Entry Name Platelet activation - Suncus etruscus (white-toothed pygmy shrew)
Description Platelets play a key and beneficial role for primary hemostasis on the disruption of the integrity of vessel wall. Platelet adhesion and activation at sites of vascular wall injury is initiated by adhesion to adhesive macromolecules, such as collagen and von Willebrand factor (vWF), or by soluble platelet agonists, such as ADP, thrombin, and thromboxane A2. Different receptors are stimulated by various agonists, almost converging in increasing intracellular Ca2+ concentration that stimulate platelet shape change and granule secretion and ultimately induce the "inside-out" signaling process leading to activation of the ligand-binding function of integrin alpha IIb beta 3. Binding of alpha IIb beta 3 to its ligands, mainly fibrinogen, mediates platelet adhesion and aggregation and triggers "outside-in" signaling, resulting in platelet spreading, additional granule secretion, stabilization of platelet adhesion and aggregation, and clot retraction.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Suncus etruscus (white-toothed pygmy shrew) [GN:
setr ]
Gene 126018343 GNA13; guanine nucleotide-binding protein subunit alpha-13 isoform X1 [KO:K04639 ]
126023861 PPP1CB; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269 ] [EC:3.1.3.16 ]
126022461 PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270 ]
126000737 ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056 ]
125998103 ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958 ]
126022840 ITPR2; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959 ]
126003511 guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634 ]
126017277 PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
126018105 PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
126014516 APBB1IP; amyloid beta A4 precursor protein-binding family B member 1-interacting protein [KO:K17704 ]
126014071 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
126022872 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
125997317 GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630 ]
126013317 GNAS; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632 ]
126022256 PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289 ] [EC:2.7.1.153 ]
125998048 PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290 ]
125998107 PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290 ]
126024735 COL1A2; LOW QUALITY PROTEIN: collagen alpha-2(I) chain [KO:K06236 ]
126012035 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
126012036 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
126011501 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
126030200 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
126011086 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
126001552 PIK3R1; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Li Z, Delaney MK, O'Brien KA, Du X
Title Signaling during platelet adhesion and activation.
Journal Reference Authors Broos K, De Meyer SF, Feys HB, Vanhoorelbeke K, Deckmyn H
Title Blood platelet biochemistry.
Journal Reference Authors Jurk K, Kehrel BE
Title Platelets: physiology and biochemistry.
Journal Reference Authors Offermanns S
Title Activation of platelet function through G protein-coupled receptors.
Journal Reference Authors Varga-Szabo D, Pleines I, Nieswandt B
Title Cell adhesion mechanisms in platelets.
Journal Reference Authors Yin H, Liu J, Li Z, Berndt MC, Lowell CA, Du X
Title Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway.
Journal Reference Authors Bergmeier W, Stefanini L
Title Novel molecules in calcium signaling in platelets.
Journal Reference Authors Cifuni SM, Wagner DD, Bergmeier W
Title CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin alphaIIbbeta3 in platelets.
Journal Reference Authors Heemskerk JW, Mattheij NJ, Cosemans JM
Title Platelet-based coagulation: different populations, different functions.
Journal Reference Authors Rivera J, Lozano ML, Navarro-Nunez L, Vicente V
Title Platelet receptors and signaling in the dynamics of thrombus formation.
Journal Reference Authors Banno A, Ginsberg MH
Title Integrin activation.
Journal Reference Authors Angiolillo DJ, Ferreiro JL
Title Platelet adenosine diphosphate P2Y12 receptor antagonism: benefits and limitations of current treatment strategies and future directions.
Journal Reference Authors Joo SJ
Title Mechanisms of Platelet Activation and Integrin alphaIIbeta3.
Journal Reference Authors Harper MT, Poole AW
Title Diverse functions of protein kinase C isoforms in platelet activation and thrombus formation.
Journal Reference Authors Fitch-Tewfik JL, Flaumenhaft R
Title Platelet granule exocytosis: a comparison with chromaffin cells.
Journal Reference Authors Boylan B, Gao C, Rathore V, Gill JC, Newman DK, Newman PJ
Title Identification of FcgammaRIIa as the ITAM-bearing receptor mediating alphaIIbbeta3 outside-in integrin signaling in human platelets.
Journal Related setr04610 Complement and coagulation cascades
KO pathway LinkDB All DBs
