KEGG   PATHWAY: shr04151
Entry
shr04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Sarcophilus harrisii (Tasmanian devil)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
shr04151  PI3K-Akt signaling pathway
shr04151

Other DBs
GO: 0043491
Organism
Sarcophilus harrisii (Tasmanian devil) [GN:shr]
Gene
100913231  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
100913262  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100913275  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
100913327  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
100913337  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100913423  VEGFA; vascular endothelial growth factor A [KO:K05448]
100913437  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
100913480  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
100913507  FLT3LG; fms-related tyrosine kinase 3 ligand [KO:K05454]
100913539  ITGA8; integrin alpha-8 [KO:K06584]
100913624  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100913697  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100913762  ITGB6; integrin beta-6 [KO:K06589]
100913793  THBS2; thrombospondin-2 [KO:K04659]
100913890  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
100913968  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
100913979  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100914017  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100914083  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
100914193  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X3 [KO:K04450]
100914310  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
100914332  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
100914347  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
100914443  [KO:K05415]
100914479  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
100914586  FGF23; fibroblast growth factor 23 [KO:K22428]
100914681  IL4; interleukin-4 [KO:K05430]
100914703  [KO:K05414]
100914727  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
100914734  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
100914745  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
100914865  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
100914965  [KO:K05414]
100915177  COL2A1; collagen alpha-1(II) chain isoform X2 [KO:K19719]
100915217  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
100915220  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
100915359  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100915478  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
100915526  KRAS; GTPase KRas isoform X1 [KO:K07827]
100915548  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
100915601  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
100915656  FGF22; fibroblast growth factor 22 [KO:K04358]
100915696  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
100915723  MTCP1; protein p13 MTCP-1 [KO:K16837]
100915783  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
100915961  EREG; proepiregulin [KO:K09784]
100915999  PRLR; prolactin receptor [KO:K05081]
100916041  COL1A2; collagen alpha-2(I) chain [KO:K06236]
100916102  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
100916128  G6PC; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
100916355  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
100916388  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
100916673  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100916676  FGF19; fibroblast growth factor 19 [KO:K22603]
100916681  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
100916950  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
100916991  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
100916999  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
100917006  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X6 [KO:K05629]
100917007  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
100917083  FOXO3; forkhead box protein O3 [KO:K09408]
100917212  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
100917328  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
100917396  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
100917462  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100917513  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
100917568  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
100917586  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
100917619  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100917654  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
100917856  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
100917875  PDGFB; platelet-derived growth factor subunit B isoform X2 [KO:K17386]
100917881  HSP90B1; endoplasmin [KO:K09487]
100917948  IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
100917987  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100918091  [KO:K06856]
100918116  IRS1; insulin receptor substrate 1 [KO:K16172]
100918165  TSC1; hamartin isoform X1 [KO:K07206]
100918178  [KO:K13304] [EC:2.7.11.1]
100918372  VEGFD; vascular endothelial growth factor D [KO:K05449]
100918400  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
100918445  TSC2; tuberin isoform X1 [KO:K07207]
100918487  [KO:K07205]
100918745  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
100918816  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
100919006  RHEB; GTP-binding protein Rheb [KO:K07208]
100919064  IFNAR1; LOW QUALITY PROTEIN: interferon alpha/beta receptor 1 [KO:K05130]
100919163  ITGB4; integrin beta-4 isoform X2 [KO:K06525]
100919191  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
100919485  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
100919657  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100919659  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
100919776  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
100919819  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
100919874  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
100919960  CHAD; chondroadherin [KO:K06248]
100920040  ARTN; artemin [KO:K25415]
100920108  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
100920192  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
100920266  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
100920298  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
100920321  [KO:K06643] [EC:2.3.2.27]
100920428  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
100920456  FGF9; fibroblast growth factor 9 [KO:K04358]
100920489  ITGB7; integrin beta-7 [KO:K06590]
100920537  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
100920576  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
100920602  ANGPT4; angiopoietin-4 [KO:K05467]
100920700  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
100920734  ITGB3; integrin beta-3 [KO:K06493]
100920799  [KO:K04546]
100920810  COL9A2; LOW QUALITY PROTEIN: collagen alpha-2(IX) chain [KO:K08131]
100920836  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
100920942  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
100920968  [KO:K05414]
100921029  SGK2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
100921166  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
100921255  LAMC1; laminin subunit gamma-1 [KO:K05635]
100921308  MYC; myc proto-oncogene protein [KO:K04377]
100921310  PKN1; serine/threonine-protein kinase N1 isoform X2 [KO:K06071] [EC:2.7.11.13]
100921360  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
100921523  LAMC2; laminin subunit gamma-2 [KO:K06246]
100921545  EIF4E; eukaryotic translation initiation factor 4E isoform X4 [KO:K03259]
100921764  YWHAH; 14-3-3 protein eta [KO:K16198]
100921812  FGF4; fibroblast growth factor 4 [KO:K04358]
100921894  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
100921899  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
100921980  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
100922067  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
100922075  FGF3; fibroblast growth factor 3 [KO:K04358]
100922104  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
100922143  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
100922222  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
100922223  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
100922413  VEGFB; vascular endothelial growth factor B [KO:K16858]
100922441  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
100922455  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X3 [KO:K11583]
100922473  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
100922551  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
100922583  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
100922737  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
100922824  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
100922930  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
100922990  LAMB3; LOW QUALITY PROTEIN: laminin subunit beta-3 [KO:K06244]
100922992  [KO:K05438]
100923082  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
100923118  FGF18; fibroblast growth factor 18 [KO:K04358]
100923187  ITGA5; integrin alpha-5 [KO:K06484]
100923199  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
100923249  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
100923506  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
100923854  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
100923925  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
100924075  AREG; amphiregulin [KO:K09782]
100924154  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
100924158  SPP1; osteopontin [KO:K06250]
100924454  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
100924490  EPO; erythropoietin [KO:K05437]
100924495  LAMA2; laminin subunit alpha-2 isoform X4 [KO:K05637]
100924531  LAMA5; laminin subunit alpha-5 [KO:K06240]
100924586  [KO:K05084] [EC:2.7.10.1]
100924608  PKN3; serine/threonine-protein kinase N3 [KO:K23692]
100924632  ITGA9; integrin alpha-9 [KO:K06585]
100924664  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
100924667  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
100924685  IBSP; bone sialoprotein 2 [KO:K06253]
100924976  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
100924985  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100925116  PDGFRA; platelet-derived growth factor receptor alpha isoform X2 [KO:K04363] [EC:2.7.10.1]
100925165  G6PC2; LOW QUALITY PROTEIN: glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
100925192  VTN; vitronectin [KO:K06251]
100925286  FGF20; fibroblast growth factor 20 [KO:K04358]
100925381  FGF8; fibroblast growth factor 8 isoform X3 [KO:K04358]
100925383  FGF7; fibroblast growth factor 7 [KO:K04358]
100925440  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100925445  CSF3; LOW QUALITY PROTEIN: granulocyte colony-stimulating factor [KO:K05423]
100925455  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
100925473  PGF; placenta growth factor [KO:K16859]
100925503  [KO:K06856]
100925562  TNC; tenascin isoform X1 [KO:K06252]
100925568  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
100925578  LAMA1; laminin subunit alpha-1 [KO:K05637]
100925629  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
100925631  CDK2; cyclin-dependent kinase 2 isoform X4 [KO:K02206] [EC:2.7.11.22]
100925712  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
100926054  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
100926118  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
100926139  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
100926384  EPHA2; LOW QUALITY PROTEIN: ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
100926416  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
100926531  YWHAQ; 14-3-3 protein theta [KO:K16197]
100926666  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100926698  THBS1; thrombospondin-1 [KO:K16857]
100926701  IKBKG; NF-kappa-B essential modulator isoform X3 [KO:K07210]
100926708  RXRA; retinoic acid receptor RXR-alpha isoform X3 [KO:K08524]
100926716  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
100926884  THBS4; thrombospondin-4 [KO:K04659]
100926892  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100927043  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
100927086  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
100927125  TLR4; toll-like receptor 4 [KO:K10160]
100927161  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
100927189  ITGA7; integrin alpha-7 isoform X2 [KO:K06583]
100927199  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100927200  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
100927237  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
100927252  [KO:K07827]
100927322  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
100927485  RPS6; 40S ribosomal protein S6 [KO:K02991]
100927509  FN1; fibronectin isoform X4 [KO:K05717]
100927576  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
100927581  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
100927655  GHR; growth hormone receptor isoform X1 [KO:K05080]
100927720  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
100927939  EFNA1; ephrin-A1 [KO:K05462]
100928055  CDKN1B; cyclin-dependent kinase inhibitor 1B isoform X1 [KO:K06624]
100928068  IGF2; insulin-like growth factor II [KO:K13769]
100928148  PDGFC; platelet-derived growth factor C [KO:K05450]
100928183  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]
100928224  FGF5; fibroblast growth factor 5 [KO:K04358]
100928379  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
100928380  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100928637  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
100928648  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
100928707  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
100928742  VEGFC; vascular endothelial growth factor C [KO:K05449]
100928770  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
100928870  EFNA2; ephrin-A2 [KO:K05462]
100928896  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
100928900  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
100928932  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
100928944  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
100928953  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
100928986  NRAS; GTPase NRas [KO:K07828]
100928988  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
100929053  ITGAV; integrin alpha-V [KO:K06487]
100929086  LAMB1; laminin subunit beta-1 [KO:K05636]
100929091  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
100929099  ITGA11; integrin alpha-11 [KO:K06587]
100929168  [KO:K02833]
100929204  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
100929219  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
100929232  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691]
100929346  KIT; mast/stem cell growth factor receptor Kit isoform X2 [KO:K05091] [EC:2.7.10.1]
100929371  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
100929426  [KO:K07827]
100929695  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
100929781  IL2RG; cytokine receptor common subunit gamma isoform X2 [KO:K05070]
100929811  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100929912  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
100929957  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
100929969  ITGA1; integrin alpha-1 [KO:K06480]
100930095  TNN; tenascin-N [KO:K06252]
100930114  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
100930153  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
100930187  G6PC3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
100930217  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X7 [KO:K11584]
100930278  CSF1; macrophage colony-stimulating factor 1 isoform X2 [KO:K05453]
100930279  NGF; beta-nerve growth factor [KO:K02582]
100930353  TNR; tenascin-R isoform X1 [KO:K06252]
100930426  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
100930507  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
100930707  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X2 [KO:K04688] [EC:2.7.11.1]
100930970  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
100931009  SOS1; son of sevenless homolog 1 isoform X2 [KO:K03099]
100931238  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
100931239  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
100931317  FGF21; fibroblast growth factor 21 [KO:K22429]
100931469  [KO:K06243]
100931480  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
100931481  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
100931514  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
100931618  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
100931663  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
100931703  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
100931776  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
100931911  [KO:K02583]
100931978  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
100932021  ITGA2B; integrin alpha-IIb [KO:K06476]
100932059  FGF17; fibroblast growth factor 17 [KO:K04358]
100932071  PSPN; persephin [KO:K25416]
100932099  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100932215  FGFR2; fibroblast growth factor receptor 2 isoform X4 [KO:K05093] [EC:2.7.10.1]
100932232  BCL2L11; LOW QUALITY PROTEIN: bcl-2-like protein 11 [KO:K16341]
100932241  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
100932306  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
100932324  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
100932455  YWHAG; 14-3-3 protein gamma [KO:K16198]
100932473  RELA; transcription factor p65 [KO:K04735]
100932534  [KO:K04289]
100932612  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
100932648  [KO:K04382] [EC:3.1.3.16]
100932708  TNXB; tenascin-X isoform X1 [KO:K06252]
100932842  PRL; prolactin [KO:K05439]
100932859  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
100932899  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100932966  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
100932981  TLR2; toll-like receptor 2 [KO:K10159]
100932999  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100933019  PTK2; focal adhesion kinase 1 isoform X6 [KO:K05725] [EC:2.7.10.2]
100933047  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
100933169  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
100933266  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X3 [KO:K04354]
100933417  COL6A2; LOW QUALITY PROTEIN: collagen alpha-2(VI) chain [KO:K06238]
100933451  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
100933453  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
100933673  VWF; von Willebrand factor [KO:K03900]
100933735  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
100934145  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
100934321  OSMR; oncostatin-M-specific receptor subunit beta [KO:K05057]
100934330  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100934452  KITLG; kit ligand isoform X1 [KO:K05461]
100934542  FGF2; fibroblast growth factor 2 [KO:K18497]
100934583  COMP; cartilage oligomeric matrix protein [KO:K04659]
100934653  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
100934666  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
100934722  FGF6; fibroblast growth factor 6 [KO:K04358]
100934743  FGF16; fibroblast growth factor 16 [KO:K04358]
100934757  F2R; proteinase-activated receptor 1 [KO:K03914]
100934810  BDNF; brain-derived neurotrophic factor isoform X2 [KO:K04355]
100934873  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
100935068  [KO:K05429]
100935081  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
100935143  SGK1; serine/threonine-protein kinase Sgk1 isoform X3 [KO:K13302] [EC:2.7.11.1]
100935179  LAMC3; laminin subunit gamma-3 isoform X1 [KO:K06247]
100935202  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
100935230  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100935274  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
100935579  [KO:K06856]
105749408  NRTN; neurturin [KO:K25414]
105749464  [KO:K05418]
105749727  ITGA2; integrin alpha-2 [KO:K06481]
105749898  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
105749979  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
105749995  [KO:K04737]
105750087  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
105750469  [KO:K08270]
105750698  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
105750762  IL6; interleukin-6 [KO:K05405]
111718631  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
111719421  [KO:K06243]
111721183  [KO:K06238]
111721579  [KO:K05096] [EC:2.7.10.1]
116419913  HRAS; GTPase HRas [KO:K02833]
116419978  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
116419987  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
116420560  IL7; interleukin-7 [KO:K05431]
116420987  [KO:K05414]
116420989  [KO:K05414]
116421948  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
116422035  [KO:K04359]
116423189  FGF10; fibroblast growth factor 10 [KO:K04358]
116423339  EFNA3; LOW QUALITY PROTEIN: ephrin-A3 [KO:K05462]
116423340  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
shr00010  Glycolysis / Gluconeogenesis
shr04010  MAPK signaling pathway
shr04012  ErbB signaling pathway
shr04062  Chemokine signaling pathway
shr04064  NF-kappa B signaling pathway
shr04068  FoxO signaling pathway
shr04110  Cell cycle
shr04115  p53 signaling pathway
shr04150  mTOR signaling pathway
shr04210  Apoptosis
shr04370  VEGF signaling pathway
shr04510  Focal adhesion
shr04620  Toll-like receptor signaling pathway
shr04630  JAK-STAT signaling pathway
shr04662  B cell receptor signaling pathway
shr04910  Insulin signaling pathway
KO pathway
ko04151   

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