KEGG   PATHWAY: tfd04144
Entry
tfd04144                    Pathway                                
Name
Endocytosis - Tachysurus fulvidraco (yellow catfish)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
tfd04144  Endocytosis
tfd04144

Other DBs
GO: 0006897
Organism
Tachysurus fulvidraco (yellow catfish) [GN:tfd]
Gene
113644542  arf6a; ADP-ribosylation factor 6a [KO:K07941]
113659357  arf6b; ADP-ribosylation factor 6b [KO:K07941]
113653085  pip5k1ba; phosphatidylinositol-4-phosphate 5-kinase, type I, beta a isoform X1 [KO:K00889] [EC:2.7.1.68]
113641338  pip5k1aa; phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a [KO:K00889] [EC:2.7.1.68]
113657864  pip5k1ca; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
113644452  pip5k1ab; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
113634299  pip5k1bb; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
113645246  pip5k1cb; phosphatidylinositol-4-phosphate 5-kinase, type I, gamma b isoform X1 [KO:K00889] [EC:2.7.1.68]
113637246  pip5kl1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1 [KO:K13712] [EC:2.7.1.68]
113655460  si:ch211-168k14.2; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
113641488  pld2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
113637715  phospholipase D1-like isoform X1 [KO:K01115] [EC:3.1.4.4]
113660358  pld1b; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
113636565  dnm1a; dynamin-1a isoform X1 [KO:K01528] [EC:3.6.5.5]
113662257  dynamin-3-like isoform X1 [KO:K01528] [EC:3.6.5.5]
113642250  dnm1b; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
113661948  dnm2a; dynamin-3 isoform X4 [KO:K23484] [EC:3.6.5.5]
113635351  clta; clathrin light chain A isoform X2 [KO:K04644]
113637445  cltb; clathrin light chain B isoform X1 [KO:K04645]
113658899  cltcb; clathrin, heavy chain b (Hc) isoform X1 [KO:K04646]
113646146  AP-2 complex subunit alpha-2 isoform X2 [KO:K11824]
113648528  ap2a1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
113663364  ap2b1; AP-2 complex subunit beta [KO:K11825]
113647121  ap2m1a; AP-2 complex subunit mu-A isoform X1 [KO:K11826]
113640508  ap2m1b; AP-2 complex subunit mu-B isoform X1 [KO:K11826]
113643592  ap2s1; AP-2 complex subunit sigma [KO:K11827]
113663386  ehd2a; EH domain-containing protein 2 [KO:K12469]
113660871  ehd2b; EH domain-containing protein 2b isoform X1 [KO:K12469]
113644833  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
113644505  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
113654227  tgfbr2l; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
113648975  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
113638398  zfyve16; zinc finger FYVE domain-containing protein 16 [KO:K04679]
113657819  zfyve9b; zinc finger FYVE domain-containing protein 9 [KO:K04679]
113651693  zfyve9a; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
113639291  smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
125145338  smad3a; mothers against decapentaplegic homolog 3a isoform X1 [KO:K23605]
113652352  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
113650136  tfr1a; transferrin receptor 1a [KO:K06503]
113650137  transferrin receptor protein 1-like [KO:K06503]
113660336  tfr1b; transferrin receptor 1b [KO:K06503]
113655514  egfra; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
113642582  pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
113655309  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
113639345  ephrin type-A receptor 4a-like [KO:K05093] [EC:2.7.10.1]
113645004  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
113662459  fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
113653192  igf1rb; insulin-like growth factor 1b receptor [KO:K05087] [EC:2.7.10.1]
113652381  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
113660469  cbl; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
113645586  cblb; E3 ubiquitin-protein ligase CBL-B [KO:K22517] [EC:2.3.2.27]
113644461  cblc; E3 ubiquitin-protein ligase CBL-C isoform X1 [KO:K22518] [EC:2.3.2.27]
113660345  sh3kbp1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
113647397  sh3gl1b; SH3-domain GRB2-like 1b isoform X1 [KO:K11247]
113652697  sh3gl3a; endophilin-A3a [KO:K11247]
113636106  sh3gl3b; endophilin-A3b [KO:K11247]
113636949  sh3gl1a; SH3-domain GRB2-like 1a [KO:K11247]
125140070  endophilin-A1-like [KO:K11247]
113653061  LOW QUALITY PROTEIN: endophilin-A1-like [KO:K11247]
113634099  sh3gl2a; SH3 domain containing GRB2 like 2a, endophilin A1 [KO:K11247]
113647510  sh3glb1a; endophilin-B1a [KO:K11248]
113638496  sh3glb1b; endophilin-B1b isoform X3 [KO:K11248]
113637244  sh3glb2b; endophilin-B2b isoform X1 [KO:K21269]
113654124  myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
113657342  amph; amphiphysin isoform X1 [KO:K12562]
113642687  bin1b; myc box-dependent-interacting protein 1b [KO:K12562]
113652905  epn3a; epsin-3 isoform X1 [KO:K12471]
113636353  epn3b; epsin-3 isoform X1 [KO:K12471]
113641352  epn1b; epsin-1 [KO:K12471]
113643020  epn1a; epsin-1 isoform X1 [KO:K12471]
113643980  epn2; epsin-2 [KO:K12471]
113655793  eps15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
113650547  eps15l1a; epidermal growth factor receptor substrate 15-like 1 isoform X3 [KO:K12472]
113645160  eps15l1b; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
113638259  sparta; spartin a isoform X1 [KO:K19366]
113651696  spartb; spartin b isoform X1 [KO:K19366]
113643803  nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X3 [KO:K13305] [EC:2.3.2.26]
113655477  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
113636662  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
113635255  rnf41; E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
113655279  itchb; itchy E3 ubiquitin protein ligase b isoform X1 [KO:K05632] [EC:2.3.2.26]
113643040  itcha; itchy E3 ubiquitin protein ligase a isoform X1 [KO:K05632] [EC:2.3.2.26]
113639683  smurf2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
113660597  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
113634456  E3 ubiquitin-protein ligase SMURF2-like isoform X1 [KO:K04678] [EC:2.3.2.26]
113644388  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
113639611  ldlra; low density lipoprotein receptor a [KO:K12473]
113634480  ldlrb; low-density lipoprotein receptor isoform X1 [KO:K12473]
113655326  ldlrap1b; low density lipoprotein receptor adapter protein 1b isoform X1 [KO:K12474]
113644228  si:dkey-71h2.2; low density lipoprotein receptor adapter protein 1-B isoform X1 [KO:K12474]
113634671  ldlrap1a; low density lipoprotein receptor adapter protein 1a isoform X1 [KO:K12474]
113637659  si:ch211-204c21.1; disabled homolog 2 isoform X1 [KO:K12475]
113655157  dab2; disabled homolog 2 isoform X1 [KO:K12475]
113662727  C-C chemokine receptor type 5-like [KO:K04180]
113662730  C-C chemokine receptor type 5-like [KO:K04180]
113662732  C-C chemokine receptor type 5-like isoform X1 [KO:K04180]
113662733  C-C chemokine receptor type 5-like [KO:K04180]
113662734  C-C chemokine receptor type 5-like [KO:K04180]
113662755  C-C chemokine receptor type 1-like [KO:K04180]
113663702  C-C chemokine receptor type 5-like isoform X1 [KO:K04180]
113663704  C-C chemokine receptor type 5-like [KO:K04180]
113663705  C-C chemokine receptor type 4-like [KO:K04180]
113663724  C-C chemokine receptor type 5-like [KO:K04180]
113663723  C-C chemokine receptor type 5-like [KO:K04180]
113663703  C-C chemokine receptor type 5-like isoform X1 [KO:K04180]
113653103  C-X-C chemokine receptor type 1 [KO:K05050]
113653161  cxcr2; C-X-C chemokine receptor type 1 [KO:K05050]
113653167  cxcr4b; C-X-C chemokine receptor type 4b [KO:K04189]
113663578  cxcr4a; C-X-C chemokine receptor type 4a [KO:K04189]
113638503  grk7a; rhodopsin kinase grk7a [KO:K00909] [EC:2.7.11.14]
113648879  grk1a; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
113638351  grk3; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
113656830  grk5l; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
113662442  grk6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
113638442  grk5; G protein-coupled receptor kinase 5 isoform X2 [KO:K08291] [EC:2.7.11.16]
113645021  arrb2a; arrestin, beta 2a isoform X1 [KO:K04439]
113642333  arrb1; beta-arrestin-1 isoform X1 [KO:K04439]
113635154  arrb2b; arrestin, beta 2b [KO:K04439]
113645843  neural Wiskott-Aldrich syndrome protein-like [KO:K23612]
113660121  wasla; WASP like actin nucleation promoting factor a isoform X4 [KO:K23612]
113645060  actr2b; actin-related protein 2-B [KO:K17260]
113662990  zgc:101810; actin-related protein 2-B [KO:K17260]
113663602  actr2a; actin-related protein 2-A [KO:K17260]
113654252  actr3; actin-related protein 3 [KO:K18584]
113656629  actr3b; actin-related protein 3B isoform X1 [KO:K18584]
113663522  zgc:86896; actin-related protein 2/3 complex subunit 1A-A isoform X1 [KO:K05757]
113650738  arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
113650736  arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
113653150  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
113646458  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
113648556  arpc4l; actin related protein 2/3 complex, subunit 4, like isoform X1 [KO:K05755]
113642825  arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
113663937  arpc5la; actin related protein 2/3 complex, subunit 5-like, a [KO:K05754]
113640713  arpc5b; actin-related protein 2/3 complex subunit 5b [KO:K05754]
113643653  arpc5a; actin-related protein 2/3 complex subunit 5a [KO:K05754]
113654588  wipf1a; WAS/WASL-interacting protein family member 1a isoform X1 [KO:K19475]
113648419  wipf2b; WAS/WASL-interacting protein family member 2b isoform X1 [KO:K19475]
113657679  wipf2a; WAS/WASL-interacting protein family member 2 [KO:K19475]
113641599  wipf3; WAS/WASL-interacting protein family member 3 isoform X3 [KO:K19475]
113651273  wipf1b; WAS/WASL-interacting protein family member 1 [KO:K19475]
125138828  heat shock 70 kDa protein-like [KO:K03283]
113652235  heat shock 70 kDa protein-like [KO:K03283]
125138829  heat shock 70 kDa protein-like [KO:K03283]
113645341  heat shock cognate 71 kDa protein-like [KO:K03283]
113645389  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
113643689  hsc70; heat shock cognate 71 kDa protein [KO:K03283]
113652206  heat shock 70 kDa protein [KO:K03283]
113652236  heat shock 70 kDa protein-like isoform X1 [KO:K03283]
113660461  hspa8b; heat shock protein family A (Hsp70) member 8b [KO:K03283]
113643058  dnajc6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
113660070  washc4; WASH complex subunit 4 isoform X1 [KO:K18465]
113661846  washc5; WASH complex subunit 5 [KO:K18464]
113639860  washc2c; WASH complex subunit 2 isoform X4 [KO:K18462]
113650801  wash1; WASH complex subunit 1 [KO:K18461]
113653988  washc3; WASH complex subunit 3 [KO:K18463]
113655777  capza1b; F-actin-capping protein subunit alpha-1b [KO:K10364]
113642943  capza1a; F-actin-capping protein subunit alpha-1a [KO:K10364]
113648823  capzb; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
113646440  vps29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
113661053  vps26a; vacuolar protein sorting-associated protein 26A isoform X1 [KO:K18466]
113645572  vps26bl; vacuolar protein sorting-associated protein 26B-like [KO:K18466]
113660434  vps26b; vacuolar protein sorting-associated protein 26B [KO:K18466]
113660636  vps35; vacuolar protein sorting-associated protein 35 [KO:K18468]
113649051  snx12; sorting nexin-12 isoform X1 [KO:K17918]
113643373  snx3; sorting nexin-3 [KO:K17918]
113638755  usp8; ubiquitin carboxyl-terminal hydrolase 8 isoform X2 [KO:K11839] [EC:3.4.19.12]
113644384  stambpb; STAM binding protein b [KO:K11866] [EC:3.4.19.12]
113646486  rab7b; ras-related protein Rab-7b [KO:K07897]
113648578  rab7a; ras-related protein Rab-7a [KO:K07897]
113642822  ras-related protein rab7 [KO:K07897]
113652896  hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X7 [KO:K12182]
113654297  stam2; signal transducing adapter molecule 2 [KO:K04705]
113636796  tsg101b; tumor susceptibility gene 101 protein [KO:K12183]
113659999  tumor susceptibility gene 101 protein isoform X1 [KO:K12183]
113658432  mvb12a; multivesicular body subunit 12A isoform X1 [KO:K12186]
113656680  mvb12ba; multivesicular body subunit 12Ba isoform X2 [KO:K12186]
113661498  vps28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
113663478  vps37d; vacuolar protein sorting-associated protein 37D isoform X1 [KO:K12185]
113638467  vps37bb; VPS37B subunit of ESCRT-I b [KO:K12185]
113639008  vps37ba; VPS37B subunit of ESCRT-I a [KO:K12185]
113642475  vps37c; vacuolar protein sorting-associated protein 37C [KO:K12185]
113636750  vacuolar protein sorting-associated protein 37B-like [KO:K12185]
113635409  vps37a; vacuolar protein sorting-associated protein 37A isoform X1 [KO:K12185]
113637151  snf8; vacuolar-sorting protein SNF8 [KO:K12188]
113644924  vps36; vacuolar protein-sorting-associated protein 36 isoform X1 [KO:K12190]
113653596  vps25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
113653501  chmp6b; charged multivesicular body protein 6 [KO:K12195]
113639529  chmp6a; charged multivesicular body protein 6 [KO:K12195]
113656218  charged multivesicular body protein 4b-like [KO:K12194]
113643070  chmp4ba; charged multivesicular body protein 4b isoform X1 [KO:K12194]
113660000  chmp4c; charged multivesicular body protein 4c [KO:K24782]
113659794  chmp3; charged multivesicular body protein 3 [KO:K12193]
113637155  chmp2a; charged multivesicular body protein 2a [KO:K12191]
113654004  chmp2bb; charged multivesicular body protein 2b [KO:K12192]
113654184  chmp2ba; charged multivesicular body protein 2Ba [KO:K12192]
113646479  chmp7; charged multivesicular body protein 7 isoform X1 [KO:K15053]
113640090  vps4b; vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196]
113657929  vacuolar protein sorting-associated protein 4B-like [KO:K12196]
113651917  vps4a; vacuolar protein sorting-associated protein 4A [KO:K12196]
113637382  vta1; vacuolar protein sorting-associated protein VTA1 homolog isoform X1 [KO:K12199]
113662890  chmp1b; charged multivesicular body protein 1b [KO:K12197]
113651939  chmp1a; charged multivesicular body protein 1a [KO:K12197]
113657375  chmp5a; charged multivesicular body protein 5 isoform X1 [KO:K12198]
113657379  chmp5b; charged multivesicular body protein 5 [KO:K12198]
113646746  ist1; IST1 homolog isoform X2 [KO:K19476]
113661402  programmed cell death 6-interacting protein isoform X1 [KO:K12200]
113653018  spg21; maspardin [KO:K19367]
113648305  igf2r; cation-independent mannose-6-phosphate receptor [KO:K06564]
113656256  snx2; sorting nexin-2 isoform X1 [KO:K17917]
113660100  snx1a; sorting nexin-1a [KO:K17917]
113640745  si:dkey-28n18.9; uncharacterized protein si:dkey-28n18.9 isoform X1 [KO:K17920]
113659557  snx6; sorting nexin-6 isoform X1 [KO:K17920]
113661997  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
113641944  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
113636822  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
113660166  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
113650520  il2rb; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
113636124  il2rgb; interleukin 2 receptor, gamma b [KO:K05070]
113650230  il2rga; interleukin 2 receptor, gamma a [KO:K05070]
113637004  rho-related GTP-binding protein RhoA-B-like isoform X1 [KO:K04513]
113655778  rhocb; rho-related GTP-binding protein RhoA-D [KO:K04513]
113656907  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
113650696  rhoac; rho-related GTP-binding protein RhoA-C [KO:K04513]
113642944  rhoca; ras homolog family member Ca [KO:K04513]
113634850  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
113647467  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
113647470  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
113638640  H-2 class I histocompatibility antigen, alpha chain-like [KO:K06751]
113638842  major histocompatibility complex class I-related gene protein-like [KO:K06751]
113660587  class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
113652900  class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
113656557  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
113652873  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
113660586  DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X1 [KO:K06751]
113639822  DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X1 [KO:K06751]
125145457  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
113647469  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751]
113657268  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
113647473  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
113647471  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
113653639  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
113647456  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
113647457  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
113660596  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
113637838  folr; folate receptor [KO:K13649]
113650452  rtbdn; retbindin [KO:K13649]
113651495  cav1; caveolin-1 isoform X1 [KO:K06278]
113648582  cav4a; caveolin-2 [KO:K12958]
113658246  cav4b; caveolin-2 [KO:K12958]
113651475  cav2; caveolin-2 [KO:K12958]
113643180  cav3; caveolin-3 [KO:K12959]
113637398  ehd3; EH domain-containing protein 3 [KO:K12476]
113659832  ehd4; EH domain-containing protein 4 [KO:K12477]
113652447  eea1; early endosome antigen 1 isoform X1 [KO:K12478]
113649573  rab5aa; RAB5A, member RAS oncogene family, a [KO:K07887]
113649746  rab5ab; RAB5A, member RAS oncogene family, b [KO:K07887]
113641064  rab5b; ras-related protein Rab-5B [KO:K07888]
113662145  ras-related protein Rab-5C-like [KO:K07889]
113652213  rab5c; ras-related protein Rab-5C [KO:K07889]
113663381  rabep1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
113656051  rabenosyn-5 isoform X1 [KO:K12481]
113661050  rab4a; ras-related protein Rab-4A [KO:K07879]
113661040  rufy2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
113646008  rufy1; RUN and FYVE domain-containing protein 1 isoform X1 [KO:K12482]
125139148  RUN and FYVE domain-containing protein 1-like isoform X1 [KO:K12482]
113650259  ehd1b; EH domain-containing protein 1b [KO:K12483]
113635650  ehd1a; EH domain-containing protein 1a [KO:K12483]
113661646  vps45; vacuolar protein sorting-associated protein 45 [KO:K12479]
113654426  snx4; sorting nexin-4 [KO:K17919]
113634555  rab22a; ras-related protein Rab-22A isoform X1 [KO:K07891]
113645224  rab31; ras-related protein Rab-31 [KO:K07891]
113658619  rab10; ras-related protein Rab-10 [KO:K07903]
113659509  ras-related protein Rab-10-like [KO:K07903]
113645290  rab8a; ras-related protein Rab-8A [KO:K07901]
113637257  rab35a; ras-related protein Rab-35 [KO:K07876]
113656177  rab35b; ras-related protein Rab-35b [KO:K07876]
113635378  si:dkey-16l2.16; ras-related protein Rab-35 [KO:K07876]
113649731  rab11al; RAB11a, member RAS oncogene family, like [KO:K07904]
113652468  rab11a; ras-related protein Rab-11A [KO:K07904]
113657880  rab11ba; RAB11B, member RAS oncogene family, a isoform X1 [KO:K07905]
113645269  rab11bb; RAB11B, member RAS oncogene family, b [KO:K07905]
113635954  uncharacterized protein LOC113635954 isoform X1 [KO:K12484]
113655358  rab11 family-interacting protein 2 [KO:K12484]
113639346  rab11fip1b; putative autophagy-related protein 11 isoform X1 [KO:K12484]
113656147  rab11fip1a; rab11 family-interacting protein 1 [KO:K12484]
113639898  rab11fip5a; uncharacterized protein rab11fip5a isoform X1 [KO:K12484]
113636394  zfyve27; protrudin isoform X4 [KO:K19368]
113646232  kif5c; kinesin heavy chain isoform X1 [KO:K10396]
113662662  kif5bb; kinesin-1 heavy chain isoform X1 [KO:K10396]
113651023  kinesin heavy chain isoform X1 [KO:K10396]
113658551  kif5aa; kinesin family member 5Aa [KO:K10396]
113643250  kif5ab; kinesin heavy chain isoform X2 [KO:K10396]
113663706  rab11fip3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
113656866  rab11fip4b; rab11 family-interacting protein 4B isoform X2 [KO:K12485]
113659081  rab11fip4a; rab11 family-interacting protein 4A isoform X1 [KO:K12485]
113644397  pard3aa; partitioning defective 3 homolog isoform X1 [KO:K04237]
113652723  pard6a; partitioning defective 6 homolog alpha [KO:K06093]
113647394  pard6ga; par-6 family cell polarity regulator gamma a [KO:K06093]
113658299  pard6b; partitioning defective 6 homolog beta [KO:K06093]
113658996  pard6gb; par-6 family cell polarity regulator gamma b [KO:K06093]
113658737  prkcz; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
113647149  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
113657227  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
113641937  cdc42l2; cell division cycle 42 like 2 [KO:K04393]
113649619  cell division control protein 42 homolog isoform X1 [KO:K04393]
113636271  smap1; stromal membrane-associated protein 1 isoform X1 [KO:K12486]
113634694  smap2; stromal membrane-associated protein 2 isoform X1 [KO:K12486]
113643430  git1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
113638422  git2b; ARF GTPase-activating protein GIT2b isoform X2 [KO:K12487]
113655631  asap2b; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2b isoform X1 [KO:K12488]
113640516  asap3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 [KO:K12488]
113657446  asap1a; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1a isoform X1 [KO:K12488]
113641237  unm_sa1614; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X2 [KO:K12488]
113659635  asap2a; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2a isoform X1 [KO:K12488]
113659901  asap1b; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X2 [KO:K12488]
113661933  acap3b; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3b isoform X3 [KO:K12489]
113637904  zgc:162872; BAR_ACAPs and ArfGap_ACAP domain-containing protein [KO:K12489]
113654723  acap1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12489]
113640180  acap2a; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12489]
113649482  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12489]
113641903  acap3a; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12489]
113657218  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
113637856  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
113635131  arap2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K18440]
113635801  arap3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 [KO:K12490]
113659040  agap3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12491]
113634417  agap1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12491]
113639043  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like isoform X1 [KO:K17848]
113641761  agap2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X3 [KO:K17848]
113639046  arfgap1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
113638379  arfgap2; ADP-ribosylation factor GTPase-activating protein 2 isoform X1 [KO:K12493]
113645784  arfgap3; ADP-ribosylation factor GTPase-activating protein 3 [KO:K12493]
113661067  psda; uncharacterized protein psda [KO:K12494]
113635892  psd2; PH and SEC7 domain-containing protein 2 isoform X1 [KO:K12494]
113639364  psd3l; PH and SEC7 domain-containing protein 3 isoform X7 [KO:K12494]
113641587  PH and SEC7 domain-containing protein 1 [KO:K12494]
113634079  PH and SEC7 domain-containing protein 1 isoform X1 [KO:K12494]
113656014  iqsec2b; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
113656103  IQ motif and SEC7 domain-containing protein 1 isoform X3 [KO:K12495]
113655867  iqsec3a; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
113641297  iqsec1b; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
113650756  iqsec3b; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
113650919  iqsec1a; IQ motif and Sec7 domain ArfGEF 1a isoform X1 [KO:K12495]
113637214  cyth3a; cytohesin-3 [KO:K18441]
125138707  cytohesin-2-like isoform X1 [KO:K18441]
113639563  cyth3b; cytohesin-3 isoform X1 [KO:K18441]
113639689  cyth1a; cytohesin-1a isoform X1 [KO:K18441]
113634578  cyth4b; cytohesin 4b [KO:K18441]
113659066  cyth2; cytohesin-2 [KO:K18441]
113639007  cyth1b; cytohesin-1b isoform X1 [KO:K18441]
113658153  arfgef2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1 [KO:K18442]
113660817  arfgef1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1 [KO:K18442]
113639877  gbf1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X5 [KO:K18443]
113636554  arf1; ADP-ribosylation factor 1 [KO:K07937]
113652205  arf2a; ADP-ribosylation factor 2a [KO:K07937]
113648581  arf2b; ADP-ribosylation factor 2b [KO:K07937]
113658179  arf3a; ADP-ribosylation factor 3a [KO:K07938]
113643264  arf3b; ADP-ribosylation factor 3b [KO:K07938]
113656469  ADP-ribosylation factor 4-like [KO:K07939]
113656470  ADP-ribosylation factor 5-like [KO:K07939]
113656478  ADP-ribosylation factor 4-like [KO:K07939]
113656479  ADP-ribosylation factor 4 [KO:K07939]
113649682  ADP-ribosylation factor 5 [KO:K07939]
113649684  ADP-ribosylation factor 5-like [KO:K07939]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
tfd04060  Cytokine-cytokine receptor interaction
tfd04070  Phosphatidylinositol signaling system
tfd04130  SNARE interactions in vesicular transport
tfd04142  Lysosome
tfd04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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