KEGG   PATHWAY: rfq04714
Entry
rfq04714                    Pathway                                
Name
Thermogenesis - Rhinolophus ferrumequinum (greater horseshoe bat)
Description
Thermogenesis is essential for warm-blooded animals, ensuring normal cellular and physiological function under conditions of environmental challenge. Thermogenesis in brown and beige adipose tissue is mainly controlled by norepinephrine, which is released from sympathetic nervous system in response to cold or dietary stimuli. The mitochondrial uncoupling protein 1 (UCP1) is responsible for the process whereby chemical energy is converted into heat in these adipocytes. Activation of these adipocytes leads to an increase in calorie consumption and is expected to improve overweight conditions, providing a potential strategy for treating obesity and its related metabolic disorders.
Class
Organismal Systems; Environmental adaptation
Pathway map
rfq04714  Thermogenesis
rfq04714

Other DBs
GO: 1990845
Organism
Rhinolophus ferrumequinum (greater horseshoe bat) [GN:rfq]
Gene
117021619  ADRB3; beta-3 adrenergic receptor isoform X1 [KO:K04143]
117015708  neuroendocrine secretory protein 55 [KO:K04632]
117015705  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
117012305  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
117025090  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
117032856  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
117024169  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
117031053  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
117028303  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
117034378  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
117033942  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
117019474  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
117020442  adenylate cyclase type 10-like [KO:K11265] [EC:4.6.1.1]
117014353  ADCY10; LOW QUALITY PROTEIN: adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
117027001  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
117037860  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
117025697  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
117018063  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
117015251  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
117037901  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
117031331  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
117031476  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
117012438  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
117027275  PRDM16; histone-lysine N-methyltransferase PRDM16 isoform X1 [KO:K22410] [EC:2.1.1.367]
117011666  ZNF516; zinc finger protein 516 isoform X1 [KO:K22411]
117027824  KDM1A; lysine-specific histone demethylase 1A isoform X1 [KO:K11450] [EC:1.14.99.66]
117037978  UCP1; mitochondrial brown fat uncoupling protein 1 [KO:K08769]
117033059  KDM3A; lysine-specific demethylase 3A isoform X1 [KO:K15601] [EC:1.14.11.65]
117016630  KDM3B; lysine-specific demethylase 3B isoform X1 [KO:K15601] [EC:1.14.11.65]
117037532  SMARCA4; transcription activator BRG1 isoform X1 [KO:K11647] [EC:5.6.2.-]
117031772  SMARCA2; probable global transcription activator SNF2L2 isoform X1 [KO:K11647] [EC:5.6.2.-]
117017234  SMARCB1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 isoform X1 [KO:K11648]
117028493  SMARCC2; SWI/SNF complex subunit SMARCC2 isoform X1 [KO:K11649]
117036737  SMARCC1; SWI/SNF complex subunit SMARCC1 isoform X1 [KO:K11649]
117018105  SMARCD3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 isoform X1 [KO:K11650]
117013395  SMARCD2; LOW QUALITY PROTEIN: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 [KO:K11650]
117028208  SMARCD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 isoform X1 [KO:K11650]
117013138  SMARCE1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 isoform X1 [KO:K11651]
117013189  ACTG1; actin, cytoplasmic 2 [KO:K05692]
117016810  ACTB; actin, cytoplasmic 1 [KO:K05692]
117033760  ACTL6A; actin-like protein 6A isoform X1 [KO:K11340]
117024477  ACTL6B; actin-like protein 6B isoform X1 [KO:K11652]
117026650  ARID1A; AT-rich interactive domain-containing protein 1A isoform X1 [KO:K11653]
117016748  ARID1B; AT-rich interactive domain-containing protein 1B isoform X1 [KO:K11653]
117034686  DPF1; zinc finger protein neuro-d4 isoform X1 [KO:K22198]
117023742  DPF3; zinc finger protein DPF3 [KO:K22198]
117037017  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
117020789  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
117018399  dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
117013305  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
117020595  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
117029085  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
117029232  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
117016461  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
117022286  PPARGC1A; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
117025773  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
117037902  SIRT6; NAD-dependent protein deacetylase sirtuin-6 isoform X1 [KO:K11416] [EC:2.3.1.286]
117035017  FGF21; fibroblast growth factor 21 [KO:K22429]
117018945  PLIN1; perilipin-1 isoform X1 [KO:K08768]
117035485  LIPE; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
117029952  PNPLA2; patatin-like phospholipase domain-containing protein 2 [KO:K16816] [EC:3.1.1.3]
117011637  MGLL; monoglyceride lipase isoform X1 [KO:K01054] [EC:3.1.1.23]
117027298  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
117024471  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
117014859  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
117017198  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
117018236  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
117025890  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
117028054  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
117025801  GCG; glucagon isoform X1 [KO:K05259]
117026689  BMP8A; bone morphogenetic protein 8A isoform X1 [KO:K16622]
117026930  BMP8B; bone morphogenetic protein 8B [KO:K16622]
117019892  CNR1; cannabinoid receptor 1 [KO:K04277]
117027714  NPPA; natriuretic peptides A [KO:K12334]
117026754  NPPB; natriuretic peptides B [KO:K12335]
117015413  NPR1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
117035919  PRKG1; cGMP-dependent protein kinase 1 isoform X1 [KO:K07376] [EC:2.7.11.12]
117021894  PRKG2; cGMP-dependent protein kinase 2 isoform X1 [KO:K19477] [EC:2.7.11.12]
117022021  KLB; beta-klotho [KO:K22404]
117021283  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
117029008  FRS2; fibroblast growth factor receptor substrate 2 [KO:K12461]
117013296  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
117032869  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
117022939  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
117013636  GTPase HRas-like [KO:K02833]
117029835  HRAS; LOW QUALITY PROTEIN: GTPase HRas [KO:K02833]
117028978  KRAS; GTPase KRas isoform X1 [KO:K07827]
117014672  NRAS; GTPase NRas [KO:K07828]
117019062  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
117026980  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
117021692  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
117022043  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
117031806  TSC1; hamartin isoform X1 [KO:K07206]
117019487  TSC2; tuberin isoform X1 [KO:K07207]
117018188  RHEB; GTP-binding protein Rheb [KO:K07208]
117012918  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
117026614  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
117019556  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
117034482  AKT1S1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
117013759  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
117029822  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
117032305  RPS6; 40S ribosomal protein S6 [KO:K02991]
117025836  40S ribosomal protein S6-like [KO:K02991]
117021695  40S ribosomal protein S6-like [KO:K02991]
117030712  40S ribosomal protein S6-like [KO:K02991]
117030948  40S ribosomal protein S6-like [KO:K02991]
117017028  40S ribosomal protein S6-like [KO:K02991]
117025968  ACSL3; long-chain-fatty-acid--CoA ligase 3 [KO:K01897] [EC:6.2.1.3]
117021453  ACSL4; long-chain-fatty-acid--CoA ligase 4 isoform X1 [KO:K01897] [EC:6.2.1.3]
117021738  ACSL1; long-chain-fatty-acid--CoA ligase 1 isoform X1 [KO:K01897] [EC:6.2.1.3]
117035978  ACSL5; long-chain-fatty-acid--CoA ligase 5 isoform X1 [KO:K01897] [EC:6.2.1.3]
117016731  ACSL6; long-chain-fatty-acid--CoA ligase 6 isoform X1 [KO:K01897] [EC:6.2.1.3]
117025739  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
117014402  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
117030055  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
117025337  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
117026534  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
117025142  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
117037670  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
117030216  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
117031276  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
117011815  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
117037775  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
117020414  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
117013892  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
117016928  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
117012235  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
117034515  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
117017699  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
117032495  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
117032927  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
117012439  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
117019217  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
117033660  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
117012528  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
117034636  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
117020602  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
117028584  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
117021509  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
117022975  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
117038522  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
117018288  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
117026240  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
117026264  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
117013704  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
117029429  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
117037922  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
117032487  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
117029035  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial isoform X1 [KO:K03953]
117025900  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
117019356  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
117038340  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
117029275  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
117038310  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
117035392  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
117024244  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
117018092  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
117011836  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
117026237  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
117029978  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
117019679  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
117031556  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
117033783  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
117032446  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
117037957  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
117035923  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
117034135  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
117019764  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
117022177  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
117037559  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
117031012  NADH dehydrogenase [ubiquinone] 1 subunit C2 isoform X1 [KO:K03968]
117024102  NDUFAF1; complex I intermediate-associated protein 30, mitochondrial [KO:K18159]
117033962  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2-like [KO:K18160]
117024516  NDUFAF2; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 [KO:K18160]
117036824  NDUFAF3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 isoform X1 [KO:K09008]
117020865  NDUFAF4; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 [KO:K18161]
117015928  NDUFAF5; arginine-hydroxylase NDUFAF5, mitochondrial isoform X1 [KO:K18162] [EC:2.1.1.-]
117033582  NDUFAF6; NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 isoform X1 [KO:K18163]
117032933  NDUFAF7; protein arginine methyltransferase NDUFAF7, mitochondrial [KO:K18164]
117013495  NDUFAF8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8 [KO:K24726]
117024859  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
117011776  succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial-like [KO:K00235] [EC:1.3.5.1]
117026990  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
117032512  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236]
117014790  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
117031294  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
117034844  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
117033878  cytochrome c1, heme protein, mitochondrial [KO:K00413]
117037269  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
117019626  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
117026818  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
117033558  cytochrome b-c1 complex subunit 7 isoform X1 [KO:K00417]
117027358  cytochrome b-c1 complex subunit 7-like [KO:K00417]
117017112  LOW QUALITY PROTEIN: cytochrome b-c1 complex subunit 8 [KO:K00418]
117025581  cytochrome b-c1 complex subunit 9-like [KO:K00419]
117038111  cytochrome b-c1 complex subunit 9-like [KO:K00419]
117017273  cytochrome b-c1 complex subunit 9 [KO:K00419]
117037575  cytochrome b-c1 complex subunit 10 [KO:K00420]
117034638  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
117016057  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
117020379  cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
117023549  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
117019269  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
117021499  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
117019821  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
117014513  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
117017226  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
117025940  cytochrome c oxidase subunit 6B1-like [KO:K02267]
117034994  cytochrome c oxidase subunit 6B1 [KO:K02267]
117035277  cytochrome c oxidase subunit 6B2 [KO:K02267]
117030151  cytochrome c oxidase subunit 6B1-like [KO:K02267]
117030283  cytochrome c oxidase subunit 6B1 [KO:K02267]
117018742  cytochrome c oxidase subunit 6C [KO:K02268]
117034035  cytochrome c oxidase subunit 6C [KO:K02268]
117027440  cytochrome c oxidase subunit 6C-like [KO:K02268]
117022352  cytochrome c oxidase subunit 6C [KO:K02268]
117029880  cytochrome c oxidase subunit 6C [KO:K02268]
117016215  cytochrome c oxidase subunit 6C-like [KO:K02268]
117033425  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
117020750  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
117034995  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
117013867  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
117025637  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
117034361  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
117022452  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
117017505  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
117025294  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
117027340  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
117034022  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
117020688  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
117037164  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
117017295  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
117023071  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
117030626  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
117013489  protoheme IX farnesyltransferase, mitochondrial isoform X1 [KO:K02257] [EC:2.5.1.141]
117013015  cytochrome c oxidase assembly protein COX11, mitochondrial [KO:K02258]
117028211  cytochrome c oxidase assembly protein COX14 [KO:K18181]
117036017  cytochrome c oxidase assembly protein COX15 homolog [KO:K02259] [EC:1.17.99.9]
117023083  cytochrome c oxidase assembly protein COX16 homolog, mitochondrial [KO:K18182]
117012836  cytochrome c oxidase copper chaperone [KO:K02260]
117037154  cytochrome c oxidase copper chaperone-like [KO:K02260]
117022475  cytochrome c oxidase assembly protein COX18, mitochondrial isoform X1 [KO:K17797]
117016807  cytochrome c oxidase assembly protein COX19 [KO:K18183]
117018589  cytochrome c oxidase assembly protein COX20, mitochondrial [KO:K18184]
117021729  cytochrome c oxidase assembly protein COX20, mitochondrial-like [KO:K18184]
117012360  cytochrome c oxidase assembly factor 1 homolog [KO:K18173]
117013732  cytochrome c oxidase assembly factor 3 homolog, mitochondrial [KO:K18175]
117030989  cytochrome c oxidase assembly factor 4 homolog, mitochondrial [KO:K18177]
117033461  cytochrome c oxidase assembly factor 5 [KO:K18178]
117018526  cytochrome c oxidase assembly factor 6 homolog [KO:K18179]
117027842  cytochrome c oxidase assembly factor 7 [KO:K18180]
117011871  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
117020068  LOW QUALITY PROTEIN: ATP synthase subunit alpha, mitochondrial-like [KO:K02132]
117029084  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
117011791  LOW QUALITY PROTEIN: ATP synthase subunit gamma, mitochondrial-like [KO:K02136]
117019150  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
117038065  ATP5F1D; ATP synthase subunit delta, mitochondrial isoform X1 [KO:K02134]
117015787  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
117019165  LOW QUALITY PROTEIN: ATP synthase subunit O, mitochondrial-like [KO:K02137]
117028724  ATP synthase subunit O, mitochondrial-like [KO:K02137]
117038469  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
117031868  LOW QUALITY PROTEIN: ATP synthase subunit O, mitochondrial-like [KO:K02137]
117014298  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
117026293  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
117033685  ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
117012683  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
117029333  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
117030064  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
117024956  ATP synthase F(0) complex subunit C3, mitochondrial-like [KO:K02128]
117033824  ATP synthase subunit d, mitochondrial-like [KO:K02138]
117012942  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
117019935  ATP synthase subunit d, mitochondrial-like [KO:K02138]
117021891  ATP5ME; ATP synthase subunit e, mitochondrial [KO:K02129]
117033434  ATP synthase subunit f, mitochondrial-like isoform X1 [KO:K02130]
117035969  ATP synthase subunit f, mitochondrial-like [KO:K02130]
117016477  ATP synthase subunit f, mitochondrial-like [KO:K02130]
117024559  ATP5MF; ATP synthase subunit f, mitochondrial [KO:K02130]
117035623  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
117018339  ATP synthase subunit g, mitochondrial-like [KO:K02140]
117018343  ATP synthase subunit g, mitochondrial-like [KO:K02140]
117033383  ATP synthase subunit g, mitochondrial-like [KO:K02140]
117028248  ATP synthase subunit g, mitochondrial-like [KO:K02140]
117029903  ATP5MG; ATP synthase subunit g, mitochondrial [KO:K02140]
117026851  CPT2; carnitine O-palmitoyltransferase 2, mitochondrial isoform X1 [KO:K08766] [EC:2.3.1.21]
117036819  SLC25A20; mitochondrial carnitine/acylcarnitine carrier protein [KO:K15109]
117023513  SLC25A29; mitochondrial basic amino acids transporter [KO:K15109]
117030155  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
117028688  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
117034814  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform [KO:K19524] [EC:2.3.1.21]
Compound
C00002  ATP
C00004  NADH
C00008  ADP
C00010  CoA
C00024  Acetyl-CoA
C00040  Acyl-CoA
C00080  H+
C00116  Glycerol
C00162  Fatty acid
C00165  Diacylglycerol
C00318  L-Carnitine
C00422  Triacylglycerol
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00745  Nicotine
C00942  3',5'-Cyclic GMP
C00951  Estradiol-17beta
C01352  FADH2
C01885  1-Acylglycerol
C02301  O-Acylcarnitine
C02465  Triiodothyronine
C11695  Anandamide
C13856  2-Arachidonoylglycerol
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Nat Rev Mol Cell Biol 17:480-95 (2016)
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Nat Med 19:1252-63 (2013)
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Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity.
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Nat Commun 7:11158 (2016)
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JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.
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Nat Commun 6:7052 (2015)
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Cell Rep 15:2536-49 (2016)
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Cell Rep 17:29-36 (2016)
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Nat Rev Cardiol 11:403-12 (2014)
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Reference
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The mitochondrial carnitine/acylcarnitine carrier: function, structure and physiopathology.
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Mol Aspects Med 32:223-33 (2011)
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Reference
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Nat Rev Endocrinol 11:617-25 (2015)
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Reference
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Chronic high-fat feeding impairs adaptive induction of mitochondrial fatty acid combustion-associated proteins in brown adipose tissue of mice.
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Related
pathway
rfq00020  Citrate cycle (TCA cycle)
rfq00190  Oxidative phosphorylation
rfq04010  MAPK signaling pathway
rfq04022  cGMP-PKG signaling pathway
rfq04024  cAMP signaling pathway
rfq04150  mTOR signaling pathway
rfq04923  Regulation of lipolysis in adipocytes
KO pathway
ko04714   
LinkDB

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