KEGG   PATHWAY: mlx04024
Entry
mlx04024                    Pathway                                
Name
cAMP signaling pathway - Mirounga leonina (Southern elephant seal)
Description
cAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands including hormones, neurotransmitters, and other signaling molecules. cAMP regulates pivotal physiologic processes including metabolism, secretion, calcium homeostasis, muscle contraction, cell fate, and gene transcription. cAMP acts directly on three main targets: protein kinase A (PKA), the exchange protein activated by cAMP (Epac), and cyclic nucleotide-gated ion channels (CNGCs). PKA modulates, via phosphorylation, a number of cellular substrates, including transcription factors, ion channels, transporters, exchangers, intracellular Ca2+ -handling proteins, and the contractile machinery. Epac proteins function as guanine nucleotide exchange factors (GEFs) for both Rap1 and Rap2. Various effector proteins, including adaptor proteins implicated in modulation of the actin cytoskeleton, regulators of G proteins of the Rho family, and phospholipases, relay signaling downstream from Rap.
Class
Environmental Information Processing; Signal transduction
Pathway map
mlx04024  cAMP signaling pathway
mlx04024

Other DBs
GO: 0019933
Organism
Mirounga leonina (Southern elephant seal) [GN:mlx]
Gene
118001522  VIP; VIP peptides [KO:K05264]
118014717  CRH; corticoliberin [KO:K05256]
118000682  CGA; glycoprotein hormones alpha chain [KO:K08522]
117997963  lutropin subunit beta [KO:K08521]
118016019  GPHA2; glycoprotein hormone alpha-2 isoform X1 [KO:K25483]
118002364  GPHB5; glycoprotein hormone beta-5 [KO:K25484]
118000530  TSHB; thyrotropin subunit beta [KO:K05251]
118007404  POMC; pro-opiomelanocortin [KO:K05228]
118011814  GCG; glucagon isoform X1 [KO:K05259]
118025138  GIP; gastric inhibitory polypeptide [KO:K05258]
118015554  follitropin subunit beta [KO:K05250]
118020338  NPPA; natriuretic peptides A [KO:K12334]
118004551  ADCYAP1; pituitary adenylate cyclase-activating polypeptide [KO:K05262]
118026567  ADRB1; beta-1 adrenergic receptor [KO:K04141]
118006623  beta-2 adrenergic receptor [KO:K04142]
118006789  ADRB2; beta-2 adrenergic receptor [KO:K04142]
118015751  DRD1; D(1A) dopamine receptor [KO:K04144]
118010291  DRD5; D(1B) dopamine receptor [KO:K05840]
117999859  ADORA2A; adenosine receptor A2a [KO:K04266]
118006646  5-hydroxytryptamine receptor 4 [KO:K04160]
118006771  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
118020319  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
118002170  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
118020938  ADCYAP1R1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1 [KO:K04587]
118026748  VIPR2; vasoactive intestinal polypeptide receptor 2 isoform X1 [KO:K04590]
118027169  corticotropin-releasing factor receptor 1-like [KO:K04578]
118020932  CRHR2; corticotropin-releasing factor receptor 2 isoform X1 [KO:K04579]
118007465  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
118002568  TSHR; thyrotropin receptor isoform X1 [KO:K04249]
118016419  MC2R; adrenocorticotropic hormone receptor [KO:K04200]
118001213  GLP1R; glucagon-like peptide 1 receptor [KO:K04581]
117998158  GIPR; gastric inhibitory polypeptide receptor [KO:K04580]
118011557  GPR119; glucose-dependent insulinotropic receptor [KO:K08424]
118008145  FSHR; follicle-stimulating hormone receptor [KO:K04247]
118013821  NPR1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
118023087  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(s) subunit alpha-like [KO:K04632]
118024008  neuroendocrine secretory protein 55 [KO:K04632]
118024010  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
117997416  EDN1; endothelin-1 isoform X1 [KO:K16366]
118019612  EDN2; endothelin-2 [KO:K16367]
118024108  EDN3; endothelin-3 [KO:K05227]
118000435  SST; somatostatin [KO:K05237]
118021355  NPY; pro-neuropeptide Y [KO:K05232]
118005375  GHRL; appetite-regulating hormone [KO:K05254]
118011102  OXT; oxytocin-neurophysin 1 [KO:K05243]
118000717  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
118001269  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
118016831  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
118017343  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
118020304  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
118015629  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
118021391  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
118013064  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
118017906  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
117999714  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 isoform X1 [KO:K04615]
118014180  ADORA1; adenosine receptor A1 isoform X1 [KO:K04265]
118022264  EDNRA; endothelin-1 receptor [KO:K04197]
118022191  NPY1R; neuropeptide Y receptor type 1 isoform X1 [KO:K04204]
118002318  SSTR1; somatostatin receptor type 1 [KO:K04217]
118024319  SSTR2; somatostatin receptor type 2 [KO:K04218]
118021918  SSTR5; somatostatin receptor type 5 [KO:K04221]
118018415  HCAR1; hydroxycarboxylic acid receptor 1 [KO:K08401]
118018418  HCAR2; hydroxycarboxylic acid receptor 2 [KO:K08402]
118022847  FFAR2; free fatty acid receptor 2 [KO:K04328]
118022848  free fatty acid receptor 2-like [KO:K04328]
118005295  SUCNR1; succinate receptor 1 [KO:K10042]
118019274  PTGER3; LOW QUALITY PROTEIN: prostaglandin E2 receptor EP3 subtype [KO:K04260]
118004880  OXTR; oxytocin receptor [KO:K04229]
118000292  GHSR; growth hormone secretagogue receptor type 1 [KO:K04284]
118019030  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
118005775  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
118020679  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
118024512  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
118006264  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
118007652  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
118003693  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
118007016  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
118008901  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
118023800  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
118015219  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
118021775  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
118001457  adenylate cyclase type 10-like isoform X1 [KO:K11265] [EC:4.6.1.1]
118014524  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
118010889  CNGA1; cGMP-gated cation channel alpha-1 [KO:K04948]
118015102  CNGA2; cyclic nucleotide-gated olfactory channel [KO:K04949]
118008222  CNGA3; cyclic nucleotide-gated cation channel alpha-3 [KO:K04950]
118003875  CNGA4; cyclic nucleotide-gated cation channel alpha-4 [KO:K04951]
118023735  CNGB1; cyclic nucleotide-gated cation channel beta-1 [KO:K04952]
118014990  CNGB3; cyclic nucleotide-gated cation channel beta-3 [KO:K04953]
118008161  CALM2; calmodulin-2 [KO:K02183]
118016596  calmodulin-1-like [KO:K02183]
118002566  CALM1; calmodulin-1 [KO:K02183]
118003137  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
118012486  calmodulin-like [KO:K02183]
118019658  CALML6; calmodulin-like protein 6 [KO:K02183]
117998176  CALM3; calmodulin-3 [KO:K02183]
118020691  calmodulin-1-like [KO:K02183]
118021620  CALML3; calmodulin-like protein 3 [KO:K02183]
118021903  calmodulin-like [KO:K02183]
118024497  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
118027107  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
118006598  calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
118006728  calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
118021697  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
118017609  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
118001532  BVES; blood vessel epicardial substance [KO:K21108]
118007063  POPDC2; popeye domain-containing protein 2 isoform X1 [KO:K26206]
118001533  POPDC3; popeye domain-containing protein 3 [KO:K26207]
118014336  KCNK2; potassium channel subfamily K member 2 isoform X1 [KO:K04913]
118005864  HCN2; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 [KO:K04955]
118003022  HCN4; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [KO:K04957]
118009294  ABCC4; multidrug resistance-associated protein 4 [KO:K05673]
118008918  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
118012324  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
117998347  RRAS; ras-related protein R-Ras [KO:K07829]
118003961  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
117999965  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
118006301  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
118023942  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
118022776  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118010368  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
118026506  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
118010439  ras-related protein Rap-1A [KO:K04353]
118019003  RAP1A; ras-related protein Rap-1A [KO:K04353]
118008596  RAP1B; ras-related protein Rap-1b [KO:K07836]
118018814  TIAM1; LOW QUALITY PROTEIN: T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
118017539  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
118004859  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
118019063  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
118018155  LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
117999338  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
117998715  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
118024428  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
118004217  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
118016745  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
118005670  RHOA; transforming protein RhoA [KO:K04513]
118001767  afadin-like isoform X1 [KO:K05702]
118001899  afadin isoform X1 [KO:K05702]
118004424  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
118020028  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118006556  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
118016863  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118019468  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
118006042  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
118022658  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118002024  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118014553  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118021159  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
118005431  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
118003336  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
118004882  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
117999637  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
117999826  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
118005070  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
118019227  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
118025064  PPP1R1B; protein phosphatase 1 regulatory subunit 1B isoform X1 [KO:K15494]
118007723  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
118016125  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
118018468  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
118012101  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
118015807  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
118017967  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
118005189  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
118013832  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
118021134  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
118021299  CREB5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
117998639  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
118021774  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
118015716  BDNF; brain-derived neurotrophic factor [KO:K04355]
118002212  FOS; proto-oncogene c-Fos [KO:K04379]
118019356  JUN; transcription factor AP-1 [KO:K04448]
118024548  GLI3; transcriptional activator GLI3 isoform X1 [KO:K06230]
118008673  GLI1; zinc finger protein GLI1 [KO:K16797]
118023339  PTCH1; protein patched homolog 1 isoform X1 [KO:K06225]
118022283  HHIP; hedgehog-interacting protein isoform X1 [KO:K06231]
118002835  NF-kappa-B inhibitor alpha [KO:K04734]
118002880  NF-kappa-B inhibitor alpha [KO:K04734]
118027047  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
118016059  RELA; transcription factor p65 [KO:K04735]
118024322  SOX9; transcription factor SOX-9 [KO:K18435]
118005687  AMH; muellerian-inhibiting factor isoform X1 [KO:K04665]
117998558  PPARA; peroxisome proliferator-activated receptor alpha isoform X1 [KO:K07294]
118024250  ACOX1; peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
118010755  ACOX3; peroxisomal acyl-coenzyme A oxidase 3 isoform X1 [KO:K00232] [EC:1.3.3.6]
118004651  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
118016916  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
118016000  BAD; bcl2-associated agonist of cell death [KO:K02158]
117998053  LIPE; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
118004574  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
118007595  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
118008531  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
118011444  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
117997899  TNNI3; troponin I, cardiac muscle [KO:K12044]
118000615  PLN; cardiac phospholamban [KO:K05852]
118025163  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
118018451  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
117999657  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
118012943  RYR2; ryanodine receptor 2 [KO:K04962]
118018172  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
118021822  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
118025638  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
118024295  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
117997961  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
118017873  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
118005208  LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3B-like [KO:K05214]
118015797  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
118022427  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
118012530  GRIA3; glutamate receptor 3 [KO:K05199]
118013168  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
118020550  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
118000481  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 isoform X1 [KO:K01539] [EC:7.2.2.13]
117997950  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 [KO:K01539] [EC:7.2.2.13]
118013976  ATP1A2; sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
118013977  sodium/potassium-transporting ATPase subunit alpha-4 [KO:K01539] [EC:7.2.2.13]
118000178  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 isoform X1 [KO:K01540]
118003004  LOW QUALITY PROTEIN: sodium/potassium-transporting ATPase subunit beta-3-like [KO:K01540]
118004626  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
118012453  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
118014510  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
118013274  FXYD2; sodium/potassium-transporting ATPase subunit gamma isoform X1 [KO:K01538]
118022865  FXYD1; phospholemman [KO:K13360]
118019822  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
118018437  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
118014964  ATP2B3; plasma membrane calcium-transporting ATPase 3 [KO:K05850] [EC:7.2.2.10]
118005092  ATP2B2; plasma membrane calcium-transporting ATPase 2 [KO:K05850] [EC:7.2.2.10]
117998905  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
118014170  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
118025809  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
118006050  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
118008972  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
118014221  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
118025603  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
118004181  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
118016811  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
118018999  LOW QUALITY PROTEIN: cAMP-specific 3',5'-cyclic phosphodiesterase 4A-like [KO:K13293] [EC:3.1.4.53]
118004932  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
118005111  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
118019303  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
118001831  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
118001954  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
Compound
C00020  AMP
C00042  Succinate
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00186  (S)-Lactate
C00212  Adenosine
C00238  Potassium cation
C00288  HCO3-
C00334  4-Aminobutanoate
C00416  Phosphatidate
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00698  Cl-
C00780  Serotonin
C00788  L-Adrenaline
C01089  (R)-3-Hydroxybutanoate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C01330  Sodium cation
C01996  Acetylcholine
C03758  Dopamine
C20792  Oleoylethanolamide
C20793  3-Hydroxyoctanoate
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Related
pathway
mlx00071  Fatty acid degradation
mlx04015  Rap1 signaling pathway
mlx04020  Calcium signaling pathway
mlx04151  PI3K-Akt signaling pathway
mlx04210  Apoptosis
mlx04260  Cardiac muscle contraction
mlx04340  Hedgehog signaling pathway
mlx04720  Long-term potentiation
mlx04740  Olfactory transduction
mlx04972  Pancreatic secretion
mlx04976  Bile secretion
KO pathway
ko04024   
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