c oxidase subunit III [KO:K02262]
102139855  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
102138538  cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like [KO:K02263]
102144280  cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform X1 [KO:K02263]
102135848  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
102123322  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
102132790  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
102118619  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
102124626  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
102141433  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
102116497  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
102139072  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
102130191  cytochrome c oxidase subunit 6B2 [KO:K02267]
102143756  cytochrome c oxidase subunit 6B1 [KO:K02267]
102121560  cytochrome c oxidase subunit 6B1-like [KO:K02267]
102137297  cytochrome c oxidase subunit 6C [KO:K02268]
102126517  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
102132250  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
102118608  cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform X3 [KO:K02270]
123571146  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
102135667  cytochrome c oxidase subunit 7A-related protein, mitochondrial-like [KO:K02270]
123572206  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
123573518  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
102123270  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
102124180  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
123573477  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
102137362  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
123567561  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
123568376  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
123569483  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
123570224  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
123572509  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
123572831  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
123573956  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
102129733  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
123574408  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
123574442  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
123575162  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
102122063  cytochrome c oxidase subunit 8C, mitochondrial isoform X3 [KO:K02273]
102139510  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
102132338  protoheme IX farnesyltransferase, mitochondrial isoform X2 [KO:K02257] [EC:2.5.1.141]
102132587  cytochrome c oxidase assembly protein COX11, mitochondrial [KO:K02258]
102142811  cytochrome c oxidase assembly protein COX15 homolog isoform X1 [KO:K02259] [EC:1.17.99.9]
102115550  cytochrome c oxidase assembly protein COX16 homolog, mitochondrial isoform X2 [KO:K18182]
102136165  cytochrome c oxidase copper chaperone [KO:K02260]
102132535  cytochrome c oxidase assembly protein COX18, mitochondrial isoform X1 [KO:K17797]
102135146  cytochrome c oxidase assembly protein COX19 [KO:K18183]
102125892  cytochrome c oxidase assembly protein COX20, mitochondrial isoform X2 [KO:K18184]
102122147  LOW QUALITY PROTEIN: cytochrome c oxidase assembly protein COX20, mitochondrial-like [KO:K18184]
102137336  cytochrome c oxidase assembly factor 1 homolog [KO:K18173]
102136403  cytochrome c oxidase assembly factor 3 homolog, mitochondrial [KO:K18175]
102143795  cytochrome c oxidase assembly factor 3 homolog, mitochondrial [KO:K18175]
102123566  cytochrome c oxidase assembly factor 3 homolog, mitochondrial-like [KO:K18175]
123574026  cytochrome c oxidase assembly factor 3 homolog, mitochondrial-like [KO:K18175]
102134966  cytochrome c oxidase assembly factor 4 homolog, mitochondrial [KO:K18177]
102143000  cytochrome c oxidase assembly factor 5 isoform X1 [KO:K18178]
101925848  cytochrome c oxidase assembly factor 6 homolog isoform X1 [KO:K18179]
102118112  cytochrome c oxidase assembly factor 7 [KO:K18180]
102123745  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
102140105  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
102139602  ATP synthase subunit beta, mitochondrial-like [KO:K02133] [EC:7.1.2.2]
102133224  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X2 [KO:K02136]
102144739  ATP5F1D; ATP synthase subunit delta, mitochondrial isoform X2 [KO:K02134]
102119570  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
102127470  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
102130613  ATP synthase subunit O, mitochondrial-like [KO:K02137]
7857742  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
102115672  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial isoform X2 [KO:K02127]
102129216  LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
102133775  LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit B1, mitochondrial-like [KO:K02127]
102122149  ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
102126511  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
102137931  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
102121361  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
102144904  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
102119656  ATP synthase F(0) complex subunit C3, mitochondrial-like [KO:K02128]
102121456  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
102121583  LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
102115461  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
102129485  ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
102142021  ATP5PD; ATP synthase subunit d, mitochondrial isoform X1 [KO:K02138]
123568667  ATP synthase subunit d, mitochondrial-like [KO:K02138]
102116154  ATP synthase subunit d, mitochondrial-like [KO:K02138]
123573538  ATP5ME; ATP synthase subunit e, mitochondrial [KO:K02129]
102133377  ATP5MF; ATP synthase subunit f, mitochondrial [KO:K02130]
102135275  ATP synthase subunit f, mitochondrial-like [KO:K02130]
123567185  ATP synthase subunit f, mitochondrial-like [KO:K02130]
102141040  ATP synthase subunit f, mitochondrial-like [KO:K02130]
102135435  ATP synthase subunit f, mitochondrial-like [KO:K02130]
123569057  LOW QUALITY PROTEIN: ATP synthase subunit f, mitochondrial-like [KO:K02130]
102122469  ATP synthase subunit f, mitochondrial-like [KO:K02130]
102136666  ATP synthase subunit f, mitochondrial-like [KO:K02130]
102115810  ATP synthase subunit f, mitochondrial-like [KO:K02130]
102135002  ATP synthase subunit f, mitochondrial-like [KO:K02130]
102117567  ATP5PF; ATP synthase-coupling factor 6, mitochondrial isoform X2 [KO:K02131]
7857741  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
102134973  ATP5MG; ATP synthase subunit g, mitochondrial [KO:K02140]
102122324  ATP synthase subunit g, mitochondrial-like [KO:K02140]
123569142  ATP synthase subunit g, mitochondrial [KO:K02140]
102129796  ATP synthase subunit g, mitochondrial-like [KO:K02140]
102141399  ATP synthase subunit g, mitochondrial-like [KO:K02140]
102137160  CPT2; carnitine O-palmitoyltransferase 2, mitochondrial [KO:K08766] [EC:2.3.1.21]
102115044  SLC25A29; mitochondrial basic amino acids transporter isoform X2 [KO:K15109]
102124681  SLC25A20; mitochondrial carnitine/acylcarnitine carrier protein [KO:K15109]
101926183  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
101866032  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
102134440  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform isoform X10 [KO:K19524] [EC:2.3.1.21]
Compound
C00002  ATP
C00004  NADH
C00008  ADP
C00010  CoA
C00024  Acetyl-CoA
C00040  Acyl-CoA
C00080  H+
C00116  Glycerol
C00162  Fatty acid
C00165  Diacylglycerol
C00318  L-Carnitine
C00422  Triacylglycerol
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00745  Nicotine
C00942  3',5'-Cyclic GMP
C00951  Estradiol-17beta
C01352  FADH2
C01885  1-Acylglycerol
C02301  O-Acylcarnitine
C02465  Triiodothyronine
C11695  Anandamide
C13856  2-Arachidonoylglycerol
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Nat Rev Mol Cell Biol 17:480-95 (2016)
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Nat Commun 6:7052 (2015)
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Related
pathway
mcf00020  Citrate cycle (TCA cycle)
mcf00190  Oxidative phosphorylation
mcf04010  MAPK signaling pathway
mcf04022  cGMP-PKG signaling pathway
mcf04024  cAMP signaling pathway
mcf04150  mTOR signaling pathway
mcf04923  Regulation of lipolysis in adipocytes
KO pathway
ko04714   
LinkDB

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