KEGG   PATHWAY: mfot04060
Entry
mfot04060                   Pathway                                
Name
Cytokine-cytokine receptor interaction - Microtus fortis (reed vole)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
mfot04060  Cytokine-cytokine receptor interaction
mfot04060

Organism
Microtus fortis (reed vole) [GN:mfot]
Gene
126492363  C-C motif chemokine 1 [KO:K05514]
126491637  C-C motif chemokine 25 isoform X1 [KO:K13072]
126509854  C-C motif chemokine 19 [KO:K05512]
126509826  C-C motif chemokine 21 [KO:K16062]
126494823  C-C motif chemokine 3-like isoform X1 [KO:K05408]
126495784  C-C motif chemokine 4 [KO:K12964]
126502594  C-C motif chemokine 17 [KO:K21083]
126502595  C-C motif chemokine 22 [KO:K21095]
126494814  C-C motif chemokine 5 [KO:K12499]
126492359  C-C motif chemokine 8-like [KO:K16596]
126494813  C-C motif chemokine 9-like isoform X1 [KO:K22671]
126492357  C-C motif chemokine 2-like isoform X1 [KO:K14624]
126492360  C-C motif chemokine 12-like [KO:K14624]
126492362  eotaxin-like [KO:K16597]
126492732  C-C motif chemokine 24 [KO:K21097]
126492716  C-C motif chemokine 26 [KO:K21096]
126509810  uncharacterized protein LOC126509810 isoform X1 [KO:K16598]
126507914  C-C motif chemokine 28 [KO:K05513]
126508749  C-C motif chemokine 20 isoform X1 [KO:K14625]
126506338  C-X-C motif chemokine 3-like [KO:K05505]
126506591  C-X-C motif chemokine 2-like [KO:K05505]
126506592  growth-regulated alpha protein [KO:K05505]
126506339  alveolar macrophage chemotactic factor-like [KO:K05506]
126506342  platelet basic protein [KO:K10029]
126506343  platelet factor 4-like [KO:K05407]
126506309  C-X-C motif chemokine 9 [KO:K05416]
126506313  C-X-C motif chemokine 10 [KO:K12671]
126506312  C-X-C motif chemokine 11 [KO:K12672]
126506490  C-X-C motif chemokine 13 [KO:K10032]
126505459  stromal cell-derived factor 1 isoform X1 [KO:K10031]
126514003  C-X-C motif chemokine 16 [KO:K10035]
126502997  C-X-C motif chemokine 14 [KO:K10033]
126491453  C-X-C motif chemokine 17 [KO:K22627]
126511284  lymphotactin [KO:K05507]
126502586  fractalkine [KO:K05508]
126499332  interleukin-2 [KO:K05429]
126510971  interleukin-4 [KO:K05430]
126513375  interleukin-7 isoform X1 [KO:K05431]
126502467  interleukin-9 [KO:K05432]
126513255  interleukin-15 isoform X1 [KO:K05433]
126499171  interleukin-21 [KO:K05434]
126510951  interleukin-5 [KO:K05428]
126510957  granulocyte-macrophage colony-stimulating factor [KO:K05427]
126510962  interleukin-13 [KO:K05435]
126494007  erythropoietin [KO:K05437]
126514988  somatotropin [KO:K05438]
126501649  prolactin-5A1-like [KO:K05439]
126501733  prolactin-like [KO:K05439]
126501734  prolactin-6A1-like isoform X1 [KO:K05439]
126501878  prolactin isoform X1 [KO:K05439]
126504255  thrombopoietin isoform X1 [KO:K06854]
126510365  granulocyte colony-stimulating factor [KO:K05423]
126501109  leptin [KO:K05424]
126491159  interleukin-6 [KO:K05405]
126493667  interleukin-11 isoform X1 [KO:K05417]
126504946  interleukin-12 subunit alpha [KO:K05406]
126499523  interleukin-12 subunit beta [KO:K05425]
126492059  interleukin-23 subunit alpha isoform X1 [KO:K05426]
126488266  interleukin-27 subunit alpha [KO:K22629]
126490317  interleukin-27 subunit beta isoform X1 [KO:K24476]
126504341  interleukin-31 [KO:K22631]
126498519  cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421]
126498184  ciliary neurotrophic factor isoform X1 [KO:K05420]
126515875  cardiotrophin-1 isoform X1 [KO:K05422]
126515910  cardiotrophin-2 [KO:K24382]
126500979  leukemia inhibitory factor isoform X1 [KO:K05419]
126500689  oncostatin-M [KO:K05418]
126505054  interleukin-10 [KO:K05443]
126505134  interleukin-19 [KO:K05444]
126504984  interleukin-20 [KO:K22667]
126505126  interleukin-24 isoform X1 [KO:K22668]
126515664  interleukin-22 [KO:K05445]
126512952  interferon lambda-2-like [KO:K22669]
126486687  interferon lambda-2-like [KO:K22669]
126486688  interferon lambda-2-like [KO:K22669]
126510709  interferon alpha-12-like [KO:K05414]
126510710  interferon alpha-12-like [KO:K05414]
126510711  interferon alpha-12-like [KO:K05414]
126510712  interferon alpha-12-like [KO:K05414]
126510718  interferon alpha-12-like [KO:K05414]
126510725  interferon alpha-1-like [KO:K05414]
126510729  interferon alpha-1-like [KO:K05414]
126510739  interferon alpha-12-like [KO:K05414]
126510740  interferon alpha-12-like [KO:K05414]
126510741  interferon beta [KO:K05415]
126510726  LOW QUALITY PROTEIN: interferon epsilon [KO:K05442]
126515663  interferon gamma [KO:K04687]
126496717  interleukin-1 alpha isoform X1 [KO:K04383]
126496850  interleukin-1 beta [KO:K04519]
126500252  interleukin-1 receptor antagonist protein isoform X1 [KO:K05481]
126500245  interleukin-36 receptor antagonist protein isoform X1 [KO:K05483]
126500203  interleukin-36 alpha-like [KO:K05484]
126500202  interleukin-36 beta [KO:K05486]
126500204  interleukin-36 gamma-like [KO:K05487]
126500273  interleukin-1 family member 10 [KO:K05488]
126509990  interleukin-18 [KO:K05482]
126512157  interleukin-33 isoform X1 [KO:K12967]
126489678  interleukin-17A [KO:K05489]
126489696  interleukin-17F [KO:K05494]
126511062  interleukin-17B isoform X1 [KO:K05490]
126515562  interleukin-17C [KO:K05491]
126507678  interleukin-17D isoform X1 [KO:K05492]
126490912  interleukin-25 [KO:K05493]
126508615  pro-interleukin-16 isoform X1 [KO:K22628]
126502559  interleukin-34 isoform X1 [KO:K22633]
126491876  macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
126494877  tumor necrosis factor [KO:K03156]
126494878  lymphotoxin-alpha [KO:K05468]
126494876  lymphotoxin-beta isoform X1 [KO:K03157]
126490373  tumor necrosis factor ligand superfamily member 14 isoform X1 [KO:K05477]
126511310  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
126488362  tumor necrosis factor ligand superfamily member 15 [KO:K05478]
126501403  tumor necrosis factor ligand superfamily member 10 [KO:K04721]
126487047  ectodysplasin-A isoform X1 [KO:K05480]
126510837  beta-nerve growth factor [KO:K02582]
126513935  tumor necrosis factor ligand superfamily member 12 isoform X1 [KO:K05474]
126490334  CD70 antigen [KO:K05470]
126488363  tumor necrosis factor ligand superfamily member 8 [KO:K05471]
126512121  CD40 ligand [KO:K03161]
126490375  tumor necrosis factor ligand superfamily member 9 [KO:K05472]
126493632  tumor necrosis factor ligand superfamily member 4 [KO:K05469]
126511318  tumor necrosis factor ligand superfamily member 18 [KO:K05479]
126513937  tumor necrosis factor ligand superfamily member 13 isoform X1 [KO:K05475]
126498327  tumor necrosis factor ligand superfamily member 13B isoform X1 [KO:K05476]
126494578  transforming growth factor beta-1 proprotein [KO:K13375]
126505361  transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
126507732  transforming growth factor beta-3 proprotein [KO:K13377]
126491844  growth/differentiation factor 15 isoform X1 [KO:K05504]
126500633  growth/differentiation factor 2 [KO:K05503]
126515636  bone morphogenetic protein 10 [KO:K22670]
126513003  inhibin alpha chain [KO:K05500]
126506458  bone morphogenetic protein 3 isoform X1 [KO:K05496]
126500630  growth/differentiation factor 10 [KO:K22674]
126492070  growth/differentiation factor 11 [KO:K22679]
126511833  growth/differentiation factor 8 [KO:K05497]
126501554  inhibin beta A chain [KO:K04667]
126489897  inhibin beta B chain [KO:K22687]
126491801  embryonic growth/differentiation factor 1 [KO:K05495]
126507985  nodal-like [KO:K22672]
126514811  growth/differentiation factor 3 [KO:K22672]
126500697  nodal homolog [KO:K04666]
126510941  growth/differentiation factor 9 [KO:K22673]
126514778  inhibin beta C chain [KO:K22688]
126514787  inhibin beta E chain [KO:K22689]
126489213  muellerian-inhibiting factor [KO:K04665]
126496732  bone morphogenetic protein 2 isoform X1 [KO:K21283]
126513813  bone morphogenetic protein 4 isoform X1 [KO:K04662]
126506820  growth/differentiation factor 5 [KO:K04664]
126486742  growth/differentiation factor 6 [KO:K20012]
126501330  growth/differentiation factor 7 [KO:K20013]
126493702  bone morphogenetic protein 15 [KO:K05498]
126491550  bone morphogenetic protein 5 [KO:K04663]
126501862  bone morphogenetic protein 6 [KO:K16620]
126508032  bone morphogenetic protein 7 [KO:K16621]
126513049  bone morphogenetic protein 8A [KO:K16622]
126513183  bone morphogenetic protein 8A-like [KO:K16622]
126501099  C-C chemokine receptor type 8 [KO:K04183]
126501040  C-C chemokine receptor type 9 [KO:K04184]
126499962  atypical chemokine receptor 4 [KO:K04186]
126510494  C-C chemokine receptor type 7 [KO:K04182]
126499998  C-C chemokine receptor type 4 [KO:K04179]
126501117  C-C chemokine receptor type 5-like [KO:K04180]
126501110  C-C chemokine receptor type 3 [KO:K04178]
126501174  C-C chemokine receptor type 2 [KO:K04177]
126501125  C-C chemokine receptor 1-like protein 1 [KO:K04176]
126501235  C-C chemokine receptor type 1-like [KO:K04176]
126510202  C-C chemokine receptor type 10 isoform X1 [KO:K04185]
126497705  C-C chemokine receptor type 6 [KO:K04181]
126489478  C-X-C chemokine receptor type 1-like [KO:K04175]
126489498  C-X-C chemokine receptor type 2 [KO:K05050]
126487042  C-X-C chemokine receptor type 3 [KO:K04188]
126509954  C-X-C chemokine receptor type 5 [KO:K04190]
126505129  C-X-C chemokine receptor type 4 [KO:K04189]
126514304  atypical chemokine receptor 3 [KO:K04304]
126501060  C-X-C chemokine receptor type 6 [KO:K04191]
126501128  chemokine XC receptor 1 [KO:K04193]
126501100  CX3C chemokine receptor 1 [KO:K04192]
126506730  interleukin-2 receptor subunit alpha [KO:K05068]
126515825  interleukin-2 receptor subunit beta [KO:K05069]
126487061  cytokine receptor common subunit gamma isoform X1 [KO:K05070]
126502313  interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
126499758  interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
126497707  interleukin-9 receptor-like [KO:K05073]
126506746  interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
126502265  interleukin-21 receptor [KO:K05075]
126495531  interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
126515767  cytokine receptor common subunit beta isoform X1 [KO:K04738]
126506112  interleukin-5 receptor subunit alpha [KO:K05067]
126494996  granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066]
126488431  interleukin-13 receptor subunit alpha-1 [KO:K05076]
126492585  interleukin-13 receptor subunit alpha-2 isoform X1 [KO:K05077]
126490575  erythropoietin receptor isoform X1 [KO:K05079]
126499710  growth hormone receptor isoform X1 [KO:K05080]
126499691  prolactin receptor isoform X1 [KO:K05081]
126513162  thrombopoietin receptor isoform X1 [KO:K05082]
126507300  granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
126497971  leptin receptor isoform X1 [KO:K05062]
126516136  interleukin-6 receptor subunit alpha [KO:K05055]
126507925  interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
126509808  interleukin-11 receptor subunit alpha isoform X1 [KO:K05056]
126491780  interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063]
126493351  interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064]
126493346  interleukin-23 receptor [KO:K05065]
126487704  interleukin-27 receptor subunit alpha [KO:K19598]
126507910  interleukin-31 receptor subunit alpha [KO:K22630]
126509892  ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059]
126499658  leukemia inhibitory factor receptor isoform X1 [KO:K05058]
126499660  oncostatin-M-specific receptor subunit beta [KO:K05057]
126510075  interleukin-10 receptor subunit alpha isoform X1 [KO:K05134]
126515276  interleukin-10 receptor subunit beta isoform X1 [KO:K05135]
126511933  interleukin-20 receptor subunit alpha [KO:K05136]
126500040  interleukin-20 receptor subunit beta isoform X1 [KO:K05137]
126508350  interleukin-22 receptor subunit alpha-1 isoform X1 [KO:K05138]
126508355  interferon lambda receptor 1 isoform X1 [KO:K05140]
126515275  interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
126515274  interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
126511927  interferon gamma receptor 1 [KO:K05132]
126515265  interferon gamma receptor 2 [KO:K05133]
126496981  interleukin-1 receptor type 1 [KO:K04386]
126512301  interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
126496982  interleukin-1 receptor type 2 isoform X1 [KO:K04387]
126496980  interleukin-1 receptor-like 2 isoform X1 [KO:K05172]
126496909  interleukin-18 receptor 1 [KO:K05173]
126497019  interleukin-18 receptor accessory protein [KO:K05174]
126497010  interleukin-1 receptor-like 1 isoform X1 [KO:K05171]
126514877  interleukin-17 receptor A [KO:K05164]
126505468  interleukin-17 receptor C isoform X1 [KO:K05166]
126511173  interleukin-17 receptor B isoform X1 [KO:K05165]
126505508  interleukin-17 receptor E isoform X1 [KO:K05168]
126514916  T-cell surface glycoprotein CD4 isoform X1 [KO:K06454]
126511027  macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
126514827  tumor necrosis factor receptor superfamily member 1A [KO:K03158]
126508214  tumor necrosis factor receptor superfamily member 1B [KO:K05141]
126514853  tumor necrosis factor receptor superfamily member 3 isoform X1 [KO:K03159]
126508224  tumor necrosis factor receptor superfamily member 14 [KO:K05152]
126511231  tumor necrosis factor receptor superfamily member 6 [KO:K04390]
126508180  tumor necrosis factor receptor superfamily member 25 isoform X1 [KO:K05160]
126486846  tumor necrosis factor receptor superfamily member 21 [KO:K05157]
126502351  tumor necrosis factor receptor superfamily member EDAR [KO:K05162]
126490840  tumor necrosis factor receptor superfamily member 27 isoform X1 [KO:K05163]
126510451  tumor necrosis factor receptor superfamily member 16 [KO:K02583]
126503430  tumor necrosis factor receptor superfamily member 11B [KO:K05148]
126487114  tumor necrosis factor receptor superfamily member 11A [KO:K05147]
126496891  tumor necrosis factor receptor superfamily member 12A [KO:K05149]
126514857  CD27 antigen [KO:K05144]
126508272  tumor necrosis factor receptor superfamily member 8 isoform X1 [KO:K05145]
126507111  tumor necrosis factor receptor superfamily member 5 [KO:K03160]
126508270  tumor necrosis factor receptor superfamily member 9 isoform X1 [KO:K05146]
126493213  tumor necrosis factor receptor superfamily member 4 [KO:K05142]
126493204  tumor necrosis factor receptor superfamily member 18 isoform X1 [KO:K05154]
126498012  tumor necrosis factor receptor superfamily member 17 [KO:K05153]
126514684  tumor necrosis factor receptor superfamily member 13B [KO:K05150]
126515804  tumor necrosis factor receptor superfamily member 13C isoform X1 [KO:K05151]
126507621  tumor necrosis factor receptor superfamily member 19 [KO:K05155]
126488881  tumor necrosis factor receptor superfamily member 19L isoform X1 [KO:K05156]
126491942  RELT-like protein 2 [KO:K26541]
126506385  RELT-like protein 1 [KO:K26541]
126509812  TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
126491130  TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
126488804  serine/threonine-protein kinase receptor R3 [KO:K13594] [EC:2.7.11.30]
126500227  activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
126511851  bone morphogenetic protein receptor type-2 isoform X1 [KO:K04671] [EC:2.7.11.30]
126501184  activin receptor type-2B isoform X1 [KO:K13596] [EC:2.7.11.30]
126488781  activin receptor type-1B isoform X1 [KO:K13567] [EC:2.7.11.30]
126489422  activin receptor type-1C isoform X1 [KO:K13568] [EC:2.7.11.30]
126488629  activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
126491184  anti-Muellerian hormone type-2 receptor isoform X1 [KO:K04672] [EC:2.7.11.30]
126500597  bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
126488355  bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   
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