KEGG   PATHWAY: pswi04350
Entry
pswi04350                   Pathway                                
Name
TGF-beta signaling pathway - Pseudoliparis swirei (Mariana hadal snailfish)
Description
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
Class
Environmental Information Processing; Signal transduction
Pathway map
pswi04350  TGF-beta signaling pathway
pswi04350

Other DBs
GO: 0007179
Organism
Pseudoliparis swirei (Mariana hadal snailfish) [GN:pswi]
Gene
130188395  [KO:K04658]
130188543  smad9; mothers against decapentaplegic homolog 9 [KO:K16791]
130188720  crebbpb; CREB binding protein b isoform X1 [KO:K04498] [EC:2.3.1.48]
130188952  smurf2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
130188990  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
130189005  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
130189125  rps6kb1a; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
130189219  ep300b; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
130189362  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
130189470  crebbpa; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
130189607  cdkn2a/b; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
130190011  [KO:K04688] [EC:2.7.11.1]
130190195  smad1; mothers against decapentaplegic homolog 1 [KO:K04676]
130190649  [KO:K04678] [EC:2.3.2.26]
130191533  admp; anti-dorsalizing morphogenic protein [KO:K21283]
130192293  neo1a; neogenin 1a isoform X1 [KO:K06766]
130192366  [KO:K11644]
130192382  bmp8a; bone morphogenetic protein 8A isoform X1 [KO:K16622]
130192418  adamtsl7; thrombospondin type-1 domain-containing protein 4 isoform X1 [KO:K23377]
130192646  [KO:K04682]
130192850  [KO:K04677]
130193273  [KO:K23605]
130193477  zfyve9b; zinc finger FYVE domain-containing protein 9 [KO:K04679]
130194244  rgmd; RGM domain family, member D [KO:K23096]
130194422  amh; muellerian-inhibiting factor isoform X1 [KO:K04665]
130194905  [KO:K04388] [EC:2.7.11.30]
130194946  smad6b; mothers against decapentaplegic homolog 6b [KO:K04677]
130195064  sin3aa; SIN3 transcription regulator family member Aa isoform X1 [KO:K11644]
130195103  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
130195194  e2f4; transcription factor E2F4 [KO:K04682]
130195727  rgma; repulsive guidance molecule A [KO:K23096]
130195862  si:dkey-5i3.5; transmembrane protein 53-A [KO:K28359]
130195946  gdf6b; growth/differentiation factor 6-B [KO:K20012]
130196398  [KO:K04382] [EC:3.1.3.16]
130196458  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
130196486  spaw; southpaw [KO:K04666]
130196843  [KO:K04500]
130196919  [KO:K04501]
130197127  rgmb; RGM domain family member B [KO:K06847]
130197281  fsta; LOW QUALITY PROTEIN: follistatin-A [KO:K04661]
130197529  [KO:K14736]
130197530  [KO:K14736]
130197543  [KO:K06503]
130197544  acvr2ba; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
130197664  zfyve9a; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
130198068  skila; ski-like protein isoform X1 [KO:K18499]
130198072  tmem53; transmembrane protein 53 [KO:K28359]
130198291  e2f5; transcription factor E2F5 isoform X1 [KO:K04682]
130198434  [KO:K14736]
130199147  [KO:K04513]
130199263  [KO:K26257]
130199269  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
130199296  skia; v-ski avian sarcoma viral oncogene homolog a [KO:K26503]
130199381  [KO:K04513]
130199386  [KO:K04513]
130199682  acvr1ba; activin A receptor type 1Ba [KO:K13567] [EC:2.7.11.30]
130199851  bmp7b; bone morphogenetic protein 7b [KO:K16621]
130199993  [KO:K04675] [EC:2.7.11.30]
130200477  lemd3; inner nuclear membrane protein Man1 [KO:K19410]
130200773  dcn; decorin [KO:K04660]
130200779  [KO:K28359]
130201274  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
130201417  id2a; DNA-binding protein inhibitor ID-2a [KO:K17693]
130201544  [KO:K06067] [EC:3.5.1.98]
130201604  grem1b; gremlin-1 [KO:K23318]
130201662  [KO:K16857]
130201724  [KO:K04675] [EC:2.7.11.30]
130201895  id3; DNA-binding protein inhibitor ID-3 [KO:K17694]
130201919  bmp4; bone morphogenetic protein 4 [KO:K04662]
130202603  bmp2b; bone morphogenetic protein 2b [KO:K21283]
130202755  thbs1b; thrombospondin-1 [KO:K16857]
130202865  grem1a; gremlin-1a [KO:K23318]
130202874  [KO:K13377]
130203082  lft1; lefty1 isoform X1 [KO:K04668]
130203276  [KO:K04498] [EC:2.3.1.48]
130203593  nog2; noggin-2 [KO:K04658]
130204030  ndr2; nodal-related 2 [KO:K04666]
130204138  [KO:K21283]
130204365  [KO:K04671] [EC:2.7.11.30]
130204385  [KO:K04670] [EC:2.7.11.30]
130204393  [KO:K22687]
130204493  [KO:K13568] [EC:2.7.11.30]
130204904  smad7; mothers against decapentaplegic homolog 7 isoform X1 [KO:K19631]
130204922  zfyve16; zinc finger FYVE domain-containing protein 16 [KO:K04679]
130204974  smad4a; mothers against decapentaplegic homolog 4a isoform X1 [KO:K04501]
130205015  smad2; mothers against decapentaplegic homolog 2 [KO:K04500]
130205122  hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
130205176  bmpr1bb; bone morphogenetic protein receptor, type IBb isoform X1 [KO:K13578] [EC:2.7.11.30]
130205339  [KO:K04671] [EC:2.7.11.30]
130205498  [KO:K04683]
130205597  [KO:K04666]
130205957  [KO:K03347]
130205974  bmp6; bone morphogenetic protein 6 [KO:K16620]
130206014  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
130206043  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
130206098  tgif1; homeobox protein TGIF1 [KO:K19383]
130206120  bambia; BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a [KO:K10162]
130206166  id4; DNA-binding protein inhibitor ID-4 [KO:K17695]
130206280  inhbaa; inhibin subunit beta Aa [KO:K04667]
130206345  tfr1b; transferrin receptor 1b [KO:K06503]
130206475  tgfb2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
130206496  myca; transcriptional regulator Myc-A [KO:K04377]
130206551  nrros; transforming growth factor beta activator LRRC33 [KO:K26317]
130206817  grem2a; gremlin-2 [KO:K23318]
130206829  [KO:K04673] [EC:2.7.11.30]
130206978  acvr2aa; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
130207035  inhbb; inhibin beta B chain [KO:K22687]
130207372  bmp5; bone morphogenetic protein 5 [KO:K04663]
130207902  rhoca; ras homolog family member Ca [KO:K04513]
130207945  skib; v-ski avian sarcoma viral oncogene homolog b [KO:K26503]
130208047  rbl1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
130208155  [KO:K04513]
130208156  nbl1; neuroblastoma suppressor of tumorigenicity 1 [KO:K19558]
130208244  gdf5; growth/differentiation factor 5 [KO:K04664]
130208373  [KO:K16621]
130208378  id1; DNA-binding protein inhibitor ID-1 [KO:K04680]
130208613  emp3a; epithelial membrane protein 3 [KO:K26257]
130208799  [KO:K22687]
130208812  sp1; transcription factor Sp1 isoform X1 [KO:K04684]
130208868  [KO:K13567] [EC:2.7.11.30]
130208887  [KO:K19553]
130209050  fmoda; fibromodulin a [KO:K08121]
130209106  smad10a; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
130209608  smad5; mothers against decapentaplegic homolog 5 isoform X1 [KO:K16790]
130209644  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
130209852  pitx2; pituitary homeobox 2 isoform X1 [KO:K04686]
130209935  [KO:K04382] [EC:3.1.3.16]
130210189  ncor1; nuclear receptor corepressor 1 [KO:K04650]
130210344  rps6kb1b; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
130210613  bmp16; bone morphogenetic protein 16 [KO:K21283]
130210873  ppp2r1bb; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
130210959  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
130211076  chrd; chordin isoform X1 [KO:K04657]
130211208  ppp2cab; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
130211296  skp1; S-phase kinase-associated protein 1 [KO:K03094]
130212843  hamp; hepcidin-1 [KO:K23106]
130212952  gdf6a; growth/differentiation factor 6-A [KO:K20012]
130213008  [KO:K23106]
130213062  [KO:K23106]
Compound
C14819  Fe3+
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:14534577
  Authors
Derynck R, Zhang YE.
  Title
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
  Journal
Nature 425:577-84 (2003)
DOI:10.1038/nature02006
Reference
PMID:11252892
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
DOI:10.1038/35043051
Reference
PMID:14557817
  Authors
Siegel PM, Massague J.
  Title
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
  Journal
Nat Rev Cancer 3:807-21 (2003)
DOI:10.1038/nrc1208
Reference
PMID:14769828
  Authors
Shimasaki S, Moore RK, Otsuka F, Erickson GF.
  Title
The bone morphogenetic protein system in mammalian reproduction.
  Journal
Endocr Rev 25:72-101 (2004)
DOI:10.1210/er.2003-0007
Reference
PMID:11252746
  Authors
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O.
  Title
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
  Journal
Nat Rev Genet 1:171-81 (2000)
DOI:10.1038/35042039
Reference
PMID:12163231
  Authors
Gumienny TL, Padgett RW.
  Title
The other side of TGF-beta superfamily signal regulation: thinking outside the cell.
  Journal
Trends Endocrinol Metab 13:295-9 (2002)
DOI:10.1016/S1043-2760(02)00615-X
Reference
PMID:11836504
  Authors
Hamada H, Meno C, Watanabe D, Saijoh Y.
  Title
Establishment of vertebrate left-right asymmetry.
  Journal
Nat Rev Genet 3:103-13 (2002)
DOI:10.1038/nrg732
Reference
PMID:12466190
  Authors
Chang H, Brown CW, Matzuk MM.
  Title
Genetic analysis of the mammalian transforming growth factor-beta superfamily.
  Journal
Endocr Rev 23:787-823 (2002)
DOI:10.1210/er.2002-0003
Reference
PMID:10021351
  Authors
Morita K, Chow KL, Ueno N.
  Title
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
  Journal
Development 126:1337-47 (1999)
Reference
PMID:9847239
  Authors
Krishna S, Maduzia LL, Padgett RW.
  Title
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
  Journal
Development 126:251-60 (1999)
Reference
PMID:15063168
  Authors
Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF.
  Title
ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.
  Journal
Dev Biol 268:280-94 (2004)
DOI:10.1016/j.ydbio.2003.12.035
Reference
PMID:10519551
  Authors
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C
  Title
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
  Journal
Nature 401:480-5 (1999)
DOI:10.1038/46794
Reference
PMID:19758997
  Authors
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG
  Title
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
  Journal
J Biol Chem 284:30097-104 (2009)
DOI:10.1074/jbc.M109.049304
Reference
PMID:8093006
  Authors
Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E
  Title
Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.
  Journal
Biochem J 302 ( Pt 2):527-34 (1994)
DOI:10.1042/bj3020527
Reference
PMID:10934147
  Authors
Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K
  Title
Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair.
  Journal
Am J Pathol 157:423-33 (2000)
DOI:10.1016/s0002-9440(10)64555-5
Reference
PMID:16642010
  Authors
Anderson GJ, Frazer DM
  Title
Iron metabolism meets signal transduction.
  Journal
Nat Genet 38:503-4 (2006)
DOI:10.1038/ng0506-503
Reference
PMID:26735394
  Authors
Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL
  Title
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
  Journal
Endocrinology 157:1146-62 (2016)
DOI:10.1210/en.2015-1747
Reference
PMID:26160612
  Authors
Ganz T, Nemeth E
  Title
Iron homeostasis in host defence and inflammation.
  Journal
Nat Rev Immunol 15:500-10 (2015)
DOI:10.1038/nri3863
Reference
PMID:15975920
  Authors
Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY
  Title
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:29820-7 (2005)
DOI:10.1074/jbc.M503511200
Reference
PMID:15671031
  Authors
Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ
  Title
DRAGON, a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:14122-9 (2005)
DOI:10.1074/jbc.M410034200
Reference
PMID:33925597
  Authors
Vogt AS, Arsiwala T, Mohsen M, Vogel M, Manolova V, Bachmann MF
  Title
On Iron Metabolism and Its Regulation.
  Journal
Int J Mol Sci 22:ijms22094591 (2021)
DOI:10.3390/ijms22094591
Reference
PMID:20495575
  Authors
Ikushima H, Miyazono K
  Title
TGFbeta signalling: a complex web in cancer progression.
  Journal
Nat Rev Cancer 10:415-24 (2010)
DOI:10.1038/nrc2853
Reference
PMID:38267638
  Authors
Wu M, Wu S, Chen W, Li YP
  Title
The roles and regulatory mechanisms of TGF-beta and BMP signaling in bone and cartilage development, homeostasis and disease.
  Journal
Cell Res 34:101-123 (2024)
DOI:10.1038/s41422-023-00918-9
Related
pathway
pswi04010  MAPK signaling pathway
pswi04110  Cell cycle
pswi04120  Ubiquitin mediated proteolysis
pswi04210  Apoptosis
KO pathway
ko04350   

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