KEGG   PATHWAY: pswi04110
Entry
pswi04110                   Pathway                                
Name
Cell cycle - Pseudoliparis swirei (Mariana hadal snailfish)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
pswi04110  Cell cycle
pswi04110

Other DBs
GO: 0000278
Organism
Pseudoliparis swirei (Mariana hadal snailfish) [GN:pswi]
Gene
130187942  ccne2; G1/S-specific cyclin-E2 [KO:K06626]
130188144  cdc27; cell division cycle protein 27 homolog [KO:K03350]
130188225  cdk21; cyclin-dependent kinase 4 isoform X1 [KO:K02091] [EC:2.7.11.22]
130188266  anapc2; anaphase-promoting complex subunit 2 isoform X1 [KO:K03349]
130188720  crebbpb; CREB binding protein b isoform X1 [KO:K04498] [EC:2.3.1.48]
130189005  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
130189054  ccndx; cyclin Dx [KO:K10151]
130189129  mcm5; DNA replication licensing factor MCM5 [KO:K02209] [EC:5.6.2.3]
130189219  ep300b; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
130189448  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
130189470  crebbpa; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
130189543  cdc6; cell division control protein 6 homolog [KO:K02213]
130189607  cdkn2a/b; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
130190015  cdkn2d; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
130190036  ccna1; cyclin-A1 [KO:K06627]
130190065  stag2a; cohesin subunit SA-2a isoform X1 [KO:K06671]
130190101  smc3; structural maintenance of chromosomes protein 3 [KO:K06669]
130190186  pds5a; sister chromatid cohesion protein PDS5 homolog A [KO:K11267]
130190230  plk1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
130190357  anapc11; anaphase-promoting complex subunit 11 [KO:K03358]
130190596  mad1l1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
130191212  ppp2r5ca; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
130191630  [KO:K08866] [EC:2.7.12.1]
130191681  rb1; retinoblastoma-associated protein [KO:K06618]
130191694  [KO:K10779]
130191765  ywhag1; 14-3-3 protein gamma-1 [KO:K16198]
130191823  [KO:K06630]
130192280  ccnd1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
130192646  [KO:K04682]
130192721  ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
130192945  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
130193186  cdkn1ca; cyclin dependent kinase inhibitor 1Ca [KO:K09993]
130193273  [KO:K23605]
130193500  cdc14ab; dual specificity protein phosphatase CDC14AB [KO:K06639] [EC:3.1.3.16 3.1.3.48]
130193555  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
130193595  anapc4; anaphase-promoting complex subunit 4 [KO:K03351]
130193695  sgo1; shugoshin 1 [KO:K11580]
130194234  cdkn2c; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
130194295  mau2; MAU2 chromatid cohesion factor homolog [KO:K11266]
130194356  [KO:K02603]
130194394  [KO:K02603]
130194699  wee2; wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
130194787  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
130194907  [KO:K04503]
130194939  smc1b; structural maintenance of chromosomes protein 1B [KO:K06636]
130195080  cdkn1cb; cyclin-dependent kinase inhibitor 1C [KO:K09993]
130195103  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
130195164  cdkn1bb; cyclin dependent kinase inhibitor 1Bb [KO:K06624]
130195189  cdca5; sororin [KO:K17390]
130195190  ccnd2a; G1/S-specific cyclin-D2a [KO:K10151]
130195194  e2f4; transcription factor E2F4 [KO:K04682]
130195370  anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
130195415  ddx11; ATP-dependent DNA helicase DDX11 isoform X1 [KO:K11273] [EC:5.6.2.7]
130195950  [KO:K06626]
130195960  ticrr; LOW QUALITY PROTEIN: treslin [KO:K26117]
130195981  wee1; wee1-like protein kinase [KO:K06632] [EC:2.7.11.1]
130196137  anapc7; anaphase-promoting complex subunit 7 [KO:K03354]
130196263  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
130196398  [KO:K04382] [EC:3.1.3.16]
130196411  [KO:K06672]
130196449  anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
130196459  pcna; proliferating cell nuclear antigen [KO:K04802]
130196775  chek2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
130196819  cdc14b; dual specificity protein phosphatase CDC14B isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
130196843  [KO:K04500]
130196919  [KO:K04501]
130196988  cdc45; cell division control protein 45 homolog [KO:K06628]
130197222  [KO:K06670]
130197229  cdk7; cyclin-dependent kinase 7 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
130197245  [KO:K03363]
130197302  ndc80; kinetochore protein NDC80 homolog [KO:K11547]
130197327  ccnh; cyclin-H isoform X1 [KO:K06634]
130197622  [KO:K06639] [EC:3.1.3.16 3.1.3.48]
130197816  fzr1a; fizzy/cell division cycle 20 related 1a [KO:K03364]
130197892  mcm6; LOW QUALITY PROTEIN: DNA replication licensing factor MCM6 [KO:K02542] [EC:5.6.2.3]
130197932  mcm4; DNA replication licensing factor MCM4 [KO:K02212] [EC:5.6.2.3]
130197972  cdc20; cell division cycle protein 20 homolog [KO:K03363]
130198002  cdc7; cell division cycle 7-related protein kinase isoform X1 [KO:K02214] [EC:2.7.11.1]
130198041  orc2; origin recognition complex subunit 2 [KO:K02604]
130198291  e2f5; transcription factor E2F5 isoform X1 [KO:K04682]
130198330  fzr1b; fizzy-related protein homolog [KO:K03364]
130199282  mad2l2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
130199519  [KO:K16197]
130199606  rad21l1; double-strand-break repair protein rad21-like protein 1 [KO:K06670]
130199847  smc1a; structural maintenance of chromosomes protein 1A [KO:K06636]
130199858  zbtb17; zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500]
130200020  e2f1; transcription factor E2F1 [KO:K17454]
130200549  cdkn1ba; LOW QUALITY PROTEIN: cyclin-dependent kinase inhibitor 1Ba [KO:K06624]
130200639  [KO:K10151]
130200655  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
130200673  cdkn1d; cyclin-dependent kinase inhibitor 1D [KO:K06625]
130200788  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
130200794  orc5; origin recognition complex subunit 5 [KO:K02607]
130201025  atr; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
130201032  stag1a; cohesin subunit SA-1a isoform X1 [KO:K06671]
130201213  orc3; origin recognition complex subunit 3 [KO:K02605]
130201274  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
130201347  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
130201456  ppp2r5eb; protein phosphatase 2, regulatory subunit B', epsilon isoform X1 [KO:K11584]
130201521  [KO:K04402]
130201544  [KO:K06067] [EC:3.5.1.98]
130201831  bub1bb; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
130201894  e2f2; transcription factor E2F2 [KO:K09389]
130202055  [KO:K16197]
130202287  ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
130202409  ppp2r5cb; protein phosphatase 2, regulatory subunit B', gamma b isoform X1 [KO:K11584]
130202489  mcm3; DNA replication licensing factor MCM3 [KO:K02541] [EC:5.6.2.3]
130202747  [KO:K11542]
130202871  esco2; N-acetyltransferase ESCO2 isoform X1 [KO:K11268] [EC:2.3.1.-]
130202874  [KO:K13377]
130202980  bub1; mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
130203276  [KO:K04498] [EC:2.3.1.48]
130203379  anapc16; anaphase-promoting complex subunit 16 [KO:K25229]
130203494  bub3; mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
130203684  [KO:K25163]
130203976  dbf4b; uncharacterized protein dbf4b [KO:K06629]
130204072  pkmyt1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
130204499  orc4; origin recognition complex subunit 4 isoform X1 [KO:K02606]
130204911  abl1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
130204966  cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
130204974  smad4a; mothers against decapentaplegic homolog 4a isoform X1 [KO:K04501]
130204995  ccnb1; G2/mitotic-specific cyclin-B1 isoform X1 [KO:K05868]
130205015  smad2; mothers against decapentaplegic homolog 2 [KO:K04500]
130205111  skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
130205122  hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
130205257  [KO:K06672]
130205329  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 isoform X1 [KO:K04402]
130205428  [KO:K04402]
130205498  [KO:K04683]
130205957  [KO:K03347]
130205973  [KO:K06642] [EC:2.7.11.1]
130206059  [KO:K06642] [EC:2.7.11.1]
130206071  ywhaz; 14-3-3 protein zeta/delta [KO:K16197]
130206475  tgfb2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
130206496  myca; transcriptional regulator Myc-A [KO:K04377]
130207070  mad2l1bp; MAD2L1-binding protein [KO:K26093]
130207089  cdc16; cell division cycle protein 16 homolog [KO:K03353]
130207286  wapla; wings apart-like protein homolog [KO:K25163]
130207300  e2f3; transcription factor E2F3 isoform X1 [KO:K06620]
130207440  cdt1; DNA replication factor Cdt1 [KO:K10727]
130207511  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
130207745  ywhaba; 14-3-3 protein beta/alpha-A [KO:K16197]
130208047  rbl1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
130208048  mcm2; DNA replication licensing factor MCM2 [KO:K02540] [EC:5.6.2.3]
130208146  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
130208340  cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
130208515  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
130208696  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
130209032  espl1; separin [KO:K02365] [EC:3.4.22.49]
130209106  smad10a; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
130209207  atrx; transcriptional regulator ATRX isoform X1 [KO:K10779]
130209326  [KO:K11542]
130209440  [KO:K11479] [EC:2.7.11.1]
130209454  pttg1; securin [KO:K06635]
130209520  mcm7; DNA replication licensing factor MCM7 [KO:K02210] [EC:5.6.2.3]
130209574  [KO:K11479] [EC:2.7.11.1]
130209580  ccna2; cyclin-A2 [KO:K06627]
130209644  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
130209700  [KO:K06671]
130209873  cdc23; cell division cycle protein 23 homolog [KO:K03355]
130209935  [KO:K04382] [EC:3.1.3.16]
130210119  stag2b; cohesin subunit SA-2 [KO:K06671]
130210378  [KO:K11267]
130210408  [KO:K04728] [EC:2.7.11.1]
130210412  [KO:K04728] [EC:2.7.11.1]
130210444  ywhae1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 [KO:K06630]
130210498  ccnp; cyclin N-terminal domain-containing protein 2 [KO:K21770]
130210873  ppp2r1bb; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
130210959  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
130211132  ywhag2; 14-3-3 protein gamma-1 [KO:K16198]
130211208  ppp2cab; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
130211296  skp1; S-phase kinase-associated protein 1 [KO:K03094]
130211385  anapc15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
130211731  mad2l1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
130211854  ccnb3; G2/mitotic-specific cyclin-B3 [KO:K21771]
130211870  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
130211962  hdac8; histone deacetylase 8 isoform X1 [KO:K11405] [EC:3.5.1.98]
130211988  ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
130212249  anapc10; anaphase-promoting complex subunit 10 [KO:K03357]
130212754  [KO:K06670]
130212825  trip13; pachytene checkpoint protein 2 homolog [KO:K22399]
130212938  dbf4; protein DBF4 homolog A isoform X1 [KO:K06629]
130213169  mtbp; mdm2-binding protein [KO:K26116]
130213349  [KO:K06620]
Reference
PMID:7908906
  Authors
Matsuoka S, Yamaguchi M, Matsukage A
  Title
D-type cyclin-binding regions of proliferating cell nuclear antigen.
  Journal
J Biol Chem 269:11030-6 (1994)
Reference
PMID:8242749
  Authors
Welch PJ, Wang JY
  Title
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.
  Journal
Cell 75:779-90 (1993)
DOI:10.1016/0092-8674(93)90497-E
Reference
PMID:16936746
  Authors
Macaluso M, Montanari M, Giordano A
  Title
Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes.
  Journal
Oncogene 25:5263-7 (2006)
DOI:10.1038/sj.onc.1209680
Reference
PMID:15838516
  Authors
Cobrinik D
  Title
Pocket proteins and cell cycle control.
  Journal
Oncogene 24:2796-809 (2005)
DOI:10.1038/sj.onc.1208619
Reference
PMID:17568790
  Authors
Boutros R, Lobjois V, Ducommun B
  Title
CDC25 phosphatases in cancer cells: key players? Good targets?
  Journal
Nat Rev Cancer 7:495-507 (2007)
DOI:10.1038/nrc2169
Reference
PMID:9832503
  Authors
Diehl JA, Cheng M, Roussel MF, Sherr CJ
  Title
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
  Journal
Genes Dev 12:3499-511 (1998)
DOI:10.1101/gad.12.22.3499
Reference
PMID:19020303
  Authors
Klein EA, Assoian RK
  Title
Transcriptional regulation of the cyclin D1 gene at a glance.
  Journal
J Cell Sci 121:3853-7 (2008)
DOI:10.1242/jcs.039131
Reference
PMID:10385618
  Authors
Sherr CJ, Roberts JM
  Title
CDK inhibitors: positive and negative regulators of G1-phase progression.
  Journal
Genes Dev 13:1501-12 (1999)
DOI:10.1101/gad.13.12.1501
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:12925736
  Authors
Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H, Hatakeyama S, Nakayama K, Nakayama KI
  Title
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
  Journal
Proc Natl Acad Sci U S A 100:10231-6 (2003)
DOI:10.1073/pnas.1831009100
Reference
PMID:16212951
  Authors
Bond M, Sala-Newby GB, Wu YJ, Newby AC
  Title
Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI 3-kinase and Skp2-mediated degradation.
  Journal
Cardiovasc Res 69:198-206 (2006)
DOI:10.1016/j.cardiores.2005.08.020
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11099028
  Authors
Vogelstein B, Lane D, Levine AJ
  Title
Surfing the p53 network.
  Journal
Nature 408:307-10 (2000)
DOI:10.1038/35042675
Reference
PMID:7973727
  Authors
Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM, Fornace AJ Jr
  Title
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
  Journal
Science 266:1376-80 (1994)
DOI:10.1126/science.7973727
Reference
PMID:9889196
  Authors
Petersen BO, Lukas J, Sorensen CS, Bartek J, Helin K
  Title
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
  Journal
EMBO J 18:396-410 (1999)
DOI:10.1093/emboj/18.2.396
Reference
PMID:17018296
  Authors
Sheu YJ, Stillman B
  Title
Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.
  Journal
Mol Cell 24:101-13 (2006)
DOI:10.1016/j.molcel.2006.07.033
Reference
PMID:9029154
  Authors
Martinez AM, Afshar M, Martin F, Cavadore JC, Labbe JC, Doree M
  Title
Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.
  Journal
EMBO J 16:343-54 (1997)
DOI:10.1093/emboj/16.2.343
Reference
PMID:15876871
  Authors
Lolli G, Johnson LN
  Title
CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
  Journal
Cell Cycle 4:572-7 (2005)
DOI:10.4161/cc.4.4.1607
Reference
PMID:17426725
  Authors
Musacchio A, Salmon ED
  Title
The spindle-assembly checkpoint in space and time.
  Journal
Nat Rev Mol Cell Biol 8:379-93 (2007)
DOI:10.1038/nrm2163
Reference
PMID:12573239
  Authors
Uhlmann F
  Title
Chromosome cohesion and separation: from men and molecules.
  Journal
Curr Biol 13:R104-14 (2003)
DOI:10.1016/S0960-9822(03)00039-3
Reference
PMID:15568976
  Authors
Stegmeier F, Amon A
  Title
Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.
  Journal
Annu Rev Genet 38:203-32 (2004)
DOI:10.1146/annurev.genet.38.072902.093051
Reference
PMID:9618481
  Authors
Moustakas A, Kardassis D
  Title
Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
  Journal
Proc Natl Acad Sci U S A 95:6733-8 (1998)
DOI:10.1073/pnas.95.12.6733
Reference
PMID:26650195
  Authors
de Boer HR, Guerrero Llobet S, van Vugt MA
  Title
Controlling the response to DNA damage by the APC/C-Cdh1.
  Journal
Cell Mol Life Sci 73:949-60 (2016)
DOI:10.1007/s00018-015-2096-7
Reference
PMID:20935501
  Authors
Qiao X, Zhang L, Gamper AM, Fujita T, Wan Y
  Title
APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.
  Journal
Cell Cycle 9:3904-12 (2010)
DOI:10.4161/cc.9.19.13585
Related
pathway
pswi03030  DNA replication
pswi04010  MAPK signaling pathway
pswi04120  Ubiquitin mediated proteolysis
pswi04210  Apoptosis
KO pathway
ko04110   

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