KEGG   PATHWAY: pmur04060
Entry
pmur04060                   Pathway                                
Name
Cytokine-cytokine receptor interaction - Protobothrops mucrosquamatus (Taiwan habu)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
pmur04060  Cytokine-cytokine receptor interaction
pmur04060

Organism
Protobothrops mucrosquamatus (Taiwan habu) [GN:pmur]
Gene
107282187  AMH; muellerian-inhibiting factor [KO:K04665]
107282271  [KO:K05152]
107282386  [KO:K10030]
107282662  NGFR; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 16 [KO:K02583]
107282734  [KO:K05149]
107282781  IL6; interleukin-6 [KO:K05405]
107282857  GDF1; embryonic growth/differentiation factor 1 [KO:K05495]
107282929  EDA; ectodysplasin-A [KO:K05480]
107282995  BMP6; bone morphogenetic protein 6 [KO:K16620]
107283079  [KO:K05417]
107283208  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
107283245  IL1B; interleukin-1 beta [KO:K04519]
107283288  [KO:K05481]
107283453  MPL; thrombopoietin receptor [KO:K05079]
107283579  TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147]
107283622  BMP10; bone morphogenetic protein 10 [KO:K22670]
107283699  BMP8A; bone morphogenetic protein 8A [KO:K16622]
107284057  NGF; beta-nerve growth factor [KO:K02582]
107284100  [KO:K03158]
107284282  TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
107284307  TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
107284378  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
107284398  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
107284403  IL22; interleukin-22 [KO:K05445]
107284417  IFNG; interferon gamma [KO:K04687]
107284513  [KO:K05482]
107284614  EDA2R; tumor necrosis factor receptor superfamily member 27 [KO:K05163]
107284772  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
107284935  INHBA; inhibin beta A chain [KO:K04667]
107284999  EPO; erythropoietin [KO:K05437]
107285119  EPOR; erythropoietin receptor [KO:K05079]
107285368  BMP2; bone morphogenetic protein 2 [KO:K21283]
107285957  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
107286004  [KO:K02583]
107286121  IL17D; interleukin-17D [KO:K05492]
107286268  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
107286388  GDF11; growth/differentiation factor 11 [KO:K22679]
107286466  [KO:K12964]
107286533  [KO:K04387]
107286546  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
107286770  INHA; inhibin alpha chain [KO:K05500]
107287037  RELT; tumor necrosis factor receptor superfamily member 19L [KO:K05156]
107287104  GDF5; growth/differentiation factor 5 [KO:K04664]
107287674  IL17RB; interleukin-17 receptor B [KO:K05165]
107287808  [KO:K22689]
107288033  IL20RB; interleukin-20 receptor subunit beta [KO:K05137]
107288201  [KO:K04386]
107288208  IL18R1; interleukin-18 receptor 1 [KO:K05173]
107288209  IL18RAP; interleukin-18 receptor accessory protein [KO:K05174]
107288280  OSMR; oncostatin-M-specific receptor subunit beta [KO:K05057]
107288322  LIFR; leukemia inhibitory factor receptor [KO:K05058]
107288328  IL17RA; interleukin-17 receptor A [KO:K05164]
107288409  TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155]
107288497  CCL28; C-C motif chemokine 28 [KO:K05513]
107288499  GHR; growth hormone receptor [KO:K05080]
107288508  MSTN; growth/differentiation factor 8 [KO:K05497]
107288745  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148]
107288961  INHBB; inhibin beta B chain [KO:K22687]
107289214  LEP; leptin [KO:K05424]
107289583  ACVR1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
107289585  ACVR1C; activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
107289607  PRL; prolactin [KO:K05439]
107289685  [KO:K05066]
107290237  [KO:K05422]
107290268  [KO:K04388] [EC:2.7.11.30]
107290470  IFNGR2; interferon gamma receptor 2 [KO:K05133]
107290564  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
107290611  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
107290621  IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135]
107290638  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
107290699  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
107290732  GDF6; growth/differentiation factor 6 [KO:K20012]
107290758  IL22RA1; interleukin-22 receptor subunit alpha-1 [KO:K05138]
107290871  ACVRL1; serine/threonine-protein kinase receptor R3 [KO:K13594] [EC:2.7.11.30]
107290891  EDAR; tumor necrosis factor receptor superfamily member EDAR [KO:K05162]
107290904  IL17RC; interleukin-17 receptor C [KO:K05166]
107290943  BMP5; bone morphogenetic protein 5 [KO:K04663]
107291003  IL17RE; interleukin-17 receptor E [KO:K05168]
107291020  ACVR1B; activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
107291205  [KO:K12672]
107291214  [KO:K12672]
107291222  IL16; pro-interleukin-16 [KO:K22628]
107291244  AMHR2; anti-Muellerian hormone type-2 receptor [KO:K04672] [EC:2.7.11.30]
107291284  [KO:K04188]
107291285  [KO:K05050]
107291483  [KO:K05050]
107291484  [KO:K05050]
107291643  [KO:K22669]
107291889  TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150]
107291932  GDF7; growth/differentiation factor 7 [KO:K20013]
107292464  IL17B; interleukin-17B [KO:K05490]
107292495  [KO:K05425]
107292942  [KO:K04722]
107293299  BMP4; bone morphogenetic protein 4 [KO:K04662]
107293441  [KO:K04179]
107293669  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
107293819  [KO:K05414]
107293830  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
107293850  [KO:K04180]
107293947  GDF2; growth/differentiation factor 2 [KO:K05503]
107294115  [KO:K04192]
107294122  TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478]
107294178  XCR1; chemokine XC receptor 1 [KO:K04193]
107294189  [KO:K04180]
107294303  ACVR2A; activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
107294425  IL15RA; interleukin-15 receptor subunit alpha [KO:K05068]
107294497  IFNGR1; interferon gamma receptor 1 [KO:K05132]
107294610  BMP7; bone morphogenetic protein 7 [KO:K16621]
107294782  BMPR1B; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
107294972  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
107294975  IL31RA; interleukin-31 receptor subunit alpha [KO:K22630]
107295274  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
107295501  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
107295691  CNTF; ciliary neurotrophic factor [KO:K05420]
107296549  [KO:K03156]
107296563  IL15; interleukin-15 [KO:K05433]
107296751  NODAL; nodal homolog [KO:K04666]
107297237  TNFSF12; tumor necrosis factor ligand superfamily member 12 [KO:K05474]
107297449  [KO:K05488]
107297453  [KO:K05488]
107297458  [KO:K05488]
107297459  [KO:K05481]
107297472  [KO:K26541]
107297703  IL10; interleukin-10 [KO:K05443]
107297752  GDF9; growth/differentiation factor 9 [KO:K22673]
107297901  CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059]
107297967  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
107298081  IL27RA; interleukin-27 receptor subunit alpha [KO:K19598]
107298129  LEPR; leptin receptor [KO:K05062]
107298384  [KO:K26541]
107298532  [KO:K04674] [EC:2.7.11.30]
107298558  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
107298993  ACKR3; atypical chemokine receptor 3 [KO:K04304]
107299019  [KO:K05149]
107299035  IL1RAP; interleukin-1 receptor accessory protein [KO:K04723]
107299152  RELL2; RELT-like protein 2 [KO:K26541]
107299193  [KO:K13376]
107299409  [KO:K03160]
107299546  [KO:K04674] [EC:2.7.11.30]
107299617  [KO:K21283]
107299644  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
107299696  [KO:K05488]
107299697  [KO:K05488]
107299698  [KO:K05488]
107300035  IL11RA; interleukin-11 receptor subunit alpha [KO:K05056]
107300162  [KO:K05441]
107300232  [KO:K05090] [EC:2.7.10.1]
107300302  [KO:K05143]
107300506  [KO:K05060]
107301119  [KO:K24476]
107301724  [KO:K04189]
107302204  [KO:K16621]
107302424  CCR10; C-C chemokine receptor type 10 [KO:K04185]
107302566  CSF2RB; cytokine receptor common subunit beta [KO:K04738]
107302587  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
107302632  IL21R; interleukin-21 receptor [KO:K05075]
107302717  [KO:K05421]
107303021  CCR7; C-C chemokine receptor type 7 [KO:K04182]
107303156  BMP3; bone morphogenetic protein 3 [KO:K05496]
107303211  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
107303226  CD40LG; CD40 ligand [KO:K03161]
107303246  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
107303318  ACVR2B; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
114922192  BMP15; bone morphogenetic protein 15 [KO:K05498]
114922203  IL12RB1; interleukin-12 receptor subunit beta-1 [KO:K05063]
114922226  [KO:K22629]
114922295  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
114922354  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
114922416  [KO:K05494]
114922421  [KO:K06454]
114922585  CXCL13; C-X-C motif chemokine 13 [KO:K10032]
114922601  TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
114922668  LIF; leukemia inhibitory factor [KO:K05419]
114922669  [KO:K05418]
114922776  [KO:K24382]
114923592  [KO:K04722]
114923595  [KO:K05417]
114923668  [KO:K05441]
114923702  IL12RB2; interleukin-12 receptor subunit beta-2 [KO:K05064]
114923706  IL23R; interleukin-23 receptor [KO:K05065]
114923726  [KO:K05490]
114923910  [KO:K05438]
114923957  [KO:K05423]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   

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