Homo sapiens (human): 6328
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Entry
6328 CDS
T01001
Symbol
SCN3A, DEE62, EIEE62, FFEVF4, NAC3, Nav1.3
Name
(RefSeq) sodium channel protein type 3 subunit alpha isoform 2
KO
K04836
voltage-gated sodium channel type III alpha
Organism
hsa
Homo sapiens (human)
Pathway
hsa04742
Taste transduction
Disease
H00606
Early infantile epileptic encephalopathy
H02214
Familial focal epilepsy with variable foci
Drug target
Actisomide:
D02762
Ajmaline:
D00199
Aminobenzoic acid (
DG00379
):
D02456
D02906
D02907
Amiodarone (
DG00204
):
D00636
<JP/US>
D02910
Aprindine (
DG00199
):
D01326
<JP>
D02969
Articaine (
DG00805
):
D02991
<US>
D07468
Benzocaine:
D00552
<JP>
Bliretrigine:
D12616
Bupivacaine (
DG00801
):
D01450
<JP/US>
D07552
<US>
Carbamazepine:
D00252
<JP/US>
Cenobamate:
D11150
<US>
Chloroprocaine (
DG00800
):
D00732
<US>
D07678
Cibenzoline (
DG00209
):
D01455
<JP>
D03492
Cinchocaine (
DG00297
):
D00733
D02220
Cocaine (
DG00808
):
D00110
D02182
<US>
Disopyramide (
DG00194
):
D00303
<JP>
D00637
<JP/US>
Eleclazine:
D11155
Encainide (
DG00203
):
D03991
D07894
Eslicarbazepine (
DG00848
):
D09215
D09612
<US>
Ethyl piperidinoacetylaminobenzoate:
D01519
Etidocaine (
DG00804
):
D00737
D04095
Flecainide (
DG00201
):
D00638
<JP/US>
D07962
Fosphenytoin (
DG00847
):
D02096
<US>
D07595
<JP>
D07993
Indecainide hydrochloride:
D04521
Lacosamide:
D07299
<JP/US>
Lamotrigine:
D00354
<JP/US>
Levobupivacaine (
DG00807
):
D01287
<JP>
D08116
Levosemotiadil fumarate:
D09833
Lidocaine (
DG00196
):
D00358
<JP/US>
D02086
<JP/US>
D08127
<JP/US>
Lorajmine:
D04774
Mephenytoin:
D00375
Mepivacaine (
DG00802
):
D00738
<JP/US>
D08181
Mexiletine (
DG00197
):
D00639
<JP/US>
D08215
Oxcarbazepine:
D00533
<US>
Oxetacaine (
DG00299
):
D01152
<JP>
D08311
Oxybuprocaine (
DG00392
):
D01768
<JP>
D08319
Phenytoin (
DG00846
):
D00512
<JP/US>
D02103
<JP/US>
Pilsicainide (
DG01257
):
D01554
<JP>
D08377
Pirmenol (
DG01381
):
D01785
<JP>
D06517
D08394
Pramocaine (
DG00300
):
D00739
D08407
Prilocaine (
DG00803
):
D00553
D01243
<US>
Procainamide (
DG00193
):
D00477
<JP/US>
D08421
Procaine (
DG00298
):
D00740
<JP>
D08422
Propafenone (
DG00200
):
D00640
<JP/US>
D08435
Proxymetacaine (
DG01145
):
D02098
<US>
D08448
Quinidine (
DG00192
):
D00642
<US>
D00643
D02272
<JP/US>
D08458
D08459
Recainam (
DG01421
):
D05708
D05709
Ropivacaine (
DG00806
):
D04048
<JP/US>
D08490
Rufinamide:
D05775
<JP/US>
Sparteine (
DG00195
):
D01041
D02239
Tetracaine (
DG00296
):
D00551
D00741
<US>
Tocainide (
DG00198
):
D02088
D06172
Topiramate:
D00537
<JP/US>
Transcainide:
D06203
Zonisamide:
D00538
<JP/US>
p-Butylaminobenzoyldiethylaminoethyl hydrochloride:
D01967
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09157 Sensory system
04742 Taste transduction
6328 (SCN3A)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04040 Ion channels [BR:
hsa04040
]
6328 (SCN3A)
Ion channels [BR:
hsa04040
]
Voltage-gated cation channels
Sodium channel, voltage-gated (Nav)
6328 (SCN3A)
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Ion_trans
Na_trans_assoc
Na_trans_cytopl
IQ_SCN5A_C
PKD_channel
GPHH
ATP-synt_B
HpsJ
IQ
Lustrin_cystein
FraC
Motif
Other DBs
NCBI-GeneID:
6328
NCBI-ProteinID:
NP_001075145
OMIM:
182391
HGNC:
10590
UniProt:
Q9NY46
Q9C007
Structure
PDB
PDBj
LinkDB
All DBs
Position
2:complement(165087526..165204050)
Genome browser
AA seq
1951 aa
AA seq
DB search
MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKN
LPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKI
AIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCL
EDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL
IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMD
SNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPN
YGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLIL
AVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGE
LLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFS
MDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEHST
FEDSESRRDSLFVPHRHGERRNSNGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIA
SILTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITIC
IVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDG
IIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL
AIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMW
DCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVG
RMQKGIDYVKNKMRECFQKAFFRKPKVIEIHEGNKIDSCMSNNTGIEISKELNYLRDGNG
TTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEES
KEKLNATSSSEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKG
KIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTY
IFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRAL
RPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTT
GNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDS
RDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQ
KKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDD
QGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEM
IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIY
AIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPD
TIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDD
FEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHC
LDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQR
NFRCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPS
YDSVTKPDKEKFEKDKPEKESKGKEVRENQK
NT seq
5856 nt
NT seq
+upstream
nt +downstream
nt
atggcacaggcactgttggtacccccaggacctgaaagcttccgcctttttactagagaa
tctcttgctgctatcgaaaaacgtgctgcagaagagaaagccaagaagcccaaaaaggaa
caagataatgatgatgagaacaaaccaaagccaaatagtgacttggaagctggaaagaac
cttccatttatttatggagacattcctccagagatggtgtcagagcccctggaggacctg
gatccctactatatcaataagaaaacttttatagtaatgaataaaggaaaggcaattttc
cgattcagtgccacctctgccttgtatattttaactccactaaaccctgttaggaaaatt
gctatcaagattttggtacattctttattcagcatgcttatcatgtgcactattttgacc
aactgtgtatttatgaccttgagcaaccctcctgactggacaaagaatgtagagtacaca
ttcactggaatctatacctttgagtcacttataaaaatcttggcaagagggttttgctta
gaagattttacgtttcttcgtgatccatggaactggctggatttcagtgtcattgtgatg
gcatatgtgacagagtttgtggacctgggcaatgtctcagcgttgagaacattcagagtt
ctccgagcactgaaaacaatttcagtcattccaggtttaaagaccattgtgggggccctg
atccagtcggtaaagaagctttctgatgtgatgatcctgactgtgttctgtctgagcgtg
tttgctctcattgggctgcagctgttcatgggcaatctgaggaataaatgtttgcagtgg
cccccaagcgattctgcttttgaaaccaacaccacttcctactttaatggcacaatggat
tcaaatgggacatttgttaatgtaacaatgagcacatttaactggaaggattacattgga
gatgacagtcacttttatgttttggatgggcaaaaagaccctttactctgtggaaatggc
tcagatgcaggccagtgtccagaaggatacatctgtgtgaaggctggtcgaaaccccaac
tatggctacacaagctttgacacctttagctgggctttcctgtctctatttcgactcatg
actcaagactactgggaaaatctttaccagttgacattacgtgctgctgggaaaacatac
atgatattttttgtcctggtcattttcttgggctcattttatttggtgaatttgatcctg
gctgtggtggccatggcctatgaggagcagaatcaggccaccttggaagaagcagaacaa
aaagaggccgaatttcagcagatgctcgaacagcttaaaaagcaacaggaagaagctcag
gcagttgcggcagcatcagctgcttcaagagatttcagtggaataggtgggttaggagag
ctgttggaaagttcttcagaagcatcaaagttgagttccaaaagtgctaaagaatggagg
aaccgaaggaagaaaagaagacagagagagcaccttgaaggaaacaacaaaggagagaga
gacagctttcccaaatccgaatctgaagacagcgtcaaaagaagcagcttccttttctcc
atggatggaaacagactgaccagtgacaaaaaattctgctcccctcatcagtctctcttg
agtatccgtggctccctgttttccccaagacgcaatagcaaaacaagcattttcagtttc
agaggtcgggcaaaggatgttggatctgaaaatgactttgctgatgatgaacacagcaca
tttgaagacagcgaaagcaggagagactcactgtttgtgccgcacagacatggagagcga
cgcaacagtaacggcaccaccacagaaacggaagtcagaaagagaaggttaagctcttac
cagatttcaatggagatgctggaggattcctctggaaggcaaagagccgtgagcatagcc
agcattctgaccaacacaatggaagaacttgaagaatctagacagaaatgtccgccatgc
tggtatagatttgccaatgtgttcttgatctgggactgctgtgatgcatggttaaaagta
aaacatcttgtgaatttaattgttatggatccatttgttgatcttgccatcactatttgc
attgtcttaaataccctctttatggccatggagcactaccccatgactgagcaattcagt
agtgtgttgactgtaggaaacctggtctttactgggattttcacagcagaaatggttctc
aagatcattgccatggatccttattactatttccaagaaggctggaatatctttgatgga
attattgtcagcctcagtttaatggagcttggtctgtcaaatgtggagggattgtctgta
ctgcgatcattcagactgcttagagttttcaagttggcaaaatcctggcccacactaaat
atgctaattaagatcattggcaattctgtgggggctctaggaaacctcaccttggtgttg
gccatcatcgtcttcatttttgctgtggtcggcatgcagctctttggtaagagctacaaa
gaatgtgtctgcaagatcaatgatgactgtacgctcccacggtggcacatgaacgacttc
ttccactccttcctgattgtgttccgcgtgctgtgtggagagtggatagagaccatgtgg
gactgtatggaggtcgctggccaaaccatgtgccttattgttttcatgttggtcatggtc
attggaaaccttgtggttctgaacctctttctggccttattgttgagttcatttagctca
gacaaccttgctgctactgatgatgacaatgaaatgaataatctgcagattgcagtagga
agaatgcaaaagggaattgattatgtgaaaaataagatgcgggagtgtttccaaaaagcc
ttttttagaaagccaaaagttatagaaatccatgaaggcaataagatagacagctgcatg
tccaataatactggaattgaaataagcaaagagcttaattatcttagagatgggaatgga
accaccagtggtgtaggtactggaagcagtgttgaaaaatacgtaatcgatgaaaatgat
tatatgtcattcataaacaaccccagcctcaccgtcacagtgccaattgctgttggagag
tctgactttgaaaacttaaatactgaagagttcagcagtgagtcagaactagaagaaagc
aaagagaaattaaatgcaaccagctcatctgaaggaagcacagttgatgttgttctaccc
cgagaaggtgaacaagctgaaactgaacccgaagaagaccttaaaccggaagcttgtttt
actgaaggatgtattaaaaagtttccattctgtcaagtaagtacagaagaaggcaaaggg
aagatctggtggaatcttcgaaaaacctgctacagtattgttgagcacaactggtttgag
actttcattgtgttcatgatccttctcagtagtggtgcattggcctttgaagatatatac
attgaacagcgaaagactatcaaaaccatgctagaatatgctgacaaagtctttacctat
atattcattctggaaatgcttctcaaatgggttgcttatggatttcaaacatatttcact
aatgcctggtgctggctagatttcttgatcgttgatgtttctttggttagcctggtagcc
aatgctcttggctactcagaactcggtgccatcaaatcattacggacattaagagcttta
agacctctaagagccttatcccggtttgaaggcatgagggtggttgtgaatgctcttgtt
ggagcaattccctctatcatgaatgtgctgttggtctgtctcatcttctggttgatcttt
agcatcatgggtgtgaatttgtttgctggcaagttctaccactgtgttaacatgacaacg
ggtaacatgtttgacattagtgatgttaacaatttgagtgactgtcaggctcttggcaag
caagctcggtggaaaaacgtgaaagtaaactttgataatgttggcgctggctatcttgca
ctgcttcaagtggccacatttaaaggctggatggatattatgtatgcagctgttgattca
cgagatgttaaacttcagcctgtatatgaagaaaatctgtacatgtatttatactttgtc
atctttatcatctttgggtcattcttcactctgaatctattcattggtgtcatcatagat
aacttcaaccagcagaaaaagaagtttggaggtcaagacatctttatgacagaggaacag
aaaaaatattacaatgcaatgaagaaacttggatccaagaaacctcagaaacccatacct
cgcccagcaaacaaattccaaggaatggtctttgattttgtaaccagacaagtctttgat
atcagcatcatgatcctcatctgcctcaacatggtcaccatgatggtggaaacggatgac
cagggcaaatacatgaccctagttttgtcccggatcaacctagtgttcattgttctgttc
actggagaatttgtgctgaagctcgtctccctcagacactactacttcactataggctgg
aacatctttgactttgtggtggtgattctctccattgtaggtatgtttctggctgagatg
atagaaaagtattttgtgtcccctaccttgttccgagtgatccgtcttgccaggattggc
cgaatcctacgtctgatcaaaggagcaaaggggatccgcacgctgctctttgctttgatg
atgtcccttcctgcgttgtttaacatcggcctcctgctcttcctggtcatgtttatctat
gccatctttgggatgtccaactttgcctatgttaaaaaggaagctggaattgatgacatg
ttcaactttgagacctttggcaacagcatgatctgcttgttccaaattacaacctctgct
ggctgggatggattgctagcacctattcttaatagtgcaccacccgactgtgaccctgac
acaattcaccctggcagctcagttaagggagactgtgggaacccatctgttgggattttc
ttttttgtcagttacatcatcatatccttcctggttgtggtgaacatgtacatcgcggtc
atcctggagaacttcagtgttgctactgaagaaagtgcagagcccctgagtgaggatgac
tttgagatgttctatgaggtttgggaaaagtttgatcccgatgcgacccagtttatagag
ttctctaaactctctgattttgcagctgccctggatcctcctcttctcatagcaaaaccc
aacaaagtccagcttattgccatggatctgcccatggtcagtggtgaccggatccactgt
cttgatattttatttgcctttacaaagcgtgttttgggtgagagtggagagatggatgcc
cttcgaatacagatggaagacaggtttatggcatcaaacccctccaaagtctcttatgag
cctattacaaccactttgaaacgtaaacaagaggaggtgtctgccgctatcattcagcgt
aatttcagatgttatcttttaaagcaaaggttaaaaaatatatcaagtaactataacaaa
gaggcaattaaagggaggattgacttacctataaaacaagacatgattattgacaaacta
aatgggaactccactccagaaaaaacagatgggagttcctctaccacctctcctccttcc
tatgatagtgtaacaaaaccagacaaggaaaagtttgagaaagacaaaccagaaaaagaa
agcaaaggaaaagaggtcagagaaaatcaaaagtaa
DBGET
integrated database retrieval system
