Entry Name Axon guidance - Microtus fortis (reed vole)
Description Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
Class Organismal Systems; Development and regenerationBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Microtus fortis (reed vole) [GN:
mfot ]
Gene 126510657 short transient receptor potential channel 1 isoform X1 [KO:K04964 ]
126499309 short transient receptor potential channel 3 isoform X1 [KO:K04966 ]
126499313 short transient receptor potential channel 4 isoform X1 [KO:K04967 ]
126513704 short transient receptor potential channel 6 isoform X1 [KO:K04969 ]
126491367 serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
126487431 nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
126502736 nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
126489822 ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
126500329 ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861 ]
126510830 leucine-rich repeats and immunoglobulin-like domains protein 2 isoform X1 [KO:K24609 ]
126512093 guanine nucleotide-binding protein G(i) subunit alpha-3-like [KO:K04630 ]
126499907 guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
126500134 guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
126487932 guanine nucleotide-binding protein G(i) subunit alpha-3 isoform X1 [KO:K04630 ]
126499912 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
126508229 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
126491758 phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
126512534 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
126494148 phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
126487410 LOW QUALITY PROTEIN: partitioning defective 6 homolog beta [KO:K06093 ]
Compound Reference Authors Guan KL, Rao Y.
Title Signalling mechanisms mediating neuronal responses to guidance cues.
Journal Reference Authors Govek EE, Newey SE, Van Aelst L.
Title The role of the Rho GTPases in neuronal development.
Journal Reference Authors Huber AB, Kolodkin AL, Ginty DD, Cloutier JF.
Title Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance.
Journal Reference Authors Negishi M, Oinuma I, Katoh H.
Title Plexins: axon guidance and signal transduction.
Journal Reference Authors Huot J.
Title Ephrin signaling in axon guidance.
Journal Reference Authors Patel BN, Van Vactor DL.
Title Axon guidance: the cytoplasmic tail.
Journal Reference Authors Yu TW, Bargmann CI.
Title Dynamic regulation of axon guidance.
Journal Reference Authors Dickson BJ.
Title Molecular mechanisms of axon guidance.
Journal Reference Authors Barallobre MJ, Pascual M, Del Rio JA, Soriano E.
Title The Netrin family of guidance factors: emphasis on Netrin-1 signalling.
Journal Reference Authors Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M.
Title The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.
Journal Reference Authors Fujita Y, Yamashita T
Title Axon growth inhibition by RhoA/ROCK in the central nervous system.
Journal Reference Authors Yamashita T, Mueller BK, Hata K
Title Neogenin and repulsive guidance molecule signaling in the central nervous system.
Journal Reference Authors van Erp S, van den Heuvel DMA, Fujita Y, Robinson RA, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JAA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ
Title Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.
Journal Related mfot04060 Cytokine-cytokine receptor interaction
KO pathway LinkDB All DBs
