KEGG   PATHWAY: mlx04714
Entry
mlx04714                    Pathway                                
Name
Thermogenesis - Mirounga leonina (Southern elephant seal)
Description
Thermogenesis is essential for warm-blooded animals, ensuring normal cellular and physiological function under conditions of environmental challenge. Thermogenesis in brown and beige adipose tissue is mainly controlled by norepinephrine, which is released from sympathetic nervous system in response to cold or dietary stimuli. The mitochondrial uncoupling protein 1 (UCP1) is responsible for the process whereby chemical energy is converted into heat in these adipocytes. Activation of these adipocytes leads to an increase in calorie consumption and is expected to improve overweight conditions, providing a potential strategy for treating obesity and its related metabolic disorders.
Class
Organismal Systems; Environmental adaptation
Pathway map
mlx04714  Thermogenesis
mlx04714

Other DBs
GO: 1990845
Organism
Mirounga leonina (Southern elephant seal) [GN:mlx]
Gene
118009967  ADRB3; beta-3 adrenergic receptor isoform X1 [KO:K04143]
118023087  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(s) subunit alpha-like [KO:K04632]
118024008  neuroendocrine secretory protein 55 [KO:K04632]
118024010  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
118024512  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
118006264  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
118007652  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
118003693  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
118007016  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
118008901  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
118023800  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
118015219  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
118021775  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
118001457  adenylate cyclase type 10-like isoform X1 [KO:K11265] [EC:4.6.1.1]
118014524  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
118005070  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
118019227  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
118012101  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
118015807  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
118017967  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
118005189  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
118013832  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
118021134  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
118021299  CREB5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
118019654  PRDM16; histone-lysine N-methyltransferase PRDM16 [KO:K22410] [EC:2.1.1.367]
118004659  ZNF516; zinc finger protein 516 isoform X1 [KO:K22411]
118019904  KDM1A; lysine-specific histone demethylase 1A isoform X1 [KO:K11450] [EC:1.14.99.66]
118022548  UCP1; mitochondrial brown fat uncoupling protein 1 [KO:K08769]
118007892  KDM3A; lysine-specific demethylase 3A [KO:K15601] [EC:1.14.11.65]
118016684  KDM3B; lysine-specific demethylase 3B isoform X1 [KO:K15601] [EC:1.14.11.65]
118026333  SMARCA2; probable global transcription activator SNF2L2 isoform X1 [KO:K11647] [EC:5.6.2.-]
118005743  SMARCA4; transcription activator BRG1 isoform X1 [KO:K11647] [EC:5.6.2.-]
117999836  SMARCB1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 isoform X1 [KO:K11648]
118008719  SMARCC2; SWI/SNF complex subunit SMARCC2 isoform X1 [KO:K11649]
118005357  SMARCC1; SWI/SNF complex subunit SMARCC1 [KO:K11649]
118008861  SMARCD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 isoform X1 [KO:K11650]
118024380  SMARCD2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 [KO:K11650]
118026813  SMARCD3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 isoform X1 [KO:K11650]
118024870  SMARCE1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 [KO:K11651]
118024176  ACTG1; actin, cytoplasmic 2 [KO:K05692]
117999316  ACTB; actin, cytoplasmic 1 [KO:K05692]
118006641  ACTL6A; actin-like protein 6A isoform X1 [KO:K11340]
117999237  ACTL6B; actin-like protein 6B [KO:K11652]
118001829  AT-rich interactive domain-containing protein 1B isoform X1 [KO:K11653]
118001952  AT-rich interactive domain-containing protein 1B-like isoform X1 [KO:K11653]
118019833  ARID1A; AT-rich interactive domain-containing protein 1A isoform X1 [KO:K11653]
118022913  DPF1; zinc finger protein neuro-d4 [KO:K22198]
118002629  DPF3; zinc finger protein DPF3 [KO:K22198]
118005676  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
118000829  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
118000167  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
118001095  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
118001265  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
117997742  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
117997743  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
118010659  PPARGC1A; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
118012308  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
118005296  SIRT6; NAD-dependent protein deacetylase sirtuin-6 isoform X1 [KO:K11416] [EC:2.3.1.286]
117998046  FGF21; fibroblast growth factor 21 [KO:K22429]
118023050  PLIN1; perilipin-1 [KO:K08768]
117998053  LIPE; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
118016211  PNPLA2; patatin-like phospholipase domain-containing protein 2 [KO:K16816] [EC:3.1.1.3]
118005902  MGLL; monoglyceride lipase [KO:K01054] [EC:3.1.1.23]
118019366  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
118006331  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
118006463  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
118000245  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
118018532  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
118008887  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
118026822  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
118012033  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200]
118011814  GCG; glucagon isoform X1 [KO:K05259]
117998460  bone morphogenetic protein 8B [KO:K16622]
118001282  CNR1; cannabinoid receptor 1 [KO:K04277]
118020338  NPPA; natriuretic peptides A [KO:K12334]
118020337  NPPB; natriuretic peptides B [KO:K12335]
118013821  NPR1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
118012977  PRKG1; cGMP-dependent protein kinase 1 isoform X1 [KO:K07376] [EC:2.7.11.12]
118010403  PRKG2; cGMP-dependent protein kinase 2 [KO:K19477] [EC:2.7.11.12]
118010603  KLB; beta-klotho [KO:K22404]
118009956  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
118008582  FRS2; fibroblast growth factor receptor substrate 2 isoform X1 [KO:K12461]
118024273  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
118007794  SOS1; son of sevenless homolog 1 [KO:K03099]
118002069  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
118016228  HRAS; GTPase HRas isoform X1 [KO:K02833]
118025572  KRAS; GTPase KRas isoform X1 [KO:K07827]
118000495  NRAS; GTPase NRas [KO:K07828]
118001843  ribosomal protein S6 kinase alpha-2-like isoform X1 [KO:K04373] [EC:2.7.11.1]
118001950  ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
118026062  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
118019834  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
118007563  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
118017558  TSC1; hamartin isoform X1 [KO:K07206]
118021717  TSC2; tuberin isoform X1 [KO:K07207]
118026819  RHEB; GTP-binding protein Rheb [KO:K07208]
118024187  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
118020008  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
118021723  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
117998320  AKT1S1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
118016129  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
118024673  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
118015851  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
118002114  40S ribosomal protein S6-like [KO:K02991]
118017309  40S ribosomal protein S6-like [KO:K02991]
118018960  40S ribosomal protein S6-like [KO:K02991]
117999029  RPS6; 40S ribosomal protein S6 [KO:K02991]
118016612  ACSL6; long-chain-fatty-acid--CoA ligase 6 isoform X1 [KO:K01897] [EC:6.2.1.3]
118010070  ACSL1; long-chain-fatty-acid--CoA ligase 1 isoform X1 [KO:K01897] [EC:6.2.1.3]
118026236  ACSL5; long-chain-fatty-acid--CoA ligase 5 isoform X1 [KO:K01897] [EC:6.2.1.3]
118012000  ACSL3; long-chain-fatty-acid--CoA ligase 3 isoform X1 [KO:K01897] [EC:6.2.1.3]
118012021  ACSL4; long-chain-fatty-acid--CoA ligase 4 isoform X1 [KO:K01897] [EC:6.2.1.3]
4355870  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
4355871  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
4355872  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
4355873  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
4355874  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
4355875  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
4355876  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
118012110  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
118014015  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935] [EC:7.1.1.2]
118015844  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
118006687  NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
118006809  NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
118021333  NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial-like [KO:K03937]
118027278  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
118019589  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
117998200  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
117999059  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
118006183  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
118005112  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
118016147  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
118016140  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
118016431  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
118026972  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
118024594  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
118005005  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
118012420  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
118006077  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
117999192  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
118006627  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
118016727  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
118008941  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
118026286  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
117997916  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
118013193  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
118000306  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
118008679  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
118017566  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
118011073  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
118025972  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
118004320  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
118019915  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
118013652  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
118013723  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
118020809  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
118021900  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
118000958  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
118021036  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
117998612  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
118005969  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
118009157  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8-like [KO:K03952]
118016476  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8-like [KO:K03952]
118017734  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 isoform X1 [KO:K03952]
118025758  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
118011878  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
117999128  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
118005738  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
117997521  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12-like [KO:K11352]
117998878  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
118005260  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
118009264  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
118002675  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
118025455  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
118021161  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
118012157  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
118007053  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
118006688  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
118018036  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
118005924  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
118025000  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
118015199  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
118026254  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9-like [KO:K03965]
118021712  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
118009645  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
118022312  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
118023788  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial-like [KO:K03967]
118008977  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial-like [KO:K03967]
118004305  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
118003268  NDUFAF1; complex I intermediate-associated protein 30, mitochondrial [KO:K18159]
118016819  NDUFAF2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 [KO:K18160]
118005945  NDUFAF3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 isoform X1 [KO:K09008]
118001446  NDUFAF4; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 [KO:K18161]
118011527  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4-like [KO:K18161]
118011227  NDUFAF5; arginine-hydroxylase NDUFAF5, mitochondrial isoform X1 [KO:K18162] [EC:2.1.1.-]
118015035  NDUFAF6; NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 isoform X1 [KO:K18163]
118007771  NDUFAF7; protein arginine methyltransferase NDUFAF7, mitochondrial [KO:K18164]
118024179  NDUFAF8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8 [KO:K24726]
118006277  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
118019953  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
118001049  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236]
118014021  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
118013236  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
118022759  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
4355869  CYTB; cytochrome b [KO:K00412]
118015299  cytochrome c1, heme protein, mitochondrial [KO:K00413]
118005048  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
117999153  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
118019464  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
118015043  cytochrome b-c1 complex subunit 7 [KO:K00417]
118008962  cytochrome b-c1 complex subunit 7-like [KO:K00417]
118009132  cytochrome b-c1 complex subunit 7-like [KO:K00417]
118014721  cytochrome b-c1 complex subunit 7-like [KO:K00417]
118016628  cytochrome b-c1 complex subunit 8 [KO:K00418]
118018636  cytochrome b-c1 complex subunit 9 [KO:K00419]
118006000  cytochrome b-c1 complex subunit 10 [KO:K00420]
4355866  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
4355867  COX2; cytochrome c oxidase subunit II [KO:K02261]
4355868  COX3; cytochrome c oxidase subunit III [KO:K02262]
118023493  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
118001502  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
118011354  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
118003100  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
118008215  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
118009813  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
118002938  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
118018546  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
117999554  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
118022877  cytochrome c oxidase subunit 6B1 [KO:K02267]
118001264  cytochrome c oxidase subunit 6B1-like [KO:K02267]
118003073  cytochrome c oxidase subunit 6B1-like [KO:K02267]
117997912  cytochrome c oxidase subunit 6B2 isoform X1 [KO:K02267]
118012351  cytochrome c oxidase subunit 6B1-like [KO:K02267]
118025026  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 6C [KO:K02268]
118005417  cytochrome c oxidase subunit 6C-like [KO:K02268]
118007814  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
118022879  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
118008635  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
118001468  LOW QUALITY PROTEIN: uncharacterized protein LOC118001468 [KO:K02270]
118015405  cytochrome c oxidase subunit 7B2, mitochondrial-like [KO:K02271]
118010248  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
118026049  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
118016969  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
118013136  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
118014377  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
118009891  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
117998533  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
118015981  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
118023545  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
118010255  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
118025936  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
117998506  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
118000091  protoheme IX farnesyltransferase, mitochondrial isoform X1 [KO:K02257] [EC:2.5.1.141]
118024734  cytochrome c oxidase assembly protein COX11, mitochondrial [KO:K02258]
118008863  cytochrome c oxidase assembly protein COX14 [KO:K18181]
118024866  cytochrome c oxidase assembly protein COX15 homolog isoform X1 [KO:K02259] [EC:1.17.99.9]
118017768  cytochrome c oxidase assembly protein COX16 homolog, mitochondrial-like [KO:K18182]
118018528  cytochrome c oxidase assembly protein COX16 homolog, mitochondrial-like [KO:K18182]
118007067  cytochrome c oxidase copper chaperone [KO:K02260]
118010463  cytochrome c oxidase assembly protein COX18, mitochondrial isoform X1 [KO:K17797]
117999271  cytochrome c oxidase assembly protein COX19 isoform X1 [KO:K18183]
118024540  cytochrome c oxidase assembly factor 1 homolog [KO:K18173]
118024935  cytochrome c oxidase assembly factor 3 homolog, mitochondrial [KO:K18175]
118008228  cytochrome c oxidase assembly factor 5 [KO:K18178]
118012917  cytochrome c oxidase assembly factor 6 homolog [KO:K18179]
118019403  cytochrome c oxidase assembly factor 7 [KO:K18180]
118004416  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
118012585  LOW QUALITY PROTEIN: ATP synthase subunit alpha, mitochondrial-like [KO:K02132]
118008699  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
118014290  LOW QUALITY PROTEIN: ATP synthase subunit gamma, mitochondrial-like [KO:K02136]
118021601  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
118005812  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
118024015  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
118013637  LOW QUALITY PROTEIN: ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
118013662  ATP synthase subunit epsilon, mitochondrial [KO:K02135]
118001601  ATP synthase subunit O, mitochondrial-like [KO:K02137]
118004098  ATP synthase subunit O, mitochondrial-like [KO:K02137]
118018842  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
4355864  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
118019006  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
118000847  ATP synthase F(0) complex subunit C3, mitochondrial-like [KO:K02128]
118023337  LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
118008780  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
118016240  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
118024792  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
118026484  ATP synthase F(0) complex subunit C3, mitochondrial-like [KO:K02128]
118012240  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
118012306  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
118021108  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
118024289  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
118010299  ATP synthase subunit d, mitochondrial-like [KO:K02138]
118017147  ATP synthase subunit d, mitochondrial-like [KO:K02138]
118026298  ATP synthase subunit d, mitochondrial-like [KO:K02138]
117999517  ATP synthase subunit d, mitochondrial-like [KO:K02138]
118014376  ATP synthase subunit d, mitochondrial-like [KO:K02138]
118000233  ATP synthase subunit f, mitochondrial-like [KO:K02130]
118023364  ATP synthase subunit f, mitochondrial-like [KO:K02130]
118017115  ATP synthase subunit f, mitochondrial-like [KO:K02130]
118017333  ATP synthase subunit f, mitochondrial-like [KO:K02130]
118026011  ATP synthase subunit f, mitochondrial-like [KO:K02130]
117999372  ATP5MF; ATP synthase subunit f, mitochondrial [KO:K02130]
118000514  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
118018060  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
118018787  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
118019306  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
118019784  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
118020828  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
118020909  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
118014566  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
118021844  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
4355865  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
118023870  ATP synthase subunit g, mitochondrial-like [KO:K02140]
118025593  ATP synthase subunit g, mitochondrial-like [KO:K02140]
118011469  LOW QUALITY PROTEIN: ATP synthase subunit g, mitochondrial-like [KO:K02140]
118013288  ATP5MG; ATP synthase subunit g, mitochondrial [KO:K02140]
118019395  CPT2; carnitine O-palmitoyltransferase 2, mitochondrial isoform X1 [KO:K08766] [EC:2.3.1.21]
118002173  SLC25A29; mitochondrial basic amino acids transporter [KO:K15109]
118005697  SLC25A20; mitochondrial carnitine/acylcarnitine carrier protein [KO:K15109]
118016158  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
117997727  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
117998266  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform [KO:K19524] [EC:2.3.1.21]
Compound
C00002  ATP
C00004  NADH
C00008  ADP
C00010  CoA
C00024  Acetyl-CoA
C00040  Acyl-CoA
C00080  H+
C00116  Glycerol
C00162  Fatty acid
C00165  Diacylglycerol
C00318  L-Carnitine
C00422  Triacylglycerol
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00745  Nicotine
C00942  3',5'-Cyclic GMP
C00951  Estradiol-17beta
C01352  FADH2
C01885  1-Acylglycerol
C02301  O-Acylcarnitine
C02465  Triiodothyronine
C11695  Anandamide
C13856  2-Arachidonoylglycerol
Reference
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Transcriptional and epigenetic control of brown and beige adipose cell fate and function.
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Nat Rev Mol Cell Biol 17:480-95 (2016)
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Reference
PMID:24100998
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Brown and beige fat: development, function and therapeutic potential.
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Nat Med 19:1252-63 (2013)
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Reference
PMID:25154875
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Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity.
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Could burning fat start with a brite spark? Pharmacological and nutritional ways to promote thermogenesis.
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Mol Nutr Food Res 60:18-42 (2016)
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Trends Mol Med 21:571-9 (2015)
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Trends Endocrinol Metab 26:657-68 (2015)
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ASK1 signalling regulates brown and beige adipocyte function.
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Nat Commun 7:11158 (2016)
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JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.
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Nat Commun 6:7052 (2015)
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LSD1 Interacts with Zfp516 to Promote UCP1 Transcription and Brown Fat Program.
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Cell Rep 15:2536-49 (2016)
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Reference
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Reference
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  Title
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Reference
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Related
pathway
mlx00020  Citrate cycle (TCA cycle)
mlx00190  Oxidative phosphorylation
mlx04010  MAPK signaling pathway
mlx04022  cGMP-PKG signaling pathway
mlx04024  cAMP signaling pathway
mlx04150  mTOR signaling pathway
mlx04923  Regulation of lipolysis in adipocytes
KO pathway
ko04714   
LinkDB

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