Entry Name Gastric cancer - Peromyscus leucopus (white-footed mouse)
Description Gastric cancer (GC) is one of the world's most common cancers. According to Lauren's histological classification gastric cancer is divided into two distinct histological groups - the intestinal and diffuse types. Several genetic changes have been identified in intestinal-type GC. The intestinal metaplasia is characterized by mutations in p53 gene, reduced expression of retinoic acid receptor beta (RAR-beta) and hTERT expression. Gastric adenomas furthermore display mutations in the APC gene, reduced p27 expression and cyclin E amplification. In addition, amplification and overexpression of c-ErbB2, reduced TGF-beta receptor type I (TGFBRI) expression and complete loss of p27 expression are commonly observed in more advanced GC. The main molecular changes observed in diffuse-type GCs include loss of E-cadherin function by mutations in CDH1 and amplification of MET and FGFR2F.
Class Human Diseases; Cancer: specific typesBRITE hierarchy
Pathway map Disease Organism Peromyscus leucopus (white-footed mouse) [GN:
pleu ]
Gene 114683308 Dvl3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353 ]
114683897 Shc4; LOW QUALITY PROTEIN: SHC-transforming protein 4 [KO:K17449 ]
114684032 Pik3cd; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
114684081 Apc2; LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085 ]
114688301 Gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402 ]
114688966 Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649 ]
114689482 Gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402 ]
114690183 Smad4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501 ]
114693209 Dvl2; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2 [KO:K02353 ]
114693559 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
114694590 Lrp5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068 ]
114695335 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
114698210 Tgfb2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376 ]
114700921 Gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402 ]
114703850 Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
114706924 Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
114708251 Dvl1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353 ]
114710353 Lrp6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068 ]
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Tan P, Yeoh KG
Title Genetics and Molecular Pathogenesis of Gastric Adenocarcinoma.
Journal Reference Authors Riquelme I, Saavedra K, Espinoza JA, Weber H, Garcia P, Nervi B, Garrido M, Corvalan AH, Roa JC, Bizama C
Title Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy.
Journal Reference Authors Stock M, Otto F
Title Gene deregulation in gastric cancer.
Journal Reference Authors Panani AD
Title Cytogenetic and molecular aspects of gastric cancer: clinical implications.
Journal Reference Authors Vauhkonen M, Vauhkonen H, Sipponen P
Title Pathology and molecular biology of gastric cancer.
Journal Reference Authors Smith MG, Hold GL, Tahara E, El-Omar EM.
Title Cellular and molecular aspects of gastric cancer.
Journal Reference Authors Zheng L, Wang L, Ajani J, Xie K.
Title Molecular basis of gastric cancer development and progression.
Journal Reference Authors Yuasa Y
Title Control of gut differentiation and intestinal-type gastric carcinogenesis.
Journal Reference Authors Wessler S, Krisch LM, Elmer DP, Aberger F
Title From inflammation to gastric cancer - the importance of Hedgehog/GLI signaling in Helicobacter pylori-induced chronic inflammatory and neoplastic diseases.
Journal Reference Authors Yan LH, Wei WY, Xie YB, Xiao Q
Title New insights into the functions and localization of the homeotic gene CDX2 in gastric cancer.
Journal Reference Authors Hayashi K, Yokozaki H, Goodison S, Oue N, Suzuki T, Lotan R, Yasui W, Tahara E
Title Inactivation of retinoic acid receptor beta by promoter CpG hypermethylation in gastric cancer.
Journal Reference Authors Li X, Wu WK, Xing R, Wong SH, Liu Y, Fang X, Zhang Y, Wang M, Wang J, Li L, Zhou Y, Tang S, Peng S, Qiu K, Chen L, Chen K, Yang H, Zhang W, Chan MT, Lu Y, Sung JJ, Yu J
Title Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability.
Journal Reference Authors Wadhwa R, Song S, Lee JS, Yao Y, Wei Q, Ajani JA
Title Gastric cancer-molecular and clinical dimensions.
Journal Reference Authors Bertotti A, Sassi F
Title Molecular Pathways: Sensitivity and Resistance to Anti-EGFR Antibodies.
Journal Reference Authors Appleman LJ
Title MET signaling pathway: a rational target for cancer therapy.
Journal Reference Authors Eder JP, Vande Woude GF, Boerner SA, LoRusso PM
Title Novel therapeutic inhibitors of the c-Met signaling pathway in cancer.
Journal Reference Authors Feng Y, Ma PC
Title Anti-MET targeted therapy has come of age: the first durable complete response with MetMAb in metastatic gastric cancer.
Journal Reference Authors Katoh M, Nakagama H
Title FGF receptors: cancer biology and therapeutics.
Journal Reference Authors Katoh M
Title FGFR2 abnormalities underlie a spectrum of bone, skin, and cancer pathologies.
Journal Reference Authors Katoh M
Title Genetic alterations of FGF receptors: an emerging field in clinical cancer diagnostics and therapeutics.
Journal Related KO pathway
