Entry Name mTOR signaling pathway - Sarcophilus harrisii (Tasmanian devil)
Description The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Organism Sarcophilus harrisii (Tasmanian devil) [GN:
shr ]
Gene 100913487 TELO2; telomere length regulation protein TEL2 homolog [KO:K11137 ]
100916936 LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068 ]
100917313 GRB10; growth factor receptor-bound protein 10 isoform X1 [KO:K20064 ]
100919693 LAMTOR4; ragulator complex protein LAMTOR4 isoform X2 [KO:K20399 ]
100919788 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
100919911 SLC7A5; large neutral amino acids transporter small subunit 1 [KO:K13780 ]
100920393 CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081 ]
100921352 ATP6V1G2; V-type proton ATPase subunit G 2 isoform X2 [KO:K02152 ]
100921545 EIF4E; eukaryotic translation initiation factor 4E isoform X4 [KO:K03259 ]
100922213 STRADA; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271 ]
100924084 MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410 ]
100924709 ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148 ]
100924976 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649 ]
100926892 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
100928988 EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259 ]
100929387 CLIP1; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421 ]
100929811 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
100930633 LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068 ]
100930744 ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147 ]
100930970 RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204 ]
100931454 ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147 ]
100931932 DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353 ]
100932099 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
100932117 LAMTOR5; ragulator complex protein LAMTOR5 isoform X1 [KO:K16344 ]
100932119 DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353 ]
100932600 DVL1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353 ]
100933018 DEPTOR; DEP domain-containing mTOR-interacting protein [KO:K20402 ]
100934058 RICTOR; rapamycin-insensitive companion of mTOR isoform X4 [KO:K08267 ]
100934653 EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259 ]
100934681 CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1 [KO:K23080 ]
100934756 SLC38A9; sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995 ]
100935230 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
105749979 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
105750458 STRADB; STE20-related kinase adapter protein beta isoform X1 [KO:K17532 ]
111718631 EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205 ]
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Kennedy BK, Lamming DW
Title The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
Journal Reference Authors Shimobayashi M, Hall MN
Title Making new contacts: the mTOR network in metabolism and signalling crosstalk.
Journal Reference Authors Huang K, Fingar DC
Title Growing knowledge of the mTOR signaling network.
Journal Reference Authors Bockaert J, Marin P
Title mTOR in Brain Physiology and Pathologies.
Journal Reference Authors Caron A, Richard D, Laplante M
Title The Roles of mTOR Complexes in Lipid Metabolism.
Journal Reference Authors Shimobayashi M, Hall MN
Title Multiple amino acid sensing inputs to mTORC1.
Journal Reference Authors Bar-Peled L, Sabatini DM
Title Regulation of mTORC1 by amino acids.
Journal Reference Authors Fingar DC
Title Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
Journal Reference Authors Cai H, Dong LQ, Liu F
Title Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
Journal Reference Authors Eyre TA, Collins GP, Goldstone AH, Cwynarski K
Title Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
Journal Reference Authors Jewell JL, Guan KL
Title Nutrient signaling to mTOR and cell growth.
Journal Reference Authors Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
Title mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
Journal Reference Authors Kim SG, Buel GR, Blenis J
Title Nutrient regulation of the mTOR complex 1 signaling pathway.
Journal Reference Authors Laplante M, Sabatini DM
Title mTOR signaling at a glance.
Journal Reference Authors Alessi DR, Sakamoto K, Bayascas JR
Title LKB1-dependent signaling pathways.
Journal Reference Authors Dan HC, Antonia RJ, Baldwin AS
Title PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
Journal Reference Authors Saxton RA, Sabatini DM
Title mTOR Signaling in Growth, Metabolism, and Disease.
Journal Related shr04810 Regulation of actin cytoskeleton
KO pathway
