KEGG   PATHWAY: plop03013
Entry
plop03013                   Pathway                                
Name
Nucleocytoplasmic transport - Perognathus longimembris pacificus (Pacific pocket mouse)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
plop03013  Nucleocytoplasmic transport
plop03013

Other DBs
GO: 0050658
Organism
Perognathus longimembris pacificus (Pacific pocket mouse) [GN:plop]
Gene
125339647  Xpo7; exportin-7 isoform X1 [KO:K18460]
125340541  [KO:K12160]
125340564  Thoc6; THO complex subunit 6 homolog [KO:K13175]
125340870  Ube2i; SUMO-conjugating enzyme UBC9 [KO:K10577]
125341167  Xpo6; exportin-6 isoform X1 [KO:K25204]
125341227  Rnps1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
125341984  Ranbp17; ran-binding protein 17 isoform X1 [KO:K24115]
125342181  Thoc3; THO complex subunit 3 [KO:K12880]
125342881  [KO:K12877]
125343006  [KO:K14284]
125343011  [KO:K14284]
125343012  [KO:K14284]
125343329  [KO:K12160]
125343516  Upf3b; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
125343917  [KO:K13176]
125344149  Nxt2; NTF2-related export protein 2 isoform X1 [KO:K14285]
125344260  Thoc2; THO complex subunit 2 isoform X1 [KO:K12879]
125344300  Nxf3; nuclear RNA export factor 3 [KO:K14284]
125345329  [KO:K14284]
125345623  [KO:K03231]
125345700  Ncbp1; nuclear cap-binding protein subunit 1 [KO:K12882]
125346824  Nup42; nucleoporin NUP42 isoform X1 [KO:K14321]
125347116  Tnpo3; transportin-3 isoform X1 [KO:K15436]
125347179  Nup205; nuclear pore complex protein Nup205 isoform X1 [KO:K14310]
125347875  [KO:K07936]
125348005  [KO:K12160]
125348081  Upf3a; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
125348153  Ipo5; importin-5 [KO:K20222]
125348298  Kpna3; importin subunit alpha-4 isoform X1 [KO:K23583]
125348416  Nup58; nucleoporin p58/p45 isoform X1 [KO:K14307]
125348434  Sap18; histone deacetylase complex subunit SAP18 [KO:K14324]
125348442  Xpo4; exportin-4 isoform X1 [KO:K25203]
125348855  Tnpo2; transportin-2 isoform X1 [KO:K18727]
125348931  Upf1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
125349228  Ran; GTP-binding nuclear protein Ran [KO:K07936]
125349261  [KO:K13174]
125349476  [KO:K14316]
125349928  Gle1; mRNA export factor GLE1 [KO:K18723]
125350082  Nup188; nucleoporin NUP188 isoform X1 [KO:K14311]
125350276  [KO:K15043]
125350284  [KO:K15043]
125350294  [KO:K12160]
125350392  Sumo1; small ubiquitin-related modifier 1 [KO:K12160]
125350481  Nup214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
125350488  Nup35; nucleoporin NUP35 [KO:K14313]
125350618  [KO:K12160]
125350897  [KO:K10577]
125351331  [KO:K12160]
125351407  Sumo3; small ubiquitin-related modifier 3 isoform X1 [KO:K12160]
125351514  [KO:K14285]
125351691  [KO:K12160]
125351770  Kpna1; importin subunit alpha-5 isoform X1 [KO:K23940]
125351833  Ncbp2; nuclear cap-binding protein subunit 2 [KO:K12883]
125351864  [KO:K25203]
125351909  Senp2; sentrin-specific protease 2 isoform X1 [KO:K03345] [EC:3.4.22.68]
125352008  Nmd3; 60S ribosomal export protein NMD3 [KO:K07562]
125352014  Kpna4; importin subunit alpha-3 [KO:K23583]
125352261  [KO:K12160]
125352544  Xpo5; exportin-5 [KO:K14289]
125352782  Ddx39b; spliceosome RNA helicase DDX39B isoform X1 [KO:K12812] [EC:5.6.2.7]
125352844  Pom121l2; POM121-like protein 2 [KO:K14316]
125352991  Nup153; nuclear pore complex protein Nup153 [KO:K14296]
125353193  Nxt1; NTF2-related export protein 1 [KO:K14285]
125353871  Cse1l; exportin-2 [KO:K18423]
125353911  Rae1; mRNA export factor RAE1 [KO:K14298]
125353961  Eef1a2; elongation factor 1-alpha 2 [KO:K03231]
125354312  [KO:K12160]
125354663  [KO:K12160]
125354729  Srrm1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
125354848  Kpna6; importin subunit alpha-7 isoform X1 [KO:K15042]
125355044  Ipo13; importin-13 [KO:K25202]
125355177  Magoh; protein mago nashi homolog [KO:K12877]
125355181  Ndc1; nucleoporin NDC1 [KO:K14315]
125355517  Rbm8a; RNA-binding protein 8A isoform X1 [KO:K12876]
125355661  [KO:K12160]
125356141  Rgpd4; ranBP2-like and GRIP domain-containing protein 4 isoform X1 [KO:K12172] [EC:2.3.2.-]
125356364  [KO:K12160]
125356409  Xpo1; exportin-1 [KO:K14290]
125357049  Eef1a1; elongation factor 1-alpha 1 [KO:K03231]
125357212  Kpna5; importin subunit alpha-6 isoform X1 [KO:K15042]
125357232  Nup50; nuclear pore complex protein Nup50 [KO:K14295]
125357243  [KO:K03231]
125357400  Nup43; nucleoporin Nup43 [KO:K14305]
125357576  [KO:K14308]
125357926  Rangap1; ran GTPase-activating protein 1 isoform X1 [KO:K14319]
125358193  Ddx19b; LOW QUALITY PROTEIN: ATP-dependent RNA helicase DDX19B [KO:K18655] [EC:5.6.2.7]
125358194  [KO:K18655] [EC:5.6.2.7]
125358417  Nup93; nuclear pore complex protein Nup93 [KO:K14309]
125358643  [KO:K12160]
125358708  Thoc7; THO complex subunit 7 homolog isoform X1 [KO:K13176]
125358793  Sec13; protein SEC13 homolog [KO:K14004]
125358849  Nup210; nuclear pore membrane glycoprotein 210 [KO:K14314]
125359007  Phax; phosphorylated adapter RNA export protein [KO:K14291]
125359250  [KO:K12160]
125359401  [KO:K12160]
125359459  Nup37; nucleoporin Nup37 [KO:K14302]
125359489  Ipo9; importin-9 [KO:K20224]
125359673  Ahctf1; protein ELYS isoform X1 [KO:K25129]
125359939  Tpr; nucleoprotein TPR [KO:K09291]
125360092  Nup210l; nuclear pore membrane glycoprotein 210-like [KO:K14314]
125361472  Nup107; nuclear pore complex protein Nup107 isoform X1 [KO:K14301]
125361480  [KO:K12160]
125361718  Xpot; exportin-T [KO:K14288]
125362107  Nxf1; nuclear RNA export factor 1 [KO:K14284]
125362280  Nup98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
125362695  Nup160; nuclear pore complex protein Nup160 isoform X1 [KO:K14303]
125362728  Ipo7; importin-7 [KO:K20223]
125363181  Pnn; pinin [KO:K13114]
125363271  Pym1; partner of Y14 and mago isoform X1 [KO:K14294]
125363376  [KO:K12160]
125363466  Acin1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
125363468  Ipo4; importin-4 [KO:K20221]
125363959  Seh1l; nucleoporin SEH1 [KO:K14299]
125364034  Aaas; aladin isoform X1 [KO:K14320]
125364269  Thoc1; THO complex subunit 1 isoform X1 [KO:K12878]
125364415  Tmem33; transmembrane protein 33 isoform X1 [KO:K20724]
125364455  Nup54; nucleoporin p54 isoform X1 [KO:K14308]
125364488  [KO:K12160]
125364859  [KO:K12160]
125365114  Casc3; protein CASC3 [KO:K14323]
125365182  Eif4a3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
125365889  Sumo2; small ubiquitin-related modifier 2 [KO:K12160]
125365900  Kpna2; importin subunit alpha-1 [KO:K15043]
125365939  Nup88; nuclear pore complex protein Nup88 [KO:K14318]
125366011  [KO:K14308]
125366042  Alyref; THO complex subunit 4 [KO:K12881]
125366332  Ipo8; importin-8 [KO:K18755]
125366484  Nup85; nuclear pore complex protein Nup85 isoform X1 [KO:K14304]
125366500  Kpnb1; importin subunit beta-1 [KO:K14293]
125366717  Upf2; regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
125367235  Nup133; nuclear pore complex protein Nup133 [KO:K14300]
125367739  Ipo11; importin-11 isoform X1 [KO:K25201]
125367789  Nup155; nuclear pore complex protein Nup155 [KO:K14312]
125367799  Tnpo1; transportin-1 isoform X1 [KO:K18752]
125368192  Pom121c; nuclear envelope pore membrane protein POM 121C [KO:K14316]
125368234  Snupn; LOW QUALITY PROTEIN: snurportin-1 [KO:K13151]
125368314  Nup62; nuclear pore glycoprotein p62 [KO:K14306]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
plop03015  mRNA surveillance pathway
KO pathway
ko03013   

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