KEGG   PATHWAY: mun05415
Entry
mun05415                    Pathway                                
Name
Diabetic cardiomyopathy - Meriones unguiculatus (Mongolian gerbil)
Description
Diabetic cardiomyopathy has been defined as left ventricular dysfunction that occurs among patients with diabetes mellitus independent of a recognized cause such as coronary artery disease or hypertension. The pathogenesis of diabetic cardiomyopathy broadly involves hyperglycemia, increased circulating fatty acids, and insulin resistance contributing to reactive oxygen species (ROS) generation, mitochondrial dysfunction, impaired calcium metabolism, Renin-Angiotensin System (RAS) activation, and altered substrate metabolism. These effects result in cardiac fibrosis, hypertrophy, cardiomyocyte death, contractile dysfunction, endothelial cell damage and eventually heart failure. In the process of cardiac fibrosis, cardiac fibroblasts are the final effector cell.
Class
Human Diseases; Cardiovascular disease
Pathway map
mun05415  Diabetic cardiomyopathy
mun05415

Organism
Meriones unguiculatus (Mongolian gerbil) [GN:mun]
Gene
110547453  Slc2a1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
110555123  Slc2a4; solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
110563681  Gfpt1; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 [KO:K00820] [EC:2.6.1.16]
110557395  Gfpt2; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 [KO:K00820] [EC:2.6.1.16]
110565513  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
110546095  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X8 [KO:K04515] [EC:2.7.11.17]
110546686  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X3 [KO:K04515] [EC:2.7.11.17]
110551996  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X2 [KO:K04515] [EC:2.7.11.17]
110561052  Tnni3; troponin I, cardiac muscle isoform X1 [KO:K12044]
110564137  Ryr2; ryanodine receptor 2 [KO:K04962]
110557538  Pln; cardiac phospholamban [KO:K05852]
110559262  Atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
110545322  Atp2a2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
110547949  Atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
110552322  Sp1; transcription factor Sp1 isoform X1 [KO:K04684]
110555411  Agt; angiotensinogen isoform X3 [KO:K09821]
110546748  Ren; renin [KO:K01380] [EC:3.4.23.15]
110544703  mast cell protease 2 [KO:K01329] [EC:3.4.21.39]
110565884  mast cell protease 1 [KO:K01329] [EC:3.4.21.39]
110559612  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
110565392  Ager; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
110565013  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
110554210  Ncf1; neutrophil cytosol factor 1 [KO:K08011]
110545249  cytochrome b-245 light chain [KO:K08009]
110546192  Ncf2; neutrophil cytosol factor 2 [KO:K08010]
110548463  Ncf4; neutrophil cytosol factor 4 [KO:K08012]
110557417  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
110548466  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
110539373  type-1 angiotensin II receptor [KO:K04166]
110563019  Agtr1; type-1 angiotensin II receptor [KO:K04166]
110558602  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X2 [KO:K02580]
110549347  Rela; transcription factor p65 isoform X1 [KO:K04735]
110546562  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
110546585  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
110549680  Mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
110549673  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
110552285  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
110557386  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
110562875  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
110545189  Mmp2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
110549307  Mmp9; matrix metalloproteinase-9 isoform X1 [KO:K01403] [EC:3.4.24.35]
110549915  collagen alpha-1(I) chain-like [KO:K06236]
110556868  Col1a2; collagen alpha-2(I) chain [KO:K06236]
110551201  Col1a1; collagen alpha-1(I) chain [KO:K06236]
110555037  Col3a1; collagen alpha-1(III) chain [KO:K19720]
110561197  Tgfb1; transforming growth factor beta-1 proprotein [KO:K13375]
110549244  Tgfb2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376]
110558214  Tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
110564451  Cd36; platelet glycoprotein 4 [KO:K06259]
110545043  Ppara; peroxisome proliferator-activated receptor alpha isoform X2 [KO:K07294]
110549670  Cpt1b; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
110551207  Pdk2; pyruvate dehydrogenase kinase, isozyme 2 isoform X1 [KO:K00898] [EC:2.7.11.2]
110559643  Pdk4; pyruvate dehydrogenase kinase, isozyme 4 [KO:K00898] [EC:2.7.11.2]
110564184  Pdk3; pyruvate dehydrogenase kinase, isozyme 3 isoform X1 [KO:K00898] [EC:2.7.11.2]
110555335  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
110547587  Prkcd; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
110556442  Ptpa; serine/threonine-protein phosphatase 2A activator isoform X1 [KO:K17605]
110545313  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
110554524  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
110560352  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
110546566  Ctsd; cathepsin D [KO:K01379] [EC:3.4.23.5]
110559875  Prkcz; protein kinase C zeta type isoform X3 [KO:K18952] [EC:2.7.11.13]
110563903  Cpt2; carnitine O-palmitoyltransferase 2, mitochondrial [KO:K08766] [EC:2.3.1.21]
110547298  Ins; insulin [KO:K04526]
110547502  Irs1; insulin receptor substrate 1 isoform X1 [KO:K16172]
110565112  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110556252  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
110548394  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110553683  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110549145  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
110563512  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
110561175  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
110556719  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110558966  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110564898  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110548161  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
110555390  Gsk3b; glycogen synthase kinase-3 beta isoform X4 [KO:K03083] [EC:2.7.11.26]
110560640  Gys1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
110562176  Gys2; glycogen [starch] synthase, liver isoform X3 [KO:K00693] [EC:2.4.1.11]
110554366  Tbc1d4; TBC1 domain family member 4 isoform X6 [KO:K17902]
110544867  Mpc1l; mitochondrial pyruvate carrier 1-like protein [KO:K22138]
110564991  Mpc1; mitochondrial pyruvate carrier 1 [KO:K22138]
110545171  Mpc2; mitochondrial pyruvate carrier 2 [KO:K22139]
110540704  Pdha2; pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial [KO:K00161] [EC:1.2.4.1]
110540250  Pdha1; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial [KO:K00161] [EC:1.2.4.1]
110554623  Pdhb; pyruvate dehydrogenase E1 component subunit beta, mitochondrial [KO:K00162] [EC:1.2.4.1]
18129817  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
18129806  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
18129811  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
18129813  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
18129812  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
18129814  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
18129815  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
110547204  Ndufv1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
110544152  Ndufv2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1 [KO:K03943] [EC:7.1.1.2]
110554348  NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial-like [KO:K03944]
110553314  Ndufv3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X2 [KO:K03944]
110563820  Ndufa1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
110548267  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
110560771  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
110557374  Ndufa2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
110556000  Ndufa3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
110566751  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
132649951  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
110565792  Ndufa4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
110561559  Ndufa4l2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
110549558  Ndufa5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
110542118  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
110554107  Ndufa6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
110558125  Ndufa7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 isoform X1 [KO:K03951]
110541122  Ndufa8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
110545555  Ndufa9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
110545748  Ndufa10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
110550637  Ndufab1; acyl carrier protein, mitochondrial [KO:K03955]
110554838  acyl carrier protein, mitochondrial-like [KO:K03955]
110546256  Ndufa11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
110554924  Ndufa12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
110549185  Ndufa13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
110556444  Ndufb1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 isoform X1 [KO:K03957]
132646281  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
132646755  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
132652734  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
110545792  Ndufb2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
110557661  Ndufb3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
110565338  Ndufb4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
110556258  Ndufb5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
110561664  Ndufb6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
110545805  Ndufb7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
110556042  Ndufb8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
110552437  Ndufb9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
110553035  Ndufb10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
110539398  Ndufb11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
110555344  Ndufs1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
110554424  Ndufs2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X2 [KO:K03935] [EC:7.1.1.2]
110550736  Ndufs3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
110565491  Ndufs4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
110563867  Ndufs5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
110545374  Ndufs6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial isoform X1 [KO:K03939]
110559628  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
110551378  Ndufs7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X2 [KO:K03940] [EC:7.1.1.2]
110547122  Ndufs8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
110545137  Ndufc1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
110547304  Ndufc2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
110545371  Sdha; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
110542105  Sdhb; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
110565511  succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
110554447  Sdhc; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
110562010  Sdhd; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
110558163  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
18129816  CYTB; cytochrome b [KO:K00412]
110562123  cytochrome c1, heme protein, mitochondrial [KO:K00413]
110565565  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
110547840  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
110563073  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
110541587  cytochrome b-c1 complex subunit 7 isoform X1 [KO:K00417]
110566245  cytochrome b-c1 complex subunit 7-like [KO:K00417]
110548775  cytochrome b-c1 complex subunit 8 [KO:K00418]
110561759  cytochrome b-c1 complex subunit 8-like [KO:K00418]
110546118  cytochrome b-c1 complex subunit 9 [KO:K00419]
110551313  cytochrome b-c1 complex subunit 10 [KO:K00420]
132652984  cytochrome b-c1 complex subunit 10-like [KO:K00420]
18129810  COX3; cytochrome c oxidase subunit III [KO:K02262]
18129805  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
18129807  COX2; cytochrome c oxidase subunit II [KO:K02261]
110551144  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
110550097  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
110558544  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
110545438  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
110544616  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
110553739  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
110551006  cytochrome c oxidase subunit 6B1 [KO:K02267]
110561068  cytochrome c oxidase subunit 6B2 [KO:K02267]
110549789  cytochrome c oxidase subunit 6C-like [KO:K02268]
110563852  cytochrome c oxidase subunit 6C-2 isoform X2 [KO:K02268]
110551767  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
110555467  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
110562708  cytochrome c oxidase subunit 7A2, mitochondrial isoform X2 [KO:K02270]
110541909  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
110541746  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
110565114  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
132647959  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
110543482  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
110540133  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
110553885  cytochrome c oxidase subunit 8B, mitochondrial-like [KO:K02273]
110546301  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
110551609  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
110562020  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
110553531  Atp5f1a; ATP synthase subunit alpha, mitochondrial [KO:K02132]
110548986  Atp5f1b; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
110545613  Atp5f1c; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
110551379  Atp5f1d; ATP synthase subunit delta, mitochondrial [KO:K02134]
110556817  Atp5f1e; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
18129809  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
110562102  Atp5pb; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
110556580  Atp5mc3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
110553412  Atp5mc1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
110552332  Atp5mc2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
110539874  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
110559331  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
110547691  Atp5pd; ATP synthase subunit d, mitochondrial [KO:K02138]
110542169  Atp5po; ATP synthase subunit O, mitochondrial [KO:K02137]
110565199  Atp5pf; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
18129808  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
110549632  Vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
110548867  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
110556618  Vdac3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
110556812  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
110566446  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
110566972  Slc25a31; ADP/ATP translocase 4 [KO:K05863]
110565488  Ppif; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X2 [KO:K09565] [EC:5.2.1.8]
110556016  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
110562552  Nos3; nitric oxide synthase 3 isoform X1 [KO:K13242] [EC:1.14.13.39]
110548566  Gapdh; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
110550214  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
110556344  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
110559482  Parp1; poly [ADP-ribose] polymerase 1 isoform X1 [KO:K24070] [EC:2.4.2.30]
110562527  G6pd; glucose-6-phosphate 1-dehydrogenase [KO:K00036] [EC:1.1.1.49 1.1.1.363]
110548337  Gsr; glutathione reductase, mitochondrial [KO:K00383] [EC:1.8.1.7]
110551136  Tgfbr1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
110547249  Tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
110550301  Smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
110557887  Smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
110563159  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
110555720  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
110551595  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
110550598  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
110547034  angiotensin-converting enzyme-like protein Ace3 [KO:K01283] [EC:3.4.15.1]
110547055  angiotensin-converting enzyme isoform X1 [KO:K01283] [EC:3.4.15.1]
Compound
C00001  H2O
C00002  ATP
C00005  NADPH
C00006  NADP+
C00022  Pyruvate
C00024  Acetyl-CoA
C00027  Hydrogen peroxide
C00031  D-Glucose
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00051  Glutathione
C00076  Calcium cation
C00085  D-Fructose 6-phosphate
C00092  D-Glucose 6-phosphate
C00095  D-Fructose
C00118  D-Glyceraldehyde 3-phosphate
C00127  Glutathione disulfide
C00162  Fatty acid
C00165  Diacylglycerol
C00195  N-Acylsphingosine
C00236  3-Phospho-D-glyceroyl phosphate
C00318  L-Carnitine
C00352  D-Glucosamine 6-phosphate
C00369  Starch
C00533  Nitric oxide
C00546  Methylglyoxal
C00704  Superoxide
C00794  D-Sorbitol
C00873  Angiotensin I
C02135  Angiotensin II
C02843  Long-chain acyl-CoA
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06156  alpha-D-Glucosamine 1-phosphate
C16844  Hydroxyl radical
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
C22310  Fructose 3-phosphate
C22311  3-Deoxyglucosone
Reference
PMID:30443826
  Authors
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  Title
Of mice and men: models and mechanisms of diabetic cardiomyopathy.
  Journal
Basic Res Cardiol 114:2 (2018)
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Pharmacol Ther 142:375-415 (2014)
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Reference
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Lorenzo-Almoros A, Tunon J, Orejas M, Cortes M, Egido J, Lorenzo O
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Cardiovasc Diabetol 16:28 (2017)
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Reference
PMID:32080423
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Tan Y, Zhang Z, Zheng C, Wintergerst KA, Keller BB, Cai L
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Nat Rev Cardiol 17:585-607 (2020)
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Int J Mol Sci 20:E2833 (2019)
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Trends Pharmacol Sci 39:452-467 (2018)
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Diabetic Cardiomyopathy: An Immunometabolic Perspective.
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Front Endocrinol (Lausanne) 8:72 (2017)
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  Title
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  Authors
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  Title
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  Authors
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  Title
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  Authors
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  Title
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  Authors
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Reference
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  Authors
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  Journal
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Reference
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  Authors
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Related
pathway
mun00010  Glycolysis / Gluconeogenesis
mun00020  Citrate cycle (TCA cycle)
mun00190  Oxidative phosphorylation
mun00520  Amino sugar and nucleotide sugar metabolism
mun03320  PPAR signaling pathway
mun04071  Sphingolipid signaling pathway
mun04150  mTOR signaling pathway
mun04210  Apoptosis
mun04260  Cardiac muscle contraction
mun04350  TGF-beta signaling pathway
mun04614  Renin-angiotensin system
mun04910  Insulin signaling pathway
mun04930  Type II diabetes mellitus
mun04931  Insulin resistance
mun04933  AGE-RAGE signaling pathway in diabetic complications
mun04940  Type I diabetes mellitus
KO pathway
ko05415   
LinkDB

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