Entry Name Complement and coagulation cascades - Rattus norvegicus (rat)
Description The complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation: the classical pathway, the lectin pathway, and the alternative pathway. All of these pathways generate a crucial enzymatic activity that, in turn, generates the effector molecules of complement. The main consequences of complement activation are the opsonization of pathogens, the recruitment of inflammatory and immunocompetent cells, and the direct killing of pathogens. Blood coagulation is another series of proenzyme-to-serine protease conversions, culminating the formation of thrombin, the enzyme responsible for the conversion of soluble fibrinogen to the insoluble fibrin clot. Protease-activated receptors, such as those activated by thrombin, are members of G protein-coupled receptors and function as a mediator of innate immunity. The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). Kinin peptides are implicated in many physiological and pathological processes including the regulation of blood pressure and sodium homeostasis, inflammatory processes, and the cardioprotective effects of preconditioning.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map rno04610 Complement and coagulation cascades
Organism Rattus norvegicus (rat) [GN:
rno ]
Gene 102554977 Cfhr1-ps1; LOW QUALITY PROTEIN: complement factor H-related protein 1-like [KO:K23815 ]
113959 C5ar1; C5a anaphylatoxin chemotactic receptor 1 [KO:K04010 ]
24235 C4bpa; C4b-binding protein alpha chain [KO:K04002 ]
24236 C4bpb; C4b-binding protein beta chain precursor [KO:K04003 ]
24237 C6; complement component C6 precursor [KO:K03995 ]
24367 Fgg; fibrinogen gamma chain precursor [KO:K03905 ]
24548 Mbl1; mannose-binding protein A precursor [KO:K03991 ]
24617 Serpine1; plasminogen activator inhibitor 1 precursor [KO:K03982 ]
24648 Serpina1; alpha-1-antiproteinase precursor [KO:K03984 ]
25087 Kng2l1; kininogen-1 isoform 1 precursor [KO:K03898 ]
25245 Bdkrb2; B2 bradykinin receptor isoform 2 [KO:K03916 ]
25439 F2r; proteinase-activated receptor 1 precursor [KO:K03914 ]
289055 F13b; coagulation factor XIII B chain precursor [KO:K03906 ]
289057 Cfhr1; complement factor H-related protein 1 precursor [KO:K23815 ]
289395 Cr2; complement receptor type 2 precursor [KO:K04012 ]
29333 Cd46; membrane cofactor protein precursor [KO:K04007 ]
29366 Serpine2; glia-derived nexin precursor [KO:K16643 ]
29436 Tfpi; tissue factor pathway inhibitor isoform 1 precursor [KO:K03909 ]
295703 Serping1; plasma protease C1 inhibitor precursor [KO:K04001 ]
29636 F2rl2; proteinase-activated receptor 3 precursor [KO:K04235 ]
296545 C8g; complement component C8 gamma chain isoform 1 precursor [KO:K03999 ]
29687 C1qb; complement C1q subcomponent subunit B precursor [KO:K03987 ]
298288 C8a; complement component C8 alpha chain precursor [KO:K03997 ]
298566 C1qa; complement C1q subcomponent subunit A precursor [KO:K03986 ]
312102 Vsig4; V-set and immunoglobulin domain-containing protein 4 precursor [KO:K19822 ]
313421 C8b; complement component C8 beta chain precursor [KO:K03998 ]
361969 Fga; fibrinogen alpha chain isoform 1 precursor [KO:K03903 ]
362248 Procr; endothelial protein C receptor precursor [KO:K06557 ]
362634 C1qc; complement C1q subcomponent subunit C precursor [KO:K03988 ]
406161 C4b; complement component 4, gene 2 precursor [KO:K03989 ]
50692 Plaur; urokinase plasminogen activator surface receptor precursor [KO:K03985 ]
54243 Cr1l; complement component receptor 1-like protein isoform 2 precursor [KO:K04011 ]
60325 Serpinb2; plasminogen activator inhibitor 2 type A [KO:K19821 ]
64023 Masp1; mannan-binding lectin serine protease 1 precursor [KO:K03992 ] [EC:3.4.21.-]
64036 Cd55; complement decay-accelerating factor precursor [KO:K04006 ]
64668 Mbl2; mannose-binding protein C precursor [KO:K03991 ]
65051 Serpina5; plasma serine protease inhibitor isoform 1 [KO:K03913 ]
688887 Cfhr2; complement factor H-related 2 precursor [KO:K23816 ]
79224 Serpind1; heparin cofactor 2 precursor [KO:K03912 ]
81750 Pros1; vitamin K-dependent protein S precursor [KO:K03908 ]
84007 C3ar1; C3a anaphylatoxin chemotactic receptor [KO:K04009 ]
Compound C03378 Coagulation factor VIIa
C03379 Coagulation factor XIIa
C04001 Coagulation factor VIIIa
C22531 Complement component 2a
C22532 Complement component 2b
C22533 Complement component 3b
C22534 Complement component 3f
C22536 Complement component 3dg
C22537 Complement component 3c
C22538 Complement component 3d
C22541 Complement component 4a
C22542 Complement component 4b
C22543 Complement component 4c
C22544 Complement component 4d
C22545 Complement component 5b
C22546 Coagulation factor XIIIa
Reference Authors Bajic G, Degn SE, Thiel S, Andersen GR
Title Complement activation, regulation, and molecular basis for complement-related diseases.
Journal Reference Authors Mathern DR, Heeger PS
Title Molecules Great and Small: The Complement System.
Journal Reference Authors Merle NS, Church SE, Fremeaux-Bacchi V, Roumenina LT
Title Complement System Part I - Molecular Mechanisms of Activation and Regulation.
Journal Reference Authors Oikonomopoulou K, Ricklin D, Ward PA, Lambris JD
Title Interactions between coagulation and complement--their role in inflammation.
Journal Reference Authors Kurosawa S, Stearns-Kurosawa DJ
Title Complement, thrombotic microangiopathy and disseminated intravascular coagulation.
Journal Reference Authors Hillmeister P, Persson PB
Title The Kallikrein-Kinin system.
Journal Reference Authors Rau JC, Beaulieu LM, Huntington JA, Church FC
Title Serpins in thrombosis, hemostasis and fibrinolysis.
Journal Reference Authors Crooks MG, Hart SP
Title Coagulation and anticoagulation in idiopathic pulmonary fibrosis.
Journal Reference Authors Christiaans SC, Wagener BM, Esmon CT, Pittet JF
Title Protein C and acute inflammation: a clinical and biological perspective.
Journal Reference Authors Alberelli MA, De Candia E
Title Functional role of protease activated receptors in vascular biology.
Journal Reference Authors Smith HW, Marshall CJ
Title Regulation of cell signalling by uPAR.
Journal Reference Authors Ricklin D, Lambris JD
Title Complement in immune and inflammatory disorders: pathophysiological mechanisms.
Journal Reference Authors Ricklin D, Lambris JD
Title Complement in immune and inflammatory disorders: therapeutic interventions.
Journal Reference Authors Loof TG, Deicke C, Medina E
Title The role of coagulation/fibrinolysis during Streptococcus pyogenes infection.
Journal Reference Authors Jozsi M, Tortajada A, Uzonyi B, Goicoechea de Jorge E, Rodriguez de Cordoba S
Title Factor H-related proteins determine complement-activating surfaces.
Journal Related rno04662 B cell receptor signaling pathway
rno04750 Inflammatory mediator regulation of TRP channels
KO pathway
