KEGG   PATHWAY: setr04015
Entry
setr04015                   Pathway                                
Name
Rap1 signaling pathway - Suncus etruscus (white-toothed pygmy shrew)
Description
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types.
Class
Environmental Information Processing; Signal transduction
Pathway map
setr04015  Rap1 signaling pathway
setr04015

Other DBs
GO: 0007264
Organism
Suncus etruscus (white-toothed pygmy shrew) [GN:setr]
Gene
125994821  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
125994825  [KO:K04393]
125994891  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
125996266  VEGFA; vascular endothelial growth factor A [KO:K05448]
125996324  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
125996366  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
125997104  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
125997233  MAGI3; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform X1 [KO:K06112]
125997278  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
125997317  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
125997353  NGF; beta-nerve growth factor [KO:K02582]
125997372  NRAS; GTPase NRas [KO:K07828]
125997373  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
125997407  VAV3; LOW QUALITY PROTEIN: guanine nucleotide exchange factor VAV3 [KO:K05730]
125998044  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
125998045  F2R; proteinase-activated receptor 1 [KO:K03914]
125998076  SKAP1; src kinase-associated phosphoprotein 1 [KO:K17699]
125998436  PRKD1; serine/threonine-protein kinase D1 isoform X1 [KO:K06070] [EC:2.7.11.13]
125998704  [KO:K04393]
125998737  VEGFD; vascular endothelial growth factor D [KO:K05449]
125999964  FYB1; LOW QUALITY PROTEIN: FYN-binding protein 1 [KO:K17698]
126000769  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
126001049  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
126001075  FGF10; fibroblast growth factor 10 [KO:K04358]
126001221  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
126001222  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
126001307  [KO:K02183]
126001552  PIK3R1; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
126001687  KRIT1; krev interaction trapped protein 1 [KO:K17705]
126001958  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
126003322  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
126003432  PDGFC; platelet-derived growth factor C [KO:K05450]
126003511  [KO:K04634]
126003621  CALM1; calmodulin-1 [KO:K02183]
126003645  EVL; LOW QUALITY PROTEIN: ena/VASP-like protein [KO:K23487]
126003833  FGF2; fibroblast growth factor 2 [KO:K18497]
126003878  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
126003959  SIPA1L1; signal-induced proliferation-associated 1-like protein 1 isoform X1 [KO:K17701]
126004091  PGF; placenta growth factor [KO:K16859]
126004527  TEK; LOW QUALITY PROTEIN: angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
126004546  RASSF5; ras association domain-containing protein 5 [KO:K08015]
126004843  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
126005937  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
126006273  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
126006370  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
126006376  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
126006381  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
126006387  [KO:K07836]
126006402  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
126006406  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
126006483  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
126006516  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
126006533  RAP1GAP; rap1 GTPase-activating protein 1 isoform X1 [KO:K17700]
126006634  FGF6; LOW QUALITY PROTEIN: fibroblast growth factor 6 [KO:K04358]
126006724  CNR1; cannabinoid receptor 1 [KO:K04277]
126006877  FGF20; fibroblast growth factor 20 [KO:K04358]
126006944  FGF23; fibroblast growth factor 23 [KO:K22428]
126006957  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
126007180  VEGFC; vascular endothelial growth factor C [KO:K05449]
126008206  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
126008496  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
126008648  TLN1; talin-1 isoform X1 [KO:K06271]
126008650  FARP2; LOW QUALITY PROTEIN: FERM, ARHGEF and pleckstrin domain-containing protein 2 [KO:K06082]
126008753  TLN2; talin-2 isoform X1 [KO:K06271]
126008878  RALB; ras-related protein Ral-B [KO:K07835]
126009160  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
126009330  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
126009505  ANGPT1; angiopoietin-1 [KO:K05465]
126009524  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
126009589  RAPGEF1; rap guanine nucleotide exchange factor 1 [KO:K06277]
126010754  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
126010846  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
126010949  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
126011086  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
126011308  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
126011501  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
126011898  LCP2; lymphocyte cytosolic protein 2 [KO:K07361]
126011901  FGF18; fibroblast growth factor 18 [KO:K04358]
126011955  RGS14; regulator of G-protein signaling 14 [KO:K17706]
126011975  PFN1; profilin-1 [KO:K05759]
126012000  PFN3; profilin-3 [KO:K05759]
126012016  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
126012035  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
126012036  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
126012178  MRAS; ras-related protein M-Ras [KO:K07831]
126013252  P2RY1; P2Y purinoceptor 1 [KO:K04270]
126013297  [KO:K02183]
126013298  [KO:K02183]
126013317  GNAS; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
126013337  [KO:K04632]
126013353  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
126013376  ENAH; protein enabled homolog isoform X1 [KO:K05746]
126013417  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
126013539  ACTG1; actin, cytoplasmic 2 [KO:K05692]
126013729  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
126013731  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
126013733  ADORA2B; adenosine receptor A2b [KO:K04267]
126013914  MAGI1; LOW QUALITY PROTEIN: membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]
126013943  ITGB1; integrin beta-1 [KO:K05719]
126013961  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
126014071  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
126014129  RHOA; LOW QUALITY PROTEIN: transforming protein RhoA [KO:K04513]
126014516  APBB1IP; amyloid beta A4 precursor protein-binding family B member 1-interacting protein [KO:K17704]
126015702  FGF9; fibroblast growth factor 9 [KO:K04358]
126015747  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
126015921  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
126015982  CALML4; calmodulin-like protein 4 [KO:K02183]
126016055  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
126016140  DRD2; D(2) dopamine receptor [KO:K04145]
126017276  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
126017277  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
126017297  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
126017330  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
126017359  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
126017462  ID1; DNA-binding protein inhibitor ID-1 [KO:K04680]
126017588  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
126017600  CTNND1; catenin delta-1 isoform X1 [KO:K05690]
126017939  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
126018054  SIPA1; signal-induced proliferation-associated protein 1 [KO:K08013]
126018105  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
126018196  NGFR; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 16 [KO:K02583]
126018299  [KO:K04393]
126018800  FGF19; fibroblast growth factor 19 [KO:K22603]
126018801  FGF3; fibroblast growth factor 3 [KO:K04358]
126019028  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
126019083  FGF4; fibroblast growth factor 4 [KO:K04358]
126019084  HRAS; GTPase HRas [KO:K02833]
126019098  INS; insulin [KO:K04526]
126019150  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
126020032  FGF7; fibroblast growth factor 7 [KO:K04358]
126020137  EFNA4; ephrin-A4 [KO:K05462]
126020216  ITGA2B; LOW QUALITY PROTEIN: integrin alpha-IIb [KO:K06476]
126020271  ITGB3; integrin beta-3 [KO:K06493]
126020327  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
126020426  RALA; ras-related protein Ral-A [KO:K07834]
126020759  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
126020762  EFNA1; ephrin-A1 [KO:K05462]
126020805  GRIN1; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 1 [KO:K05208]
126020938  CTNNB1; catenin beta-1 [KO:K02105]
126021156  CRK; LOW QUALITY PROTEIN: adapter molecule crk [KO:K04438]
126021814  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
126021897  RAP1B; ras-related protein Rap-1b [KO:K07836]
126021920  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
126022063  DOCK4; dedicator of cytokinesis protein 4 [KO:K17697]
126022240  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
126022310  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
126022424  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
126022668  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
126022758  RAPGEF3; rap guanine nucleotide exchange factor 3 [KO:K08014]
126022823  KRAS; GTPase KRas isoform X1 [KO:K07827]
126022872  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
126022954  KITLG; kit ligand [KO:K05461]
126023857  RASGRP3; LOW QUALITY PROTEIN: ras guanyl-releasing protein 3 [KO:K12362]
126023905  PRKD3; serine/threonine-protein kinase D3 [KO:K06070] [EC:2.7.11.13]
126023953  CALM2; calmodulin-2 [KO:K02183]
126024026  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
126024051  PFN4; profilin-4 [KO:K05759]
126024373  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
126024570  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
126024665  [KO:K04393]
126024707  AFDN; afadin isoform X1 [KO:K05702]
126024782  THBS1; thrombospondin-1 [KO:K16857]
126025567  PFN2; profilin-2 isoform X1 [KO:K05759]
126025574  RAPGEF5; rap guanine nucleotide exchange factor 5 [KO:K08019]
126025916  ITGB2; integrin beta-2 [KO:K06464]
126026136  TIAM1; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor TIAM1 [KO:K05731]
126026247  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
126027080  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
126027101  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
126027209  RRAS; ras-related protein R-Ras [KO:K07829]
126027347  CDH1; cadherin-1 [KO:K05689]
126027351  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
126027420  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
126027570  EGF; pro-epidermal growth factor [KO:K04357]
126027580  SIPA1L3; signal-induced proliferation-associated 1-like protein 3 [KO:K17703]
126027709  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
126027928  FGF1; fibroblast growth factor 1 [KO:K18496]
126027948  ARAP3; LOW QUALITY PROTEIN: arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 [KO:K12490]
126027978  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
126028133  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126028268  CALM3; calmodulin-3 [KO:K02183]
126028285  PRKD2; serine/threonine-protein kinase D2 [KO:K06070] [EC:2.7.11.13]
126028574  VASP; vasodilator-stimulated phosphoprotein [KO:K06274]
126028612  FGF21; fibroblast growth factor 21 [KO:K22429]
126028736  [KO:K04393]
126029540  LAT; linker for activation of T-cells family member 1 [KO:K07362]
126029639  EFNA2; ephrin-A2 [KO:K05462]
126029670  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
126029834  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
126029883  ITGAL; integrin alpha-L [KO:K05718]
126029893  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
126030190  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
126030200  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
126030216  F2RL3; proteinase-activated receptor 4 [KO:K04236]
126030444  ACTB; actin, cytoplasmic 1 [KO:K05692]
126030482  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
126030488  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
126030532  FGF22; fibroblast growth factor 22 [KO:K04358]
126030714  SIPA1L2; signal-induced proliferation-associated 1-like protein 2 isoform X1 [KO:K17702]
126030861  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
126030989  ITGAM; integrin alpha-M [KO:K06461]
126031127  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
126031136  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
126031280  [KO:K02183]
126032236  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
126032296  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
126032299  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
126032431  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
126032628  FGF5; fibroblast growth factor 5 [KO:K04358]
126033346  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126033630  ANGPT2; angiopoietin-2 [KO:K05466]
126033693  ADORA2A; adenosine receptor A2a [KO:K04266]
126033704  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
126033713  CRKL; crk-like protein [KO:K04438]
126033783  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:11331911
  Authors
Bos JL, de Rooij J, Reedquist KA
  Title
Rap1 signalling: adhering to new models.
  Journal
Nat Rev Mol Cell Biol 2:369-77 (2001)
DOI:10.1038/35073073
Reference
PMID:17383543
  Authors
Minato N, Kometani K, Hattori M
  Title
Regulation of immune responses and hematopoiesis by the Rap1 signal.
  Journal
Adv Immunol 93:229-64 (2007)
DOI:10.1016/S0065-2776(06)93006-5
Reference
PMID:15780587
  Authors
Bos JL
  Title
Linking Rap to cell adhesion.
  Journal
Curr Opin Cell Biol 17:123-8 (2005)
DOI:10.1016/j.ceb.2005.02.009
Reference
PMID:12508104
  Authors
Caron E
  Title
Cellular functions of the Rap1 GTP-binding protein: a pattern emerges.
  Journal
J Cell Sci 116:435-40 (2003)
DOI:10.1242/jcs.00238
Reference
PMID:10579920
  Authors
Zwartkruis FJ, Bos JL
  Title
Ras and Rap1: two highly related small GTPases with distinct function.
  Journal
Exp Cell Res 253:157-65 (1999)
DOI:10.1006/excr.1999.4695
Reference
PMID:14607972
  Authors
Hattori M, Minato N
  Title
Rap1 GTPase: functions, regulation, and malignancy.
  Journal
J Biochem 134:479-84 (2003)
DOI:10.1093/jb/mvg180
Reference
PMID:19159611
  Authors
Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL
  Title
Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1788:790-6 (2009)
DOI:10.1016/j.bbamem.2008.12.010
Reference
PMID:19615876
  Authors
Boettner B, Van Aelst L
  Title
Control of cell adhesion dynamics by Rap1 signaling.
  Journal
Curr Opin Cell Biol 21:684-93 (2009)
DOI:10.1016/j.ceb.2009.06.004
Reference
PMID:15803158
  Authors
Xia Z, Storm DR.
  Title
The role of calmodulin as a signal integrator for synaptic plasticity.
  Journal
Nat Rev Neurosci 6:267-76 (2005)
DOI:10.1038/nrn1647
Reference
PMID:17624948
  Authors
Mor A, Dustin ML, Philips MR
  Title
Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
  Journal
Immunol Rev 218:114-25 (2007)
DOI:10.1111/j.1600-065X.2007.00538.x
Reference
PMID:17624944
  Authors
Burbach BJ, Medeiros RB, Mueller KL, Shimizu Y
  Title
T-cell receptor signaling to integrins.
  Journal
Immunol Rev 218:65-81 (2007)
DOI:10.1111/j.1600-065X.2007.00527.x
Reference
PMID:12765839
  Authors
Stork PJ
  Title
Does Rap1 deserve a bad Rap?
  Journal
Trends Biochem Sci 28:267-75 (2003)
DOI:10.1016/S0968-0004(03)00087-2
Reference
PMID:12351703
  Authors
Banihashemi B, Albert PR
  Title
Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.
  Journal
Mol Endocrinol 16:2393-404 (2002)
DOI:10.1210/me.2001-0220
Reference
PMID:18363565
  Authors
Banno A, Ginsberg MH
  Title
Integrin activation.
  Journal
Biochem Soc Trans 36:229-34 (2008)
DOI:10.1042/BST0360229
Reference
PMID:19710505
  Authors
Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR
  Title
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
  Journal
Blood 114:4592-600 (2009)
DOI:10.1182/blood-2009-04-217042
Reference
PMID:21402149
  Authors
Breckler M, Berthouze M, Laurent AC, Crozatier B, Morel E, Lezoualc'h F
  Title
Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications.
  Journal
Cell Signal 23:1257-66 (2011)
DOI:10.1016/j.cellsig.2011.03.007
Related
pathway
setr04010  MAPK signaling pathway
setr04014  Ras signaling pathway
setr04020  Calcium signaling pathway
setr04151  PI3K-Akt signaling pathway
setr04510  Focal adhesion
setr04520  Adherens junction
setr04660  T cell receptor signaling pathway
setr04810  Regulation of actin cytoskeleton
KO pathway
ko04015   

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