KEGG   PATHWAY: pee04060
Entry
pee04060                    Pathway                                
Name
Cytokine-cytokine receptor interaction - Phycodurus eques (leafy seadragon)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
pee04060  Cytokine-cytokine receptor interaction
pee04060

Organism
Phycodurus eques (leafy seadragon) [GN:pee]
Gene
133411848  ccl25a; C-C motif chemokine 25 [KO:K13072]
133405906  ccl25b; C-C motif chemokine 25b [KO:K13072]
133406500  ccl44; chemokine (C-C motif) ligand 44 [KO:K21083]
133400571  ccl27a; C-C motif chemokine 27a [KO:K05513]
133396249  ccl20b; C-C motif chemokine 20b [KO:K14625]
133403796  cxcl8a; interleukin-8 isoform X1 [KO:K10030]
133409486  C-X-C motif chemokine 11-like [KO:K05416]
133409680  cxcl12a; chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) [KO:K10031]
133403990  cxcl12b; chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) [KO:K10031]
133407788  cxcl14; C-X-C motif chemokine 14 [KO:K10033]
133405544  il15l; interleukin 15, like isoform X1 [KO:K05433]
133407677  il21; interleukin-21 [KO:K05434]
133397745  epoa; erythropoietin isoform X1 [KO:K05437]
133414361  gh1; somatotropin [KO:K05438]
133405015  smtla; somatolactin alpha [KO:K05438]
133415125  prl; prolactin [KO:K05439]
133397252  prl2; prolactin 2 [KO:K05439]
133395794  interleukin-6-like [KO:K05405]
133402086  il11a; uncharacterized protein il11a [KO:K05417]
133405317  il12a; interleukin-12 subunit alpha [KO:K05406]
133400601  il12b2; interleukin-12 subunit beta [KO:K05425]
133407780  il12ba; interleukin 12Ba isoform X1 [KO:K05425]
133416390  uncharacterized protein LOC133416390 [KO:K22629]
133413196  ebi3; interleukin-27 subunit beta [KO:K24476]
133408072  clcf1; uncharacterized protein clcf1 [KO:K05421]
133408596  il10; interleukin-10 [KO:K05443]
133408471  il19l; interleukin 19 like [KO:K22667]
133414847  ifnphi1; interferon phi 1 [KO:K05414]
133400081  il1b; interleukin-1 beta [KO:K04519]
133416924  il17a/f1; interleukin 17a/f1 isoform X1 [KO:K05494]
133417233  il17a/f3; interleukin 17a/f3 [KO:K05494]
133402991  il17c; interleukin-17C isoform X1 [KO:K05491]
133410414  il17d; interleukin-17D [KO:K05492]
133401250  si:dkey-92i15.4; uncharacterized protein si:dkey-92i15.4 isoform X1 [KO:K22628]
133399215  il16; pro-interleukin-16 isoform X1 [KO:K22628]
133402477  il34; interleukin-34 isoform X1 [KO:K22633]
133395629  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
133402142  tnfb; tumor necrosis factor b (TNF superfamily, member 2) [KO:K05468]
133414896  tnfsf14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
133404128  tumor necrosis factor ligand superfamily member 14-like [KO:K05477]
133406663  faslg; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
133408162  cd40lg; CD40 ligand isoform X1 [KO:K04389]
133408478  LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
133412819  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
133396336  tnfsf10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721]
133407766  eda; ectodysplasin-A [KO:K05480]
133409141  ngfb; nerve growth factor [KO:K02582]
133398716  ngfa; neurotrophin-7 [KO:K02582]
133397584  tnfsf12; tumor necrosis factor ligand superfamily member 12 [KO:K05474]
133410724  tnfsf13b; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
133405086  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
133401102  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
133407580  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
133417328  transforming growth factor beta-3 proprotein-like isoform X1 [KO:K13377]
133413080  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
133411952  growth/differentiation factor 8 [KO:K05504]
133418172  gdf2; LOW QUALITY PROTEIN: growth/differentiation factor 2 [KO:K22670]
133413999  bone morphogenetic protein 10-like [KO:K22670]
133399486  LOW QUALITY PROTEIN: bone morphogenetic protein 10-like [KO:K22670]
133404613  inha; LOW QUALITY PROTEIN: inhibin alpha chain [KO:K05500]
133400269  bmp3; bone morphogenetic protein 3 [KO:K05496]
133418043  gdf10b; growth/differentiation factor 10b [KO:K22674]
133409699  gdf10a; growth/differentiation factor 10 [KO:K22674]
133409199  growth/differentiation factor 11-like [KO:K22679]
133403213  growth/differentiation factor 8-like [KO:K05497]
133411072  mstnb; growth/differentiation factor 8 [KO:K05497]
133396544  inhbaa; inhibin subunit beta Aa [KO:K04667]
133411528  inhbab; inhibin subunit beta Ab isoform X1 [KO:K04667]
133406052  LOW QUALITY PROTEIN: inhibin beta B chain-like [KO:K22687]
133408662  inhibin beta B chain [KO:K22687]
133410841  inhbb; inhibin beta B chain [KO:K22687]
133410586  gdf3; protein DVR-1 [KO:K22672]
133417663  ndr2; nodal-related 2 [KO:K04666]
133414125  nodal homolog 2-A-like [KO:K04666]
133399536  spaw; southpaw [KO:K04666]
133407853  gdf9; growth/differentiation factor 9 [KO:K22673]
133406610  amh; muellerian-inhibiting factor [KO:K04665]
133395196  bone morphogenetic protein 2-like [KO:K21283]
133404985  bmp16; bone morphogenetic protein 16 [KO:K21283]
133411601  admp; anti-dorsalizing morphogenic protein [KO:K21283]
133417263  bmp2b; bone morphogenetic protein 2b [KO:K21283]
133412948  bmp4; bone morphogenetic protein 4 [KO:K04662]
133401991  gdf6a; growth/differentiation factor 6-A [KO:K20012]
133395773  gdf6b; growth/differentiation factor 6-B [KO:K20012]
133397956  bmp15; bone morphogenetic protein 15 [KO:K05498]
133409562  bmp5; bone morphogenetic protein 5 [KO:K04663]
133396379  bmp6; bone morphogenetic protein 6 [KO:K16620]
133408447  bone morphogenetic protein 7-like [KO:K16621]
133409302  bmp7b; bone morphogenetic protein 7b [KO:K16621]
133395852  bmp8a; bone morphogenetic protein 8A [KO:K16622]
133396647  ccr9b; C-C chemokine receptor type 9 [KO:K04184]
133396374  ackr4b; atypical chemokine receptor 4b [KO:K04186]
133404220  ccr7; C-C chemokine receptor type 7 isoform X1 [KO:K04182]
133401815  cabz01093075.1; C-C chemokine receptor type 5 [KO:K04179]
133402213  si:cabz01093077.1; C-C chemokine receptor type 8 isoform X1 [KO:K04179]
133396496  C-C chemokine receptor type 3-like [KO:K04179]
133411407  C-C chemokine receptor type 3-like isoform X1 [KO:K04179]
133411459  C-C chemokine receptor type 3-like isoform X1 [KO:K04179]
133402214  CX3C chemokine receptor 1-like [KO:K04180]
133412822  ccr6b; C-C chemokine receptor type 6 [KO:K04181]
133417619  C-X-C chemokine receptor type 1-like [KO:K05050]
133410587  C-X-C chemokine receptor type 2-like [KO:K05050]
133401372  C-X-C chemokine receptor type 3-like [KO:K04188]
133401373  cxcr3.2; C-X-C chemokine receptor type 3-2 [KO:K04188]
133402062  cxcr3.1; C-X-C chemokine receptor type 3.1 [KO:K04188]
133410506  C-X-C chemokine receptor type 4-like [KO:K04189]
133411479  C-X-C chemokine receptor type 4-like [KO:K04189]
133411011  ackr3a; atypical chemokine receptor 3a [KO:K04304]
133411932  chemokine XC receptor 1-like [KO:K04193]
133406622  xcr1a.1; chemokine (C motif) receptor 1a, duplicate 1 isoform X1 [KO:K04193]
133403744  uncharacterized protein LOC133403744 [KO:K05069]
133415463  il2rb; interleukin-2 receptor subunit beta [KO:K05069]
133415628  LOW QUALITY PROTEIN: cytokine receptor common subunit gamma-like [KO:K05070]
133410658  il7r; interleukin-7 receptor subunit alpha [KO:K05072]
133395238  interleukin-21 receptor [KO:K05075]
133401842  il21r.1; LOW QUALITY PROTEIN: interleukin 21 receptor, tandem duplicate 1 [KO:K05075]
133415451  csf2rb; cytokine receptor common subunit beta isoform X1 [KO:K04738]
133415780  il13ra2; interleukin-13 receptor subunit alpha-2 isoform X1 [KO:K05077]
133415436  epor; erythropoietin receptor isoform X1 [KO:K05079]
133413658  ghrb; growth hormone receptor b isoform X1 [KO:K05080]
133399914  ghra; growth hormone receptor a [KO:K05080]
133405911  prolactin receptor-like isoform X1 [KO:K05080]
133413917  prlra; prolactin receptor a isoform X1 [KO:K05081]
133406635  mpl; thrombopoietin receptor [KO:K05082]
133401293  csf3r; granulocyte colony-stimulating factor receptor [KO:K05061]
133406343  lepr; leptin receptor [KO:K05062]
133401251  il6r; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
133414047  il6st; interleukin-6 receptor subunit beta [KO:K05060]
133415278  il12rb2l; interleukin 12 receptor, beta 2a, like isoform X1 [KO:K05060]
133413372  il11ra; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056]
133405983  il12rb1; interleukin-12 receptor subunit beta-1 [KO:K05063]
133405987  il23r; LOW QUALITY PROTEIN: interleukin-23 receptor [KO:K05064]
133405988  il12rb2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064]
133417388  interleukin-6 receptor subunit beta-like isoform X1 [KO:K22630]
133413851  cntfr; ciliary neurotrophic factor receptor subunit alpha [KO:K05059]
133399938  lifra; LIF receptor subunit alpha a [KO:K05058]
133413654  leukemia inhibitory factor receptor-like isoform X1 [KO:K05058]
133405501  il10ra; interleukin-10 receptor subunit alpha [KO:K05134]
133411098  interferon alpha/beta receptor 1b-like isoform X1 [KO:K05135]
133402105  ifnlr1; interferon lambda receptor 1 [KO:K05136]
133416965  il20ra; interleukin-20 receptor subunit alpha [KO:K05136]
133411500  crfb16; cytokine receptor family member B16 [KO:K05137]
133409988  interferon gamma receptor 1-like [KO:K05132]
133404647  ifngr1; interferon gamma receptor 1 isoform X1 [KO:K05132]
133410457  interleukin-1 receptor type 1 isoform X1 [KO:K04386]
133405583  interleukin-1 receptor accessory protein-like isoform X1 [KO:K04723]
133410942  interleukin-1 receptor type 2 isoform X1 [KO:K04387]
133399300  interleukin-1 receptor-like 1 isoform X1 [KO:K05173]
133399302  LOW QUALITY PROTEIN: interleukin-18 receptor accessory protein-like [KO:K05174]
133403275  interleukin-17 receptor A isoform X1 [KO:K05164]
133396942  il17ra1a; interleukin 17 receptor A1a isoform X1 [KO:K05164]
133408912  il17rc; interleukin-17 receptor C isoform X1 [KO:K05166]
133399487  interleukin-17 receptor B isoform X1 [KO:K05165]
133400890  interleukin-17 receptor E isoform X1 [KO:K05168]
133402072  cd4-1; CD4-1 molecule isoform X1 [KO:K06454]
133407406  csf1ra; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
133415884  csf1rb; LOW QUALITY PROTEIN: macrophage colony-stimulating factor 1 receptor 2 [KO:K05090] [EC:2.7.10.1]
133401422  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
133408373  tnfrsf1b; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141]
133408539  tumor necrosis factor receptor superfamily member 14-like isoform X1 [KO:K05152]
133401798  tumor necrosis factor receptor superfamily member 6B-like isoform X1 [KO:K05143]
133409656  tumor necrosis factor receptor superfamily member 6-like isoform X1 [KO:K04390]
133400324  hdr; hematopoietic death receptor isoform X1 [KO:K04722]
133414193  tnfrsfa; tumor necrosis factor receptor superfamily, member a [KO:K04722]
133410597  edar; tumor necrosis factor receptor superfamily member EDAR isoform X1 [KO:K05162]
133418175  ngfrb; nerve growth factor receptor b [KO:K02583]
133401666  nradd; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
133415456  ngfra; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
133402203  tumor necrosis factor receptor superfamily member 11B-like isoform X1 [KO:K05148]
133396835  tnfrsf11a; tumor necrosis factor receptor superfamily member 11A isoform X1 [KO:K05147]
133417601  si:rp71-1c10.7; tumor necrosis factor receptor superfamily member 12A [KO:K05149]
133401427  cd27; CD27 antigen isoform X1 [KO:K05144]
133401424  tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
133413464  cd40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
133401878  tnfrsf9a; tumor necrosis factor receptor superfamily member 9a isoform X1 [KO:K05146]
133408564  si:ch73-361p23.3; tumor necrosis factor receptor superfamily member 21 isoform X1 [KO:K05142]
133417615  tumor necrosis factor receptor superfamily member 13B [KO:K05150]
133404736  tumor necrosis factor receptor superfamily member 19-like isoform X1 [KO:K05155]
133405353  relt; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 19L [KO:K05156]
133398027  RELT-like protein 1 [KO:K26541]
133396341  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
133395494  tgfbr2b; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
133410599  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
133402278  acvrl1; serine/threonine-protein kinase receptor R3 isoform X1 [KO:K13594] [EC:2.7.11.30]
133402741  activin receptor type-2A-like isoform X1 [KO:K04670] [EC:2.7.11.30]
133405945  bone morphogenetic protein receptor type-2-like isoform X1 [KO:K04671] [EC:2.7.11.30]
133411990  acvr2ba; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
133402252  acvr1ba; activin A receptor type 1Ba isoform X1 [KO:K13567] [EC:2.7.11.30]
133409145  activin receptor type-1B-like isoform X1 [KO:K13567] [EC:2.7.11.30]
133410473  activin receptor type-1C isoform X1 [KO:K13568] [EC:2.7.11.30]
133412366  acvr1l; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
133410350  activin receptor type-1-like [KO:K04675] [EC:2.7.11.30]
133409484  bone morphogenetic protein receptor type-1A-like isoform X1 [KO:K04673] [EC:2.7.11.30]
133400080  bone morphogenetic protein receptor type-1B-like isoform X1 [KO:K13578] [EC:2.7.11.30]
133413758  bmpr1bb; bone morphogenetic protein receptor, type IBb [KO:K13578] [EC:2.7.11.30]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   
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