KEGG   PATHWAY: ocu04726
Entry
ocu04726                    Pathway                                
Name
Serotonergic synapse - Oryctolagus cuniculus (rabbit)
Description
Serotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endocrine secretion, as well as in pathological states including abnormal mood and cognition. Once released from presynaptic axonal terminals, 5-HT binds to receptors, which have been divided into 7 subfamilies on the basis of conserved structures and signaling mechanisms. These families include the ionotropic 5-HT3 receptors and G-protein-coupled 5-HT receptors, the 5-HT1 (Gi /Go -coupled), 5-HT2(Gq-coupled), 5-HT4/6/7 (Gs-coupled) and 5-HT5 receptors. Presynaptically localized 5-HT1B receptors are thought to be the autoreceptors that suppress excess 5-HT release. 5-HT's actions are terminated by transporter- mediated reuptake into neurons, leading to catabolism by monoamine oxidase.
Class
Organismal Systems; Nervous system
Pathway map
ocu04726  Serotonergic synapse
ocu04726

Other DBs
GO: 0007210
Organism
Oryctolagus cuniculus (rabbit) [GN:ocu]
Gene
100009100  TPH1; tryptophan 5-hydroxylase 1 [KO:K00502] [EC:1.14.16.4]
100344397  tryptophan 5-hydroxylase 2 isoform X1 [KO:K00502] [EC:1.14.16.4]
100355492  aromatic-L-amino-acid decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
100340936  chromaffin granule amine transporter [KO:K08155]
100351780  synaptic vesicular amine transporter [KO:K08155]
100101555  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
100327259  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
100357261  voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
100009585  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
100009461  5-hydroxytryptamine receptor 2A isoform X1 [KO:K04157]
100343392  5-hydroxytryptamine receptor 2B isoform X2 [KO:K04157]
100343600  5-hydroxytryptamine receptor 2C [KO:K04157]
100340719  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
100348672  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X4 [KO:K05858] [EC:3.1.4.11]
100350395  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
100341512  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2 [KO:K05858] [EC:3.1.4.11]
103347536  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100009505  inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
100356806  inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
100008939  inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
100037720  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100037719  PRKCB; protein kinase C beta type isoform I [KO:K19662] [EC:2.7.11.13]
100009102  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100347345  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100348561  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100533118  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
100340517  cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
100340775  cytosolic phospholipase A2 delta isoform X2 [KO:K16342] [EC:3.1.1.4]
100341033  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
100008748  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
100341237  cytosolic phospholipase A2 gamma isoform X1 [KO:K16342] [EC:3.1.1.4]
100328933  CYP2C; cytochrome P450 2C3 precursor [KO:K07413] [EC:1.14.14.1]
100328936  CYP2C14; cytochrome P450 2C14 precursor [KO:K07413] [EC:1.14.14.1]
100328938  CYP2C16; cytochrome P450 2C16 precursor [KO:K07413] [EC:1.14.14.1]
100328935  CYP2C30; cytochrome P450 2C30 precursor [KO:K07413] [EC:1.14.14.1]
100349436  CYP2C4; cytochrome P450 2C4 precursor [KO:K07413] [EC:1.14.14.1]
100328549  CYP2C5; cytochrome P450 2C5 precursor [KO:K07413] [EC:1.14.14.1]
100328924  CYP2C2; cytochrome P450 2C2 precursor [KO:K07413] [EC:1.14.14.1]
100345193  cytochrome P450 2C1 [KO:K07413] [EC:1.14.14.1]
100346743  CYP2C1; cytochrome P450 2C1 isoform X1 [KO:K07413] [EC:1.14.14.1]
103351405  cytochrome P450 2C23-like isoform X4 [KO:K07413] [EC:1.14.14.1]
100346305  cytochrome P450 2C1 [KO:K07413] [EC:1.14.14.1]
100353460  cytochrome P450 2C18 isoform X1 [KO:K07413] [EC:1.14.14.1]
100348527  cytochrome P450 2D17 isoform X2 [KO:K07414] [EC:1.14.14.1]
100316858  CYP2D24; cytochrome P450 2D/II [KO:K07414] [EC:1.14.14.1]
100301544  CYP2J1; cytochrome P450 2J1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
100338914  cytochrome P450 4X1 [KO:K07428] [EC:1.14.14.1]
100341714  polyunsaturated fatty acid 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
100340525  polyunsaturated fatty acid lipoxygenase ALOX12 [KO:K00458] [EC:1.13.11.31]
100342574  arachidonate 12-lipoxygenase, 12R-type isoform X1 [KO:K08021] [EC:1.13.11.-]
100009114  ALOX15; polyunsaturated fatty acid lipoxygenase ALOX15 [KO:K00460] [EC:1.13.11.33]
100342479  polyunsaturated fatty acid lipoxygenase ALOX15B isoform X1 [KO:K08022] [EC:1.13.11.33 1.13.11.-]
100009407  PTGS1; prostaglandin G/H synthase 1 precursor [KO:K00509] [EC:1.14.99.1]
100009248  PTGS2; prostaglandin G/H synthase 2 precursor [KO:K11987] [EC:1.14.99.1]
100009570  5-hydroxytryptamine receptor 3A [KO:K04819]
100008789  5-hydroxytryptamine receptor 3B isoform X2 [KO:K04819]
100350832  5-hydroxytryptamine receptor 3C-like [KO:K04819]
100358891  LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 3C-like [KO:K04819]
100338471  5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
100345437  5-hydroxytryptamine receptor 6 [KO:K04162]
100009356  5-hydroxytryptamine receptor 7 isoform X3 [KO:K04163]
100008904  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
100346323  neuroendocrine secretory protein 55 [KO:K04632]
100009315  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
100008815  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100342212  cAMP-dependent protein kinase catalytic subunit beta isoform X3 [KO:K04345] [EC:2.7.11.11]
100342605  small conductance calcium-activated potassium channel protein 2 isoform X1 [KO:K04943]
100008841  KCND2; potassium voltage-gated channel subfamily D member 2 precursor [KO:K04892]
100341200  gamma-aminobutyric acid receptor subunit beta-3 isoform X1 [KO:K05181]
100340127  gamma-aminobutyric acid receptor subunit beta-1 [KO:K05181]
100356357  gamma-aminobutyric acid receptor subunit beta-2 isoform X2 [KO:K05181]
100356363  rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
100009546  APP; amyloid-beta precursor protein precursor [KO:K04520]
100358620  5-hydroxytryptamine receptor 1E [KO:K04153]
100008780  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
100328964  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
100345520  5-hydroxytryptamine receptor 1F [KO:K04153]
100009594  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
100328888  HTR5BP; 5-hydroxytryptamine (serotonin) receptor 5B, pseudogene [KO:K04161]
100353538  5-hydroxytryptamine receptor 5A [KO:K04161]
100338391  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
100359147  guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
100339066  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
100342283  guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
100337783  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
127489280  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
100356799  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
100346625  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
100338332  guanine nucleotide-binding protein subunit beta-4 isoform X2 [KO:K04538]
100008941  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
100352954  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
100348350  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 isoform X2 [KO:K04540]
103350926  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
108178480  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
100355417  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
108177128  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
100342201  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
108176185  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
103350153  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
127489712  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
100342450  guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
108178552  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
100008840  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100340993  dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
127486605  GTPase HRas isoform X1 [KO:K02833]
100347487  GTPase KRas isoform X1 [KO:K07827]
127489236  GTPase KRas-like [KO:K07827]
100344241  GTPase NRas [KO:K07828]
100340437  serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
100351964  serine/threonine-protein kinase B-raf isoform X6 [KO:K04365] [EC:2.7.11.1]
100347407  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100009316  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
127489461  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
100009265  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
100008979  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
100009366  G protein-activated inward rectifier potassium channel 1 [KO:K04997]
100008865  G protein-activated inward rectifier potassium channel 2 [KO:K05000]
100345513  G protein-activated inward rectifier potassium channel 3 [KO:K05002]
100352473  G protein-activated inward rectifier potassium channel 4 [KO:K04999]
100009352  TRPC1; short transient receptor potential channel 1 [KO:K04964]
100340600  sodium-dependent serotonin transporter isoform X1 [KO:K05037]
100357007  amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
100345623  amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
Compound
C00076  Calcium cation
C00078  L-Tryptophan
C00165  Diacylglycerol
C00219  Arachidonate
C00238  Potassium cation
C00427  Prostaglandin H2
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00643  5-Hydroxy-L-tryptophan
C00696  Prostaglandin D2
C00780  Serotonin
C00909  Leukotriene A4
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C04822  8(R)-HPETE
C05356  5(S)-HPETE
C05635  5-Hydroxyindoleacetate
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14812  12(R)-HPETE
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14823  8(S)-HPETE
Reference
PMID:18676031
  Authors
Millan MJ, Marin P, Bockaert J, Mannoury la Cour C
  Title
Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions.
  Journal
Trends Pharmacol Sci 29:454-64 (2008)
DOI:10.1016/j.tips.2008.06.007
Reference
PMID:16896947
  Authors
Bockaert J, Claeysen S, Becamel C, Dumuis A, Marin P
  Title
Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation.
  Journal
Cell Tissue Res 326:553-72 (2006)
DOI:10.1007/s00441-006-0286-1
Reference
PMID:11916537
  Authors
Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN
  Title
Multiplicity of mechanisms of serotonin receptor signal transduction.
  Journal
Pharmacol Ther 92:179-212 (2001)
DOI:10.1016/S0163-7258(01)00169-3
Reference
PMID:15034221
  Authors
Noda M, Higashida H, Aoki S, Wada K
  Title
Multiple signal transduction pathways mediated by 5-HT receptors.
  Journal
Mol Neurobiol 29:31-9 (2004)
DOI:10.1385/MN:29:1:31
Reference
PMID:20561690
  Authors
Daubert EA, Condron BG
  Title
Serotonin: a regulator of neuronal morphology and circuitry.
  Journal
Trends Neurosci 33:424-34 (2010)
DOI:10.1016/j.tins.2010.05.005
Reference
PMID:16826372
  Authors
Chameau P, van Hooft JA
  Title
Serotonin 5-HT(3) receptors in the central nervous system.
  Journal
Cell Tissue Res 326:573-81 (2006)
DOI:10.1007/s00441-006-0255-8
Reference
PMID:9651340
  Authors
Tournois C, Mutel V, Manivet P, Launay JM, Kellermann O
  Title
Cross-talk between 5-hydroxytryptamine receptors in a serotonergic cell line. Involvement of arachidonic acid metabolism.
  Journal
J Biol Chem 273:17498-503 (1998)
DOI:10.1074/jbc.273.28.17498
Reference
PMID:19545642
  Authors
Iliff JJ, Jia J, Nelson J, Goyagi T, Klaus J, Alkayed NJ
  Title
Epoxyeicosanoid signaling in CNS function and disease.
  Journal
Prostaglandins Other Lipid Mediat 91:68-84 (2010)
DOI:10.1016/j.prostaglandins.2009.06.004
Reference
PMID:12676358
  Authors
Adayev T, Ray I, Sondhi R, Sobocki T, Banerjee P
  Title
The G protein-coupled 5-HT1A receptor causes suppression of caspase-3 through MAPK and protein kinase Calpha.
  Journal
Biochim Biophys Acta 1640:85-96 (2003)
DOI:10.1016/S0167-4889(03)00023-5
Reference
PMID:11701344
  Authors
Albert PR, Tiberi M
  Title
Receptor signaling and structure: insights from serotonin-1 receptors.
  Journal
Trends Endocrinol Metab 12:453-60 (2001)
DOI:10.1016/S1043-2760(01)00498-2
Reference
PMID:9658404
  Authors
Durham PL, Russo AF
  Title
Serotonergic repression of mitogen-activated protein kinase control of the calcitonin gene-related peptide enhancer.
  Journal
Mol Endocrinol 12:1002-9 (1998)
DOI:10.1210/mend.12.7.0135
Reference
PMID:15710402
  Authors
Robert S, Maillet M, Morel E, Launay JM, Fischmeister R, Mercken L, Lezoualc'h F
  Title
Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac.
  Journal
FEBS Lett 579:1136-42 (2005)
DOI:10.1016/j.febslet.2005.01.010
Reference
PMID:12543273
  Authors
Lezoualc'h F, Robert SJ
  Title
The serotonin 5-HT4 receptor and the amyloid precursor protein processing.
  Journal
Exp Gerontol 38:159-66 (2003)
DOI:10.1016/S0531-5565(02)00157-2
Reference
PMID:11043573
  Authors
Durham PL, Russo AF
  Title
Differential regulation of mitogen-activated protein kinase-responsive genes by the duration of a calcium signal.
  Journal
Mol Endocrinol 14:1570-82 (2000)
DOI:10.1210/mend.14.10.0529
Reference
PMID:9542727
  Authors
Hagberg GB, Blomstrand F, Nilsson M, Tamir H, Hansson E
  Title
Stimulation of 5-HT2A receptors on astrocytes in primary culture opens voltage-independent Ca2+ channels.
  Journal
Neurochem Int 32:153-62 (1998)
DOI:10.1016/S0197-0186(97)00087-9
Reference
  Authors
Nestler EJ, Hyman SE, Malenka RC.
  Title
Molecular neuropharmacology: A foundation for clinical neuroscience
  Journal
The McGraw-Hill Companies, Inc. (2001)
Related
pathway
ocu00380  Tryptophan metabolism
ocu00590  Arachidonic acid metabolism
ocu04020  Calcium signaling pathway
ocu04721  Synaptic vesicle cycle
ocu04976  Bile secretion
KO pathway
ko04726   
LinkDB

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