KEGG   PATHWAY: scan04148
Entry
scan04148                   Pathway                                
Name
Efferocytosis - Serinus canaria (common canary)
Class
Cellular Processes; Transport and catabolism
Pathway map
scan04148  Efferocytosis
scan04148

Organism
Serinus canaria (common canary) [GN:scan]
Gene
103825669  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
103813818  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
103812509  PANX1; pannexin-1 [KO:K03443]
103818396  P2RY2; P2Y purinoceptor 2 [KO:K04269]
103818395  P2RY6; P2Y purinoceptor 6 [KO:K04272]
103815253  P2RY12; P2Y purinoceptor 12 [KO:K04298]
103819871  SPHK1; LOW QUALITY PROTEIN: sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
103814856  S1PR1; sphingosine 1-phosphate receptor 1 [KO:K04288]
103813604  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 [KO:K16343] [EC:3.1.1.4]
103821238  ABCA1; phospholipid-transporting ATPase ABCA1 isoform X4 [KO:K05641]
103822044  ABCA7; phospholipid-transporting ATPase ABCA7 isoform X1 [KO:K05641]
103826860  GPR132; probable G-protein coupled receptor 132 [KO:K08426]
103820444  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 [KO:K06059] [EC:3.4.24.86]
103816174  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
108962145  CX3CL1; fractalkine [KO:K05508]
103812986  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
103818892  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X3 [KO:K17332]
103819427  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
103816639  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
103826360  HIF1A; hypoxia-inducible factor 1-alpha isoform X2 [KO:K08268]
103823947  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
103823830  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
103818074  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103818895  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
103816936  PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
103818959  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
103816073  MFGE8; lactadherin isoform X2 [KO:K17253]
103812656  GAS6; growth arrest-specific protein 6 [KO:K05464]
103819334  MERTK; tyrosine-protein kinase Mer isoform X1 [KO:K05117] [EC:2.7.10.1]
103813543  CD36; platelet glycoprotein 4 [KO:K06259]
103826589  THBS1; thrombospondin-1 [KO:K16857]
103816115  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103824555  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103814802  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
103826835  prostaglandin E2 receptor EP2 subtype [KO:K04259]
103821076  PTGER4; LOW QUALITY PROTEIN: prostaglandin E2 receptor EP4 subtype [KO:K04261]
103814492  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
103818170  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
103820058  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
103817304  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
103822722  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
103815714  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
103813998  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
103813699  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
103823281  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
103823282  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
103813488  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103822392  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
103813960  ALOX5; arachidonate 5-lipoxygenase isoform X1 [KO:K00461] [EC:1.13.11.34]
103819717  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103813832  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103826744  DUSP8; LOW QUALITY PROTEIN: dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103826241  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103824279  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103820424  ANO6; anoctamin-6 [KO:K19500]
103822082  ANO3; anoctamin-3 isoform X1 [KO:K19498]
103813633  ANO4; anoctamin-4 isoform X1 [KO:K19499]
103823623  ANO5; anoctamin-5 [KO:K19480]
103827048  ANO9; anoctamin-9 [KO:K19503]
103822028  BSG; basigin isoform X1 [KO:K06535]
103822570  XKR8; LOW QUALITY PROTEIN: XK-related protein 8 [KO:K26813]
103812795  XKR9; XK-related protein 9 [KO:K26814]
103818669  XKR7; LOW QUALITY PROTEIN: XK-related protein 7 [KO:K26811]
103816185  XKR4; LOW QUALITY PROTEIN: XK-related protein 4 [KO:K26811]
103821328  XKR6; LOW QUALITY PROTEIN: XK-related protein 6 [KO:K26811]
103827323  ATP8A2; phospholipid-transporting ATPase IB isoform X1 [KO:K14802] [EC:7.6.2.1]
103824959  ATP8A1; phospholipid-transporting ATPase IA isoform X1 [KO:K14802] [EC:7.6.2.1]
103816586  ATP11C; phospholipid-transporting ATPase IG isoform X1 [KO:K26934] [EC:7.6.2.1]
103815319  ATP11B; probable phospholipid-transporting ATPase IF isoform X2 [KO:K26934] [EC:7.6.2.1]
103812660  ATP11A; probable phospholipid-transporting ATPase IH isoform X3 [KO:K26934] [EC:7.6.2.1]
103819669  TMEM30A; cell cycle control protein 50A [KO:K26935]
103818426  PROS1; vitamin K-dependent protein S [KO:K03908]
103814560  ITGAV; integrin alpha-V [KO:K06487]
103821681  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
103814308  ITGB5; integrin beta-5 [KO:K06588]
103826657  TYRO3; tyrosine-protein kinase receptor TYRO3 isoform X1 [KO:K05116] [EC:2.7.10.1]
103816826  ADGRB1; adhesion G protein-coupled receptor B1 isoform X5 [KO:K04596]
103817332  LOW QUALITY PROTEIN: uncharacterized protein LOC103817332 [KO:K26936]
103817147  STAB1; stabilin-1 isoform X1 [KO:K19020]
103819713  STAB2; stabilin-2 isoform X1 [KO:K19013]
103814761  PTK2; focal adhesion kinase 1 isoform X15 [KO:K05725] [EC:2.7.10.2]
103816661  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
103818004  CRKL; crk-like protein [KO:K04438]
103820104  CRK; LOW QUALITY PROTEIN: adapter molecule crk [KO:K04438]
103821112  ELMO1; engulfment and cell motility protein 1 isoform X3 [KO:K12366]
103814094  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
103817879  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103822739  disintegrin and metalloproteinase domain-containing protein 9 [KO:K06834] [EC:3.4.24.-]
103814104  disintegrin and metalloproteinase domain-containing protein 9-like [KO:K06834] [EC:3.4.24.-]
108964214  ENHANCER OF AG-4 protein 2-like [KO:K08057]
103824164  C1QB; complement C1q subcomponent subunit B [KO:K03987]
103823228  MEGF10; multiple epidermal growth factor-like domains protein 10 [KO:K24068]
103816242  MEGF11; multiple epidermal growth factor-like domains protein 11 [KO:K24068]
103820273  SCARF1; scavenger receptor class F member 1 [KO:K24318]
103814555  GULP1; PTB domain-containing engulfment adapter protein 1 isoform X1 [KO:K23285]
103814582  RAB17; ras-related protein Rab-17 [KO:K07909]
103812923  RAB5A; ras-related protein Rab-5A [KO:K07887]
103821593  RAB5C; ras-related protein Rab-5C [KO:K07889]
103812373  TGFBRAP1; transforming growth factor-beta receptor-associated protein 1 [KO:K20177]
103815668  VPS8; vacuolar protein sorting-associated protein 8 homolog isoform X1 [KO:K20178]
103822772  VPS11; vacuolar protein sorting-associated protein 11 homolog isoform X1 [KO:K20179]
108963645  LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
115485316  VPS16; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
103826667  VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
103818313  VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182]
103818942  RAB14; ras-related protein Rab-14 [KO:K07881]
103826976  VPS39; vam6/Vps39-like protein isoform X1 [KO:K20183]
103823800  VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
103817017  RAB7A; ras-related protein Rab-7a [KO:K07897]
103822317  RAB7B; ras-related protein Rab-7b [KO:K07898]
103824348  SLC66A1; lysosomal amino acid transporter 1 homolog [KO:K23678]
103826599  ARG2; arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
103820519  ODC1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
103813932  CH25H; cholesterol 25-hydroxylase [KO:K10223] [EC:1.14.99.38]
103826694  NR1H3; oxysterols receptor LXR-alpha [KO:K08536]
103826733  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
103816798  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
103821200  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X2 [KO:K11411] [EC:2.3.1.286]
103823400  PBX1; LOW QUALITY PROTEIN: pre-B-cell leukemia transcription factor 1 [KO:K09355]
103822394  IL10; interleukin-10 [KO:K05443]
103813931  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
103814075  lipase member K-like [KO:K01052] [EC:3.1.1.13]
103813937  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
103814228  putative lysosomal acid lipase/cholesteryl ester hydrolase isoform X1 [KO:K01052] [EC:3.1.1.13]
103813935  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
103816813  PLA2G15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
103823288  PPARD; peroxisome proliferator-activated receptor delta isoform X2 [KO:K04504]
103820862  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
103823260  SLC16A1; monocarboxylate transporter 1 [KO:K08179]
103820550  SGK1; serine/threonine-protein kinase Sgk1 isoform X2 [KO:K13302] [EC:2.7.11.1]
103820724  CD47; leukocyte surface antigen CD47 isoform X1 [KO:K06266]
103818795  CD24; signal transducer CD24 [KO:K06469]
103819781  PECAM1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
108962468  LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type substrate 1-like [KO:K06551]
103818852  tyrosine-protein phosphatase non-receptor type substrate 1-like [KO:K06551]
103827163  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
103818137  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
scan00010  Glycolysis / Gluconeogenesis
scan04140  Autophagy - animal
scan04145  Phagosome
KO pathway
ko04148   
LinkDB

DBGET integrated database retrieval system